JP2008511329A5 - - Google Patents
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- JP2008511329A5 JP2008511329A5 JP2007530166A JP2007530166A JP2008511329A5 JP 2008511329 A5 JP2008511329 A5 JP 2008511329A5 JP 2007530166 A JP2007530166 A JP 2007530166A JP 2007530166 A JP2007530166 A JP 2007530166A JP 2008511329 A5 JP2008511329 A5 JP 2008511329A5
- Authority
- JP
- Japan
- Prior art keywords
- culture
- medium
- per unit
- glutamine
- unit volume
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60494104P | 2004-08-27 | 2004-08-27 | |
| US60507404P | 2004-08-27 | 2004-08-27 | |
| US60509704P | 2004-08-27 | 2004-08-27 | |
| US60/604,941 | 2004-08-27 | ||
| US60/605,097 | 2004-08-27 | ||
| US60/605,074 | 2004-08-27 | ||
| PCT/US2005/030437 WO2006026445A1 (en) | 2004-08-27 | 2005-08-26 | Production of polypeptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008511329A JP2008511329A (ja) | 2008-04-17 |
| JP2008511329A5 true JP2008511329A5 (cg-RX-API-DMAC10.html) | 2008-10-16 |
| JP4864892B2 JP4864892B2 (ja) | 2012-02-01 |
Family
ID=35482353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530166A Expired - Lifetime JP4864892B2 (ja) | 2004-08-27 | 2005-08-26 | ポリペプチドの製造 |
Country Status (20)
Families Citing this family (96)
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| US7294484B2 (en) | 2004-08-27 | 2007-11-13 | Wyeth Research Ireland Limited | Production of polypeptides |
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| CN102382794B (zh) * | 2010-09-01 | 2013-09-18 | 山东新时代药业有限公司 | 一种哺乳动物细胞的灌流培养方法 |
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| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
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| US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
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| WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
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| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| NZ715246A (en) * | 2013-07-06 | 2017-07-28 | Cadila Healthcare Ltd | Improved process for production of monoclonal antibodies |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US11390663B2 (en) * | 2013-10-11 | 2022-07-19 | Regeneron Pharmaceuticals, Inc. | Metabolically optimized cell culture |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| WO2015095809A1 (en) * | 2013-12-20 | 2015-06-25 | Biogen Idec Ma Inc. | Use of perfusion seed cultures to improve biopharmaceutical fed-batch production capacity and product quality |
| RS59881B1 (sr) | 2014-02-27 | 2020-03-31 | Hoffmann La Roche | Modulacija ćelijskog rasta i glikozilacije u rekombinantnoj proizvodnji glikoproteina |
| EP3119876B1 (en) | 2014-03-19 | 2024-12-18 | Pfizer Inc. | Method of cell culture |
| TWI743024B (zh) | 2014-06-06 | 2021-10-21 | 美商健臻公司 | 灌注培養方法及其用途 |
| TWI776235B (zh) * | 2014-06-09 | 2022-09-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| CA2969225C (en) | 2014-12-01 | 2023-08-22 | Amgen Inc. | Process for manipulating the level of glycan content of a glycoprotein |
| US11597903B2 (en) * | 2015-05-29 | 2023-03-07 | Boehringer Ingelheim International Gmbh | Cell-controlled perfusion in continuous culture |
| TW202440903A (zh) | 2015-08-04 | 2024-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法（一） |
| WO2017051347A2 (en) | 2015-09-23 | 2017-03-30 | Pfizer Inc. | Cells and method of cell culture |
| IL259404B2 (en) | 2015-11-17 | 2025-08-01 | Pfizer | Media and fermentation methods for producing polysaccharides in bacterial cell culture |
| EP3440190B1 (en) * | 2016-04-05 | 2024-08-28 | Pfizer Inc. | Cell culture process |
| EP3372670B1 (en) * | 2017-03-09 | 2019-02-27 | Evonik Technochemie GmbH | Culture media comprising n-acyl-x-glutamine dipeptides |
| GB201708655D0 (en) | 2017-05-31 | 2017-07-12 | Ucb Biopharma Sprl | Cell culture methods |
| KR102190790B1 (ko) * | 2018-10-19 | 2020-12-15 | 주식회사 프로젠 | 변형된 egf 단백질의 생산 방법 |
| CN111836826B (zh) | 2017-10-23 | 2024-01-02 | 普罗根有限公司 | 修饰的egf蛋白，其制备方法及其用途 |
| CN111406112A (zh) * | 2017-11-30 | 2020-07-10 | 豪夫迈·罗氏有限公司 | 用于培养哺乳动物细胞的工艺 |
| IL307155B2 (en) | 2018-05-01 | 2025-11-01 | Amgen Inc | Antibodies with modulated glycan profiles |
| IL279782B2 (en) | 2018-07-03 | 2026-05-01 | Bristol Myers Squibb Co | Methods for producing recombinant proteins |
| CN113015805B (zh) | 2018-11-13 | 2024-12-03 | 詹森生物科技公司 | 抗cd38抗体产生期间的痕量金属的控制 |
| EP3891292A1 (en) | 2018-12-06 | 2021-10-13 | Pfizer Inc. | Cells with reduced inhibitor production and methods of use thereof |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| CN113025648B (zh) * | 2019-12-09 | 2023-06-02 | 广东菲鹏制药股份有限公司 | Expi293细胞瞬时表达目标蛋白的方法及其应用 |
| KR20230058094A (ko) | 2020-08-31 | 2023-05-02 | 리제너론 파아마슈티컬스, 인크. | 세포 배양 성능을 개선하고 아스파라긴 서열 변이체를 완화하기 위한 아스파라긴 공급 전략 |
| JP7822149B2 (ja) | 2020-10-02 | 2026-03-02 | ファイザー・インク | Ｒｓｖ ｆタンパク質生産のための細胞培養工程 |
| MX2023008527A (es) | 2021-01-20 | 2023-07-28 | Regeneron Pharma | Metodos para mejorar el valor proteico en cultivo celular. |
| JP2022184798A (ja) | 2021-06-01 | 2022-12-13 | ファイザー・インク | ｓＦＧＦＲ３ポリペプチドを生産するための細胞培養方法 |
| EP4413364A2 (en) | 2021-10-07 | 2024-08-14 | Regeneron Pharmaceuticals, Inc. | Systems and methods of ph modeling and control |
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-
2005
- 2005-08-25 US US11/213,308 patent/US7294484B2/en not_active Expired - Lifetime
- 2005-08-25 TW TW94129070A patent/TWI384069B/zh not_active IP Right Cessation
- 2005-08-26 ES ES05792494T patent/ES2628012T3/es not_active Expired - Lifetime
- 2005-08-26 CA CA 2578141 patent/CA2578141C/en not_active Expired - Lifetime
- 2005-08-26 KR KR1020117006936A patent/KR20110036780A/ko not_active Ceased
- 2005-08-26 EP EP05792494.6A patent/EP1789571B1/en not_active Revoked
- 2005-08-26 KR KR1020077004807A patent/KR101158447B1/ko not_active Expired - Lifetime
- 2005-08-26 EP EP11156236.9A patent/EP2357250B1/en not_active Revoked
- 2005-08-26 MX MX2007002380A patent/MX2007002380A/es active IP Right Grant
- 2005-08-26 BR BRPI0514703-4A patent/BRPI0514703A/pt not_active Application Discontinuation
- 2005-08-26 AR ARP050103594 patent/AR051017A1/es not_active Application Discontinuation
- 2005-08-26 AU AU2005280034A patent/AU2005280034B2/en not_active Expired
- 2005-08-26 WO PCT/US2005/030437 patent/WO2006026445A1/en not_active Ceased
- 2005-08-26 CN CN2005800368991A patent/CN101048511B/zh not_active Expired - Fee Related
- 2005-08-26 JP JP2007530166A patent/JP4864892B2/ja not_active Expired - Lifetime
- 2005-08-26 SG SG2013041199A patent/SG190674A1/en unknown
- 2005-08-26 CN CN201210189727.XA patent/CN102827905B/zh not_active Expired - Fee Related
- 2005-08-26 SG SG200907913-8A patent/SG158092A1/en unknown
-
2007
- 2007-02-27 IL IL181589A patent/IL181589A0/en unknown
- 2007-02-27 EG EGNA2007000223 patent/EG26462A/en active
- 2007-03-16 CR CR8997A patent/CR8997A/es unknown
- 2007-03-26 ZA ZA2007/02483A patent/ZA200702483B/en unknown
- 2007-03-26 NO NO20071572A patent/NO342433B1/no not_active IP Right Cessation
- 2007-03-27 EC ECSP077353 patent/ECSP077353A/es unknown
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2012
- 2012-06-14 AR ARP120102112 patent/AR086932A2/es not_active Application Discontinuation
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