JP2008516964A5 - - Google Patents

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Publication number
JP2008516964A5
JP2008516964A5 JP2007536876A JP2007536876A JP2008516964A5 JP 2008516964 A5 JP2008516964 A5 JP 2008516964A5 JP 2007536876 A JP2007536876 A JP 2007536876A JP 2007536876 A JP2007536876 A JP 2007536876A JP 2008516964 A5 JP2008516964 A5 JP 2008516964A5
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JP
Japan
Prior art keywords
pyrazol
phenyl
ethyl
compound
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007536876A
Other languages
English (en)
Japanese (ja)
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JP2008516964A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2005/036801 external-priority patent/WO2006044528A1/en
Publication of JP2008516964A publication Critical patent/JP2008516964A/ja
Publication of JP2008516964A5 publication Critical patent/JP2008516964A5/ja
Pending legal-status Critical Current

Links

JP2007536876A 2004-10-15 2005-10-14 ホスホジエステラーゼ４阻害剤としてのピラゾール誘導体 Pending JP2008516964A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61872504P 2004-10-15 2004-10-15
PCT/US2005/036801 WO2006044528A1 (en) 2004-10-15 2005-10-14 Pyrazole derivatives as phosphodiesterase 4 inhibitors

Publications (2)

Publication Number Publication Date
JP2008516964A JP2008516964A (ja) 2008-05-22
JP2008516964A5 true JP2008516964A5 (cg-RX-API-DMAC7.html) 2008-12-04

Family

ID=35759321

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007536876A Pending JP2008516964A (ja) 2004-10-15 2005-10-14 ホスホジエステラーゼ４阻害剤としてのピラゾール誘導体

Country Status (7)

Country Link
US (2) US7432266B2 (cg-RX-API-DMAC7.html)
EP (1) EP1799673A1 (cg-RX-API-DMAC7.html)
JP (1) JP2008516964A (cg-RX-API-DMAC7.html)
CN (1) CN101166733A (cg-RX-API-DMAC7.html)
AU (1) AU2005295753A1 (cg-RX-API-DMAC7.html)
CA (1) CA2584317A1 (cg-RX-API-DMAC7.html)
WO (1) WO2006044528A1 (cg-RX-API-DMAC7.html)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0612287A8 (pt) * 2005-06-27 2019-01-22 Exelixis Inc composição para uso farmacêutico no tratamento de doenças através da medicina nuclear e métodos de uso e para modulação de atividade de receptor nuclear
WO2007123953A2 (en) * 2006-04-19 2007-11-01 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
US20090318385A1 (en) * 2006-09-06 2009-12-24 Yasushi Kohno Pyrazolopyride derivative and phosphodiesterase ( pde) inhibitors containing the same as active ingredient
US7825261B2 (en) * 2006-12-05 2010-11-02 National Taiwan University Indazole compounds
KR20090094125A (ko) 2006-12-08 2009-09-03 엑셀리시스, 인코포레이티드 Ｌｘｒ 및 ｆｘｒ 조절자
FR2916758B1 (fr) * 2007-06-04 2009-10-09 Sanofi Aventis Sa Derives de 1-benzylpyrazole, leur preparation et leur application en therapeutique
TW200914048A (en) * 2007-07-17 2009-04-01 Combinatorx Inc Combinations for the treatment of B-cell proliferative disorders
AU2008276451A1 (en) * 2007-07-17 2009-01-22 Zalicus Inc. Treatments of B-cell proliferative disorders
US20100009934A1 (en) * 2008-06-09 2010-01-14 Combinatorx, Incorporated Beta adrenergic receptor agonists for the treatment of b-cell proliferative disorders
WO2014117947A1 (en) 2013-02-04 2014-08-07 Grünenthal GmbH 4-amino substituted condensed pyrimidine compounds as pde4 inhibitors
CN104230890A (zh) * 2013-06-19 2014-12-24 信诺凯（北京）化工有限公司 吡啶-2-胺衍生物及其制法和药物组合物与用途
AU2014307803A1 (en) 2013-08-16 2016-03-10 Universiteit Maastricht Treatment of cognitive impairment with PDE4 inhibitor
CN105085428B (zh) * 2014-04-25 2019-03-22 广东东阳光药业有限公司 芳杂环类衍生物及其在药物上的应用
KR20180030201A (ko) * 2015-07-23 2018-03-21 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 화합물
CN106188027B (zh) * 2015-09-02 2020-10-20 广东东阳光药业有限公司 芳杂环类衍生物及其在药物中的应用
EP3347353B1 (en) * 2015-09-11 2019-07-17 Boehringer Ingelheim International GmbH Pyrazolyl-substituted heteroaryls and their use as medicaments
WO2022063050A1 (zh) * 2020-09-28 2022-03-31 四川科伦博泰生物医药股份有限公司 吡唑类化合物及其制备方法和用途
TW202539646A (zh) * 2024-03-29 2025-10-16 瑞士商百濟神州瑞士有限責任公司 Kat6抑制劑

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4193926A (en) 1974-03-20 1980-03-18 Schering Aktiengesellschaft 4-(Polyalkoxy phenyl)-2-pyrrolidones
DE2413935A1 (de) 1974-03-20 1975-10-16 Schering Ag 4-(polyalkoxy-phenyl)-2-pyrrolidone
DE2834114A1 (de) 1978-08-01 1980-02-14 Schering Ag Polyalkoxyphenylpyrrolidone iii, verfahren zu ihrer herstellung und ihre verwendung
DE3921593A1 (de) 1989-06-28 1991-01-10 Schering Ag Verfahren zur racemattrennung von 4-aryl-2-oxo-pyrrolidin-3-carbonsaeure-ester
US5935978A (en) 1991-01-28 1999-08-10 Rhone-Poulenc Rorer Limited Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group
PT100441A (pt) 1991-05-02 1993-09-30 Smithkline Beecham Corp Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso
AU2869092A (en) 1991-10-11 1993-05-03 Smithkline Beecham Corporation Heterocyclic 3-phenylpyrrolidin-2-ones, their preparation and use for the manufacture of a medicament for inhibiting tumor necrosis factor production
ES2102036T3 (es) 1992-06-15 1997-07-16 Celltech Therapeutics Ltd Derivados con grupo fenilo trisustituido utilizados como inhibidores selectivos de la fosfodiesterasa iv.
US5814651A (en) 1992-12-02 1998-09-29 Pfizer Inc. Catechol diethers as selective PDEIV inhibitors
TW263495B (cg-RX-API-DMAC7.html) 1992-12-23 1995-11-21 Celltech Ltd
ES2293638T3 (es) 1994-03-25 2008-03-16 Isotechnika, Inc. Mejora de la eficacia de farmacos por deuteracion.
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
DK0758233T3 (da) 1994-04-21 2004-03-22 Schering Ag PDE IV-inhibitorer til behandling af multipel sklerose
GB9412383D0 (en) 1994-06-21 1994-08-10 Celltech Ltd Chemical compound
DE19518082A1 (de) 1995-05-17 1996-11-21 Merck Patent Gmbh 4(-Arylaminomethylen)-2,4-dihydropyrazol-3-one
WO1997012884A1 (en) * 1995-10-04 1997-04-10 Fmc Corporation Herbicidal 6-heterocyclic indazole derivatives
DE19601938A1 (de) 1996-01-12 1997-07-17 Schering Ag Neue Phosphodiesteraseinhibitoren
SI0912558T1 (en) * 1996-06-25 2003-10-31 Pfizer Inc. Substituted indazole derivatives and their use as phosphodiesterase (pde) type iv and tumor necrosis factor (tnf) inhibitors
JPH1072415A (ja) 1996-06-26 1998-03-17 Nikken Chem Co Ltd ３−アニリノ−２−シクロアルケノン誘導体
GB9622386D0 (en) 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
CA2295106C (en) 1997-06-24 2007-03-13 Nikken Chemicals Co., Ltd. 3-anilino-2-cycloalkenone derivatives
US6403597B1 (en) 1997-10-28 2002-06-11 Vivus, Inc. Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
IL135714A0 (en) * 1997-11-04 2001-05-20 Pfizer Prod Inc Therapeutically active compounds based on indazole bioisostere replacement of catechol in pde4 inhibitors
AU4308300A (en) * 1999-05-03 2000-11-17 Dr. Reddy's Research Foundation Pyrazoles having antiinflammatory activity
JP2001039954A (ja) * 1999-05-24 2001-02-13 Tomono Agrica Co Ltd ヘテロ環誘導体
OA12100A (en) * 1999-12-03 2006-05-04 Pfizer Prod Inc Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents.
US6372777B1 (en) 1999-12-23 2002-04-16 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
US6258833B1 (en) 1999-12-23 2001-07-10 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
GB0003257D0 (en) * 2000-02-11 2000-04-05 Darwin Discovery Ltd Heterocyclic compounds and their therapeutic use
CA2402384A1 (en) 2000-03-16 2001-09-20 Inflazyme Pharmaceuticals Ltd. Benzylated pde4 inhibitors
AU2001255600A1 (en) * 2000-04-25 2001-11-07 Pharmacia Corporation Regioselective synthesis of 3,4-di(carbocyclyl or heterocyclyl)thiophenes
EP1343528A2 (en) 2000-11-02 2003-09-17 Research Foundation of City University of New York Methods for stimulating nervous system regeneration and repair by inhibition phosphodiesterase type 4
US6495154B1 (en) 2000-11-21 2002-12-17 Vivus Inc. On demand administration of clomipramine and salts thereof to treat premature ejaculation
US6673818B2 (en) * 2001-04-20 2004-01-06 Pharmacia Corporation Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
US7074801B1 (en) * 2001-04-26 2006-07-11 Eisai Co., Ltd. Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof
US20030162824A1 (en) * 2001-11-12 2003-08-28 Krul Elaine S. Methods of treating or preventing a cardiovascular condition using a cyclooxygenase-1 inhibitor
PT1492773E (pt) * 2002-04-05 2009-05-07 Cadila Healthcare Ltd Compostos de 4-(heterociclilo)-benzenossulfoximinapara o tratamento da inflamação
UA79804C2 (en) * 2002-07-03 2007-07-25 Janssen Pharmaceutica Nv Cck-1 receptor modulators
WO2004033432A1 (ja) * 2002-10-09 2004-04-22 Ssp Co., Ltd. 抗真菌活性を有する新規ピラゾール化合物
EP1631568A1 (en) * 2003-04-18 2006-03-08 Memory Pharmaceuticals Corporation Pyrazole derivatives as phosphodiesterase 4 inhibitors
HUP0304101A3 (en) * 2003-12-22 2008-10-28 Sanofi Aventis Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates
WO2007123953A2 (en) * 2006-04-19 2007-11-01 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors

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