JP2008512374A5 - - Google Patents

Info

Publication number

JP2008512374A5

JP2008512374A5 JP2007530388A JP2007530388A JP2008512374A5 JP 2008512374 A5 JP2008512374 A5 JP 2008512374A5 JP 2007530388 A JP2007530388 A JP 2007530388A JP 2007530388 A JP2007530388 A JP 2007530388A JP 2008512374 A5 JP2008512374 A5 JP 2008512374A5

Authority

JP

Japan

Prior art keywords

nhc

substituted

unsubstituted

lower alkyl

disease

Prior art date

2005-08-31

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 125000000217 alkyl group Chemical group 0.000 claims 33
• 150000001875 compounds Chemical class 0.000 claims 28
• 125000000753 cycloalkyl group Chemical group 0.000 claims 27
• 125000000623 heterocyclic group Chemical group 0.000 claims 27
• 125000003118 aryl group Chemical group 0.000 claims 26
• 229910052736 halogen Inorganic materials 0.000 claims 26
• 150000002367 halogens Chemical class 0.000 claims 26
• 125000004093 cyano group Chemical group *C#N 0.000 claims 25
• 125000003545 alkoxy group Chemical group 0.000 claims 24
• 239000008194 pharmaceutical composition Substances 0.000 claims 19
• 210000004027 cell Anatomy 0.000 claims 9
• 201000010099 disease Diseases 0.000 claims 8
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
• 206010028980 Neoplasm Diseases 0.000 claims 7
• 230000002401 inhibitory effect Effects 0.000 claims 7
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
• 208000018737 Parkinson disease Diseases 0.000 claims 5
• 208000027866 inflammatory disease Diseases 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 239000012453 solvate Substances 0.000 claims 4
• MQLACMBJVPINKE-UHFFFAOYSA-N 10-[(3-hydroxy-4-methoxyphenyl)methylidene]anthracen-9-one Chemical compound C1=C(O)C(OC)=CC=C1C=C1C2=CC=CC=C2C(=O)C2=CC=CC=C21 MQLACMBJVPINKE-UHFFFAOYSA-N 0.000 claims 3
• 206010061218 Inflammation Diseases 0.000 claims 3
• 102000004243 Tubulin Human genes 0.000 claims 3
• 108090000704 Tubulin Proteins 0.000 claims 3
• 230000000903 blocking effect Effects 0.000 claims 3
• 201000011510 cancer Diseases 0.000 claims 3
• 230000000694 effects Effects 0.000 claims 3
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims 3
• 230000004054 inflammatory process Effects 0.000 claims 3
• 229910052757 nitrogen Inorganic materials 0.000 claims 3
• 230000008685 targeting Effects 0.000 claims 3
• 208000024827 Alzheimer disease Diseases 0.000 claims 2
• 101100296720 Dictyostelium discoideum Pde4 gene Proteins 0.000 claims 2
• 208000014094 Dystonic disease Diseases 0.000 claims 2
• 101100082610 Plasmodium falciparum (isolate 3D7) PDEdelta gene Proteins 0.000 claims 2
• 206010044565 Tremor Diseases 0.000 claims 2
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
• 125000003342 alkenyl group Chemical group 0.000 claims 2
• 125000000304 alkynyl group Chemical group 0.000 claims 2
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
• 230000033115 angiogenesis Effects 0.000 claims 2
• 206010003246 arthritis Diseases 0.000 claims 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
• 208000015114 central nervous system disease Diseases 0.000 claims 2
• 230000007850 degeneration Effects 0.000 claims 2
• 208000010118 dystonia Diseases 0.000 claims 2
• 230000006870 function Effects 0.000 claims 2
• 230000001404 mediated effect Effects 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 210000005166 vasculature Anatomy 0.000 claims 2
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
• -1 -NHC (O) OR 9 Chemical group 0.000 claims 1
• 102000014461 Ataxins Human genes 0.000 claims 1
• 108010078286 Ataxins Proteins 0.000 claims 1
• 208000035143 Bacterial infection Diseases 0.000 claims 1
• 208000009137 Behcet syndrome Diseases 0.000 claims 1
• 206010008025 Cerebellar ataxia Diseases 0.000 claims 1
• 206010008027 Cerebellar atrophy Diseases 0.000 claims 1
• 206010008748 Chorea Diseases 0.000 claims 1
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
• 206010009900 Colitis ulcerative Diseases 0.000 claims 1
• 208000011231 Crohn disease Diseases 0.000 claims 1
• 206010012289 Dementia Diseases 0.000 claims 1
• 201000011240 Frontotemporal dementia Diseases 0.000 claims 1
• 201000005569 Gout Diseases 0.000 claims 1
• 208000002972 Hepatolenticular Degeneration Diseases 0.000 claims 1
• 208000023105 Huntington disease Diseases 0.000 claims 1
• 208000026350 Inborn Genetic disease Diseases 0.000 claims 1
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
• 208000009829 Lewy Body Disease Diseases 0.000 claims 1
• 201000002832 Lewy body dementia Diseases 0.000 claims 1
• 208000026139 Memory disease Diseases 0.000 claims 1
• 201000009906 Meningitis Diseases 0.000 claims 1
• 208000026072 Motor neurone disease Diseases 0.000 claims 1
• 208000001089 Multiple system atrophy Diseases 0.000 claims 1
• 208000007101 Muscle Cramp Diseases 0.000 claims 1
• 206010052904 Musculoskeletal stiffness Diseases 0.000 claims 1
• 240000007817 Olea europaea Species 0.000 claims 1
• 208000003076 Osteolysis Diseases 0.000 claims 1
• 208000024777 Prion disease Diseases 0.000 claims 1
• 201000004681 Psoriasis Diseases 0.000 claims 1
• 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
• 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
• 206010063837 Reperfusion injury Diseases 0.000 claims 1
• 206010040047 Sepsis Diseases 0.000 claims 1
• 206010040070 Septic Shock Diseases 0.000 claims 1
• 208000009106 Shy-Drager Syndrome Diseases 0.000 claims 1
• 208000005392 Spasm Diseases 0.000 claims 1
• 208000009415 Spinocerebellar Ataxias Diseases 0.000 claims 1
• 208000006045 Spondylarthropathies Diseases 0.000 claims 1
• 102000019355 Synuclein Human genes 0.000 claims 1
• 108050006783 Synuclein Proteins 0.000 claims 1
• 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
• 208000036142 Viral infection Diseases 0.000 claims 1
• 208000018839 Wilson disease Diseases 0.000 claims 1
• 208000026935 allergic disease Diseases 0.000 claims 1
• 206010002022 amyloidosis Diseases 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 201000004562 autosomal dominant cerebellar ataxia Diseases 0.000 claims 1
• 208000022362 bacterial infectious disease Diseases 0.000 claims 1
• 210000004227 basal ganglia Anatomy 0.000 claims 1
• 210000004204 blood vessel Anatomy 0.000 claims 1
• 230000010261 cell growth Effects 0.000 claims 1
• 210000003169 central nervous system Anatomy 0.000 claims 1
• 208000012601 choreatic disease Diseases 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 208000037976 chronic inflammation Diseases 0.000 claims 1
• 230000006020 chronic inflammation Effects 0.000 claims 1
• 230000002566 clonic effect Effects 0.000 claims 1
• 208000010877 cognitive disease Diseases 0.000 claims 1
• 230000001054 cortical effect Effects 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 206010014599 encephalitis Diseases 0.000 claims 1
• 210000003038 endothelium Anatomy 0.000 claims 1
• 230000003176 fibrotic effect Effects 0.000 claims 1
• 230000008014 freezing Effects 0.000 claims 1
• 238000007710 freezing Methods 0.000 claims 1
• 230000005021 gait Effects 0.000 claims 1
• 208000016361 genetic disease Diseases 0.000 claims 1
• 230000012010 growth Effects 0.000 claims 1
• 230000001660 hyperkinetic effect Effects 0.000 claims 1
• 230000002757 inflammatory effect Effects 0.000 claims 1
• 208000014674 injury Diseases 0.000 claims 1
• 230000000302 ischemic effect Effects 0.000 claims 1
• 230000007787 long-term memory Effects 0.000 claims 1
• 208000029791 lytic metastatic bone lesion Diseases 0.000 claims 1
• 206010027175 memory impairment Diseases 0.000 claims 1
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
• 208000027061 mild cognitive impairment Diseases 0.000 claims 1
• 208000005264 motor neuron disease Diseases 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 201000008482 osteoarthritis Diseases 0.000 claims 1
• 238000007911 parenteral administration Methods 0.000 claims 1
• 230000001575 pathological effect Effects 0.000 claims 1
• 201000002212 progressive supranuclear palsy Diseases 0.000 claims 1
• 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
• 208000016691 refractory malignant neoplasm Diseases 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 230000036303 septic shock Effects 0.000 claims 1
• 208000019116 sleep disease Diseases 0.000 claims 1
• 208000020685 sleep-wake disease Diseases 0.000 claims 1
• 201000005671 spondyloarthropathy Diseases 0.000 claims 1
• 208000011580 syndromic disease Diseases 0.000 claims 1
• 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
• 230000008733 trauma Effects 0.000 claims 1
• 230000003612 virological effect Effects 0.000 claims 1