JP2008509905A - キウイフルーツの抽出物を含む脱毛および脂漏性皮膚疾患の予防および治療用組成物 - Google Patents
キウイフルーツの抽出物を含む脱毛および脂漏性皮膚疾患の予防および治療用組成物 Download PDFInfo
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- JP2008509905A JP2008509905A JP2007525527A JP2007525527A JP2008509905A JP 2008509905 A JP2008509905 A JP 2008509905A JP 2007525527 A JP2007525527 A JP 2007525527A JP 2007525527 A JP2007525527 A JP 2007525527A JP 2008509905 A JP2008509905 A JP 2008509905A
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- kiwifruit
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Abstract
Description
一方、脱毛症の治療および予防のために漢方薬成分から有效な薬物を開発するために多くの研究がなされている。
本発明のキウイフルーツの抽出物は下記の方法で製造され得る。
本発明のキウイフルーツの抽出物はキウイフルーツを乾燥・切断・粉砕した後、キウイフルーツの乾燥重量の5〜25倍、好ましくは約10倍に至る容量の水を低級アルコール(例えば、メタノール、エタノールおよびブタノール)またはこれらの混合物、好ましくはメタノールと混合し、その混合液を20〜100℃、好ましくは60〜100℃の温度で約1〜24時間熱水で処理し、熱水、冷水、還流冷却または超音波を用いた抽出方法によって1〜5回、好ましくは2〜3回連続抽出し、残渣を濾過して上澄液を得た後、回転蒸発器で20〜100℃、好ましくは50〜70℃で濃縮し、凍結真空乾燥法、熱風乾燥法または噴霧乾燥法を用いて乾燥させることで製造することができる。この乾燥キウイフルーツの抽出物の粉末は水、低級アルコールまたはこれらの混合溶媒に可溶である。
同様に、前記キウイフルーツの抽出物は更に乳糖、カゼイン、ブドウ糖、グルコース、ショ糖およびソルビトールのうち少なくとも一つを含み得る。
1−1.キウイフルーツの抽出物の水抽出物の製造
ソウルに所在するギョンドン市場で購入した100gのサルナシの乾燥実および乾燥幹、ミヤママタタビおよびマタタビの乾燥実を粉砕して1lの蒸留水と混合し、90〜95℃を維持する抽出温度で3時間3回還流抽出した後、抽出物を濾過し、回転蒸発器(N−1000,Eyela Co.,Japan)を用いて55〜65℃で、減圧下で濃縮した後、凍結乾燥させて、サルナシの乾燥実抽出物15.6gおよび乾燥幹抽出物10.4g、ミヤママタタビの乾燥実抽出物16.2gおよびマタタビの乾燥実抽出物17.0gをそれぞれ収得した。これらの乾燥粉末をそれぞれ蒸留水に溶解させた(100mg/ml)。
抽出溶媒としてエタノールの割合が30%、50%および70%である水−アルコール混合溶媒を用いることを除いては前記実施例1−1と同様な工程を行って11g〜13gのキウイフルーツ乾燥粉末を収得し、それぞれの乾燥粉末を蒸留水に溶解させた(100mg/ml)。
前記実施例1−1で製造された水抽出物を次のような方法で分画した。
2−1.クロロホルム可溶性分画の製造
前記実施例1−1で製造されたキウイフルーツの抽出物5gを50mlの蒸留水に添加した後、クロロホルム50mlと共に分液漏斗(separatory funnel)に入れて強く攪拌してからクロロホルム層と水層とに分離した。
前記実施例2−1で収得した水層を酢酸エチル50mlと混合した後、酢酸エチル層と最終水層とに分離した。
前記クロロホルム層、酢酸エチル層および最終水層を回転蒸発器で濃縮した後、凍結乾燥してクロロホルム可溶性分画0.34g、酢酸エチル可溶性分画0.05g、水分画4.61gの粉末をそれぞれ収得した。
前記実施例2−2の酢酸エチル可溶性分画2.784mgをシリカゲルカラムクロマトグラフィー(Daisogel IR−60−W−40:63mm)で分画した。展開溶媒としては開始時にクロロホルム:メタノール:水混合溶媒([1]90:11:1、[2]60:10:1、[3]60:20:2)を、また終結時にはメタノール[4]を使用し、溶離速度を時間当り300mlとして4個のサブ分画物([1]2,381mg、[2]135mg、[3]148mg、[4]98mg)を収得した。
前記水抽出物、酢酸エチル可溶性分画および4個のサブ分画物を用いてTLC(TLC plate:Merck社、展開溶媒:クロロホルム:メタノール:水=9:5:1)を行い、その結果を図1に示した。図1に示すように、レーン1は水抽出物、レーン2は酢酸エチル可溶性分画、レーン3はシリカゲル分画[4]、レーン4はシリカゲル分画[3]、レーン5はシリカゲル分画[2]、およびレーン6はシリカゲル分画[1]である。
前記シリカゲル分画[1]および[2]に対して2D−TLCを行い、この時1次展開溶媒としてはクロロホルム:メタノール:水=9:5:1、2次展開溶媒としてはクロロホルム:アセトン:水=3:8:0.5を用いた(図1および図2参照)。
1−1.キウイフルーツの極性溶媒の可溶性抽出物の血中DHT濃度抑制效果
キウイフルーツの抽出物の血中DHT濃度に対する抑制效果を確認するために、キウイフルーツの水抽出物およびエタノール抽出物をマウスに服用させた後、血中DHTの濃度を次のように測定した:
6週齢のC57BL/6雄マウス(ソウル国立大学校動物実験センター)を購入して一週間環境に適応させた。7週齢になった時、16匹を4群に分けて各群に3週間100μlのキウイフルーツ水抽出物(1500μg/mouse/day)、100μlのキウイフルーツエタノール抽出物(1500μg/mouse/day)、100μlのフィナステライド(finasteride、100μg/mouse/day)および100μlの飲用水(100μg/mouse/day)をそれぞれ経口投与した。マウスを犠牲させて採取した血液から血清および脾臓器官を分離した後、血中DHTの濃度をELISA(IBL−Hamburg GmbH)法で測定した。
図4から分かるように、キウイフルーツの抽出物が投与された群では、フィナステライドが投与された群と同じように血中DHTの濃度が約90%減少したことを確認した。
C57BL/6マウスの血中DHT濃度を測定するために、前記実施例2で製造した酢酸エチル可溶性分画および水溶性分画に対して前記実験例1−1と同様な実験を行った。
50μlのクロロホルム可溶性分画、酢酸エチル可溶性分画および水溶性分画をそれぞれC57BL/6マウスに投与し、対照群には100μlの飲用水を投与した。
図5から分かるように、血中DHTの濃度がキウイフルーツの酢酸エチル可溶性分画が投与された群では約95%減少し、キウイフルーツの水溶性分画が投与された群では少し減少したことを確認した。しかし、キウイフルーツのクロロホルム可溶性分画は血中DHT濃度に影響を及ぼさなかった。
C57BL/6マウスの血中DHT濃度を測定するために、前記実施例3で製造したシリカゲルカラムクロマトグラフィー分画[1]、[2]、[3]および[4]に対して前記実験例1−1と同様な実験を行った。
30μlのシリカゲルカラムクロマトグラフィー分画[1]、[2]、[3]および[4]をそれぞれC57BL/6マウスに投与し、対照群には100μlの飲用水を投与した。
図6から分かるように、前記分画[1]および[2]で処理したマウス群においてDHTが相当抑制されたことが確認できた。
C57BL/6マウスの血中DHT濃度を測定するために、水溶性分画に対して前記実験例1−1と同様な実験を行った。
7週齢になった時、8匹を2群で分けて各群に3週間100μlのキウイフルーツ幹の水抽出物(1500μg/mouse/day)および100μlの飲用水(100μg/mouse/day)をそれぞれ経口投与した。マウスを犠牲させて採取した血液から血清および脾臓器官を分離した後、血中DHTの濃度を測定した。キウイフルーツ幹の水抽出物が投与された群では血中DHT濃度がそれぞれ142pg/ml、193pg/ml、362pg/mlおよび1625pg/mlであった。即ち、キウイフルーツ幹抽出物およびキウイフルーツ抽出物がDHT形成を抑制することを確認した。
2−1.キウイフルーツの水溶性抽出物の毛根形成促進效果
キウイフルーツの水溶性抽出物の毛根形成促進效果を確認するために、次のようにマウスモデルを用いた実験を行った。
6週齢のC57BL/6雌マウス(ソウル国立大学校動物実験センター)を購入して7日間環境に適応させた。7週齢になった時から電気かみそりを用いて各マウスの背中を除毛した。次いでに、10匹のマウスを2個の群に分けてキウイフルーツの水抽出物100μl(1500μg/mouse/day)と100μlの飲用水(100μg/mouse/day)を4週間経口投与した。毛根の活性化現象は毛根の除去された肌がメラニン色素によって鮮紅色から暗色になる変化を通じてよく観察できる。また、毛の成長を直接観察することでキウイフルーツの抽出物が毛根形成に及ぼす影響を観察した。
図7および8から分かるように、キウイフルーツの水抽出物を投与したマウス群から2週に至る前に除毛された部位の肌色が暗くなる発毛現象が観察された。しかし、飲用水を投与した対照群のマウスでは肌色の変化および毛髪成長が全然観察されなかった。投与してから4週目にはキウイフルーツの抽出物を投与したマウスの背中が殆ど毛で覆われた一方、対照群のマウスの背中は依然として新しく発毛しなかったことが観察された。即ち、キウイフルーツの抽出物がマウスの毛根形成を促進して毛髪成長を刺激することを確認した。
前記実施例2で製造されたクロロホルム可溶性分画、酢酸エチル可溶性分画および水溶性分画の毛根形成促進效果を確認するために、前記実験例2−1と同様な実験を行った。
20匹のマウスを4群に分けて各群に100μlのキウイフルーツの水分画、100μlの酢酸エチル可溶性分画、100μlのクロロホルム可溶性分画、100μlの飲用水をそれぞれ投与した。
その結果、酢酸エチル可溶性分画を投与したマウス群において発毛が他の群に比べて発毛が顕著に促進されることを観察した。
キウイフルーツの抽出物の脂漏性皮膚疾患改善效果を確認するために、脂漏性皮膚に悩まされている三人の志願者にそれぞれキウイフルーツ水抽出物1gを4週間毎日1回投与して脂漏性皮膚疾患が改善されたか否かを調査した。
3−1.志願者Kは29歳の韓国女性であって激しい皮膚脂漏現象および過度なふけ発生に起因して脱毛に進む症状を示す。1gのキウイフルーツの水抽出物を含む錠剤を2週間一日に1回服用した後、脂漏および角質皮膚疾患が顕著に減少し、脱毛現象が50%以上減少した。
3−2.志願者Pは27歳の韓国男性であって顔および頭皮が脂性であり、ふけだらけの症状を示す。1gのキウイフルーツ水抽出物を含む錠剤を2週間一日に1回服用した後、脂顔が顕著に緩和され、脱毛現象が約70%以上減少した。
3−3.志願者Uは29歳の韓国男性であって脂漏性皮膚、特に脂顔、頭皮に痒みおよび斑点が生じる症状を示す。1gのキウイフルーツの水抽出物を含む錠剤を2週間一日に1回服用した後、頭皮の痒みが消え、脂顔に起因するトラブル、例えばにきびも相当消えた。
キウイフルーツの抽出物の毒性を調べるために、マウスに対して繰り返し毒性実験を行った。
Balb/c雌マウスを10匹ずつ2群に分けて一群の雌には本発明のキウイフルーツの抽出物(150mg/kg)を4週間投与し、対照群には水を投与した。毒性の症状は4週間の体重の変化、血液学的分析、組職検査を通じて確認した。
実験結果、本発明のキウイフルーツの抽出物(150mg/kg)を投与したマウス群では死亡例が見られず、体重の増加、飼料攝取量、組職検査、血液検査などでも有意義な異常が発見できなかった。これによってキウイフルーツの抽出物が安全な薬物であることが確認できた。
(1)体重および肉眼観察:如何なる非正常的な体重の変化も観察されなかった。
(2)血液学的検査:WBC、リンパ球(lymphocyte)、単球(monocyte)、好中球(neutrophil)、好酸球(eosinophil)、好塩基球(basophil)、RBC、ヘモグロビン(hemoglobin)、血小板(platelet)の数において如何なる異常症状も見られなかった。
(3)血清生化学的な検査:血清のAST、ALT、LDH、ビリルビン(bilirubin)、クレアチニン(creatinine)、グルコース(glucose)、コレステロール(cholesterol)、ミネラル(mineral)、アルブミン(albumin)、BUN、リパーゼ(lipase)、アミラーゼ(amylase)の数値において如何なる症状も見られなかった。
(4)組職検査:腎臓、脾臓、肝、胸腺の組職において如何なる異常も見られなかった。
以下、製型化方法および用いられる賦形剤の種類を説明するが、これによって本発明が限定されない。代表的な製剤例は次の通りである。
実施例1のキウイフルーツの水抽出物・・・・・・・・・・・・・・・・・・ 50mg
メタ重亜硫酸ナトリウム・・・・・・・・・・・・・・・・・・・・・・・ 3.0mg
メチルパラベン・・・・・・・・・・・・・・・・・・・・・・・・・・・ 0.8mg
プロピルパラベン・・・・・・・・・・・・・・・・・・・・・・・・・・ 0.1mg
注射用蒸留水・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 適量
通常の方法によって前記成分を混合して2mlアンプルに入れた後、滅菌することで注射剤を製造した。
実施例1のキウイフルーツの水抽出物・・・・・・・・・・・・・・・・・・ 50mg
コーンスターチ・・・・・・・・・・・・・・・・・・・・・・・・・・・ 100mg
乳糖・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 100mg
ステアリン酸マグネシウム・・・・・・・・・・・・・・・・・・・・・・・・ 2mg
前記成分を混合して打錠することで製造した。
実施例1のキウイフルーツの水抽出物・・・・・・・・・・・・・・・・・ 100mg
コーンスターチ・・・・・・・・・・・・・・・・・・・・・・・・・・・ 100mg
乳糖・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 100mg
滑石・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 2mg
ステアリン酸マグネシウム ・・・・・・・・・・・・・・・・・・・・・・・・ 適量
通常のゼラチンの製法によって前記成分を混合してゼラチンカプセルに充填することでカプセルを製造した。
キウイフルーツの70%エタノール抽出物・・・・・・・・・・・・・・・ 100mg
糖・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 20mg
果糖・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 20mg
レモン香味・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 適量
蒸留水・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 100ml
通常の方法によって前記成分を混合して100ml茶色瓶に入れた後、滅菌することで液剤を製造した。
実施例1のキウイフルーツの抽出物・・・・・・・・・・・・・・・・・ 1000mg
ビタミン混合物・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 20g
ビタミンA酢酸塩・・・・・・・・・・・・・・・・・・・・・・・・・・・ 70μg
ビタミンE・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 1.0mg
ビタミンB1・・・・・・・・・・・・・・・・・・・・・・・・・・・ 0.13mg
ビタミンB2・・・・・・・・・・・・・・・・・・・・・・・・・・・ 0.15mg
ビタミンB6・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 0.5mg
ビタミンB12・・・・・・・・・・・・・・・・・・・・・・・・・・・ 0.2μg
ビタミンC・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 10mg
ビオチン・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 10μg
ニコチン酸アミド・・・・・・・・・・・・・・・・・・・・・・・・・・ 1.7mg
葉酸・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 50μg
パントテン酸カルシウム・・・・・・・・・・・・・・・・・・・・・・・ 0.5mg
無機質混合物・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 適量
硫酸第一鉄・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 1.75mg
酸化亜鉛・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 0.82mg
炭酸マグネシウム・・・・・・・・・・・・・・・・・・・・・・・・・ 25.3mg
第一リン酸カリウム・・・・・・・・・・・・・・・・・・・・・・・・・・ 15mg
第二リン酸カルシウム・・・・・・・・・・・・・・・・・・・・・・・・・ 55mg
クエン酸カリウム・・・・・・・・・・・・・・・・・・・・・・・・・・・ 90mg
炭酸カルシウム・・・・・・・・・・・・・・・・・・・・・・・・・・・ 100mg
塩化マグネシウム・・・・・・・・・・・・・・・・・・・・・・・・・ 24.8mg
前記ビタミンおよびミネラル混合物の組成比は様々な方式で変形され得る。そのような変形は本発明の思想および範囲内に属すると見なされる。
実施例1のキウイフルーツの抽出物・・・・・・・・・・・・・・・・・ 1000mg
クエン酸・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 100mg
オリゴ糖・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 100g
ウメ濃縮液・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 2g
タウリン・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 1g
蒸留水・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 900ml
通常の健康飲料製造方法によって前記成分を混合してから85℃で1時間攪拌し、溶液を濾過した後、2l容器に充填して滅菌することで健康飲料を製造した。
実施例1のキウイフルーツの水抽出物・・・・・・・・・・・・・・・・ 1.00(%)
グリセロール・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 3.00
エタノール・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 1.00
プロピレングリコール・・・・・・・・・・・・・・・・・・・・・・・・・ 0.10
香料・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 極微量
蒸留水・・・・・・・・・・・・・・・・・・・・・・・・・・100%にならしめる量
通常のローション製造方法によって前記活性成分を蒸留水に溶解させることでスキンを製造した。
実施例1のキウイフルーツの水抽出物・・・・・・・・・・・・・・・・ 3.00(%)
L−アスコルビン酸−2−リン酸マグネシウム・・・・・・・・・・・・・・ 1.00
可溶性コラーゲン(1%溶液)・・・・・・・・・・・・・・・・・・・・・・ 1.00
クエン酸ナトリウム・・・・・・・・・・・・・・・・・・・・・・・・・・ 0.10
クエン酸・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 0.05
1,3−ブチレングリコール・・・・・・・・・・・・・・・・・・・・・・ 3.00
蒸留水・・・・・・・・・・・・・・・・・・・・・・・・・・100%にならしめる量
通常のローション製造方法によって前記活性成分を蒸留水に溶解させることでローションを製造した。
実施例1のキウイフルーツの水抽出物・・・・・・・・・・・・・・・・ 3.00(%)
モノステアリン酸ポリエチレングリコール・・・・・・・・・・・・・・・・ 2.00
モノステアリン酸グリセリン・・・・・・・・・・・・・・・・・・・・・・ 1.00
セチルアルコール・・・・・・・・・・・・・・・・・・・・・・・・・・・ 4.00
スクワレン・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 6.00
トリ2−エチルヘキサン酸グリセリル・・・・・・・・・・・・・・・・・・・ 600
スフィンゴ糖脂質・・・・・・・・・・・・・・・・・・・・・・・・・・・ 1.00
1,3−ブチレングリコール・・・・・・・・・・・・・・・・・・・・・・ 7.00
蒸留水・・・・・・・・・・・・・・・・・・・・・・・・・・100%にならしめる量
通常のクリーム製造方法によって前記活性成分を蒸留水に溶解させることでクリームを製造した。
実施例1のキウイフルーツの水抽出物・・・・・・・・・・・・・・・・ 5.00(%)
ポリビニルアルコール・・・・・・・・・・・・・・・・・・・・・・・・ 13.00
L−アスコルビン酸−2−リン酸マグネシウム・・・・・・・・・・・・・・ 1.00
ラウロイルヒドロキシプロリン・・・・・・・・・・・・・・・・・・・・・ 1.00
可溶性コラーゲン(1%溶液)・・・・・・・・・・・・・・・・・・・・・・ 2.00
1,3−ブチレングリコール・・・・・・・・・・・・・・・・・・・・・・ 3.00
エタノール・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 5.00
蒸留水・・・・・・・・・・・・・・・・・・・・・・・・・・100%にならしめる量
通常のパック製造方法によって前記活性成分を蒸留水に溶解させることでパックを製造した。
実施例1のキウイフルーツの水抽出物・・・・・・・・・・・・・・・・ 2.00(%)
ヒドロキシエチレンセルロース(2%溶液)・・・・・・・・・・・・・・・ 12.00
キサンタンガム(2%溶液)・・・・・・・・・・・・・・・・・・・・・・・ 2.00
1,3−ブチレングリコール・・・・・・・・・・・・・・・・・・・・・・ 3.00
濃縮グリセリン・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 4.00
ヒアルロン酸ナトリウム・・・・・・・・・・・・・・・・・・・・・・・・ 5.00
蒸留水・・・・・・・・・・・・・・・・・・・・・・・・・・100%にならしめる量
通常の美容液の製造方法によって前記活性成分を蒸留水に溶解させることで美容液を製造した。
Claims (31)
- ヒトおよび哺乳類の脱毛症および脂漏性皮膚疾患(seborrheic skin disease)を予防および治療するための治療剤を製造するためのキウイフルーツ(hardy kiwifruit)の粗抽出物、非極性溶媒可溶性抽出物または精製抽出物の用途。
- 前記キウイフルーツがサルナシ(Actinidia arguta)、ミヤママタタビ(Actinidia kolomikta)およびマタタビ(Actinidia polygama)から選択されることを特徴とする、請求項1に記載の用途。
- 前記キウイフルーツの抽出物がキウイフルーツの実、幹または根の何れか一つから抽出されたものであることを特徴とする、請求項1に記載の用途。
- 前記粗抽出物が蒸留水、低級アルコールまたはこれらの混合溶媒から選択された極性溶媒中に可溶性であることを特徴とする、請求項1に記載の用途。
- 前記非極性溶媒可溶抽出物がクロロホルム、酢酸エチル、ヘキサン、ジクロロメタンまたはエーテルに可溶性であることを特徴とする、請求項1に記載の用途。
- 前記精製抽出物がカラムクロマトグラフィー精製によって得られた分画のうち何れか一つであることを特徴とする、請求項1に記載の用途。
- 前記精製抽出物が図1〜図3に示したTLC(thin layer chromatography)スペクトルを有することを特徴とする、請求項1に記載の用途。
- 前記抽出物が前記治療剤の全量を基準として0.01〜80重量%で用いられることを特徴とする、請求項1に記載の用途。
- キウイフルーツの粗抽出物、非極性溶媒の可溶性抽出物または精製抽出物を活性成分として含む、脱毛および脂漏性皮膚疾患の予防および治療用薬剤学的組成物。
- キウイフルーツの粗抽出物、非極性溶媒の可溶性抽出物または精製抽出物、および食品学的に許容可能な添加剤を含む、脱毛および脂漏性皮膚疾患の予防および改善用のヘルスケア食品。
- 前記キウイフルーツがサルナシ(Actinidia arguta)、ミヤママタタビ(Actinidia kolomikta)およびマタタビ(Actinidia polygama)から選択されることを特徴とする、請求項10に記載のヘルスケア食品。
- 前記キウイフルーツの抽出物がキウイフルーツの実、幹または根の何れか一つから抽出されたものであることを特徴とする、請求項10に記載のヘルスケア食品。
- 前記抽出物が前記治療剤の全量を基準として0.01〜80重量%で用いられることを特徴とする、請求項10に記載のヘルスケア食品。
- 前記食品が粉末、顆粒、錠剤、カプセルまたは飲料の形態で提供されることを特徴とする、請求項10に記載のヘルスケア食品。
- キウイフルーツの粗抽出物を含む、脱毛および脂漏性皮膚疾患の予防および改善用の食品添加剤。
- 乳糖、カゼイン、デキストリン、グルコース、ショ糖およびソルビトールから選択された少なくとも1つを更に含むことを特徴とする、請求項15に記載の食品添加剤。
- 前記食品添加剤が組成物の重量濃度は100w/w%当り0.01〜20w/w%の範囲で添加されることを特徴とする、請求項15に記載の食品添加剤。
- 前記食品添加剤が香辛料、甘味料または食品材料として用いられることを特徴とする、請求項15〜17の何れか一項に記載の食品添加剤。
- 前記食品添加剤が蒸着法、噴霧法または混合法によって食品に添加されることを特徴とする、請求項15に記載の食品添加剤。
- 前記食品添加剤が果物、野菜およびこれらの乾燥食品またはカッティング(cutting)製品;果物ジュース、野菜ジュースまたはこれらの混合ジュース;酸−飲料含有ドリンク類;クッキー、キャンデー、カラメルおよびガムなどのお菓子類;パン;アイスクリーム、お茶、ヨーグルトなどの発酵製品;乳製品、香辛料、アルコール性飲料類、缶類、瓶類、麺類、加工された家畜類、加工された海産類、発酵食品、豆食品、シリアル食品、加工された肉類、甘草類およびハーブ類から選択される少なくとも一つの食品に添加されることを特徴とする、請求項15に記載の食品添加剤。
- キウイフルーツの粗抽出物を含む、脱毛および脂漏性皮膚疾患の予防および改善用飼料添加剤。
- 前記粗抽出物が蒸留水、メタノール、エタノール、ブタノールなどの低級アルコール、またはこれらの混合溶媒から選択された極性溶媒に可溶性であることを特徴とする、請求項21に記載の飼料添加剤。
- 前記キウイフルーツがサルナシ(Actinidia arguta)、ミヤママタタビ(Actinidia kolomikta)およびマタタビ(Actinidia polygama)から選択されることを特徴とする、請求項21に記載の飼料添加剤。
- 前記飼料添加剤が液体、粉末または顆粒の形態で提供されることを特徴とする、請求項21に記載の飼料添加剤。
- 前記飼料添加剤が蒸着法、噴霧法または混合法によって飼料に添加されることを特徴とする、請求項21に記載の飼料添加剤。
- 請求項21〜25の何れか一項の飼料添加剤を含む飼料組成物。
- キウイフルーツの粗抽出物を含む、脱毛および脂漏性皮膚疾患の予防、改善および治療用化粧品組成物。
- 前記粗抽出物が蒸留水、メタノール、エタノール、ブタノールなどの低級アルコール、またはこれらの混合溶媒から選択された極性溶媒に可溶性であることを特徴とする化粧品組成物。
- 前記粗抽出物が組成物の全量を基準として0.01〜30重量%の範囲で用いられることを特徴とする、請求項27に記載の化粧品組成物。
- 前記化粧品組成物がスキン、ローション、クリーム、エッセンス、トナー、エマルジョン、パック、せっけん、シャンプー、リンス、クレンザー、ボディー洗浄液、洗浄液またはトリートメントの形態で提供されることを特徴とする、請求項27〜29の何れか一項に記載の化粧品組成物。
- キウイフルーツの粗抽出物を含む、脱毛および脂漏性皮膚疾患の予防、改善および治療用化粧品添加剤。
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PCT/KR2004/002010 WO2006016728A1 (en) | 2004-08-10 | 2004-08-10 | Composition comprising the extract of actinidia arguta for preventing and treating baldness disorders and seborrheic skin disorders |
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JP2008509905A true JP2008509905A (ja) | 2008-04-03 |
JP5006193B2 JP5006193B2 (ja) | 2012-08-22 |
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US (1) | US20090226555A1 (ja) |
EP (1) | EP1793792B1 (ja) |
JP (1) | JP5006193B2 (ja) |
CN (1) | CN101027071B (ja) |
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JP2007099751A (ja) * | 2005-09-12 | 2007-04-19 | Oriza Yuka Kk | 美肌用組成物 |
KR101315975B1 (ko) | 2011-11-22 | 2013-10-08 | 재단법인나주시천연염색문화재단 | 참다래 추출물을 함유한 각질제거 효과 조성물 |
WO2014088134A1 (ko) * | 2012-12-06 | 2014-06-12 | 주식회사 삼부메디칼 | 만병초, 비수리 및 다래나무 추출물을 포함하는 샴푸 조성물의 제조방법 |
JP2014185131A (ja) * | 2013-03-25 | 2014-10-02 | Maruzen Pharmaceut Co Ltd | 育毛剤及び育毛用頭髪化粧料 |
US8969523B2 (en) | 2009-12-28 | 2015-03-03 | Lotte Co., Ltd. | Sebum secretion-blocking composition, and food or beverage containing same |
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AT503521A1 (de) | 2006-05-05 | 2007-11-15 | Omnica Gmbh | Verwendung eines extraktes von kiwi-frucht |
JP5306605B2 (ja) * | 2007-03-12 | 2013-10-02 | 株式会社ノエビア | 皮膚外用剤 |
AU2011338643B2 (en) | 2010-12-07 | 2016-03-03 | University Of Oslo | Cardio-protective agents from kiwifruits |
CN102861114A (zh) * | 2012-10-08 | 2013-01-09 | 河南大学 | 猕猴桃提取物及其提取方法和应用 |
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- 2004-08-10 CN CN2004800437766A patent/CN101027071B/zh not_active Expired - Fee Related
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- 2004-08-10 JP JP2007525527A patent/JP5006193B2/ja not_active Expired - Fee Related
- 2004-08-10 WO PCT/KR2004/002010 patent/WO2006016728A1/en active Application Filing
- 2004-08-10 US US11/573,445 patent/US20090226555A1/en not_active Abandoned
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Also Published As
Publication number | Publication date |
---|---|
ATE547112T1 (de) | 2012-03-15 |
CN101027071B (zh) | 2013-05-29 |
WO2006016728A1 (en) | 2006-02-16 |
EP1793792A4 (en) | 2007-11-28 |
JP5006193B2 (ja) | 2012-08-22 |
US20090226555A1 (en) | 2009-09-10 |
EP1793792A1 (en) | 2007-06-13 |
EP1793792B1 (en) | 2012-02-29 |
CN101027071A (zh) | 2007-08-29 |
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