JP2008512391A - 心臓血管に対して選択的にホーミングするペプチド、ならびに関連する結合体および方法 - Google Patents

心臓血管に対して選択的にホーミングするペプチド、ならびに関連する結合体および方法 Download PDF

Info

Publication number
JP2008512391A
JP2008512391A JP2007530506A JP2007530506A JP2008512391A JP 2008512391 A JP2008512391 A JP 2008512391A JP 2007530506 A JP2007530506 A JP 2007530506A JP 2007530506 A JP2007530506 A JP 2007530506A JP 2008512391 A JP2008512391 A JP 2008512391A
Authority
JP
Japan
Prior art keywords
peptidomimetic
seq
homing
peptide
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007530506A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008512391A5 (https=
Inventor
リャンリン チャン，
ジェイソン エー． ホフマン，
エルッキ ルオスラーティ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanford Burnham Prebys Medical Discovery Institute
Original Assignee
Sanford Burnham Prebys Medical Discovery Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanford Burnham Prebys Medical Discovery Institute filed Critical Sanford Burnham Prebys Medical Discovery Institute
Publication of JP2008512391A publication Critical patent/JP2008512391A/ja
Publication of JP2008512391A5 publication Critical patent/JP2008512391A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2007530506A 2004-09-07 2005-09-07 心臓血管に対して選択的にホーミングするペプチド、ならびに関連する結合体および方法 Pending JP2008512391A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93602704A 2004-09-07 2004-09-07
PCT/US2005/032205 WO2006029343A2 (en) 2004-09-07 2005-09-07 Peptides that selectively home to heart vasculature and related conjugates and methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011243980A Division JP2012051934A (ja) 2004-09-07 2011-11-07 心臓血管に対して選択的にホーミングするペプチド、ならびに関連する結合体および方法

Publications (2)

Publication Number Publication Date
JP2008512391A true JP2008512391A (ja) 2008-04-24
JP2008512391A5 JP2008512391A5 (https=) 2008-09-18

Family

ID=36037029

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2007530506A Pending JP2008512391A (ja) 2004-09-07 2005-09-07 心臓血管に対して選択的にホーミングするペプチド、ならびに関連する結合体および方法
JP2011243980A Pending JP2012051934A (ja) 2004-09-07 2011-11-07 心臓血管に対して選択的にホーミングするペプチド、ならびに関連する結合体および方法
JP2014158521A Expired - Fee Related JP5993413B2 (ja) 2004-09-07 2014-08-04 心臓血管に対して選択的にホーミングするペプチド、ならびに関連する結合体および方法
JP2016041667A Expired - Fee Related JP6417347B2 (ja) 2004-09-07 2016-03-04 心臓血管に対して選択的にホーミングするペプチド、ならびに関連する結合体および方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2011243980A Pending JP2012051934A (ja) 2004-09-07 2011-11-07 心臓血管に対して選択的にホーミングするペプチド、ならびに関連する結合体および方法
JP2014158521A Expired - Fee Related JP5993413B2 (ja) 2004-09-07 2014-08-04 心臓血管に対して選択的にホーミングするペプチド、ならびに関連する結合体および方法
JP2016041667A Expired - Fee Related JP6417347B2 (ja) 2004-09-07 2016-03-04 心臓血管に対して選択的にホーミングするペプチド、ならびに関連する結合体および方法

Country Status (5)

Country Link
EP (1) EP1796707B1 (https=)
JP (4) JP2008512391A (https=)
CN (2) CN101052408B (https=)
AT (1) ATE538806T1 (https=)
WO (1) WO2006029343A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2099821B1 (en) * 2006-12-01 2013-07-03 Georgetown University Medical School Gene and protein that homes to developing microvessels
US9173890B2 (en) * 2007-09-20 2015-11-03 Abbott Cardiovascular Systems Inc. Sustained release of Apo A-I mimetic peptides and methods of treatment
CN110938128B (zh) * 2019-11-08 2021-07-13 上海交通大学 一种生物活性多肽pkcpkcdkevyfaervtsl及其制备方法和应用
CN112646022B (zh) * 2020-12-16 2022-03-29 熊猫乳品集团股份有限公司 一种生物活性肽pkcpkcdkevyfaerv及其制备方法和应用
CN113278591B (zh) * 2021-05-13 2023-07-25 厦门大学附属心血管病医院 一种心脏靶向性基因工程外泌体及其制备方法和应用

Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990014098A1 (en) * 1989-05-17 1990-11-29 Plant Genetic Systems N.V. Bactericidal and/or bacteriostatic peptide isolated from coleopteran insects
WO1994002626A1 (en) * 1992-07-20 1994-02-03 Merck & Co., Inc. Immunological conjugates of ompc and hiv-specific selected principal neutralization epitopes
JPH06211898A (ja) * 1992-12-25 1994-08-02 Takara Shuzo Co Ltd 神経α−カテニン
WO1996041172A1 (en) * 1995-06-07 1996-12-19 Cytogen Corporation Functional surrogates of analytes of interest and methods of obtaining and using same
WO1999058552A2 (en) * 1998-05-08 1999-11-18 Norsk Hydro Asa Peptides that ellicit t, cellular immunity
JP2001501600A (ja) * 1996-09-10 2001-02-06 ザ バーナム インスティテュート 腫瘍ホーミング分子、それに由来する結合体、およびその使用方法
WO2001027158A2 (en) * 1999-10-08 2001-04-19 Digiscents Olfactory receptor sequences
JP2001516055A (ja) * 1997-09-10 2001-09-25 ザ バーナム インスティチュート 腫瘍中の血管形成血管系にホーミングする分子を同定する方法
WO2001081581A2 (en) * 2000-04-21 2001-11-01 Corixa Corporation Compositions and methods for the therapy and diagnosis of acne vulgaris
WO2002001633A1 (en) * 2000-06-28 2002-01-03 Institut National D'optique Miniature microdevice package and process for making thereof
JP2002506079A (ja) * 1998-03-13 2002-02-26 ザ バーナム インスティチュート 種々の選択された器官または組織にホーミングする分子
JP2002535258A (ja) * 1999-01-22 2002-10-22 ザ バーナム インスティチュート ホーミングプロアポトーシス結合体およびホーミングプロアポトーシス結合体を使用する方法
WO2003020751A2 (en) * 2001-09-05 2003-03-13 King's College London Homing peptides
WO2003040693A2 (en) * 2001-11-08 2003-05-15 The Burnham Institute Peptides that home to tumor lymphatic vasculature and methods of using same
JP2003520808A (ja) * 2000-01-21 2003-07-08 ザ バーナム インスティチュート プロアポトーシス活性を有するキメラ前立腺ホーミングペプチド
US20040031072A1 (en) * 1999-05-06 2004-02-12 La Rosa Thomas J. Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement
US20040123343A1 (en) * 2000-04-19 2004-06-24 La Rosa Thomas J. Rice nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
US20040172684A1 (en) * 2000-05-08 2004-09-02 Kovalic David K. Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6528481B1 (en) * 1999-02-16 2003-03-04 The Burnam Institute NG2/HM proteoglycan-binding peptides that home to angiogenic vasculature and related methods
US6303573B1 (en) * 1999-06-07 2001-10-16 The Burnham Institute Heart homing peptides and methods of using same

Patent Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990014098A1 (en) * 1989-05-17 1990-11-29 Plant Genetic Systems N.V. Bactericidal and/or bacteriostatic peptide isolated from coleopteran insects
WO1994002626A1 (en) * 1992-07-20 1994-02-03 Merck & Co., Inc. Immunological conjugates of ompc and hiv-specific selected principal neutralization epitopes
JPH06211898A (ja) * 1992-12-25 1994-08-02 Takara Shuzo Co Ltd 神経α−カテニン
WO1996041172A1 (en) * 1995-06-07 1996-12-19 Cytogen Corporation Functional surrogates of analytes of interest and methods of obtaining and using same
JP2001501600A (ja) * 1996-09-10 2001-02-06 ザ バーナム インスティテュート 腫瘍ホーミング分子、それに由来する結合体、およびその使用方法
JP2001516055A (ja) * 1997-09-10 2001-09-25 ザ バーナム インスティチュート 腫瘍中の血管形成血管系にホーミングする分子を同定する方法
JP2002506079A (ja) * 1998-03-13 2002-02-26 ザ バーナム インスティチュート 種々の選択された器官または組織にホーミングする分子
WO1999058552A2 (en) * 1998-05-08 1999-11-18 Norsk Hydro Asa Peptides that ellicit t, cellular immunity
JP2002535258A (ja) * 1999-01-22 2002-10-22 ザ バーナム インスティチュート ホーミングプロアポトーシス結合体およびホーミングプロアポトーシス結合体を使用する方法
US20040031072A1 (en) * 1999-05-06 2004-02-12 La Rosa Thomas J. Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement
WO2001027158A2 (en) * 1999-10-08 2001-04-19 Digiscents Olfactory receptor sequences
JP2003520808A (ja) * 2000-01-21 2003-07-08 ザ バーナム インスティチュート プロアポトーシス活性を有するキメラ前立腺ホーミングペプチド
US20040123343A1 (en) * 2000-04-19 2004-06-24 La Rosa Thomas J. Rice nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
WO2001081581A2 (en) * 2000-04-21 2001-11-01 Corixa Corporation Compositions and methods for the therapy and diagnosis of acne vulgaris
US20040172684A1 (en) * 2000-05-08 2004-09-02 Kovalic David K. Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
WO2002001633A1 (en) * 2000-06-28 2002-01-03 Institut National D'optique Miniature microdevice package and process for making thereof
WO2003020751A2 (en) * 2001-09-05 2003-03-13 King's College London Homing peptides
WO2003040693A2 (en) * 2001-11-08 2003-05-15 The Burnham Institute Peptides that home to tumor lymphatic vasculature and methods of using same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YU, T.S. ET AL.: ""The heart LIM protein gene (Hlp), expressed in the developing and adult heart, defines a new tissue", MECH. DEV., vol. Vol.116, No.1-2, JPN6011022736, August 2002 (2002-08-01), pages 187 - 192, ISSN: 0001910894 *

Also Published As

Publication number Publication date
EP1796707A4 (en) 2009-09-09
CN102558334B (zh) 2016-08-03
JP2016128505A (ja) 2016-07-14
EP1796707B1 (en) 2011-12-28
CN101052408A (zh) 2007-10-10
JP2012051934A (ja) 2012-03-15
ATE538806T1 (de) 2012-01-15
JP5993413B2 (ja) 2016-09-14
WO2006029343A2 (en) 2006-03-16
CN101052408B (zh) 2013-03-27
CN102558334A (zh) 2012-07-11
JP2015038064A (ja) 2015-02-26
WO2006029343A3 (en) 2007-03-01
JP6417347B2 (ja) 2018-11-07
EP1796707A2 (en) 2007-06-20

Similar Documents

Publication Publication Date Title
US8637635B2 (en) Peptides that selectively home to heart vasculature and related conjugates and methods
US6303573B1 (en) Heart homing peptides and methods of using same
JP6417347B2 (ja) 心臓血管に対して選択的にホーミングするペプチド、ならびに関連する結合体および方法
US7488792B2 (en) Collagen-binding molecules that selectively home to tumor vasculature and methods of using same
US8329859B2 (en) Peptides that home to tumor lymphatic vasculature and methods of using same
US9320810B2 (en) HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells
CN103703140B (zh) 用于靶向哺乳动物中的脂肪细胞的方法和组合物
US20100076175A1 (en) Molecules that selectively home to vasculature of premalignant or malignant lesions of the pancreas and other organs
WO2003087124A2 (en) Hmgn2 peptides and related melecules that selectively home to tumor blood vessels and tumor cells
JP2005514348A (ja) 腫瘍リンパ性脈管構造を目指すペプチドおよびその使用方法
KR101052525B1 (ko) 활성화 내피세포 및 동맥경화 표적용 펩티드 및 이의 용도
KR20240032207A (ko) Trop2에 결합하는 펩타이드 및 이의 용도
CN116194462A (zh) 选择性结合癌细胞来源外泌体的肽及其用途
KR20220020220A (ko) 암세포 유래 엑소좀에 선택적으로 결합하는 펩타이드 및 이의 용도

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080801

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080801

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110506

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110727

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110803

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20111107

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20111107

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120216

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120515

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120522

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20121012