CN101065491B - 生产胶原的植物及其生成和使用方法 - Google Patents

生产胶原的植物及其生成和使用方法 Download PDF

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Publication number
CN101065491B
CN101065491B CN2005800408217A CN200580040821A CN101065491B CN 101065491 B CN101065491 B CN 101065491B CN 2005800408217 A CN2005800408217 A CN 2005800408217A CN 200580040821 A CN200580040821 A CN 200580040821A CN 101065491 B CN101065491 B CN 101065491B
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Chinese (zh)
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CN101065491A (zh
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O·肖塞约夫
H·斯泰恩
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Collplant Ltd
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Collplant Ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8273—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for drought, cold, salt resistance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Botany (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fertilizers (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cosmetics (AREA)
CN2005800408217A 2004-09-29 2005-09-28 生产胶原的植物及其生成和使用方法 Expired - Lifetime CN101065491B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61371904P 2004-09-29 2004-09-29
US60/613,719 2004-09-29
PCT/IL2005/001045 WO2006035442A2 (en) 2004-09-29 2005-09-28 Collagen producing plants and methods of generating and using same

Publications (2)

Publication Number Publication Date
CN101065491A CN101065491A (zh) 2007-10-31
CN101065491B true CN101065491B (zh) 2012-01-11

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CN2005800408217A Expired - Lifetime CN101065491B (zh) 2004-09-29 2005-09-28 生产胶原的植物及其生成和使用方法

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EP (6) EP2816117B1 (enExample)
JP (2) JP5100386B2 (enExample)
KR (1) KR20070083870A (enExample)
CN (1) CN101065491B (enExample)
AT (1) ATE479762T1 (enExample)
BR (1) BRPI0516303B1 (enExample)
CA (1) CA2582051C (enExample)
DE (1) DE602005023332D1 (enExample)
HK (1) HK1251611B (enExample)
IL (1) IL182320A (enExample)
MX (1) MX2007003767A (enExample)
NZ (1) NZ554787A (enExample)
WO (1) WO2006035442A2 (enExample)
ZA (1) ZA200703369B (enExample)

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WO2005069845A2 (en) 2004-01-14 2005-08-04 Ohio University Methods of producing peptides/proteins in plants and peptides/proteins produced thereby
US8623812B2 (en) 2004-04-19 2014-01-07 Ohio University Cross-linkable glycoproteins and methods of making the same
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US8455717B2 (en) 2004-09-29 2013-06-04 Collplant Ltd. Collagen producing plants and methods of generating and using same
WO2008008766A2 (en) * 2006-07-10 2008-01-17 Ohio University Co-expression of proline hydroxylases to facilitate hyp-glycosylation of proteins expressed and secreted in plant cells
EP2220246B1 (en) * 2007-10-26 2015-05-20 Collplant Ltd. Methods of processing recombinant procollagen
US8431158B2 (en) 2007-11-26 2013-04-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions comprising fibrous polypeptides and polysaccharides
CA2721507C (en) * 2008-04-18 2017-10-03 Collplant Ltd. Methods of generating and using procollagen
WO2011064773A1 (en) 2009-11-24 2011-06-03 Collplant Ltd. Method of generating collagen fibers
WO2012066543A2 (en) 2010-11-16 2012-05-24 Collplant Ltd. Collagen structures and method of fabricating the same
WO2013030840A2 (en) 2011-09-01 2013-03-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Adhesive biopolymers and uses thereof
WO2013093921A1 (en) 2011-12-20 2013-06-27 Collplant Ltd. Collagen coated synthetic polymer fibers
KR102063686B1 (ko) * 2012-01-02 2020-02-11 (주)아모레퍼시픽 콩뿌리 추출물을 함유하는 피부 외용제 조성물
EP2976097B1 (en) 2013-03-21 2021-05-26 CollPlant Ltd. Compositions comprising collagen and prp for tissue regeneration and their production method
EP2976352B1 (en) * 2013-03-21 2021-08-18 Evonik Operations GmbH Purification of triple helical proteins
GB201308120D0 (en) * 2013-05-06 2013-06-12 Baden Wuerttemberg Stiftung Gmbh Recombinant protein and method for its production
KR102384622B1 (ko) 2013-09-09 2022-04-11 에보닉 오퍼레이션스 게엠베하 변형된 세균 콜라겐-유사 단백질
EP3221455B1 (en) 2014-11-20 2020-08-12 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells
JP7339889B2 (ja) 2017-06-09 2023-09-06 コルプラント リミテッド 組換えコラーゲン含有配合物を使用した積層造形
US20210032311A1 (en) * 2017-09-25 2021-02-04 Yu-Chun Wu Non-human gene-edited mammal, protein crude extract separated from connective tissue of non-human gene-edited mammal, method for protein crude extract and uses of protein crude extract
ES2989582T3 (es) 2018-05-03 2024-11-27 Collplant Ltd Rellenos dérmicos y aplicaciones de los mismos
BR112021001586A2 (pt) * 2018-07-31 2021-05-04 Collplant Ltd. evento transgênico do tabaco e métodos para detecção e uso dos mesmos
CN109988234A (zh) * 2019-02-20 2019-07-09 江苏悦智生物医药有限公司 酵母重组人源I型胶原α1链蛋白、合成方法及其应用
CH718385B1 (de) * 2019-11-11 2025-07-15 Welldrinks Ltd Getränk mit Kollagen und weiteren Zusätzen.
FR3105792B1 (fr) 2019-12-26 2022-08-12 Michel Assor Matériau biocomposite collagène/matrice polymérique poreuse et son utilisation comme implant de réparation de lésions méniscales du genou et/ou de prévention ou de traitement de l’arthrose du genou
WO2021229577A1 (en) 2020-05-12 2021-11-18 Collplant Ltd. Collagen as a delivery tool for metal-based anti-viral agents
CN119173524A (zh) 2022-04-04 2024-12-20 斯威夫特制药有限责任公司 在植物中产生的重组蜘蛛丝强化的胶原蛋白及其应用
KR20250046260A (ko) 2022-08-02 2025-04-02 가부시키가이샤 유니바이오 콜라겐 산생 방법
CN117209592A (zh) * 2023-07-26 2023-12-12 浙江大学 一种人源化i型胶原蛋白及其制备方法与应用

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Publication number Publication date
EP3088528A1 (en) 2016-11-02
HK1251611B (en) 2020-06-19
ATE479762T1 (de) 2010-09-15
EP1809751B1 (en) 2010-09-01
EP2357241B1 (en) 2015-03-04
EP3312282B1 (en) 2019-07-03
WO2006035442A2 (en) 2006-04-06
EP1809751A2 (en) 2007-07-25
HK1114405A1 (en) 2008-10-31
EP3088528B1 (en) 2019-07-03
BRPI0516303B1 (pt) 2021-04-13
EP2816117B1 (en) 2016-11-30
EP3312282A1 (en) 2018-04-25
EP2357241A1 (en) 2011-08-17
JP5517309B2 (ja) 2014-06-11
HK1160176A1 (en) 2012-08-10
JP5100386B2 (ja) 2012-12-19
WO2006035442A8 (en) 2006-06-29
IL182320A0 (en) 2007-07-24
JP2008514225A (ja) 2008-05-08
EP2360261A1 (en) 2011-08-24
NZ554787A (en) 2009-05-31
WO2006035442A3 (en) 2006-05-04
ZA200703369B (en) 2008-08-27
DE602005023332D1 (de) 2010-10-14
JP2012085644A (ja) 2012-05-10
EP2816117A3 (en) 2015-05-27
KR20070083870A (ko) 2007-08-24
CN101065491A (zh) 2007-10-31
CA2582051A1 (en) 2006-04-06
CA2582051C (en) 2015-08-11
IL182320A (en) 2015-06-30
EP2816117A2 (en) 2014-12-24
MX2007003767A (es) 2007-07-17
BRPI0516303A (pt) 2008-09-02

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