JP2008509970A5 - - Google Patents

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Publication number
JP2008509970A5
JP2008509970A5 JP2007526459A JP2007526459A JP2008509970A5 JP 2008509970 A5 JP2008509970 A5 JP 2008509970A5 JP 2007526459 A JP2007526459 A JP 2007526459A JP 2007526459 A JP2007526459 A JP 2007526459A JP 2008509970 A5 JP2008509970 A5 JP 2008509970A5
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JP
Japan
Prior art keywords
composition
microvesicles
gas
composition according
filled
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JP2007526459A
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English (en)
Japanese (ja)
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JP4837663B2 (ja
JP2008509970A (ja
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Priority claimed from PCT/EP2005/054041 external-priority patent/WO2006018433A1/en
Publication of JP2008509970A publication Critical patent/JP2008509970A/ja
Publication of JP2008509970A5 publication Critical patent/JP2008509970A5/ja
Application granted granted Critical
Publication of JP4837663B2 publication Critical patent/JP4837663B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2007526459A 2004-08-18 2005-08-17 造影画像化のためのガス充填微小胞組成物 Expired - Fee Related JP4837663B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04019557 2004-08-18
EP04019557.0 2004-08-18
PCT/EP2005/054041 WO2006018433A1 (en) 2004-08-18 2005-08-17 Gas-filled microvesicles composition for contrast imaging

Publications (3)

Publication Number Publication Date
JP2008509970A JP2008509970A (ja) 2008-04-03
JP2008509970A5 true JP2008509970A5 (cg-RX-API-DMAC10.html) 2008-05-15
JP4837663B2 JP4837663B2 (ja) 2011-12-14

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JP2007526459A Expired - Fee Related JP4837663B2 (ja) 2004-08-18 2005-08-17 造影画像化のためのガス充填微小胞組成物

Country Status (7)

Country Link
US (2) US9248204B2 (cg-RX-API-DMAC10.html)
EP (1) EP1784228B1 (cg-RX-API-DMAC10.html)
JP (1) JP4837663B2 (cg-RX-API-DMAC10.html)
CN (2) CN101005858A (cg-RX-API-DMAC10.html)
AU (1) AU2005273865B2 (cg-RX-API-DMAC10.html)
CA (1) CA2575677C (cg-RX-API-DMAC10.html)
WO (1) WO2006018433A1 (cg-RX-API-DMAC10.html)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004069284A2 (en) 2003-02-04 2004-08-19 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
CA2547024C (en) 2003-12-22 2013-12-17 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
US7846100B2 (en) 2005-03-03 2010-12-07 Bracco International Bv Medical imaging system based on a targeted contrast agent
CA2624636C (en) * 2005-11-10 2016-04-05 Bracco Research Sa Instantaneous visualization of contrast agent concentration in imaging applications
US9198639B2 (en) 2005-11-10 2015-12-01 Bracco Suisse S.A. Detection of immobilized contrast agent in medical imaging applications based on flow dynamics analysis
CA2670932C (en) 2006-12-21 2016-03-22 Bracco International Bv Detection of the detachment of immobilized contrast agent in medical imaging applications
US10130342B2 (en) 2007-12-28 2018-11-20 Bracco Suisse Sa Initialization of fitting parameters for perfusion assessment based on bolus administration
US9072492B2 (en) 2007-12-28 2015-07-07 Bracco Suisse Sa Quantification analysis of immobilized contrast agent in medical imaging applications
JP2010005512A (ja) * 2008-06-25 2010-01-14 Kao Corp 微細気泡前駆体組成物
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
CN101745126B (zh) * 2008-12-10 2012-04-25 温州医学院 一种包载水溶性药物超声造影剂的制备方法
US10058837B2 (en) 2009-08-28 2018-08-28 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for production of gas-filled microbubbles
EP2566459A1 (en) * 2010-05-01 2013-03-13 The Trustees of Columbia University in the City of New York Methods devices and systems of preparing targeted microbubble shells
WO2011149985A1 (en) * 2010-05-24 2011-12-01 Nanovalent Pharmaceuticals, Inc. Polymerized shell lipid microbubbles and uses thereof
US9734584B2 (en) 2012-12-21 2017-08-15 Bracco Suisse Sa Segmentation in diagnostic imaging applications based on statistical analysis over time
US10368842B2 (en) 2014-04-07 2019-08-06 Bracco Suisse S.A. Estimation of acoustic level in-situ with non-fundamental analysis
WO2017097738A1 (en) 2015-12-10 2017-06-15 Bracco Suisse Sa Detection of immobilized contrast agent with dynamic thresholding
CN110831665B (zh) * 2017-06-29 2022-03-04 医视特有限公司 用于破坏靶组织以进行治疗以及评估靶组织破坏的系统
US11035740B1 (en) * 2017-07-31 2021-06-15 Prasidiux, Llc Stimulus indicating device employing thermoreversible amphiphilic gels
ES3002682T3 (en) * 2018-03-07 2025-03-07 Bracco Suisse Sa Preparation of size-controlled microvesicles
EP3897954B1 (en) * 2018-12-21 2024-05-01 Bracco Suisse SA Gas-filled microvesicles with ligand
US11246945B2 (en) 2019-06-07 2022-02-15 National Defense Medical Center Cisplatin-loaded microbubbles, pharmaceutical composition for treatment of cancer, method for preparing pharmaceutical compositions and method for treating cancer
WO2022186224A1 (ja) * 2021-03-01 2022-09-09 国立大学法人 東京大学 マイクロ粒子及びマイクロ粒子分散液
NL2033467B1 (en) 2022-11-04 2024-05-24 Demcon Curonix B V System for generating microvesicles having a predefined size and/or size distribution
NL2037565B1 (en) 2024-04-26 2025-11-11 Demcon Curonix B V Fluid delivery system for providing a flow of microvesicle containing liquid to a subject

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
DE3463211D1 (en) 1983-07-01 1987-05-21 Battelle Memorial Institute Biodegradable polypeptide and its use in the sustained release of medicaments
SE463651B (sv) 1983-12-21 1991-01-07 Nycomed As Diagnostikum och kontrastmedel
ATE60340T1 (de) 1984-10-19 1991-02-15 Battelle Memorial Institute Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten.
CH667874A5 (fr) 1985-12-19 1988-11-15 Battelle Memorial Institute Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments.
IE61591B1 (en) 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
IN172208B (cg-RX-API-DMAC10.html) 1990-04-02 1993-05-01 Sint Sa
US5556610A (en) 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5487390A (en) 1990-10-05 1996-01-30 Massachusetts Institute Of Technology Gas-filled polymeric microbubbles for ultrasound imaging
US5562099A (en) 1990-10-05 1996-10-08 Massachusetts Institute Of Technology Polymeric microparticles containing agents for imaging
JP2974083B2 (ja) 1990-11-26 1999-11-08 株式会社 小松製作所 静油圧―機械式伝動機の制御装置
JPH06511481A (ja) 1991-07-05 1994-12-22 ユニバーシティ オブ ロチェスター 気泡を取り込む超微小非凝集多孔質粒子
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
DE4208527A1 (de) 1992-03-17 1993-09-23 Max Planck Gesellschaft Liposomen mit negativer ueberschussladung
WO1994001140A1 (de) 1992-07-03 1994-01-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Echokontrastmittelzubereitung
US5464696A (en) 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
DK0711179T3 (da) 1993-07-30 2005-02-14 Imcor Pharmaceutical Co Stabiliserede sammensætninger med mikrobobler til ultralyd
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
CA2154867C (en) * 1993-12-15 2007-05-29 Feng Yan Gas mixtures useful as ultrasound contrast media
NO940711D0 (no) 1994-03-01 1994-03-01 Nycomed Imaging As Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging
EP0699445A3 (en) * 1994-08-04 1996-04-17 Gakko Houjin Toin Gakuen Process for the preparation of an ultrasonic microbubble contrast agent with a surfactant
GB9417941D0 (en) * 1994-09-06 1994-10-26 Nycomed Imaging As Improvements in or relating to contrast agents
WO1996009037A1 (en) 1994-09-23 1996-03-28 The Liposome Company, Inc. Method of producing a lyophilized liposome product
US6333021B1 (en) 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
IL116328A (en) 1994-12-16 1999-09-22 Bracco Research Sa Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US5833948A (en) 1995-06-15 1998-11-10 Bracco Research S.A. Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant
US6165442A (en) 1996-02-19 2000-12-26 Nycomed Imaging As Thermally stabilized ultrasound contrast agent
JP4250747B2 (ja) 1996-02-19 2009-04-08 ジーイー・ヘルスケア・アクスイェ・セルスカプ 熱安定化された造影剤
ES2197986T3 (es) 1996-02-19 2004-01-16 Amersham Health As Mejoras introducidas en o relacionadas con agentes de contraste.
WO1998004074A1 (en) 1996-07-22 1998-01-29 Seagate Technology, Inc. Phase detector estimator
EP0918546B1 (en) 1996-08-02 2008-10-15 GE Healthcare AS Improvements in or relating to contrast agents
ATE238073T1 (de) 1996-10-21 2003-05-15 Amersham Health As Verbesserungen für oder in bezug auf kontrastmitteln in ultraschallbilddarstellung
US6331289B1 (en) 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors
EP0973552B1 (en) 1996-10-28 2006-03-01 Amersham Health AS Improvements in or relating to diagnostic/therapeutic agents
IL129445A0 (en) 1996-10-28 2000-02-29 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
GB9701237D0 (en) * 1997-01-22 1997-03-12 Nycomed Imaging As Improvements in or relating to contrast agents
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6245318B1 (en) 1997-05-27 2001-06-12 Mallinckrodt Inc. Selectively binding ultrasound contrast agents
GB9717589D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
WO1999020312A1 (en) 1997-10-21 1999-04-29 Nycomed Imaging As Ultrasound imaging with contrast agent targeted to microvasculature and a vasodilator drug
US20020169138A1 (en) 1997-10-24 2002-11-14 Southern Research Institute Delivery vehicles for bioactive agents and uses thereof
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
NZ506051A (en) * 1998-02-09 2003-08-29 Bracco Res S Targeted delivery of biologically active media
GB9808599D0 (en) 1998-04-22 1998-06-24 Nycomed Imaging As Improvements in or realting to contrast agents
GB9809084D0 (en) 1998-04-28 1998-06-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
FR2782006B1 (fr) 1998-08-07 2002-04-19 Gattefosse Ets Sa Composition a liberation prolongee apte a former une micro-emulsion
JP2000143550A (ja) 1998-11-10 2000-05-23 Toin Gakuen 超音波造影剤
DE10013850A1 (de) * 2000-03-15 2001-09-20 Schering Ag Gasgefüllte Mikrokapseln enthaltend funktionalisiertes Polyalkylcyanacrylat, sowie Verfahren zu deren Herstellung
EP1348026A2 (en) 2000-12-23 2003-10-01 Dyax Corp. Fibrin binding moieties useful as imaging agents
JP2002212108A (ja) 2001-01-17 2002-07-31 Fuji Photo Film Co Ltd 超音波散乱体
US6793626B2 (en) 2001-01-17 2004-09-21 Fuji Photo Film Co., Ltd. Ultrasonic scatterer, ultrasonic imaging method and ultrasonic imaging apparatus
US7179449B2 (en) 2001-01-30 2007-02-20 Barnes-Jewish Hospital Enhanced ultrasound detection with temperature-dependent contrast agents
DK1228770T3 (da) 2001-01-31 2005-11-07 Bracco Int Bv Törret kontrastmiddel
AU2002317095A1 (en) 2001-07-03 2003-01-21 Governors Of The University Of Alberta Magnetic nanoparticles for bioseparation application and methods for producing same
KR20040030121A (ko) 2001-08-16 2004-04-08 브리스톨-마이어스 스퀴브 파마 컴퍼니 기체 마이크로스피어 리포좀 복합체
CA2477935C (en) 2002-03-01 2015-01-06 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
SI2301587T1 (sl) 2002-03-01 2014-11-28 Dyax Corp. KDR in VEGF/KDR vezavni peptidi in njihova uporaba pri diagnozi
AU2002344871A1 (en) 2002-06-19 2004-01-06 Dimitrios Patsalaridis Support device designed to be anchored in the ground
WO2004083902A2 (en) 2002-10-25 2004-09-30 Georgia Tech Research Corporation Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring
WO2004069284A2 (en) 2003-02-04 2004-08-19 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
CA2547024C (en) 2003-12-22 2013-12-17 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
CN1897978B (zh) 2003-12-22 2011-11-23 博莱科瑞士股份有限公司 具有用于反差成像的活性组分的充气微囊组件
US8708909B2 (en) 2004-01-20 2014-04-29 Fujifilm Visualsonics, Inc. High frequency ultrasound imaging using contrast agents

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