JP2008512374A - ジフェニルエチレン化合物及びその使用 - Google Patents
ジフェニルエチレン化合物及びその使用 Download PDFInfo
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- JP2008512374A JP2008512374A JP2007530388A JP2007530388A JP2008512374A JP 2008512374 A JP2008512374 A JP 2008512374A JP 2007530388 A JP2007530388 A JP 2007530388A JP 2007530388 A JP2007530388 A JP 2007530388A JP 2008512374 A JP2008512374 A JP 2008512374A
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- nhc
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- 0 COC(C*C(C(C(CC=C1)=CC(N(*)*)=C1O)=*C#N)=CC1)=C1O* Chemical compound COC(C*C(C(C(CC=C1)=CC(N(*)*)=C1O)=*C#N)=CC1)=C1O* 0.000 description 4
- NKEKHUQLJHIYAW-FMQZQXMHSA-N C/C=C(/c(cc1)cc(OC)c1OC)\c1cc(OC)cc(OC)c1 Chemical compound C/C=C(/c(cc1)cc(OC)c1OC)\c1cc(OC)cc(OC)c1 NKEKHUQLJHIYAW-FMQZQXMHSA-N 0.000 description 1
- QWBNLZJUKNKPCA-UHFFFAOYSA-N CC(C=CC=C1OC)=CC=C1N Chemical compound CC(C=CC=C1OC)=CC=C1N QWBNLZJUKNKPCA-UHFFFAOYSA-N 0.000 description 1
- CGHRPXAQQCRFSV-UHFFFAOYSA-N COc(cc1)ccc1C(c(cc1)ccc1OC)=CN Chemical compound COc(cc1)ccc1C(c(cc1)ccc1OC)=CN CGHRPXAQQCRFSV-UHFFFAOYSA-N 0.000 description 1
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- C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Oncology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
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- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/934,974 US7470723B2 (en) | 2003-03-05 | 2004-09-03 | Diphenylethylene compounds and uses thereof |
| PCT/US2005/031282 WO2006026747A2 (en) | 2004-09-03 | 2005-08-31 | Diphenylethylene compounds and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008512374A true JP2008512374A (ja) | 2008-04-24 |
| JP2008512374A5 JP2008512374A5 (enExample) | 2008-10-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530388A Pending JP2008512374A (ja) | 2004-09-03 | 2005-08-31 | ジフェニルエチレン化合物及びその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7470723B2 (enExample) |
| EP (1) | EP1799634A2 (enExample) |
| JP (1) | JP2008512374A (enExample) |
| KR (1) | KR20070061854A (enExample) |
| CN (1) | CN101056846A (enExample) |
| AR (1) | AR050558A1 (enExample) |
| AU (1) | AU2005279788A1 (enExample) |
| BR (1) | BRPI0514890A (enExample) |
| CA (1) | CA2578772A1 (enExample) |
| IL (1) | IL181675A0 (enExample) |
| MX (1) | MX2007002525A (enExample) |
| WO (1) | WO2006026747A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011523657A (ja) * | 2008-06-04 | 2011-08-18 | サントル、ナショナール、ド、ラ、ルシェルシュ、シアンティフィク、(セーエヌエルエス) | ジヒドロイソca−4および類似体:強力な細胞傷害剤、チューブリン重合阻害剤 |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004218364A1 (en) * | 2003-03-05 | 2004-09-16 | Celgene Corporation | Diphenylethylene compounds and uses thereof |
| US7470723B2 (en) * | 2003-03-05 | 2008-12-30 | Celgene Corporation | Diphenylethylene compounds and uses thereof |
| US20050142104A1 (en) * | 2003-11-06 | 2005-06-30 | Zeldis Jerome B. | Methods of using and compositions comprising PDE4 modulators for the treatment and management of asbestos-related diseases and disorders |
| NZ562109A (en) * | 2005-06-16 | 2011-03-31 | Myrexis Inc | Pharmaceutical compositions containing substituted (4-Phenyl)-methyl-(quinazolin-4-yl)-amine compounds, uses thereof, and methods of preparing the same |
| US8569356B2 (en) * | 2005-10-25 | 2013-10-29 | University Of Florida Research Foundation, Inc. | Cyclin dependent kinase inhibitors |
| FR2914640B1 (fr) * | 2007-04-04 | 2012-11-16 | Centre Nat Rech Scient | Iso ca-4 et analogues : puissants cytotoxiques, inhibiteurs de polymerisation de la tubuline |
| NZ580866A (en) * | 2007-04-10 | 2011-02-25 | Myriad Pharmaceuticals Inc | Method of treating brain cancer |
| CA2720987A1 (en) * | 2007-04-10 | 2008-10-16 | Myrexis, Inc. | Dosages and methods for the treatment of cancer |
| EP2144886A4 (en) * | 2007-04-10 | 2012-10-03 | Myrexis Inc | METHOD OF TREATING MELANOMA |
| WO2008124826A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Methods for treating cancer |
| WO2008124828A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Methods for treating vascular disruption disorders |
| US10772858B2 (en) | 2015-05-01 | 2020-09-15 | Georgia State University Research Foundation, Inc. | Benzhydrol derivatives for the management of conditions related to hypoxia inducible factors |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| CN115624959B (zh) * | 2022-09-30 | 2023-11-24 | 河南省尤里卡生物科技有限公司 | 一种尿激酶吸附材料及其制备方法和应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3059021A (en) * | 1960-02-12 | 1962-10-16 | Monsanto Chemicals | 1, 1, 1-trichloro-2, 2-bis[(carboalkoxy-amino) aryl] ethane |
| JPS63216882A (ja) * | 1987-02-13 | 1988-09-09 | チバ−ガイギー アクチエンゲゼル シヤフト | 置換α,α−ジフェニルエチレン誘導体、その製造方法、中間体並びに有害生物防除のための使用方法 |
| WO2003002495A1 (en) * | 2001-06-27 | 2003-01-09 | Ingvar Brandt | Novel treatment of adrenocortical hypersecretion and tumour growth |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR61627B (en) * | 1975-08-28 | 1978-12-04 | Lilly Co Eli | Preparation process of carbonyl-substituted 1-sulfonylbenzimidazoles |
| US4420479A (en) | 1982-04-08 | 1983-12-13 | Eli Lilly And Company | Olefinic benzimidazoles, formulations, and antiviral methods |
| US4492708A (en) * | 1982-09-27 | 1985-01-08 | Eli Lilly And Company | Antiviral benzimidazoles |
| JPS58188868A (ja) | 1983-04-08 | 1983-11-04 | イ−ライ・リリ−・アンド・カンパニ− | オレフイン系ベンズイミダゾ−ル類 |
| ES2059467T3 (es) | 1987-10-21 | 1994-11-16 | Du Pont Merck Pharma | Derivados de aminometil-oxooxazolidinil-etenilbenceno utiles como agentes antibacterianos. |
| JPH0566591A (ja) | 1991-09-10 | 1993-03-19 | Canon Inc | 電子写真感光体、該電子写真感光体を備えた電子写真装置並びにフアクシミリ |
| DE4220983A1 (de) * | 1992-06-26 | 1994-01-05 | Bayer Ag | Imidazolyl-substituierte Phenylpropion- und -zimtsäurederivate |
| US5466861A (en) * | 1992-11-25 | 1995-11-14 | Sri International | Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors |
| US5591776A (en) | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
| US5929117A (en) * | 1996-08-12 | 1999-07-27 | Celgene Corporation | Immunotherapeutic agents |
| AU4849199A (en) | 1998-07-01 | 2000-01-24 | Celgro | Fungal growth inhibitors |
| US7470723B2 (en) | 2003-03-05 | 2008-12-30 | Celgene Corporation | Diphenylethylene compounds and uses thereof |
| AU2004218364A1 (en) | 2003-03-05 | 2004-09-16 | Celgene Corporation | Diphenylethylene compounds and uses thereof |
-
2004
- 2004-09-03 US US10/934,974 patent/US7470723B2/en not_active Expired - Fee Related
-
2005
- 2005-08-31 CA CA002578772A patent/CA2578772A1/en not_active Abandoned
- 2005-08-31 BR BRPI0514890-1A patent/BRPI0514890A/pt not_active IP Right Cessation
- 2005-08-31 MX MX2007002525A patent/MX2007002525A/es not_active Application Discontinuation
- 2005-08-31 JP JP2007530388A patent/JP2008512374A/ja active Pending
- 2005-08-31 WO PCT/US2005/031282 patent/WO2006026747A2/en not_active Ceased
- 2005-08-31 AU AU2005279788A patent/AU2005279788A1/en not_active Abandoned
- 2005-08-31 KR KR1020077007532A patent/KR20070061854A/ko not_active Withdrawn
- 2005-08-31 CN CNA2005800369763A patent/CN101056846A/zh active Pending
- 2005-08-31 EP EP05812254A patent/EP1799634A2/en not_active Withdrawn
- 2005-09-02 AR ARP050103696A patent/AR050558A1/es unknown
-
2007
- 2007-03-01 IL IL181675A patent/IL181675A0/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3059021A (en) * | 1960-02-12 | 1962-10-16 | Monsanto Chemicals | 1, 1, 1-trichloro-2, 2-bis[(carboalkoxy-amino) aryl] ethane |
| JPS63216882A (ja) * | 1987-02-13 | 1988-09-09 | チバ−ガイギー アクチエンゲゼル シヤフト | 置換α,α−ジフェニルエチレン誘導体、その製造方法、中間体並びに有害生物防除のための使用方法 |
| WO2003002495A1 (en) * | 2001-06-27 | 2003-01-09 | Ingvar Brandt | Novel treatment of adrenocortical hypersecretion and tumour growth |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011523657A (ja) * | 2008-06-04 | 2011-08-18 | サントル、ナショナール、ド、ラ、ルシェルシュ、シアンティフィク、(セーエヌエルエス) | ジヒドロイソca−4および類似体:強力な細胞傷害剤、チューブリン重合阻害剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005279788A1 (en) | 2006-03-09 |
| CA2578772A1 (en) | 2006-03-09 |
| US7470723B2 (en) | 2008-12-30 |
| IL181675A0 (en) | 2007-07-04 |
| BRPI0514890A (pt) | 2007-11-27 |
| EP1799634A2 (en) | 2007-06-27 |
| MX2007002525A (es) | 2007-05-09 |
| WO2006026747A3 (en) | 2006-04-06 |
| AR050558A1 (es) | 2006-11-01 |
| WO2006026747A2 (en) | 2006-03-09 |
| US20050107339A1 (en) | 2005-05-19 |
| KR20070061854A (ko) | 2007-06-14 |
| CN101056846A (zh) | 2007-10-17 |
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