JP2008509970A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008509970A5 JP2008509970A5 JP2007526459A JP2007526459A JP2008509970A5 JP 2008509970 A5 JP2008509970 A5 JP 2008509970A5 JP 2007526459 A JP2007526459 A JP 2007526459A JP 2007526459 A JP2007526459 A JP 2007526459A JP 2008509970 A5 JP2008509970 A5 JP 2008509970A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- microvesicles
- gas
- composition according
- filled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 34
- 238000009472 formulation Methods 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 239000008365 aqueous carrier Substances 0.000 claims 3
- 230000005540 biological transmission Effects 0.000 claims 3
- 238000009826 distribution Methods 0.000 claims 3
- 238000003384 imaging method Methods 0.000 claims 3
- 238000007689 inspection Methods 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 239000000843 powder Substances 0.000 claims 3
- 239000002243 precursor Substances 0.000 claims 3
- 239000012867 bioactive agent Substances 0.000 claims 2
- 239000000032 diagnostic agent Substances 0.000 claims 2
- 229940039227 diagnostic agent Drugs 0.000 claims 2
- OGQYPPBGSLZBEG-UHFFFAOYSA-N dimethyl(dioctadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC OGQYPPBGSLZBEG-UHFFFAOYSA-N 0.000 claims 2
- 239000000839 emulsion Substances 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 239000003094 microcapsule Substances 0.000 claims 2
- 150000003904 phospholipids Chemical class 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 239000002872 contrast media Substances 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000004530 micro-emulsion Substances 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 229920000771 poly (alkylcyanoacrylate) Polymers 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000003223 protective agent Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04019557 | 2004-08-18 | ||
| EP04019557.0 | 2004-08-18 | ||
| PCT/EP2005/054041 WO2006018433A1 (en) | 2004-08-18 | 2005-08-17 | Gas-filled microvesicles composition for contrast imaging |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008509970A JP2008509970A (ja) | 2008-04-03 |
| JP2008509970A5 true JP2008509970A5 (cg-RX-API-DMAC10.html) | 2008-05-15 |
| JP4837663B2 JP4837663B2 (ja) | 2011-12-14 |
Family
ID=34926209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007526459A Expired - Fee Related JP4837663B2 (ja) | 2004-08-18 | 2005-08-17 | 造影画像化のためのガス充填微小胞組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9248204B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1784228B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP4837663B2 (cg-RX-API-DMAC10.html) |
| CN (2) | CN101005858A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2005273865B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2575677C (cg-RX-API-DMAC10.html) |
| WO (1) | WO2006018433A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004069284A2 (en) | 2003-02-04 | 2004-08-19 | Bracco International B.V. | Ultrasound contrast agents and process for the preparation thereof |
| CA2547024C (en) | 2003-12-22 | 2013-12-17 | Bracco Research Sa | Gas-filled microvesicle assembly for contrast imaging |
| US7846100B2 (en) | 2005-03-03 | 2010-12-07 | Bracco International Bv | Medical imaging system based on a targeted contrast agent |
| CA2624636C (en) * | 2005-11-10 | 2016-04-05 | Bracco Research Sa | Instantaneous visualization of contrast agent concentration in imaging applications |
| US9198639B2 (en) | 2005-11-10 | 2015-12-01 | Bracco Suisse S.A. | Detection of immobilized contrast agent in medical imaging applications based on flow dynamics analysis |
| CA2670932C (en) | 2006-12-21 | 2016-03-22 | Bracco International Bv | Detection of the detachment of immobilized contrast agent in medical imaging applications |
| US10130342B2 (en) | 2007-12-28 | 2018-11-20 | Bracco Suisse Sa | Initialization of fitting parameters for perfusion assessment based on bolus administration |
| US9072492B2 (en) | 2007-12-28 | 2015-07-07 | Bracco Suisse Sa | Quantification analysis of immobilized contrast agent in medical imaging applications |
| JP2010005512A (ja) * | 2008-06-25 | 2010-01-14 | Kao Corp | 微細気泡前駆体組成物 |
| GB0811856D0 (en) | 2008-06-27 | 2008-07-30 | Ucl Business Plc | Magnetic microbubbles, methods of preparing them and their uses |
| CN101745126B (zh) * | 2008-12-10 | 2012-04-25 | 温州医学院 | 一种包载水溶性药物超声造影剂的制备方法 |
| US10058837B2 (en) | 2009-08-28 | 2018-08-28 | The Trustees Of Columbia University In The City Of New York | Systems, methods, and devices for production of gas-filled microbubbles |
| EP2566459A1 (en) * | 2010-05-01 | 2013-03-13 | The Trustees of Columbia University in the City of New York | Methods devices and systems of preparing targeted microbubble shells |
| WO2011149985A1 (en) * | 2010-05-24 | 2011-12-01 | Nanovalent Pharmaceuticals, Inc. | Polymerized shell lipid microbubbles and uses thereof |
| US9734584B2 (en) | 2012-12-21 | 2017-08-15 | Bracco Suisse Sa | Segmentation in diagnostic imaging applications based on statistical analysis over time |
| US10368842B2 (en) | 2014-04-07 | 2019-08-06 | Bracco Suisse S.A. | Estimation of acoustic level in-situ with non-fundamental analysis |
| WO2017097738A1 (en) | 2015-12-10 | 2017-06-15 | Bracco Suisse Sa | Detection of immobilized contrast agent with dynamic thresholding |
| CN110831665B (zh) * | 2017-06-29 | 2022-03-04 | 医视特有限公司 | 用于破坏靶组织以进行治疗以及评估靶组织破坏的系统 |
| US11035740B1 (en) * | 2017-07-31 | 2021-06-15 | Prasidiux, Llc | Stimulus indicating device employing thermoreversible amphiphilic gels |
| ES3002682T3 (en) * | 2018-03-07 | 2025-03-07 | Bracco Suisse Sa | Preparation of size-controlled microvesicles |
| EP3897954B1 (en) * | 2018-12-21 | 2024-05-01 | Bracco Suisse SA | Gas-filled microvesicles with ligand |
| US11246945B2 (en) | 2019-06-07 | 2022-02-15 | National Defense Medical Center | Cisplatin-loaded microbubbles, pharmaceutical composition for treatment of cancer, method for preparing pharmaceutical compositions and method for treating cancer |
| WO2022186224A1 (ja) * | 2021-03-01 | 2022-09-09 | 国立大学法人 東京大学 | マイクロ粒子及びマイクロ粒子分散液 |
| NL2033467B1 (en) | 2022-11-04 | 2024-05-24 | Demcon Curonix B V | System for generating microvesicles having a predefined size and/or size distribution |
| NL2037565B1 (en) | 2024-04-26 | 2025-11-11 | Demcon Curonix B V | Fluid delivery system for providing a flow of microvesicle containing liquid to a subject |
Family Cites Families (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4276885A (en) * | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
| DE3463211D1 (en) | 1983-07-01 | 1987-05-21 | Battelle Memorial Institute | Biodegradable polypeptide and its use in the sustained release of medicaments |
| SE463651B (sv) | 1983-12-21 | 1991-01-07 | Nycomed As | Diagnostikum och kontrastmedel |
| ATE60340T1 (de) | 1984-10-19 | 1991-02-15 | Battelle Memorial Institute | Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten. |
| CH667874A5 (fr) | 1985-12-19 | 1988-11-15 | Battelle Memorial Institute | Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments. |
| IE61591B1 (en) | 1987-12-29 | 1994-11-16 | Molecular Biosystems Inc | Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production |
| US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
| US6146657A (en) | 1989-12-22 | 2000-11-14 | Imarx Pharmaceutical Corp. | Gas-filled lipid spheres for use in diagnostic and therapeutic applications |
| US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
| US5776429A (en) | 1989-12-22 | 1998-07-07 | Imarx Pharmaceutical Corp. | Method of preparing gas-filled microspheres using a lyophilized lipids |
| US5733572A (en) * | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
| IN172208B (cg-RX-API-DMAC10.html) | 1990-04-02 | 1993-05-01 | Sint Sa | |
| US5556610A (en) | 1992-01-24 | 1996-09-17 | Bracco Research S.A. | Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method |
| US5445813A (en) | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
| AU636481B2 (en) * | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
| US5487390A (en) | 1990-10-05 | 1996-01-30 | Massachusetts Institute Of Technology | Gas-filled polymeric microbubbles for ultrasound imaging |
| US5562099A (en) | 1990-10-05 | 1996-10-08 | Massachusetts Institute Of Technology | Polymeric microparticles containing agents for imaging |
| JP2974083B2 (ja) | 1990-11-26 | 1999-11-08 | 株式会社 小松製作所 | 静油圧―機械式伝動機の制御装置 |
| JPH06511481A (ja) | 1991-07-05 | 1994-12-22 | ユニバーシティ オブ ロチェスター | 気泡を取り込む超微小非凝集多孔質粒子 |
| IL104084A (en) | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them |
| DE4208527A1 (de) | 1992-03-17 | 1993-09-23 | Max Planck Gesellschaft | Liposomen mit negativer ueberschussladung |
| WO1994001140A1 (de) | 1992-07-03 | 1994-01-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Echokontrastmittelzubereitung |
| US5464696A (en) | 1992-08-13 | 1995-11-07 | Bracco International B.V. | Particles for NMR imaging |
| US5798091A (en) | 1993-07-30 | 1998-08-25 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
| DK0711179T3 (da) | 1993-07-30 | 2005-02-14 | Imcor Pharmaceutical Co | Stabiliserede sammensætninger med mikrobobler til ultralyd |
| US7083572B2 (en) | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
| CA2154867C (en) * | 1993-12-15 | 2007-05-29 | Feng Yan | Gas mixtures useful as ultrasound contrast media |
| NO940711D0 (no) | 1994-03-01 | 1994-03-01 | Nycomed Imaging As | Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging |
| EP0699445A3 (en) * | 1994-08-04 | 1996-04-17 | Gakko Houjin Toin Gakuen | Process for the preparation of an ultrasonic microbubble contrast agent with a surfactant |
| GB9417941D0 (en) * | 1994-09-06 | 1994-10-26 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| WO1996009037A1 (en) | 1994-09-23 | 1996-03-28 | The Liposome Company, Inc. | Method of producing a lyophilized liposome product |
| US6333021B1 (en) | 1994-11-22 | 2001-12-25 | Bracco Research S.A. | Microcapsules, method of making and their use |
| IL116328A (en) | 1994-12-16 | 1999-09-22 | Bracco Research Sa | Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging |
| US6139819A (en) | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
| US5833948A (en) | 1995-06-15 | 1998-11-10 | Bracco Research S.A. | Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant |
| US6165442A (en) | 1996-02-19 | 2000-12-26 | Nycomed Imaging As | Thermally stabilized ultrasound contrast agent |
| JP4250747B2 (ja) | 1996-02-19 | 2009-04-08 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 熱安定化された造影剤 |
| ES2197986T3 (es) | 1996-02-19 | 2004-01-16 | Amersham Health As | Mejoras introducidas en o relacionadas con agentes de contraste. |
| WO1998004074A1 (en) | 1996-07-22 | 1998-01-29 | Seagate Technology, Inc. | Phase detector estimator |
| EP0918546B1 (en) | 1996-08-02 | 2008-10-15 | GE Healthcare AS | Improvements in or relating to contrast agents |
| ATE238073T1 (de) | 1996-10-21 | 2003-05-15 | Amersham Health As | Verbesserungen für oder in bezug auf kontrastmitteln in ultraschallbilddarstellung |
| US6331289B1 (en) | 1996-10-28 | 2001-12-18 | Nycomed Imaging As | Targeted diagnostic/therapeutic agents having more than one different vectors |
| EP0973552B1 (en) | 1996-10-28 | 2006-03-01 | Amersham Health AS | Improvements in or relating to diagnostic/therapeutic agents |
| IL129445A0 (en) | 1996-10-28 | 2000-02-29 | Nycomed Imaging As | Improvements in or relating to diagnostic/therapeutic agents |
| GB9701237D0 (en) * | 1997-01-22 | 1997-03-12 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
| US6143276A (en) | 1997-03-21 | 2000-11-07 | Imarx Pharmaceutical Corp. | Methods for delivering bioactive agents to regions of elevated temperatures |
| US6416740B1 (en) | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
| US6245318B1 (en) | 1997-05-27 | 2001-06-12 | Mallinckrodt Inc. | Selectively binding ultrasound contrast agents |
| GB9717589D0 (en) | 1997-08-19 | 1997-10-22 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| WO1999020312A1 (en) | 1997-10-21 | 1999-04-29 | Nycomed Imaging As | Ultrasound imaging with contrast agent targeted to microvasculature and a vasodilator drug |
| US20020169138A1 (en) | 1997-10-24 | 2002-11-14 | Southern Research Institute | Delivery vehicles for bioactive agents and uses thereof |
| US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
| NZ506051A (en) * | 1998-02-09 | 2003-08-29 | Bracco Res S | Targeted delivery of biologically active media |
| GB9808599D0 (en) | 1998-04-22 | 1998-06-24 | Nycomed Imaging As | Improvements in or realting to contrast agents |
| GB9809084D0 (en) | 1998-04-28 | 1998-06-24 | Nycomed Imaging As | Improvements in or relating to diagnostic/therapeutic agents |
| FR2782006B1 (fr) | 1998-08-07 | 2002-04-19 | Gattefosse Ets Sa | Composition a liberation prolongee apte a former une micro-emulsion |
| JP2000143550A (ja) | 1998-11-10 | 2000-05-23 | Toin Gakuen | 超音波造影剤 |
| DE10013850A1 (de) * | 2000-03-15 | 2001-09-20 | Schering Ag | Gasgefüllte Mikrokapseln enthaltend funktionalisiertes Polyalkylcyanacrylat, sowie Verfahren zu deren Herstellung |
| EP1348026A2 (en) | 2000-12-23 | 2003-10-01 | Dyax Corp. | Fibrin binding moieties useful as imaging agents |
| JP2002212108A (ja) | 2001-01-17 | 2002-07-31 | Fuji Photo Film Co Ltd | 超音波散乱体 |
| US6793626B2 (en) | 2001-01-17 | 2004-09-21 | Fuji Photo Film Co., Ltd. | Ultrasonic scatterer, ultrasonic imaging method and ultrasonic imaging apparatus |
| US7179449B2 (en) | 2001-01-30 | 2007-02-20 | Barnes-Jewish Hospital | Enhanced ultrasound detection with temperature-dependent contrast agents |
| DK1228770T3 (da) | 2001-01-31 | 2005-11-07 | Bracco Int Bv | Törret kontrastmiddel |
| AU2002317095A1 (en) | 2001-07-03 | 2003-01-21 | Governors Of The University Of Alberta | Magnetic nanoparticles for bioseparation application and methods for producing same |
| KR20040030121A (ko) | 2001-08-16 | 2004-04-08 | 브리스톨-마이어스 스퀴브 파마 컴퍼니 | 기체 마이크로스피어 리포좀 복합체 |
| CA2477935C (en) | 2002-03-01 | 2015-01-06 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| SI2301587T1 (sl) | 2002-03-01 | 2014-11-28 | Dyax Corp. | KDR in VEGF/KDR vezavni peptidi in njihova uporaba pri diagnozi |
| AU2002344871A1 (en) | 2002-06-19 | 2004-01-06 | Dimitrios Patsalaridis | Support device designed to be anchored in the ground |
| WO2004083902A2 (en) | 2002-10-25 | 2004-09-30 | Georgia Tech Research Corporation | Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring |
| WO2004069284A2 (en) | 2003-02-04 | 2004-08-19 | Bracco International B.V. | Ultrasound contrast agents and process for the preparation thereof |
| CA2547024C (en) | 2003-12-22 | 2013-12-17 | Bracco Research Sa | Gas-filled microvesicle assembly for contrast imaging |
| CN1897978B (zh) | 2003-12-22 | 2011-11-23 | 博莱科瑞士股份有限公司 | 具有用于反差成像的活性组分的充气微囊组件 |
| US8708909B2 (en) | 2004-01-20 | 2014-04-29 | Fujifilm Visualsonics, Inc. | High frequency ultrasound imaging using contrast agents |
-
2005
- 2005-08-17 EP EP05772044.3A patent/EP1784228B1/en not_active Expired - Lifetime
- 2005-08-17 CA CA2575677A patent/CA2575677C/en not_active Expired - Lifetime
- 2005-08-17 WO PCT/EP2005/054041 patent/WO2006018433A1/en not_active Ceased
- 2005-08-17 CN CNA2005800280529A patent/CN101005858A/zh active Pending
- 2005-08-17 AU AU2005273865A patent/AU2005273865B2/en not_active Ceased
- 2005-08-17 US US11/660,188 patent/US9248204B2/en active Active
- 2005-08-17 CN CN201310032548XA patent/CN103120799A/zh active Pending
- 2005-08-17 JP JP2007526459A patent/JP4837663B2/ja not_active Expired - Fee Related
-
2015
- 2015-12-28 US US14/981,745 patent/US10076580B2/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008509970A5 (cg-RX-API-DMAC10.html) | ||
| JP4901469B2 (ja) | 生物学的利用能および/または溶解度を増大させるための含浸粉末とその製造方法 | |
| JP4205779B2 (ja) | 生体内に注入可能な安定な微小泡懸濁液 | |
| DE69535203T2 (de) | Mikrokapseln, verfahren zur herstellung und ihre anwendung | |
| US10076580B2 (en) | Gas-filled microvesicles composition for contrast imaging | |
| JP2523069B2 (ja) | 経口投与用薬物の微細カプセル化方法 | |
| KR101330096B1 (ko) | 구연산, 산화 마그네슘, 중탄산칼륨 및 피코황산나트륨을 포함하는 의약품의 제조 방법, 이러한 방법에 의해 제조된 과립을 포함하는 약제학적 조성물 및 중간체 | |
| CN109316440A (zh) | 一种温敏性液晶纳米水凝胶及其制备方法与应用 | |
| JPWO2006115198A1 (ja) | 多孔質セルロース凝集体及びその成型体組成物 | |
| EP0717617A1 (de) | Wirkstoffe und gas enthaltende mikropartikel | |
| JP2002080398A (ja) | pHに依存する多相的な放出を伴う経口用の固体の薬学的組成物 | |
| WO2005073286A1 (ja) | 多孔質セルロース凝集体及びその成型体組成物 | |
| Zhou et al. | Folate-targeted perfluorohexane nanoparticles carrying bismuth sulfide for use in US/CT dual-mode imaging and synergistic high-intensity focused ultrasound ablation of cervical cancer | |
| US20230039515A1 (en) | Nanodroplets with improved properties | |
| CN105079829B (zh) | 一种口服高回声腹部胃肠道超声检查助显剂及其制备方法 | |
| CN102764456A (zh) | 血管栓塞剂及其用途、制备方法 | |
| JPS61227520A (ja) | マイクロスフエア | |
| US20220288227A1 (en) | Ultrasound Responsive Microbubbles And Related Methods | |
| CN109966514A (zh) | 一种相转变靶向纳米泡、制备方法及应用 | |
| CN108498849A (zh) | 一种液晶凝胶肝动脉栓塞剂及其制备方法 | |
| CN101721719B (zh) | 超声造影剂及其制备方法 | |
| CN105106963B (zh) | 马来酸曲美布汀缓释制剂及其制备方法 | |
| CN101015701A (zh) | 在体反应式微气泡超声造影剂及其制备方法 | |
| CN102125610A (zh) | 小金缓释微丸及其组合物 | |
| CN100500223C (zh) | 高分子聚合材料声学造影剂及其制备方法 |