JP2008511634A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008511634A5 JP2008511634A5 JP2007530141A JP2007530141A JP2008511634A5 JP 2008511634 A5 JP2008511634 A5 JP 2008511634A5 JP 2007530141 A JP2007530141 A JP 2007530141A JP 2007530141 A JP2007530141 A JP 2007530141A JP 2008511634 A5 JP2008511634 A5 JP 2008511634A5
- Authority
- JP
- Japan
- Prior art keywords
- galactosylceramide
- alkene
- glycosylceramide
- group
- alkane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C(C([C@]1O)O)O)(OC[C@](C(*)O)NC(*)=O)O[C@@]1(CO)N Chemical compound CC(C(C([C@]1O)O)O)(OC[C@](C(*)O)NC(*)=O)O[C@@]1(CO)N 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60536204P | 2004-08-27 | 2004-08-27 | |
| US60/605,362 | 2004-08-27 | ||
| PCT/US2005/030330 WO2006026389A2 (en) | 2004-08-27 | 2005-08-26 | Ceramide derivatives as modulators of immunity and autoimmunity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012152661A Division JP2012211182A (ja) | 2004-08-27 | 2012-07-06 | 免疫及び自己免疫の調節因子としてのセラミド誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008511634A JP2008511634A (ja) | 2008-04-17 |
| JP2008511634A5 true JP2008511634A5 (https=) | 2008-10-16 |
| JP5226311B2 JP5226311B2 (ja) | 2013-07-03 |
Family
ID=36000590
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530141A Expired - Fee Related JP5226311B2 (ja) | 2004-08-27 | 2005-08-26 | 免疫及び自己免疫の調節因子としてのセラミド誘導体 |
| JP2012152661A Withdrawn JP2012211182A (ja) | 2004-08-27 | 2012-07-06 | 免疫及び自己免疫の調節因子としてのセラミド誘導体 |
| JP2014185949A Expired - Fee Related JP5870327B2 (ja) | 2004-08-27 | 2014-09-12 | 免疫及び自己免疫の調節因子としてのセラミド誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012152661A Withdrawn JP2012211182A (ja) | 2004-08-27 | 2012-07-06 | 免疫及び自己免疫の調節因子としてのセラミド誘導体 |
| JP2014185949A Expired - Fee Related JP5870327B2 (ja) | 2004-08-27 | 2014-09-12 | 免疫及び自己免疫の調節因子としてのセラミド誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7772380B2 (https=) |
| EP (1) | EP1784196B1 (https=) |
| JP (3) | JP5226311B2 (https=) |
| KR (2) | KR101377116B1 (https=) |
| CN (1) | CN101010086B (https=) |
| AU (1) | AU2005280163B2 (https=) |
| CA (1) | CA2577009C (https=) |
| IL (1) | IL181054A (https=) |
| NZ (1) | NZ553320A (https=) |
| WO (1) | WO2006026389A2 (https=) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9809654B2 (en) | 2002-09-27 | 2017-11-07 | Vaccinex, Inc. | Targeted CD1d molecules |
| US7645873B2 (en) | 2003-03-20 | 2010-01-12 | The Scripps Research Institute | 6″-amino-6″-deoxygalactosylceramides |
| CA2577009C (en) * | 2004-08-27 | 2017-05-02 | Albert Einstein College Of Medicine, Inc. | Ceramide derivatives as modulators of immunity and autoimmunity |
| US8022043B2 (en) * | 2004-08-27 | 2011-09-20 | Albert Einstein College Of Medicine Of Yeshiva University | Ceramide derivatives as modulators of immunity and autoimmunity |
| GB0419846D0 (en) | 2004-09-07 | 2004-10-13 | Chiron Srl | Vaccine adjuvants for saccharides |
| US7923013B2 (en) | 2004-12-28 | 2011-04-12 | The Rockefeller University | Glycolipids and analogues thereof as antigens for NKT cells |
| JP5090928B2 (ja) | 2004-12-28 | 2012-12-05 | ザ ロックフェラー ユニバーシティ | Nkt細胞に対する抗原としての糖脂質及びその類似体 |
| JPWO2007043630A1 (ja) * | 2005-10-06 | 2009-04-16 | 独立行政法人理化学研究所 | 上気道粘膜下に投与されるnkt細胞刺激剤 |
| GB0605247D0 (en) * | 2006-03-15 | 2006-04-26 | Chiron Srl | Compositions and methods for immunisation |
| PL2056842T3 (pl) | 2006-04-07 | 2013-03-29 | Scripps Research Inst | Modyfikowany galaktozyloceramid do leczenia chorób nowotworowych |
| AU2007269299B2 (en) * | 2006-06-30 | 2013-01-17 | Brigham Young University | Adjuvants and methods of use |
| WO2008048410A2 (en) * | 2006-09-19 | 2008-04-24 | Human Biomolecular Research Institute | Diagnostic methods and genetic markers for alzheimer disease |
| WO2008047174A1 (en) * | 2006-10-18 | 2008-04-24 | Centre National De La Recherche Scientifique | Alpha-galactosylceramide analogs, their methods of manufacture, intermediate compounds useful in these methods, and pharmaceutical compositions containing them |
| KR100868959B1 (ko) * | 2006-12-30 | 2008-11-17 | 재단법인서울대학교산학협력재단 | 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물 |
| JP5357782B2 (ja) * | 2007-02-21 | 2013-12-04 | バクシネックス インコーポレーティッド | 抗原負荷CD1d分子によるNKT細胞活性の調節 |
| US7959907B2 (en) | 2007-02-21 | 2011-06-14 | Vib Vzw | Method of treating cancer by combination therapy using TNF and alpha-galactosylceramide |
| US8802098B2 (en) | 2007-04-25 | 2014-08-12 | Immurx, Inc. | Methods of promoting antitumor immunity by administering CD40 agonists and alpha-galactosyl ceramide |
| US8916164B2 (en) * | 2007-08-29 | 2014-12-23 | Abivax | Methods of enhancing adjuvaticity of vaccine compositions |
| CN102066394B (zh) | 2007-10-12 | 2015-04-01 | 路易吉·潘扎 | 用作免疫佐剂的糖脂的类似物 |
| EP2058011A1 (en) | 2007-11-07 | 2009-05-13 | Wittycell | Nkt cell activating gycolipids covalently bound antigens and/or drug |
| US7928077B2 (en) * | 2008-07-11 | 2011-04-19 | Academia Sinica | Alpha-galactosyl ceramide analogs and their use as immunotherapies |
| US9457097B2 (en) | 2008-09-08 | 2016-10-04 | Children's Medical Corporation | Mucosal delivery of therapeutic molecules, proteins, or particles coupled to ceramide lipids |
| EP2336144B1 (en) | 2008-09-11 | 2015-01-21 | Riken | Esterified alpha-galactosylceramide |
| JP5809560B2 (ja) | 2008-10-08 | 2015-11-11 | アビヴァックス | インフルエンザに対して使用するためのワクチン組成物 |
| DK2385980T3 (en) * | 2009-01-08 | 2018-07-30 | Albert Einstein College Medicine Inc | BACTERIA VACCINES WITH CELL-WALL-ASSOCIATED CERAMIDE-LIKE GLYCOLIPIDS AND APPLICATIONS THEREOF |
| KR20110045545A (ko) * | 2009-10-27 | 2011-05-04 | 서울대학교산학협력단 | 신규 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 면역보조용 약학적 조성물 |
| WO2011112889A2 (en) * | 2010-03-12 | 2011-09-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | β-MANNOSYLCERAMIDE AND STIMULATION OF NKT CELL ANTI-TUMOR IMMUNITY |
| WO2013007792A1 (en) * | 2011-07-14 | 2013-01-17 | Thurgauische Stiftung Für Wissenschaft Und Forschung | Novel th2 polarizing compounds |
| BR112014009962A2 (pt) * | 2011-10-27 | 2019-09-24 | Nkt Therapeutics Inc | anticorpos humanizados para inkt |
| US20140329766A1 (en) * | 2011-11-28 | 2014-11-06 | Uti Limited Partnership | Prophylactic Compositions for Management of Microbial Infections in Patients with Brain Injury |
| EP2811831B1 (en) | 2012-02-07 | 2018-04-11 | The Regents Of The University Of California | Glycosphingolipids for use in modulating immune responses |
| KR101969814B1 (ko) * | 2012-02-24 | 2019-04-18 | 주식회사 진영바이오 | 글리코실 세라마이드 화합물 및 그 제조방법 |
| CN104321079A (zh) * | 2012-03-19 | 2015-01-28 | 马普科技促进协会 | 糖类-糖脂类缀合物疫苗 |
| ES2617510T3 (es) * | 2012-04-26 | 2017-06-19 | Riken | Nuevo carbamato de glicolípido y uso del mismo |
| US9708601B2 (en) | 2012-04-26 | 2017-07-18 | Vaccinex, Inc. | Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus |
| KR102162619B1 (ko) * | 2012-07-26 | 2020-10-08 | 빅토리아 링크 엘티디 | 유기 화합물 |
| WO2014053482A1 (en) | 2012-10-03 | 2014-04-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the prophylactic treatment of bacterial superinfections post-influenza with invariant nkt cell agonists |
| CA2925878A1 (en) | 2012-10-12 | 2014-04-17 | The Brigham And Women's Hospital, Inc. | Glycosphingolipids and methods of use thereof |
| US9861702B2 (en) | 2012-10-22 | 2018-01-09 | Wisconsin Alumni Research Foundation | Lipid-conjugated rhamnose for immune system recruitment and oncotherapy |
| CA2893918C (en) * | 2012-12-06 | 2020-11-24 | Callaghan Innovation Research Limited | Conjugate compounds |
| CN105339379B (zh) * | 2013-02-08 | 2019-11-26 | 瓦克纳斯有限公司 | 改性的糖脂及其制备和使用方法 |
| US9371352B2 (en) | 2013-02-08 | 2016-06-21 | Vaccinex, Inc. | Modified glycolipids and methods of making and using the same |
| CA2906839A1 (en) * | 2013-03-15 | 2014-09-18 | Perkinelmer Health Sciences, Inc. | Compounds and methods relating to testing for lysosomal storage disorders |
| US9782476B2 (en) * | 2013-09-06 | 2017-10-10 | Academia Sinica | Human iNKT cell activation using glycolipids with altered glycosyl groups |
| CN105461681A (zh) * | 2014-09-05 | 2016-04-06 | 中国科学院生态环境研究中心 | 具有抗肿瘤活性的krn7000类似物及合成方法 |
| CA2960712A1 (en) * | 2014-09-08 | 2016-03-17 | Academia Sinica | Human inkt cell activation using glycolipids |
| KR101589633B1 (ko) * | 2014-09-18 | 2016-02-01 | 한국과학기술연구원 | 당세라마이드 유도체 및 이의 제조방법 |
| CN104497065B (zh) * | 2014-11-24 | 2017-10-24 | 浙江大学 | α‑半乳糖神经酰胺新异构体及其用途 |
| CN104497064B (zh) * | 2014-11-24 | 2017-10-24 | 浙江大学 | α‑半乳糖神经酰胺新异构体及其合成方法 |
| CN105384785B (zh) * | 2015-11-24 | 2018-06-19 | 中国人民解放军第二军医大学 | 含有半乳糖类脂肪酸衍生物的制备方法及其在医药领域的应用 |
| IL262232B2 (en) | 2016-04-22 | 2024-06-01 | Vaccinex Inc | Integral membrane protein display on poxvirus extracellular enveloped virions |
| WO2017207040A1 (en) | 2016-06-01 | 2017-12-07 | Vib Vzw | ANTI-CANCER THERAPY USING A LEPTIN ANTAGONIST AND AN iNKT-CELL ACTIVATOR |
| KR102449406B1 (ko) | 2016-08-02 | 2022-09-29 | 백시넥스 인코포레이티드 | 백시니아 바이러스/진핵 세포에서 폴리뉴클레오티드 라이브러리를 생산하기 위한 개선된 방법 |
| AU2018354422A1 (en) | 2017-10-27 | 2020-05-28 | Children's Medical Center Corporation | Short chain ceramide-based lipids and uses thereof |
| AU2019252912A1 (en) | 2018-04-12 | 2020-10-22 | The Children's Medical Center Corporation | Ceramide-like lipid-based delivery vehicles and uses thereof |
| CN109701009A (zh) * | 2019-01-03 | 2019-05-03 | 华中师范大学 | 疫苗制剂及其应用 |
| KR102146226B1 (ko) * | 2019-03-07 | 2020-08-20 | 경희대학교 산학협력단 | 피토세라마이드 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 신경계 자가면역질환의 예방 또는 치료용 조성물 |
| JP7714237B2 (ja) * | 2020-11-12 | 2025-07-29 | 国立研究開発法人理化学研究所 | 擬似糖脂質誘導体並びにその合成中間体、製造方法及び用途 |
| CN117222414A (zh) * | 2021-03-01 | 2023-12-12 | 脱落性治疗公司 | 用于激活恒定自然杀伤t-细胞的化合物和用于消除炎性衰老细胞的方法 |
| WO2023096715A2 (en) * | 2021-10-22 | 2023-06-01 | President And Fellows Of Harvard College | Immunomodulatory glycosphingolipids and methods of use thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5936076A (en) | 1991-08-29 | 1999-08-10 | Kirin Beer Kabushiki Kaisha | αgalactosylceramide derivatives |
| EP0666268B1 (en) * | 1992-10-22 | 2000-04-19 | Kirin Beer Kabushiki Kaisha | Novel sphingoglycolipid and use thereof |
| US5679347A (en) * | 1992-12-10 | 1997-10-21 | Brigham And Women's Hospital | Methods of isolating CD1-presented antigens, vaccines comprising CD1-presented antigens, and cell lines for use in said methods |
| US5853737A (en) * | 1992-12-10 | 1998-12-29 | Brigham And Women's Hospital | Method for inducing a CD1-restricted immune response |
| US6238676B1 (en) * | 1992-12-10 | 2001-05-29 | Brigham And Women's Hospital | Presentation of hydrophobic antigens to T-cells by CD1 molecules |
| EP0694558B1 (en) | 1993-04-15 | 1999-01-27 | Kirin Beer Kabushiki Kaisha | Novel sphingoglycolipid and use thereof |
| US5973128A (en) * | 1996-11-22 | 1999-10-26 | The Hospital For Sick Children Research And Development Lp | Glycolipid mimics and methods of use thereof |
| JP2004131481A (ja) * | 1997-04-10 | 2004-04-30 | Kirin Brewery Co Ltd | α−グリコシルセラミドを含有するNKT細胞活性化剤 |
| ATE286735T1 (de) * | 1997-04-10 | 2005-01-15 | Kirin Brewery | Verwendung von a-glycosylceramiden zur herstellung eines therapeutischen mittelszur behandlung von autoimmunkrankheiten |
| WO1999034209A1 (en) * | 1997-12-31 | 1999-07-08 | The Brigham And Women's Hospital, Inc. | DIAGNOSTIC AND THERAPEUTIC METHODS BASED UPON Vα24JαQ T CELLS |
| CN1561389A (zh) * | 2001-07-25 | 2005-01-05 | 纽约大学 | 糖基神经酰胺作为用于抗传染病和癌症的疫苗的佐剂的用途 |
| DE60215530T2 (de) * | 2001-08-16 | 2007-05-31 | Daiichi Asubio Pharma Co., Ltd. | Neues glykolipid, und heilmittel für autoimmunerkrankungen, das dieses als wirkstoff enthält |
| WO2003105769A2 (en) * | 2002-06-13 | 2003-12-24 | New York University | Synthetic c-glycolipid and its use for treating cancer infectious diseases and autoimmune diseases |
| WO2004028475A2 (en) * | 2002-09-27 | 2004-04-08 | Biomira, Inc. | Glycosylceramide analogues |
| WO2004072091A1 (ja) * | 2003-02-14 | 2004-08-26 | Daiichi Suntory Pharma Co., Ltd. | 糖脂質誘導体及びその製造法並びにそれらの合成中間体及びその製造法 |
| CA2577009C (en) * | 2004-08-27 | 2017-05-02 | Albert Einstein College Of Medicine, Inc. | Ceramide derivatives as modulators of immunity and autoimmunity |
-
2005
- 2005-08-26 CA CA2577009A patent/CA2577009C/en not_active Expired - Fee Related
- 2005-08-26 CN CN2005800289881A patent/CN101010086B/zh not_active Expired - Fee Related
- 2005-08-26 WO PCT/US2005/030330 patent/WO2006026389A2/en not_active Ceased
- 2005-08-26 JP JP2007530141A patent/JP5226311B2/ja not_active Expired - Fee Related
- 2005-08-26 EP EP05808439.3A patent/EP1784196B1/en not_active Expired - Lifetime
- 2005-08-26 AU AU2005280163A patent/AU2005280163B2/en not_active Ceased
- 2005-08-26 KR KR1020077003168A patent/KR101377116B1/ko not_active Expired - Fee Related
- 2005-08-26 US US11/211,653 patent/US7772380B2/en not_active Expired - Fee Related
- 2005-08-26 NZ NZ553320A patent/NZ553320A/en not_active IP Right Cessation
- 2005-08-26 KR KR1020127025454A patent/KR20120116511A/ko not_active Ceased
-
2007
- 2007-01-30 IL IL181054A patent/IL181054A/en active IP Right Grant
-
2012
- 2012-07-06 JP JP2012152661A patent/JP2012211182A/ja not_active Withdrawn
-
2014
- 2014-09-12 JP JP2014185949A patent/JP5870327B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008511634A5 (https=) | ||
| JP6742403B2 (ja) | アレナウイルス科およびコロナウイルス科のウイルス感染を処置するための方法 | |
| JP6905053B2 (ja) | ベンジルフェニルエーテル誘導体、その調製方法、並びにその医薬組成物及び使用 | |
| RU2636587C2 (ru) | Способы получения гликосфинголипидов и их применение | |
| JP2013541503A5 (https=) | ||
| ES2865163T3 (es) | Derivados de ácido oleanólico modificado en C4 para la inhibición de il-17 y otros usos | |
| UA130059C2 (uk) | ІНГІБУВАННЯ ІНТЕГРИНУ <font face="Symbol">a<sub></font>4</sub><font face="Symbol">b<sub></font>7</sub> ЛЮДИНИ | |
| AU2025205450A1 (en) | Bridged tricyclic carbamoylpyridone compounds and uses thereof | |
| EP1619199A1 (en) | Glycolipid derivatives, process for production of the same, intermediates for synthesis thereof, and process for production of the intermediates | |
| TW401400B (en) | Morphinan derivatives and medical uses thereof | |
| EA018757B1 (ru) | 2'-фтор-2'-дезокситетрагидроуридины в качестве ингибиторов цитидиндеаминазы | |
| JP6265985B2 (ja) | 多量体マンノシド類、その製造方法および医薬としての使用 | |
| JP2016501840A (ja) | E−セレクチンアンタゴニスト化合物および使用方法 | |
| KR20170060162A (ko) | 안드로겐 수용체 조절제의 에스터 유도체 및 그의 이용 방법 | |
| EP2928476A1 (en) | Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells | |
| US20020032158A1 (en) | Novel glycolipid derivatives | |
| RU2009135016A (ru) | Твердые формы, содержащие (-)-о-десметилвенлафаксин, и их применения | |
| JP2009511599A5 (https=) | ||
| JPWO2019168999A5 (https=) | ||
| ES2300877T3 (es) | Derivados de esteroides glucosilados con actividad antimigratoria. | |
| JP5126684B2 (ja) | 新規糖脂質及びその用途 | |
| PT99659A (pt) | Processo para preparacao de composicoes farmaceuticas com actividade imuno-supressora contendo xantinas | |
| TW200529809A (en) | HIV protease inhibiting compounds | |
| CN102083806A (zh) | 用于治疗急性和慢性炎性疾病的5-(4-甲基磺酰基-苯基)-噻唑衍生物 | |
| RU2060249C1 (ru) | Полициклические биоцидные соединения и фармацевтическая композиция на их основе |