JP2008516610A5 - - Google Patents

Info

Publication number

JP2008516610A5

JP2008516610A5 JP2007537026A JP2007537026A JP2008516610A5 JP 2008516610 A5 JP2008516610 A5 JP 2008516610A5 JP 2007537026 A JP2007537026 A JP 2007537026A JP 2007537026 A JP2007537026 A JP 2007537026A JP 2008516610 A5 JP2008516610 A5 JP 2008516610A5

Authority

JP

Japan

Prior art keywords

hcv

protein

seq

positions

fusion protein

Prior art date

2005-10-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 239000000203 mixture Substances 0.000 claims 51
• 108020001507 fusion proteins Proteins 0.000 claims 38
• 102000037865 fusion proteins Human genes 0.000 claims 38
• 230000002163 immunogen Effects 0.000 claims 18
• 240000004808 Saccharomyces cerevisiae Species 0.000 claims 17
• 239000003981 vehicle Substances 0.000 claims 16
• 108700039791 Hepatitis C virus nucleocapsid Proteins 0.000 claims 14
• 230000028993 immune response Effects 0.000 claims 14
• 235000018102 proteins Nutrition 0.000 claims 14
• 102000004169 proteins and genes Human genes 0.000 claims 14
• 108090000623 proteins and genes Proteins 0.000 claims 14
• 150000001413 amino acids Chemical class 0.000 claims 11
• 108700008783 Hepatitis C virus E1 Proteins 0.000 claims 10
• 101710144111 Non-structural protein 3 Proteins 0.000 claims 10
• 101800001838 Serine protease/helicase NS3 Proteins 0.000 claims 10
• 235000001014 amino acid Nutrition 0.000 claims 10
• 238000000034 method Methods 0.000 claims 8
• SHFKGANKURXVMY-LCWPZEQJSA-N hcv e2 protein Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)CC1=CC=CC=C1 SHFKGANKURXVMY-LCWPZEQJSA-N 0.000 claims 6
• 150000007523 nucleic acids Chemical class 0.000 claims 6
• 108020004707 nucleic acids Proteins 0.000 claims 5
• 102000039446 nucleic acids Human genes 0.000 claims 5
• 239000000427 antigen Substances 0.000 claims 4
• 108091007433 antigens Proteins 0.000 claims 4
• 102000036639 antigens Human genes 0.000 claims 4
• 238000009472 formulation Methods 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 102100038132 Endogenous retrovirus group K member 6 Pro protein Human genes 0.000 claims 2
• 108060004795 Methyltransferase Proteins 0.000 claims 2
• 230000024932 T cell mediated immunity Effects 0.000 claims 2
• 210000004899 c-terminal region Anatomy 0.000 claims 2
• 230000003197 catalytic effect Effects 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 108700008776 hepatitis C virus NS-5 Proteins 0.000 claims 2
• 230000002209 hydrophobic effect Effects 0.000 claims 2
• 230000003053 immunization Effects 0.000 claims 2
• 230000001939 inductive effect Effects 0.000 claims 2
• 101710121417 Envelope glycoprotein Proteins 0.000 claims 1
• 101710125507 Integrase/recombinase Proteins 0.000 claims 1
• 102000004310 Ion Channels Human genes 0.000 claims 1
• 102000005741 Metalloproteases Human genes 0.000 claims 1
• 108010006035 Metalloproteases Proteins 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• 108091005804 Peptidases Proteins 0.000 claims 1
• 108010076039 Polyproteins Proteins 0.000 claims 1
• 239000004365 Protease Substances 0.000 claims 1
• 101710185720 Putative ethidium bromide resistance protein Proteins 0.000 claims 1
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
• 101800001473 Spike glycoprotein E2 Proteins 0.000 claims 1
• 230000005856 abnormality Effects 0.000 claims 1
• 235000004279 alanine Nutrition 0.000 claims 1
• 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
• 230000008512 biological response Effects 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000004927 fusion Effects 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 239000003607 modifier Substances 0.000 claims 1
• 230000035772 mutation Effects 0.000 claims 1
• 230000002797 proteolythic effect Effects 0.000 claims 1
• 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1