MX2007002525A - Compuestos de difeniletileno y usos de los mismos. - Google Patents

Compuestos de difeniletileno y usos de los mismos.

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Publication number
MX2007002525A
MX2007002525A MX2007002525A MX2007002525A MX2007002525A MX 2007002525 A MX2007002525 A MX 2007002525A MX 2007002525 A MX2007002525 A MX 2007002525A MX 2007002525 A MX2007002525 A MX 2007002525A MX 2007002525 A MX2007002525 A MX 2007002525A
Authority
MX
Mexico
Prior art keywords
diphenylethylene compounds
diphenylethylene
relates
present
compounds
Prior art date
Application number
MX2007002525A
Other languages
English (en)
Spanish (es)
Inventor
George W Muller
Michael J Robarge
Alexander L Ruchelman
Faribourz Payvandi
Ling H Zhang
Roger Chen
Hon-Wah Man
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of MX2007002525A publication Critical patent/MX2007002525A/es

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    • C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
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    • C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
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    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

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US7470723B2 (en) 2003-03-05 2008-12-30 Celgene Corporation Diphenylethylene compounds and uses thereof
AU2004218364A1 (en) * 2003-03-05 2004-09-16 Celgene Corporation Diphenylethylene compounds and uses thereof
US20050142104A1 (en) * 2003-11-06 2005-06-30 Zeldis Jerome B. Methods of using and compositions comprising PDE4 modulators for the treatment and management of asbestos-related diseases and disorders
KR20080027253A (ko) * 2005-06-16 2008-03-26 미리어드 제네틱스, 인크. 약제학적 조성물 및 이의 용도
US8569356B2 (en) * 2005-10-25 2013-10-29 University Of Florida Research Foundation, Inc. Cyclin dependent kinase inhibitors
FR2914640B1 (fr) * 2007-04-04 2012-11-16 Centre Nat Rech Scient Iso ca-4 et analogues : puissants cytotoxiques, inhibiteurs de polymerisation de la tubuline
CA2720983A1 (en) * 2007-04-10 2008-10-16 Myrexis, Inc. Method of treating melanoma
WO2008124828A1 (en) * 2007-04-10 2008-10-16 Myriad Genetics, Inc. Methods for treating vascular disruption disorders
NZ580869A (en) * 2007-04-10 2011-02-25 Myriad Pharmaceuticals Inc Methods for treating cancer
WO2008124824A1 (en) * 2007-04-10 2008-10-16 Myriad Genetics, Inc. Dosages and methods for the treatment of cancer
JP2010523696A (ja) * 2007-04-10 2010-07-15 ミリアド ファーマシューティカルズ， インコーポレイテッド 脳腫瘍を治療する方法
FR2932180B1 (fr) * 2008-06-04 2012-08-10 Centre Nat Rech Scient Dihydro iso ca-4 et analogues : puissants cytotoxiques, inhibiteurs de la polymerisation de la tubuline
CN107846898B (zh) * 2015-05-01 2023-07-14 佐治亚州立大学研究基金会 用于管理低氧诱导因子相关病症的二苯基甲醇衍生物
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
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Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3059021A (en) * 1960-02-12 1962-10-16 Monsanto Chemicals 1, 1, 1-trichloro-2, 2-bis[(carboalkoxy-amino) aryl] ethane
GR61627B (en) 1975-08-28 1978-12-04 Lilly Co Eli Preparation process of carbonyl-substituted 1-sulfonylbenzimidazoles
US4420479A (en) 1982-04-08 1983-12-13 Eli Lilly And Company Olefinic benzimidazoles, formulations, and antiviral methods
US4492708A (en) 1982-09-27 1985-01-08 Eli Lilly And Company Antiviral benzimidazoles
JPS58188868A (ja) 1983-04-08 1983-11-04 イ−ライ・リリ−・アンド・カンパニ− オレフイン系ベンズイミダゾ−ル類
ZA88960B (en) * 1987-02-13 1988-08-15 Ciba-Geigy Ag. Diphenylethylene derivatives
EP0316594B1 (en) 1987-10-21 1993-09-29 The Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
JPH0566591A (ja) 1991-09-10 1993-03-19 Canon Inc 電子写真感光体、該電子写真感光体を備えた電子写真装置並びにフアクシミリ
DE4220983A1 (de) 1992-06-26 1994-01-05 Bayer Ag Imidazolyl-substituierte Phenylpropion- und -zimtsäurederivate
US5466861A (en) 1992-11-25 1995-11-14 Sri International Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors
US5591776A (en) 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
NZ334148A (en) 1996-08-12 2001-12-21 Celgene Corp 3-Substituted phenyl-ethyl or ethenyl derivatives terminated with a nitrile, alkane, carboxyl or carbamoyl group useful to reduce cytokine levels
AU4849199A (en) 1998-07-01 2000-01-24 Celgro Fungal growth inhibitors
SE0102320D0 (sv) * 2001-06-27 2001-06-27 Ingvar Brandt Novel treatment of adrenocortical hypersecretion and tumour growth
US7470723B2 (en) 2003-03-05 2008-12-30 Celgene Corporation Diphenylethylene compounds and uses thereof
AU2004218364A1 (en) 2003-03-05 2004-09-16 Celgene Corporation Diphenylethylene compounds and uses thereof

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WO2006026747A3 (en) 2006-04-06
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