JP2008512391A5 - - Google Patents

Info

Publication number

JP2008512391A5

JP2008512391A5 JP2007530506A JP2007530506A JP2008512391A5 JP 2008512391 A5 JP2008512391 A5 JP 2008512391A5 JP 2007530506 A JP2007530506 A JP 2007530506A JP 2007530506 A JP2007530506 A JP 2007530506A JP 2008512391 A5 JP2008512391 A5 JP 2008512391A5

Authority

JP

Japan

Prior art keywords

peptidomimetic

seq

amino acid

acid sequence

peptide

Prior art date

2005-09-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 239000000816 peptidomimetic Substances 0.000 claims 132
• 108090000765 processed proteins & peptides Proteins 0.000 claims 102
• 125000003275 alpha amino acid group Chemical group 0.000 claims 56
• 150000001875 compounds Chemical class 0.000 claims 17
• 239000012634 fragment Substances 0.000 claims 16
• 230000027455 binding Effects 0.000 claims 13
• 238000000034 method Methods 0.000 claims 13
• 235000018102 proteins Nutrition 0.000 claims 13
• 102000004169 proteins and genes Human genes 0.000 claims 13
• 108090000623 proteins and genes Proteins 0.000 claims 13
• 102100030929 Single Ig IL-1-related receptor Human genes 0.000 claims 11
• 102100032757 Cysteine-rich protein 2 Human genes 0.000 claims 10
• 101150034627 SIGIRR gene Proteins 0.000 claims 9
• 101710107435 Single Ig IL-1-related receptor Proteins 0.000 claims 9
• 101000942088 Homo sapiens Cysteine-rich protein 2 Proteins 0.000 claims 7
• 239000003814 drug Substances 0.000 claims 6
• 229940124597 therapeutic agent Drugs 0.000 claims 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
• 230000002526 effect on cardiovascular system Effects 0.000 claims 5
• 102000005962 receptors Human genes 0.000 claims 4
• 108020003175 receptors Proteins 0.000 claims 4
• 101710185482 Cysteine and glycine-rich protein 2 Proteins 0.000 claims 3
• 101710202823 Cysteine-rich protein 2 Proteins 0.000 claims 3
• 102000010789 Interleukin-2 Receptors Human genes 0.000 claims 3
• 108010038453 Interleukin-2 Receptors Proteins 0.000 claims 3
• 230000002491 angiogenic effect Effects 0.000 claims 3
• 239000003146 anticoagulant agent Substances 0.000 claims 3
• 239000000427 antigen Substances 0.000 claims 3
• 102000036639 antigens Human genes 0.000 claims 3
• 108091007433 antigens Proteins 0.000 claims 3
• 229960004676 antithrombotic agent Drugs 0.000 claims 3
• 239000003795 chemical substances by application Substances 0.000 claims 3
• 206010005003 Bladder cancer Diseases 0.000 claims 2
• 229940127291 Calcium channel antagonist Drugs 0.000 claims 2
• 102000002045 Endothelin Human genes 0.000 claims 2
• 108050009340 Endothelin Proteins 0.000 claims 2
• 101100310318 Mus musculus Sigirr gene Proteins 0.000 claims 2
• 101000652738 Mus musculus Single Ig IL-1-related receptor Proteins 0.000 claims 2
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
• 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 2
• 239000002260 anti-inflammatory agent Substances 0.000 claims 2
• 229940121363 anti-inflammatory agent Drugs 0.000 claims 2
• 239000003416 antiarrhythmic agent Substances 0.000 claims 2
• 239000003443 antiviral agent Substances 0.000 claims 2
• 230000003115 biocidal effect Effects 0.000 claims 2
• 239000000480 calcium channel blocker Substances 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 claims 2
• 239000003018 immunosuppressive agent Substances 0.000 claims 2
• 229940125721 immunosuppressive agent Drugs 0.000 claims 2
• 239000003112 inhibitor Substances 0.000 claims 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
• 230000009870 specific binding Effects 0.000 claims 2
• 239000002451 tumor necrosis factor inhibitor Substances 0.000 claims 2
• 201000005112 urinary bladder cancer Diseases 0.000 claims 2
• 239000013603 viral vector Substances 0.000 claims 2
• 239000005541 ACE inhibitor Substances 0.000 claims 1
• 101710129690 Angiotensin-converting enzyme inhibitor Proteins 0.000 claims 1
• 101710086378 Bradykinin-potentiating and C-type natriuretic peptides Proteins 0.000 claims 1
• 108010028784 Interleukin-18 Receptor alpha Subunit Proteins 0.000 claims 1
• 102100039340 Interleukin-18 receptor 1 Human genes 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• -1 antibiotic Substances 0.000 claims 1
• 230000004071 biological effect Effects 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 150000003384 small molecules Chemical class 0.000 claims 1