JP2008514655A - 凝固因子Ｘａの阻害剤として用いられるカルボニル化合物 - Google Patents
凝固因子Ｘａの阻害剤として用いられるカルボニル化合物 Download PDFInfo
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- JP2008514655A JP2008514655A JP2007533891A JP2007533891A JP2008514655A JP 2008514655 A JP2008514655 A JP 2008514655A JP 2007533891 A JP2007533891 A JP 2007533891A JP 2007533891 A JP2007533891 A JP 2007533891A JP 2008514655 A JP2008514655 A JP 2008514655A
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- diyl
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- hal
- mono
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Hematology (AREA)
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- Hospice & Palliative Care (AREA)
- Surgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004047254A DE102004047254A1 (de) | 2004-09-29 | 2004-09-29 | Carbonylverbindungen |
| PCT/EP2005/009418 WO2006034769A1 (de) | 2004-09-29 | 2005-09-01 | Carbonylverbindungen verwendbar als inhibitoren des koagulationsfaktors xa |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008514655A true JP2008514655A (ja) | 2008-05-08 |
| JP2008514655A5 JP2008514655A5 (https=) | 2008-10-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007533891A Pending JP2008514655A (ja) | 2004-09-29 | 2005-09-01 | 凝固因子Ｘａの阻害剤として用いられるカルボニル化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20080081814A1 (https=) |
| EP (1) | EP1797071A1 (https=) |
| JP (1) | JP2008514655A (https=) |
| KR (1) | KR20070057878A (https=) |
| CN (1) | CN101031561A (https=) |
| AU (1) | AU2005289164A1 (https=) |
| BR (1) | BRPI0515577A (https=) |
| CA (1) | CA2581732A1 (https=) |
| DE (1) | DE102004047254A1 (https=) |
| MX (1) | MX2007003470A (https=) |
| RU (1) | RU2007116036A (https=) |
| WO (1) | WO2006034769A1 (https=) |
| ZA (1) | ZA200703443B (https=) |
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| USRE50453E1 (en) | 2006-04-07 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| EP2674428B1 (en) | 2006-04-07 | 2016-04-06 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US8673920B2 (en) | 2009-05-06 | 2014-03-18 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| MX353408B (es) | 2010-04-22 | 2018-01-11 | Vertex Pharma | Proceso para producir compuestos de cicloalquilcarboxamido-indol. |
| WO2012058116A1 (en) | 2010-10-27 | 2012-05-03 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| EP2632464B1 (en) | 2010-10-29 | 2015-04-29 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| AU2012299227A1 (en) | 2011-08-19 | 2014-02-20 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| WO2013039802A1 (en) | 2011-09-16 | 2013-03-21 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| EP2771004B1 (en) | 2011-10-25 | 2016-05-18 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| US8999990B2 (en) | 2011-10-25 | 2015-04-07 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| EP2773206B1 (en) | 2011-10-31 | 2018-02-21 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| WO2013066714A1 (en) | 2011-10-31 | 2013-05-10 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| EP2773351B1 (en) | 2011-10-31 | 2017-08-23 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| EP2790511B1 (en) | 2011-12-16 | 2016-09-14 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| JP5903499B2 (ja) | 2011-12-22 | 2016-04-13 | ノバルティス アーゲー | ジヒドロ−ベンゾ−オキサジンおよびジヒドロ−ピリド−オキサジン誘導体 |
| AR092857A1 (es) | 2012-07-16 | 2015-05-06 | Vertex Pharma | Composiciones farmaceuticas de (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)-n-(1-(2,3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-il)-1h-indol-5-il)ciclopropancarboxamida y administracion de las mismas |
| AR092031A1 (es) | 2012-07-26 | 2015-03-18 | Merck Sharp & Dohme | Inhibidores del canal de potasio medular externo renal |
| EP2925322B1 (en) | 2012-11-29 | 2018-10-24 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| US9573961B2 (en) | 2012-12-19 | 2017-02-21 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| WO2014126944A2 (en) | 2013-02-18 | 2014-08-21 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| EP2968288B1 (en) | 2013-03-15 | 2018-07-04 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| EP3027625B1 (en) | 2013-07-31 | 2018-05-30 | Merck Sharp & Dohme Corp. | Spiro-fused derivatives of piperidine useful for the treatment of inter alia hypertension and acute or chronic heart failure |
| RU2744460C2 (ru) | 2014-04-15 | 2021-03-09 | Вертекс Фармасьютикалз Инкорпорейтед | Фармацевтические композиции для лечения заболеваний, опосредованных муковисцидозным трансмембранным регулятором проводимости |
| WO2016127358A1 (en) | 2015-02-12 | 2016-08-18 | Merck Sharp & Dohme Corp. | Inhibitors of renal outer medullary potassium channel |
| US10669528B2 (en) | 2015-06-25 | 2020-06-02 | Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance |
| WO2017161001A1 (en) | 2016-03-15 | 2017-09-21 | Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion |
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| CN108997200A (zh) * | 2018-07-17 | 2018-12-14 | 成都睿智化学研究有限公司 | 一种5-氨甲基-哌啶-2-酮的制备方法 |
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| WO2003045912A1 (en) * | 2001-11-29 | 2003-06-05 | Warner-Lambert Company Llc | Inhibitors of factor xa and other serine proteases involved in the coagulation cascade |
| JP2008513387A (ja) * | 2004-09-22 | 2008-05-01 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | カルボニル化合物を含む医薬およびこの使用 |
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|---|---|---|---|---|
| PL377633A1 (pl) * | 2003-04-03 | 2006-02-06 | Merck Patent Gmbh | Związki karbonylowe |
| DE10329457A1 (de) * | 2003-04-03 | 2005-01-20 | Merck Patent Gmbh | Ethinylprolinderivate |
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2004
- 2004-09-29 DE DE102004047254A patent/DE102004047254A1/de not_active Withdrawn
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2005
- 2005-09-01 CA CA002581732A patent/CA2581732A1/en not_active Abandoned
- 2005-09-01 MX MX2007003470A patent/MX2007003470A/es not_active Application Discontinuation
- 2005-09-01 CN CNA2005800327898A patent/CN101031561A/zh active Pending
- 2005-09-01 RU RU2007116036/04A patent/RU2007116036A/ru unknown
- 2005-09-01 BR BRPI0515577-0A patent/BRPI0515577A/pt not_active Application Discontinuation
- 2005-09-01 KR KR1020077007053A patent/KR20070057878A/ko not_active Withdrawn
- 2005-09-01 US US11/576,207 patent/US20080081814A1/en not_active Abandoned
- 2005-09-01 EP EP05790356A patent/EP1797071A1/de not_active Withdrawn
- 2005-09-01 JP JP2007533891A patent/JP2008514655A/ja active Pending
- 2005-09-01 WO PCT/EP2005/009418 patent/WO2006034769A1/de not_active Ceased
- 2005-09-01 AU AU2005289164A patent/AU2005289164A1/en not_active Abandoned
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003045912A1 (en) * | 2001-11-29 | 2003-06-05 | Warner-Lambert Company Llc | Inhibitors of factor xa and other serine proteases involved in the coagulation cascade |
| JP2008513387A (ja) * | 2004-09-22 | 2008-05-01 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | カルボニル化合物を含む医薬およびこの使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20080081814A1 (en) | 2008-04-03 |
| AU2005289164A1 (en) | 2006-04-06 |
| CN101031561A (zh) | 2007-09-05 |
| MX2007003470A (es) | 2007-05-10 |
| ZA200703443B (en) | 2008-08-27 |
| WO2006034769A1 (de) | 2006-04-06 |
| KR20070057878A (ko) | 2007-06-07 |
| BRPI0515577A (pt) | 2008-07-29 |
| CA2581732A1 (en) | 2006-04-06 |
| DE102004047254A1 (de) | 2006-04-13 |
| EP1797071A1 (de) | 2007-06-20 |
| RU2007116036A (ru) | 2008-11-10 |
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