CN101052408B - 选择性锚定到心脏脉管系统上的肽和相关结合物和方法 - Google Patents

选择性锚定到心脏脉管系统上的肽和相关结合物和方法 Download PDF

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Publication number
CN101052408B
CN101052408B CN2005800375158A CN200580037515A CN101052408B CN 101052408 B CN101052408 B CN 101052408B CN 2005800375158 A CN2005800375158 A CN 2005800375158A CN 200580037515 A CN200580037515 A CN 200580037515A CN 101052408 B CN101052408 B CN 101052408B
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China
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seq
anchor
peptide
peptides
cardiac
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Expired - Fee Related
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CN2005800375158A
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English (en)
Chinese (zh)
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CN101052408A (zh
Inventor
张良林
贾森·A·霍夫曼
埃尔基·罗斯拉赫蒂
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Sanford Burnham Prebys Medical Discovery Institute
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Sanford Burnham Prebys Medical Discovery Institute
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN2005800375158A 2004-09-07 2005-09-07 选择性锚定到心脏脉管系统上的肽和相关结合物和方法 Expired - Fee Related CN101052408B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93602704A 2004-09-07 2004-09-07
US10/936,027 2004-09-07
PCT/US2005/032205 WO2006029343A2 (en) 2004-09-07 2005-09-07 Peptides that selectively home to heart vasculature and related conjugates and methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201110433287.3A Division CN102558334B (zh) 2004-09-07 2005-09-07 选择性锚定到心脏脉管系统上的肽和相关结合物和方法

Publications (2)

Publication Number Publication Date
CN101052408A CN101052408A (zh) 2007-10-10
CN101052408B true CN101052408B (zh) 2013-03-27

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CN2005800375158A Expired - Fee Related CN101052408B (zh) 2004-09-07 2005-09-07 选择性锚定到心脏脉管系统上的肽和相关结合物和方法
CN201110433287.3A Expired - Fee Related CN102558334B (zh) 2004-09-07 2005-09-07 选择性锚定到心脏脉管系统上的肽和相关结合物和方法

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Country Status (5)

Country Link
EP (1) EP1796707B1 (https=)
JP (4) JP2008512391A (https=)
CN (2) CN101052408B (https=)
AT (1) ATE538806T1 (https=)
WO (1) WO2006029343A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2099821B1 (en) * 2006-12-01 2013-07-03 Georgetown University Medical School Gene and protein that homes to developing microvessels
US9173890B2 (en) * 2007-09-20 2015-11-03 Abbott Cardiovascular Systems Inc. Sustained release of Apo A-I mimetic peptides and methods of treatment
CN110938128B (zh) * 2019-11-08 2021-07-13 上海交通大学 一种生物活性多肽pkcpkcdkevyfaervtsl及其制备方法和应用
CN112646022B (zh) * 2020-12-16 2022-03-29 熊猫乳品集团股份有限公司 一种生物活性肽pkcpkcdkevyfaerv及其制备方法和应用
CN113278591B (zh) * 2021-05-13 2023-07-25 厦门大学附属心血管病医院 一种心脏靶向性基因工程外泌体及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303573B1 (en) * 1999-06-07 2001-10-16 The Burnham Institute Heart homing peptides and methods of using same

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GB8911333D0 (en) * 1989-05-17 1989-07-05 Plant Genetic Systems Nv New bacterial and/or bacteriostatic peptides,isolated from coleopteran insects
CA2139517A1 (en) * 1992-07-20 1994-02-03 Paul M. Keller Immunological conjugates of ompc and hiv-specific selected principal neutralization epitopes
JPH06211898A (ja) * 1992-12-25 1994-08-02 Takara Shuzo Co Ltd 神経α−カテニン
WO1996041172A1 (en) * 1995-06-07 1996-12-19 Cytogen Corporation Functional surrogates of analytes of interest and methods of obtaining and using same
CA2265484C (en) * 1996-09-10 2008-12-02 The Burnham Institute Tumor homing molecules, conjugates derived therefrom, and methods of using same
JP2001516055A (ja) * 1997-09-10 2001-09-25 ザ バーナム インスティチュート 腫瘍中の血管形成血管系にホーミングする分子を同定する方法
ES2313779T3 (es) * 1998-03-13 2009-03-01 The Burnham Institute Moleculas que migran a diversos organos o tejidos seleccionados.
NO315238B1 (no) * 1998-05-08 2003-08-04 Gemvax As Peptider som stammer fra leserammeforskyvingsmutasjoner i TBF<beta>II- eller BAX-genet, og farmasöytiske sammensetninger inneholdende disse,nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slikenukleinsy
JP4531267B2 (ja) * 1999-01-22 2010-08-25 ザ バーナム インスティチュート ホーミングプロアポトーシス結合体およびホーミングプロアポトーシス結合体を使用する方法
US6528481B1 (en) * 1999-02-16 2003-03-04 The Burnam Institute NG2/HM proteoglycan-binding peptides that home to angiogenic vasculature and related methods
US20040031072A1 (en) * 1999-05-06 2004-02-12 La Rosa Thomas J. Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement
WO2001027158A2 (en) * 1999-10-08 2001-04-19 Digiscents Olfactory receptor sequences
WO2001053342A1 (en) * 2000-01-21 2001-07-26 The Burnham Institute Chimeric prostate-homing peptides with pro-apoptotic activity
US20110131679A2 (en) * 2000-04-19 2011-06-02 Thomas La Rosa Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
JP2004520803A (ja) * 2000-04-21 2004-07-15 コリクサ コーポレイション 尋常性挫瘡の治療および診断のための組成物および方法
US7834146B2 (en) * 2000-05-08 2010-11-16 Monsanto Technology Llc Recombinant polypeptides associated with plants
CA2312646A1 (en) * 2000-06-28 2001-12-28 Institut National D'optique Hybrid micropackaging of microdevices
WO2003020751A2 (en) * 2001-09-05 2003-03-13 King's College London Homing peptides
EP1581790B1 (en) * 2001-11-08 2009-01-07 The Burnham Institute Peptides that home to tumor lymphatic vasculature and methods of using same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303573B1 (en) * 1999-06-07 2001-10-16 The Burnham Institute Heart homing peptides and methods of using same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Lianglin Zhang等.Molecular Profiling of Heart Endothelial Cells.Circulation112.2005,112第1601页摘要，第1604页右栏倒数第3段，第1605页图2，第1607页右栏倒数第1段，第1608页左栏第1和2段. *

Also Published As

Publication number Publication date
EP1796707A4 (en) 2009-09-09
CN102558334B (zh) 2016-08-03
JP2016128505A (ja) 2016-07-14
EP1796707B1 (en) 2011-12-28
CN101052408A (zh) 2007-10-10
JP2008512391A (ja) 2008-04-24
JP2012051934A (ja) 2012-03-15
ATE538806T1 (de) 2012-01-15
JP5993413B2 (ja) 2016-09-14
WO2006029343A2 (en) 2006-03-16
CN102558334A (zh) 2012-07-11
JP2015038064A (ja) 2015-02-26
WO2006029343A3 (en) 2007-03-01
JP6417347B2 (ja) 2018-11-07
EP1796707A2 (en) 2007-06-20

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