BRPI0514890A - composto ou um sal, solvato ou hidrato farmaceuticamente aceitável do mesmo, composição farmacêutica, e, métodos para inibir a angiogênese, para inibir ou reduzir a polimerização da tubulina ou a estabilidade da tubulina em uma célula, para inibir a atividade de pde4 em uma célula, para inibir a atividade do fator-alfa de necrose de tumor (tnf-alfa) em uma célula, para tratar ou melhorar um distúrbio inflamatório, para tratar ou melhorar cáncer, para inibir a proliferação de célula cancerosa, para marcar, bloquear ou destruir a função da vasculatura tumoral, para marcar, bloquear ou destruir o endotélio de vasos de tumor, para marcar, bloquear ou destruir a função de vasculatura tumoral e inibir a angiogênese em um tumor e para tratar ou melhorar um distúrbio do sistema nervoso central - Google Patents

composto ou um sal, solvato ou hidrato farmaceuticamente aceitável do mesmo, composição farmacêutica, e, métodos para inibir a angiogênese, para inibir ou reduzir a polimerização da tubulina ou a estabilidade da tubulina em uma célula, para inibir a atividade de pde4 em uma célula, para inibir a atividade do fator-alfa de necrose de tumor (tnf-alfa) em uma célula, para tratar ou melhorar um distúrbio inflamatório, para tratar ou melhorar cáncer, para inibir a proliferação de célula cancerosa, para marcar, bloquear ou destruir a função da vasculatura tumoral, para marcar, bloquear ou destruir o endotélio de vasos de tumor, para marcar, bloquear ou destruir a função de vasculatura tumoral e inibir a angiogênese em um tumor e para tratar ou melhorar um distúrbio do sistema nervoso central

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Publication number
BRPI0514890A
BRPI0514890A BRPI0514890-1A BRPI0514890A BRPI0514890A BR PI0514890 A BRPI0514890 A BR PI0514890A BR PI0514890 A BRPI0514890 A BR PI0514890A BR PI0514890 A BRPI0514890 A BR PI0514890A
Authority
BR
Brazil
Prior art keywords
cell
treat
inhibit
block
ameliorate
Prior art date
Application number
BRPI0514890-1A
Other languages
English (en)
Portuguese (pt)
Inventor
George W Muller
Faribourz Payvandi
Ling H Zhang
Michael J Robarge
Roger Chen
Hon-Wah Man
Alexander L Ruchelman
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of BRPI0514890A publication Critical patent/BRPI0514890A/pt

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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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BRPI0514890-1A 2004-09-03 2005-08-31 composto ou um sal, solvato ou hidrato farmaceuticamente aceitável do mesmo, composição farmacêutica, e, métodos para inibir a angiogênese, para inibir ou reduzir a polimerização da tubulina ou a estabilidade da tubulina em uma célula, para inibir a atividade de pde4 em uma célula, para inibir a atividade do fator-alfa de necrose de tumor (tnf-alfa) em uma célula, para tratar ou melhorar um distúrbio inflamatório, para tratar ou melhorar cáncer, para inibir a proliferação de célula cancerosa, para marcar, bloquear ou destruir a função da vasculatura tumoral, para marcar, bloquear ou destruir o endotélio de vasos de tumor, para marcar, bloquear ou destruir a função de vasculatura tumoral e inibir a angiogênese em um tumor e para tratar ou melhorar um distúrbio do sistema nervoso central BRPI0514890A (pt)

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