JP2008514225A5 - - Google Patents
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- Publication number
- JP2008514225A5 JP2008514225A5 JP2007534176A JP2007534176A JP2008514225A5 JP 2008514225 A5 JP2008514225 A5 JP 2008514225A5 JP 2007534176 A JP2007534176 A JP 2007534176A JP 2007534176 A JP2007534176 A JP 2007534176A JP 2008514225 A5 JP2008514225 A5 JP 2008514225A5
- Authority
- JP
- Japan
- Prior art keywords
- collagen
- chain
- plant
- exogenous
- genetically modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000196324 Embryophyta Species 0.000 claims 40
- 108010035532 Collagen Proteins 0.000 claims 31
- 102000008186 Collagen Human genes 0.000 claims 31
- 229920001436 collagen Polymers 0.000 claims 31
- 238000000034 method Methods 0.000 claims 20
- 210000003934 vacuole Anatomy 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 8
- 230000008685 targeting Effects 0.000 claims 7
- 101710096389 Collagen alpha chain Proteins 0.000 claims 6
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 6
- 108060002894 fibrillar collagen Proteins 0.000 claims 5
- 102000013373 fibrillar collagen Human genes 0.000 claims 5
- 210000004899 c-terminal region Anatomy 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108010042388 protease C Proteins 0.000 claims 3
- 108010043393 protease N Proteins 0.000 claims 3
- 230000000640 hydroxylating effect Effects 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 235000014698 Brassica juncea var multisecta Nutrition 0.000 claims 1
- 235000006008 Brassica napus var napus Nutrition 0.000 claims 1
- 240000000385 Brassica napus var. napus Species 0.000 claims 1
- 235000006618 Brassica rapa subsp oleifera Nutrition 0.000 claims 1
- 235000004977 Brassica sinapistrum Nutrition 0.000 claims 1
- 108010022452 Collagen Type I Proteins 0.000 claims 1
- 102000012422 Collagen Type I Human genes 0.000 claims 1
- 229920000742 Cotton Polymers 0.000 claims 1
- 244000000626 Daucus carota Species 0.000 claims 1
- 235000002767 Daucus carota Nutrition 0.000 claims 1
- 244000068988 Glycine max Species 0.000 claims 1
- 235000010469 Glycine max Nutrition 0.000 claims 1
- 244000299507 Gossypium hirsutum Species 0.000 claims 1
- 240000005979 Hordeum vulgare Species 0.000 claims 1
- 235000007340 Hordeum vulgare Nutrition 0.000 claims 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims 1
- 240000004658 Medicago sativa Species 0.000 claims 1
- 235000017587 Medicago sativa ssp. sativa Nutrition 0.000 claims 1
- 244000061176 Nicotiana tabacum Species 0.000 claims 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 1
- 240000007594 Oryza sativa Species 0.000 claims 1
- 235000007164 Oryza sativa Nutrition 0.000 claims 1
- 108010050808 Procollagen Proteins 0.000 claims 1
- 240000003768 Solanum lycopersicum Species 0.000 claims 1
- 244000061456 Solanum tuberosum Species 0.000 claims 1
- 235000002595 Solanum tuberosum Nutrition 0.000 claims 1
- 241000218632 Strawberry vein banding virus Species 0.000 claims 1
- 235000021307 Triticum Nutrition 0.000 claims 1
- 244000098338 Triticum aestivum Species 0.000 claims 1
- 102400000757 Ubiquitin Human genes 0.000 claims 1
- 108090000848 Ubiquitin Proteins 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 240000008042 Zea mays Species 0.000 claims 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 235000005822 corn Nutrition 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000033444 hydroxylation Effects 0.000 claims 1
- 238000005805 hydroxylation reaction Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 1
- 235000009566 rice Nutrition 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61371904P | 2004-09-29 | 2004-09-29 | |
| US60/613,719 | 2004-09-29 | ||
| PCT/IL2005/001045 WO2006035442A2 (en) | 2004-09-29 | 2005-09-28 | Collagen producing plants and methods of generating and using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011259678A Division JP5517309B2 (ja) | 2004-09-29 | 2011-11-29 | コラーゲン生産植物及びその作成方法及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008514225A JP2008514225A (ja) | 2008-05-08 |
| JP2008514225A5 true JP2008514225A5 (enExample) | 2008-11-06 |
| JP5100386B2 JP5100386B2 (ja) | 2012-12-19 |
Family
ID=35788568
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007534176A Expired - Lifetime JP5100386B2 (ja) | 2004-09-29 | 2005-09-28 | コラーゲン生産植物及びその作成方法及びその使用 |
| JP2011259678A Expired - Fee Related JP5517309B2 (ja) | 2004-09-29 | 2011-11-29 | コラーゲン生産植物及びその作成方法及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011259678A Expired - Fee Related JP5517309B2 (ja) | 2004-09-29 | 2011-11-29 | コラーゲン生産植物及びその作成方法及びその使用 |
Country Status (14)
| Country | Link |
|---|---|
| EP (6) | EP3088528B1 (enExample) |
| JP (2) | JP5100386B2 (enExample) |
| KR (1) | KR20070083870A (enExample) |
| CN (1) | CN101065491B (enExample) |
| AT (1) | ATE479762T1 (enExample) |
| BR (1) | BRPI0516303B1 (enExample) |
| CA (1) | CA2582051C (enExample) |
| DE (1) | DE602005023332D1 (enExample) |
| HK (1) | HK1251611B (enExample) |
| IL (1) | IL182320A (enExample) |
| MX (1) | MX2007003767A (enExample) |
| NZ (1) | NZ554787A (enExample) |
| WO (1) | WO2006035442A2 (enExample) |
| ZA (1) | ZA200703369B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6639050B1 (en) | 1997-07-21 | 2003-10-28 | Ohio University | Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins |
| US7378506B2 (en) | 1997-07-21 | 2008-05-27 | Ohio University | Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins |
| NZ548513A (en) | 2004-01-14 | 2010-05-28 | Univ Ohio | Methods of producing peptides/proteins in plants and peptides/proteins produced thereby |
| WO2005110015A2 (en) | 2004-04-19 | 2005-11-24 | Ohio University | Cross-linkable glycoproteins and methods of making the same |
| WO2006035442A2 (en) | 2004-09-29 | 2006-04-06 | Collplant Ltd. | Collagen producing plants and methods of generating and using same |
| US8455717B2 (en) | 2004-09-29 | 2013-06-04 | Collplant Ltd. | Collagen producing plants and methods of generating and using same |
| EP2084285A4 (en) * | 2006-07-10 | 2010-01-13 | Univ Ohio | COEXPRESSION OF PROLIN HYDROXYLASES TO FACILITATE HYP-GLYCOSYLATION OF PROTEINS EXPRESSED AND SEPARATED IN PLANT CELLS |
| EP2220246B1 (en) | 2007-10-26 | 2015-05-20 | Collplant Ltd. | Methods of processing recombinant procollagen |
| AU2008331099B2 (en) * | 2007-11-26 | 2013-10-24 | Collplant Ltd. | Compositions comprising fibrous polypeptides and polysaccharides |
| CA2721507C (en) * | 2008-04-18 | 2017-10-03 | Collplant Ltd. | Methods of generating and using procollagen |
| WO2011064773A1 (en) | 2009-11-24 | 2011-06-03 | Collplant Ltd. | Method of generating collagen fibers |
| US20130230573A1 (en) | 2010-11-16 | 2013-09-05 | Oded Shoseyov | Collagen structures and method of fabricating the same |
| WO2013030840A2 (en) | 2011-09-01 | 2013-03-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Adhesive biopolymers and uses thereof |
| WO2013093921A1 (en) | 2011-12-20 | 2013-06-27 | Collplant Ltd. | Collagen coated synthetic polymer fibers |
| KR102063686B1 (ko) * | 2012-01-02 | 2020-02-11 | (주)아모레퍼시픽 | 콩뿌리 추출물을 함유하는 피부 외용제 조성물 |
| WO2014147622A1 (en) | 2013-03-21 | 2014-09-25 | Collplant Ltd. | Compositions comprising collagen and prp for tissue regeneration |
| WO2014146175A1 (en) | 2013-03-21 | 2014-09-25 | Commonwealth Scientific And Industrial Research Organisation | Purification of triple helical proteins |
| GB201308120D0 (en) * | 2013-05-06 | 2013-06-12 | Baden Wuerttemberg Stiftung Gmbh | Recombinant protein and method for its production |
| TWI738631B (zh) | 2013-09-09 | 2021-09-11 | 德商贏創運營有限公司 | 經修飾之細菌類膠原蛋白蛋白質 |
| EA038931B9 (ru) | 2014-11-20 | 2022-02-18 | Йиссум Рисерч Дивелопмент Компани Оф Зе Хебрю Юниверсити Оф Иерусалим Лтд. | Композиции и способы получения полипептидов с модифицированным профилем гликозилирования в клетках растений |
| EP3634512A4 (en) | 2017-06-09 | 2021-04-14 | CollPlant Ltd. | GENERATIVE MANUFACTURING USING A RECOMBINANT COLLAGEN-CONTAINING FORMULATION |
| WO2019056377A1 (zh) * | 2017-09-25 | 2019-03-28 | 吴侑峻 | 非人类转基因哺乳动物及从其结缔组织分离的蛋白质粗萃物及其方法与用途 |
| IL306070A (en) | 2018-05-03 | 2023-11-01 | Collplant Ltd | Dermal fillers and their uses |
| KR20210042430A (ko) | 2018-07-31 | 2021-04-19 | 콜플랜트 리미티드 | 담배 형질전환 이벤트 및 이의 검출 방법 및 용도 |
| CN109988234A (zh) * | 2019-02-20 | 2019-07-09 | 江苏悦智生物医药有限公司 | 酵母重组人源I型胶原α1链蛋白、合成方法及其应用 |
| WO2021094947A1 (en) * | 2019-11-11 | 2021-05-20 | Kamcharov Alexander Evgenievich | Beverage with collagen and additional additives |
| FR3105792B1 (fr) | 2019-12-26 | 2022-08-12 | Michel Assor | Matériau biocomposite collagène/matrice polymérique poreuse et son utilisation comme implant de réparation de lésions méniscales du genou et/ou de prévention ou de traitement de l’arthrose du genou |
| WO2021229577A1 (en) | 2020-05-12 | 2021-11-18 | Collplant Ltd. | Collagen as a delivery tool for metal-based anti-viral agents |
| CN119173524A (zh) | 2022-04-04 | 2024-12-20 | 斯威夫特制药有限责任公司 | 在植物中产生的重组蜘蛛丝强化的胶原蛋白及其应用 |
| KR20250046260A (ko) * | 2022-08-02 | 2025-04-02 | 가부시키가이샤 유니바이오 | 콜라겐 산생 방법 |
| CN117209592A (zh) * | 2023-07-26 | 2023-12-12 | 浙江大学 | 一种人源化i型胶原蛋白及其制备方法与应用 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| CA1192510A (en) | 1981-05-27 | 1985-08-27 | Lawrence E. Pelcher | Rna plant virus vector or portion thereof, a method of construction thereof, and a method of producing a gene derived product therefrom |
| JPS6054684A (ja) | 1983-09-05 | 1985-03-29 | Teijin Ltd | 新規ｄνａ及びハイブリツドｄνａ |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| CA1288073C (en) | 1985-03-07 | 1991-08-27 | Paul G. Ahlquist | Rna transformation vector |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| GB8608850D0 (en) | 1986-04-11 | 1986-05-14 | Diatech Ltd | Packaging system |
| JPS6314693A (ja) | 1986-07-04 | 1988-01-21 | Sumitomo Chem Co Ltd | 植物ウイルスｒｎａベクタ− |
| ES2060646T3 (es) | 1987-02-09 | 1994-12-01 | Lubrizol Genetics Inc | Virus rna hibrido. |
| US5316931A (en) | 1988-02-26 | 1994-05-31 | Biosource Genetics Corp. | Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes |
| US5693507A (en) | 1988-09-26 | 1997-12-02 | Auburn University | Genetic engineering of plant chloroplasts |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5593859A (en) | 1991-10-23 | 1997-01-14 | Thomas Jefferson University | Synthesis of human procollagens and collagens in recombinant DNA systems |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| FR2757874B1 (fr) | 1996-12-17 | 2003-04-25 | Biocem | Collagenes recombinants et proteines derivees produits par les plantes, leurs procedes d'obtention et leurs utilisations |
| AU746032B2 (en) | 1997-09-30 | 2002-04-11 | Regents Of The University Of California, The | Production of proteins in plant seeds |
| WO2001029242A2 (en) * | 1999-10-21 | 2001-04-26 | Monsanto Company | Post-translational modification of recombinant proteins produced in plants |
| CN1285612C (zh) * | 1999-11-12 | 2006-11-22 | 法布罗根股份有限公司 | 动物胶原和明胶 |
| RU2002112750A (ru) * | 1999-11-12 | 2004-01-27 | Файброджен, Инк. (Us) | Коллагены и желатины животного происхождения |
| JP2005525081A (ja) * | 2001-06-05 | 2005-08-25 | カレン ケイ． オオイシ | 植物からの生物活性ミュラー管抑制物質を含むＴＧＦ−βタンパク質の遺伝子発現および産生法 |
| JP4426307B2 (ja) * | 2002-02-08 | 2010-03-03 | ノボザイムス アクティーゼルスカブ | フィターゼ変異体 |
| BR0317304A (pt) * | 2002-12-19 | 2005-11-08 | Univ Bristol | Processo para a produção de compostos, sequência de ácido nucleico isolada, sequência de aminoácidos, construção gênica, vetor, e, organismo |
| AU2003293906A1 (en) * | 2002-12-20 | 2004-07-22 | Basf Aktiengesellschaft | Malate dehydrogenase as a target for herbicides |
| WO2006035442A2 (en) | 2004-09-29 | 2006-04-06 | Collplant Ltd. | Collagen producing plants and methods of generating and using same |
-
2005
- 2005-09-28 WO PCT/IL2005/001045 patent/WO2006035442A2/en not_active Ceased
- 2005-09-28 EP EP16171177.5A patent/EP3088528B1/en active Active
- 2005-09-28 EP EP05789469A patent/EP1809751B1/en not_active Revoked
- 2005-09-28 BR BRPI0516303-0A patent/BRPI0516303B1/pt active IP Right Grant
- 2005-09-28 NZ NZ554787A patent/NZ554787A/en not_active IP Right Cessation
- 2005-09-28 EP EP10168971.9A patent/EP2357241B1/en not_active Revoked
- 2005-09-28 KR KR1020077009817A patent/KR20070083870A/ko not_active Withdrawn
- 2005-09-28 AT AT05789469T patent/ATE479762T1/de not_active IP Right Cessation
- 2005-09-28 EP EP14185576.7A patent/EP2816117B1/en not_active Revoked
- 2005-09-28 EP EP17205280.5A patent/EP3312282B1/en not_active Expired - Lifetime
- 2005-09-28 MX MX2007003767A patent/MX2007003767A/es active IP Right Grant
- 2005-09-28 EP EP10181115A patent/EP2360261A1/en not_active Ceased
- 2005-09-28 JP JP2007534176A patent/JP5100386B2/ja not_active Expired - Lifetime
- 2005-09-28 CA CA2582051A patent/CA2582051C/en active Active
- 2005-09-28 DE DE602005023332T patent/DE602005023332D1/de active Active
- 2005-09-28 CN CN2005800408217A patent/CN101065491B/zh not_active Expired - Lifetime
-
2007
- 2007-03-29 IL IL182320A patent/IL182320A/en active IP Right Grant
- 2007-04-25 ZA ZA200703369A patent/ZA200703369B/xx unknown
-
2011
- 2011-11-29 JP JP2011259678A patent/JP5517309B2/ja not_active Expired - Fee Related
-
2018
- 2018-08-23 HK HK18110838.5A patent/HK1251611B/en not_active IP Right Cessation
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