JP2008511634A5 - - Google Patents

Download PDF

Info

Publication number
JP2008511634A5
JP2008511634A5 JP2007530141A JP2007530141A JP2008511634A5 JP 2008511634 A5 JP2008511634 A5 JP 2008511634A5 JP 2007530141 A JP2007530141 A JP 2007530141A JP 2007530141 A JP2007530141 A JP 2007530141A JP 2008511634 A5 JP2008511634 A5 JP 2008511634A5
Authority
JP
Japan
Prior art keywords
galactosylceramide
alkene
glycosylceramide
group
alkane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007530141A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008511634A (ja
JP5226311B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2005/030330 external-priority patent/WO2006026389A2/en
Publication of JP2008511634A publication Critical patent/JP2008511634A/ja
Publication of JP2008511634A5 publication Critical patent/JP2008511634A5/ja
Application granted granted Critical
Publication of JP5226311B2 publication Critical patent/JP5226311B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2007530141A 2004-08-27 2005-08-26 免疫及び自己免疫の調節因子としてのセラミド誘導体 Expired - Fee Related JP5226311B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60536204P 2004-08-27 2004-08-27
US60/605,362 2004-08-27
PCT/US2005/030330 WO2006026389A2 (en) 2004-08-27 2005-08-26 Ceramide derivatives as modulators of immunity and autoimmunity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012152661A Division JP2012211182A (ja) 2004-08-27 2012-07-06 免疫及び自己免疫の調節因子としてのセラミド誘導体

Publications (3)

Publication Number Publication Date
JP2008511634A JP2008511634A (ja) 2008-04-17
JP2008511634A5 true JP2008511634A5 (https=) 2008-10-16
JP5226311B2 JP5226311B2 (ja) 2013-07-03

Family

ID=36000590

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2007530141A Expired - Fee Related JP5226311B2 (ja) 2004-08-27 2005-08-26 免疫及び自己免疫の調節因子としてのセラミド誘導体
JP2012152661A Withdrawn JP2012211182A (ja) 2004-08-27 2012-07-06 免疫及び自己免疫の調節因子としてのセラミド誘導体
JP2014185949A Expired - Fee Related JP5870327B2 (ja) 2004-08-27 2014-09-12 免疫及び自己免疫の調節因子としてのセラミド誘導体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2012152661A Withdrawn JP2012211182A (ja) 2004-08-27 2012-07-06 免疫及び自己免疫の調節因子としてのセラミド誘導体
JP2014185949A Expired - Fee Related JP5870327B2 (ja) 2004-08-27 2014-09-12 免疫及び自己免疫の調節因子としてのセラミド誘導体

Country Status (10)

Country Link
US (1) US7772380B2 (https=)
EP (1) EP1784196B1 (https=)
JP (3) JP5226311B2 (https=)
KR (2) KR20120116511A (https=)
CN (1) CN101010086B (https=)
AU (1) AU2005280163B2 (https=)
CA (1) CA2577009C (https=)
IL (1) IL181054A (https=)
NZ (1) NZ553320A (https=)
WO (1) WO2006026389A2 (https=)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
US7645873B2 (en) 2003-03-20 2010-01-12 The Scripps Research Institute 6″-amino-6″-deoxygalactosylceramides
EP1784196B1 (en) * 2004-08-27 2016-12-21 Albert Einstein College Of Medicine Of Yeshiva University Ceramide derivatives as modulators of immunity and autoimmunity
US8022043B2 (en) * 2004-08-27 2011-09-20 Albert Einstein College Of Medicine Of Yeshiva University Ceramide derivatives as modulators of immunity and autoimmunity
GB0419846D0 (en) 2004-09-07 2004-10-13 Chiron Srl Vaccine adjuvants for saccharides
US7534434B2 (en) 2004-12-28 2009-05-19 The Rockefeller University Glycolipids and analogues thereof as antigens for NK T cells
US7923013B2 (en) * 2004-12-28 2011-04-12 The Rockefeller University Glycolipids and analogues thereof as antigens for NKT cells
JPWO2007043630A1 (ja) * 2005-10-06 2009-04-16 独立行政法人理化学研究所 上気道粘膜下に投与されるｎｋｔ細胞刺激剤
GB0605247D0 (en) * 2006-03-15 2006-04-26 Chiron Srl Compositions and methods for immunisation
DK2056842T3 (da) 2006-04-07 2013-01-14 Univ Chicago Modificeret galactosylceramid til behandling af cancerøse sygdomme
EP2040541B1 (en) * 2006-06-30 2016-03-23 The Scripps Research Institute Adjuvants and methods of use
CA2663954A1 (en) * 2006-09-19 2008-04-24 Human Biomolecular Research Institute Curcumin analogs, diagnostic methods and genetic markers for diagnosing and treating alzheimer's disease
WO2008047174A1 (en) 2006-10-18 2008-04-24 Centre National De La Recherche Scientifique Alpha-galactosylceramide analogs, their methods of manufacture, intermediate compounds useful in these methods, and pharmaceutical compositions containing them
KR100868959B1 (ko) 2006-12-30 2008-11-17 재단법인서울대학교산학협력재단 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물
AU2008219020B2 (en) 2007-02-21 2013-08-22 Vaccinex, Inc. Modulation of NKT cell activity with antigen-loaded CDId molecules
US7959907B2 (en) 2007-02-21 2011-06-14 Vib Vzw Method of treating cancer by combination therapy using TNF and alpha-galactosylceramide
JP5331100B2 (ja) 2007-04-25 2013-10-30 イミュアールエックス・インコーポレーテッド Ｎｋｔアクチベータ、ｃｄ４０アゴニスト、及び任意選択的に抗原を含んでなるアジュバント組合せと、細胞性免疫において相乗的な増強を誘導するためのその使用
US8916164B2 (en) * 2007-08-29 2014-12-23 Abivax Methods of enhancing adjuvaticity of vaccine compositions
ES2574825T3 (es) 2007-10-12 2016-06-22 Luigi Panza Análogos de glicolípidos útiles como inmunoadyuvantes
EP2058011A1 (en) 2007-11-07 2009-05-13 Wittycell Nkt cell activating gycolipids covalently bound antigens and/or drug
US7928077B2 (en) * 2008-07-11 2011-04-19 Academia Sinica Alpha-galactosyl ceramide analogs and their use as immunotherapies
ES2798257T3 (es) 2008-09-08 2020-12-10 Childrens Medical Center Administración mucosa de moléculas, proteínas o partículas terapéuticas acopladas a lípidos de ceramida
EP2336144B1 (en) * 2008-09-11 2015-01-21 Riken Esterified alpha-galactosylceramide
JP5809560B2 (ja) 2008-10-08 2015-11-11 アビヴァックス インフルエンザに対して使用するためのワクチン組成物
CN102325875B (zh) * 2009-01-08 2018-04-10 阿尔伯爱因斯坦医学有限公司 具有细胞壁结合神经酰胺类糖脂的细菌疫苗及其应用
KR20110045545A (ko) * 2009-10-27 2011-05-04 서울대학교산학협력단 신규 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 면역보조용 약학적 조성물
WO2011112889A2 (en) * 2010-03-12 2011-09-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services β-MANNOSYLCERAMIDE AND STIMULATION OF NKT CELL ANTI-TUMOR IMMUNITY
WO2013007792A1 (en) * 2011-07-14 2013-01-17 Thurgauische Stiftung Für Wissenschaft Und Forschung Novel th2 polarizing compounds
JP2015502340A (ja) * 2011-10-27 2015-01-22 エヌケーティー セラピューティクス インコーポレーテッドＮｋｔ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． ｉＮＫＴに対するヒト化抗体
CA2857226A1 (en) * 2011-11-28 2013-06-06 Uti Limited Partnership Prophylactic compositions for management of microbial infections in patients with brain injury
EP2811831B1 (en) * 2012-02-07 2018-04-11 The Regents Of The University Of California Glycosphingolipids for use in modulating immune responses
KR101969814B1 (ko) * 2012-02-24 2019-04-18 주식회사 진영바이오 글리코실 세라마이드 화합물 및 그 제조방법
TWI633112B (zh) 2012-03-19 2018-08-21 馬克斯普朗克科學發展組織 醣類－醣脂類結合性疫苗
EP2842961B1 (en) * 2012-04-26 2016-12-14 Riken New carbamate glycolipid and use thereof
US9708601B2 (en) 2012-04-26 2017-07-18 Vaccinex, Inc. Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus
IN2015KN00492A (https=) * 2012-07-26 2015-07-17 Callaghan Innovation Res Ltd
WO2014053482A1 (en) 2012-10-03 2014-04-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the prophylactic treatment of bacterial superinfections post-influenza with invariant nkt cell agonists
EP2906576B1 (en) 2012-10-12 2019-09-11 The Brigham and Women's Hospital, Inc. Glycosphingolipids and methods of use thereof
US9861702B2 (en) 2012-10-22 2018-01-09 Wisconsin Alumni Research Foundation Lipid-conjugated rhamnose for immune system recruitment and oncotherapy
WO2014088432A1 (en) * 2012-12-06 2014-06-12 Callaghan Innovation Research Limited Conjugate compounds
US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
AU2014214770B2 (en) * 2013-02-08 2018-09-06 Albert Einstein College Of Medicine Inc. Modified glycolipids and methods of making and using the same
TWI773147B (zh) * 2013-03-15 2022-08-01 美商珀金埃爾默健康科技公司 關於用於溶酶體儲積症之測試的化合物及方法
JP6486368B2 (ja) * 2013-09-06 2019-03-20 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 改変されたグリコシル基を含む糖脂質を用いたヒトｉＮＫＴ細胞の活性化
CN105461681A (zh) * 2014-09-05 2016-04-06 中国科学院生态环境研究中心 具有抗肿瘤活性的krn7000类似物及合成方法
TWI745275B (zh) * 2014-09-08 2021-11-11 中央研究院 使用醣脂激活人類ｉＮＫＴ細胞
KR101589633B1 (ko) * 2014-09-18 2016-02-01 한국과학기술연구원 당세라마이드 유도체 및 이의 제조방법
CN104497065B (zh) * 2014-11-24 2017-10-24 浙江大学 α‑半乳糖神经酰胺新异构体及其用途
CN104497064B (zh) * 2014-11-24 2017-10-24 浙江大学 α‑半乳糖神经酰胺新异构体及其合成方法
CN105384785B (zh) * 2015-11-24 2018-06-19 中国人民解放军第二军医大学 含有半乳糖类脂肪酸衍生物的制备方法及其在医药领域的应用
US10577427B2 (en) 2016-04-22 2020-03-03 Vaccinex, Inc. Integral membrane protein display on poxvirus extracellular enveloped virions
WO2017207040A1 (en) 2016-06-01 2017-12-07 Vib Vzw ANTI-CANCER THERAPY USING A LEPTIN ANTAGONIST AND AN iNKT-CELL ACTIVATOR
BR112019001944A2 (pt) 2016-08-02 2019-05-07 Vaccinex, Inc. métodos aperfeiçoados para produção de bibiliotecas de polinucleotídeo em células eucarióticas/vírus de vaccínia
EP3700549A4 (en) 2017-10-27 2021-08-18 Children's Medical Center Corporation LIPIDS BASED ON SHORT CHAIN CERAMIDES AND THEIR USES
AU2019252912A1 (en) 2018-04-12 2020-10-22 The Children's Medical Center Corporation Ceramide-like lipid-based delivery vehicles and uses thereof
CN109701009A (zh) * 2019-01-03 2019-05-03 华中师范大学 疫苗制剂及其应用
KR102146226B1 (ko) * 2019-03-07 2020-08-20 경희대학교 산학협력단 피토세라마이드 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 신경계 자가면역질환의 예방 또는 치료용 조성물
JP7714237B2 (ja) * 2020-11-12 2025-07-29 国立研究開発法人理化学研究所 擬似糖脂質誘導体並びにその合成中間体、製造方法及び用途
EP4301374A4 (en) * 2021-03-01 2025-09-10 Deciduous Therapeutics Inc COMPOUNDS FOR ACTIVATING INVARIANT NATURAL KILLER T CELLS AND METHODS OF USE IN ELIMINATING INFLAMMATORY SENESCENT CELLS
WO2023096715A2 (en) * 2021-10-22 2023-06-01 President And Fellows Of Harvard College Immunomodulatory glycosphingolipids and methods of use thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5936076A (en) * 1991-08-29 1999-08-10 Kirin Beer Kabushiki Kaisha αgalactosylceramide derivatives
AU683026B2 (en) 1992-10-22 1997-10-30 Kirin Pharma Kabushiki Kaisha Novel shingoglycolipid and use thereof
US6238676B1 (en) 1992-12-10 2001-05-29 Brigham And Women's Hospital Presentation of hydrophobic antigens to T-cells by CD1 molecules
US5853737A (en) 1992-12-10 1998-12-29 Brigham And Women's Hospital Method for inducing a CD1-restricted immune response
US5679347A (en) 1992-12-10 1997-10-21 Brigham And Women's Hospital Methods of isolating CD1-presented antigens, vaccines comprising CD1-presented antigens, and cell lines for use in said methods
EP0694558B1 (en) 1993-04-15 1999-01-27 Kirin Beer Kabushiki Kaisha Novel sphingoglycolipid and use thereof
US5973128A (en) * 1996-11-22 1999-10-26 The Hospital For Sick Children Research And Development Lp Glycolipid mimics and methods of use thereof
JP2004131481A (ja) * 1997-04-10 2004-04-30 Kirin Brewery Co Ltd α−グリコシルセラミドを含有するＮＫＴ細胞活性化剤
JP3495740B2 (ja) * 1997-04-10 2004-02-09 麒麟麦酒株式会社 α−グリコシルセラミドを含有するＮＫＴ細胞活性化剤
AU2087799A (en) 1997-12-31 1999-07-19 Brigham And Women's Hospital Diagnostic and therapeutic methods based upon valpha24jalphaq t cells
EP1434859A2 (en) 2001-07-25 2004-07-07 New York University Use of glycosylceramides as adjuvants for vaccines against infections and cancer
EP1437358B1 (en) * 2001-08-16 2006-10-18 Daiichi Asubio Pharma Co., Ltd. Novel glycolipid and remedial agent for autoimmune disease containing the same as active ingredient
AU2003251518B2 (en) 2002-06-13 2009-07-02 New York University Synthetic C-glycolipid and its use for treating cancer infectious diseases and autoimmune diseases
AU2003277021A1 (en) * 2002-09-27 2004-04-19 Biomira, Inc. Glycosylceramide analogues
ES2676345T3 (es) * 2003-02-14 2018-07-18 Japan As Represented By President Of National Center Of Neurology And Psychiatry Ministry Of Health Derivados del glicolípido, proceso para su producción, intermedios para la síntesis del mismo, y proceso para la producción de los intermedios
EP1784196B1 (en) * 2004-08-27 2016-12-21 Albert Einstein College Of Medicine Of Yeshiva University Ceramide derivatives as modulators of immunity and autoimmunity

Similar Documents

Publication Publication Date Title
JP2008511634A5 (https=)
JP6742403B2 (ja) アレナウイルス科およびコロナウイルス科のウイルス感染を処置するための方法
JP6905053B2 (ja) ベンジルフェニルエーテル誘導体、その調製方法、並びにその医薬組成物及び使用
RU2636587C2 (ru) Способы получения гликосфинголипидов и их применение
JP2013541503A5 (https=)
ES2865163T3 (es) Derivados de ácido oleanólico modificado en C4 para la inhibición de il-17 y otros usos
UA130059C2 (uk) ІНГІБУВАННЯ ІНТЕГРИНУ <font face="Symbol">a<sub></font>4</sub><font face="Symbol">b<sub></font>7</sub> ЛЮДИНИ
US11638713B2 (en) Patentiflorin A analogs as antiviral agents
AU2025205450A1 (en) Bridged tricyclic carbamoylpyridone compounds and uses thereof
EP1619199A1 (en) Glycolipid derivatives, process for production of the same, intermediates for synthesis thereof, and process for production of the intermediates
TW401400B (en) Morphinan derivatives and medical uses thereof
SA08290661B1 (ar) 2' - فلورو -2' – ديوكسي تترا هيدرو يوريدين كمثبطات سيتيدين دياميناز
JP6265985B2 (ja) 多量体マンノシド類、その製造方法および医薬としての使用
JP2016501840A (ja) Ｅ−セレクチンアンタゴニスト化合物および使用方法
KR20160013072A (ko) 안드로겐 수용체 조절제의 에스터 유도체 및 그의 이용 방법
EP2928476A1 (en) Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells
US20020032158A1 (en) Novel glycolipid derivatives
RU2009135016A (ru) Твердые формы, содержащие (-)-о-десметилвенлафаксин, и их применения
JP2009511599A5 (https=)
ES2300877T3 (es) Derivados de esteroides glucosilados con actividad antimigratoria.
JP5126684B2 (ja) 新規糖脂質及びその用途
PT99659A (pt) Processo para preparacao de composicoes farmaceuticas com actividade imuno-supressora contendo xantinas
RU2005128831A (ru) Обладающие противоопухолевым действием 2-замещенные эстра-1,3,5( 10 )-триен-3-илсульфаматы
CN102083806A (zh) 用于治疗急性和慢性炎性疾病的5-(4-甲基磺酰基-苯基)-噻唑衍生物
RU2060249C1 (ru) Полициклические биоцидные соединения и фармацевтическая композиция на их основе