JP2008508299A5 - - Google Patents

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JP2008508299A5
JP2008508299A5 JP2007523777A JP2007523777A JP2008508299A5 JP 2008508299 A5 JP2008508299 A5 JP 2008508299A5 JP 2007523777 A JP2007523777 A JP 2007523777A JP 2007523777 A JP2007523777 A JP 2007523777A JP 2008508299 A5 JP2008508299 A5 JP 2008508299A5
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pharmaceutical composition
compound according
patient
treating
preventing
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JP2007523777A
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Japanese (ja)
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JP2008508299A (ja
JP5586830B2 (ja
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Priority claimed from US10/900,270 external-priority patent/US7244759B2/en
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JP2007523777A 2004-07-28 2005-07-27 イソインドリン化合物及びその製造法及び使用法 Expired - Lifetime JP5586830B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/900,270 2004-07-28
US10/900,270 US7244759B2 (en) 2004-07-28 2004-07-28 Isoindoline compounds and methods of making and using the same
PCT/US2005/026680 WO2006025991A2 (en) 2004-07-28 2005-07-27 Isoindoline compounds and methods of making and using the same

Publications (3)

Publication Number Publication Date
JP2008508299A JP2008508299A (ja) 2008-03-21
JP2008508299A5 true JP2008508299A5 (enExample) 2009-02-12
JP5586830B2 JP5586830B2 (ja) 2014-09-10

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JP2007523777A Expired - Lifetime JP5586830B2 (ja) 2004-07-28 2005-07-27 イソインドリン化合物及びその製造法及び使用法

Country Status (15)

Country Link
US (3) US7244759B2 (enExample)
EP (1) EP1778635B1 (enExample)
JP (1) JP5586830B2 (enExample)
KR (2) KR20070047808A (enExample)
CN (1) CN101031546A (enExample)
AT (1) ATE507204T1 (enExample)
AU (1) AU2005280499B2 (enExample)
BR (1) BRPI0513843A (enExample)
CA (1) CA2577222C (enExample)
DE (1) DE602005027707D1 (enExample)
ES (1) ES2362104T3 (enExample)
IL (1) IL180979A (enExample)
NZ (1) NZ553028A (enExample)
WO (1) WO2006025991A2 (enExample)
ZA (1) ZA200701661B (enExample)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8030343B2 (en) * 2000-06-08 2011-10-04 Celgene Corporation Pharmaceutically active isoindoline derivatives
US7311905B2 (en) * 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
KR100915482B1 (ko) 2000-12-06 2009-09-03 하리리 로버트 제이 태반 줄기 세포의 회수 방법
ES2548591T3 (es) 2001-02-14 2015-10-19 Anthrogenesis Corporation Placenta post-parto de mamífero, su uso y células madre placentarias de la misma
US7498171B2 (en) * 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
AU2003228509B2 (en) 2002-10-15 2008-06-26 Celgene Corporation Selective cytokine inhibitory drugs for treating myelodysplastic syndrome
BR0316695A (pt) * 2002-11-26 2005-10-18 Anthrogenesis Corp Unidade citoterapêutica, kit para tratamento, método de tratamento de uma enfermidade, biblioteca de unidades citoterapêuticas e método de tratamento de um paciente
US20050143344A1 (en) * 2003-12-30 2005-06-30 Zeldis Jerome B. Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases
NZ550027A (en) * 2004-03-26 2009-03-31 Celgene Corp Systems and methods for providing a stem cell bank
US20080213213A1 (en) * 2004-04-14 2008-09-04 Zeldis Jerome B Method For the Treatment of Myelodysplastic Syndromes Using (+)-2-[1-(3-Ethoxy-4-Methoxyphenyl)-2-Methylsulfonylethyl]-4-Acetylaminoisoindoline-1,3-Dione
US7244759B2 (en) * 2004-07-28 2007-07-17 Celgene Corporation Isoindoline compounds and methods of making and using the same
CA2590903A1 (en) * 2004-12-13 2006-06-22 Celgene Corporation Compositions comprising pde4 modulators and their use for the treatment or prevention of airway inflammation
CA2823088C (en) * 2005-06-30 2015-10-06 Celgene Corporation Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds
WO2007005807A2 (en) * 2005-06-30 2007-01-11 Anthrogenesis Corporation Repair of tympanic membrane using placenta derived collagen biofabric
US20070021762A1 (en) * 2005-07-13 2007-01-25 Qing Liu Ocular plug formed from placenta derived collagen biofabric
WO2007009062A2 (en) * 2005-07-13 2007-01-18 Anthrogenesis Corporation Treatment of leg ulcers using placenta derived collagen biofabric
US20070066512A1 (en) * 2005-09-12 2007-03-22 Dominique Verhelle Methods and compositions using immunomodulatory compounds for the treatment of disorders associated with low plasma leptin levels
US7878970B2 (en) 2005-09-28 2011-02-01 Boston Scientific Scimed, Inc. Apparatus and method for suspending a uterus
MX343814B (es) 2005-10-13 2016-11-24 Anthrogenesis Corp Inmunomodulación usando celulas madre de la placenta.
JP5203212B2 (ja) * 2005-10-13 2013-06-05 アントフロゲネシス コーポレーション 胎盤由来幹細胞からのオリゴデンドロサイトの産生
JP2009521931A (ja) 2005-12-29 2009-06-11 アントフロゲネシス コーポレーション 胎盤幹細胞を収集及び保存するための改善された組成物、及び該組成物の使用方法
EP1976978A2 (en) * 2005-12-29 2008-10-08 Anthrogenesis Corporation Co-culture of placental stem cells and stem cells from a second source
EP2471903B1 (en) 2005-12-29 2018-02-14 Anthrogenesis Corporation Placental stem cell populations
US9144483B2 (en) 2006-01-13 2015-09-29 Boston Scientific Scimed, Inc. Placing fixation devices
WO2007109508A1 (en) 2006-03-16 2007-09-27 Boston Scientific Limited System and method for treating tissue wall prolapse
US20080064876A1 (en) * 2006-05-16 2008-03-13 Muller George W Process for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
TW200806625A (en) * 2006-05-26 2008-02-01 Astrazeneca Ab Therapeutic compounds
US7993918B2 (en) 2006-08-04 2011-08-09 Anthrogenesis Corporation Tumor suppression using placental stem cells
US8105634B2 (en) * 2006-08-15 2012-01-31 Anthrogenesis Corporation Umbilical cord biomaterial for medical use
US20080131522A1 (en) * 2006-10-03 2008-06-05 Qing Liu Use of placental biomaterial for ocular surgery
WO2008060377A2 (en) 2006-10-04 2008-05-22 Anthrogenesis Corporation Placental or umbilical cord tissue compositions
CN104623642A (zh) 2006-10-06 2015-05-20 人类起源公司 天然(端肽)胎盘胶原组合物
EP2418271A3 (en) 2006-10-23 2015-09-30 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
JP2010518812A (ja) 2007-02-12 2010-06-03 アンスロジェネシス コーポレーション 接着性胎盤幹細胞由来の肝細胞および軟骨細胞、ならびにcd34+、cd45−胎盤幹細胞の濃縮細胞集団
CN101657206B (zh) 2007-02-12 2013-07-03 人类起源公司 利用胎盘干细胞治疗炎性疾病
US9200253B1 (en) 2007-08-06 2015-12-01 Anthrogenesis Corporation Method of producing erythrocytes
CN101878034B (zh) 2007-09-28 2013-11-20 细胞基因细胞疗法公司 使用人胎盘灌洗液和人来自胎盘的中间体自然杀伤细胞的肿瘤抑制
US20090155207A1 (en) * 2007-11-29 2009-06-18 Hariri Robert J Use of Immunomodulatory Compounds for the Treatment of Transverse Myelitis, Multiple Sclerosis, and Other Disorders
WO2009085234A2 (en) * 2007-12-20 2009-07-09 Signal Pharmaceuticals, Inc. Use of micro-rna as a biomarker of immunomodulatory drug activity
US9078728B2 (en) 2007-12-28 2015-07-14 Boston Scientific Scimed, Inc. Devices and methods for delivering female pelvic floor implants
US8430807B2 (en) 2007-12-28 2013-04-30 Boston Scientific Scimed, Inc. Devices and methods for treating pelvic floor dysfunctions
WO2009105256A2 (en) * 2008-02-20 2009-08-27 Celgene Corporation Method of treating cancer by administering an immunomodulatory compound in combination with a cd40 antibody or cd40 ligand
KR20240052847A (ko) 2008-08-20 2024-04-23 셀룰래리티 인코포레이티드 개선된 세포 조성물 및 그의 제조 방법
US8728805B2 (en) 2008-08-22 2014-05-20 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
NZ592726A (en) 2008-11-19 2012-12-21 Anthrogenesis Corp Amnion derived adherent cells
BRPI1007500A2 (pt) 2009-02-10 2016-02-16 Celgene Corp métodos de uso e composições que compreendem moduladores de pde4 para tratamento, prevenção e gerenciamento de tuberculose
CA3110964A1 (en) 2009-03-25 2010-09-30 Xiaokui Zhang Preventing a symptom of graft-versus-host disease using human placenta-derived intermediate natural killer cells
US9125716B2 (en) 2009-04-17 2015-09-08 Boston Scientific Scimed, Inc. Delivery sleeve for pelvic floor implants
JP5645816B2 (ja) 2009-05-25 2014-12-24 国立大学法人東京工業大学 中枢神経細胞の増殖及び分化に係る中核因子を含む医薬組成物
ES2568629T3 (es) * 2009-06-18 2016-05-03 Concert Pharmaceuticals Inc. Derivados deuterados de isoindolin-1,3-diona como inhibidores de PDE4 y TNF-alfa
AU2013263763B2 (en) * 2009-06-18 2016-05-19 Concert Pharmaceuticals, Inc. Deuterated isoindoline-1,3-dione derivatives as PDE4 and TNF-alpha inhibitors
AR077369A1 (es) 2009-07-02 2011-08-24 Anthrogenesis Corp Metodopara producir eritrocitos sin celulas alimentadoras
CN102639498A (zh) * 2009-10-09 2012-08-15 细胞基因公司 制备2-(1-苯乙基)异吲哚啉-1-酮化合物的方法
WO2011084968A1 (en) 2010-01-05 2011-07-14 Celgene Corporation A combination of an immunomodulatory compound and an artemisinin or a derivative thereof for treating cancer
ES2646750T3 (es) 2010-01-26 2017-12-15 Anthrogenesis Corporation Tratamiento de cánceres relacionados con hueso utilizando células madre placentarias
RS59275B1 (sr) * 2010-02-11 2019-10-31 Celgene Corp Derivati arilmetoksi izoindolina i kompozicije koje ih obuhvataju i postupci njihove primene
LT2556145T (lt) 2010-04-07 2016-11-10 Anthrogenesis Corporation Angiogenezė naudojant placentos kamienines ląsteles
MX2012011543A (es) 2010-04-08 2013-05-06 Anthrogenesis Corp Tratamiento de sarcoidosis empleando celulas madre placentarias.
AU2011268450B2 (en) 2010-06-15 2015-07-16 Amgen (Europe) GmbH Biomarkers for the treatment of psoriasis
JP5996533B2 (ja) 2010-07-13 2016-09-21 アントフロゲネシス コーポレーション ナチュラルキラー細胞を生成させる方法
US8911348B2 (en) 2010-09-02 2014-12-16 Boston Scientific Scimed, Inc. Pelvic implants and methods of implanting the same
CN102558022B (zh) * 2010-12-22 2016-06-15 康塞特医药品有限公司 取代的异吲哚啉-1,3二酮衍生物
US8969315B2 (en) 2010-12-31 2015-03-03 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules
MX347928B (es) 2011-01-10 2017-05-19 Celgene Corp Derivados de fenetilsulfona isoindolina y su uso.
US9045417B2 (en) 2011-01-14 2015-06-02 Celgene Corporation Isotopologues of isoindole derivatives
JP2014517915A (ja) 2011-04-18 2014-07-24 セルジーン コーポレイション 多発性骨髄腫治療のためのバイオマーカー
WO2012149299A2 (en) 2011-04-29 2012-11-01 Celgene Corporaiton Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor
EP2714059B1 (en) 2011-06-01 2018-10-03 Celularity, Inc. Treatment of pain using placental stem cells
US9938269B2 (en) 2011-06-30 2018-04-10 Abbvie Inc. Inhibitor compounds of phosphodiesterase type 10A
US9925221B2 (en) 2011-09-09 2018-03-27 Celularity, Inc. Treatment of amyotrophic lateral sclerosis using placental stem cells
US9168120B2 (en) 2011-09-09 2015-10-27 Boston Scientific Scimed, Inc. Medical device and methods of delivering the medical device
EP3904875B1 (en) 2012-06-29 2024-11-20 Celgene Corporation Methods for determining drug efficacy using ikzf3 (aiolos)
US9587281B2 (en) 2012-08-14 2017-03-07 Celgene Corporation Cereblon isoforms and their use as biomarkers for therapeutic treatment
JP5934658B2 (ja) * 2013-01-29 2016-06-15 Jxエネルギー株式会社 イミド−ウレア化合物及びその製造方法、グリース用増ちょう剤並びにグリース組成物
US9763983B2 (en) 2013-02-05 2017-09-19 Anthrogenesis Corporation Natural killer cells from placenta
US9814555B2 (en) 2013-03-12 2017-11-14 Boston Scientific Scimed, Inc. Medical device for pelvic floor repair and method of delivering the medical device
CN105358177B (zh) 2013-04-17 2018-11-23 西格诺药品有限公司 包含tor激酶抑制剂和imid化合物的联合疗法用于治疗癌症
US9962251B2 (en) 2013-10-17 2018-05-08 Boston Scientific Scimed, Inc. Devices and methods for delivering implants
EP3142663A1 (en) 2014-05-16 2017-03-22 Celgene Corporation Compositions and methods for the treatment of atherosclerotic cardiovascular diseases with pde4 modulators
US10092555B2 (en) 2014-06-27 2018-10-09 Celgene Corporation Compositions and methods for inducing conformational changes in cereblon and other E3 ubiquitin ligases
WO2017070291A1 (en) 2015-10-21 2017-04-27 Celgene Corporation Pde4 modulators for treating and preventing immune reconstitution inflammatory syndrome (iris)
WO2017117118A1 (en) 2015-12-28 2017-07-06 Celgene Corporation Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases
KR20230156808A (ko) 2016-12-03 2023-11-14 주노 쎄러퓨티크스 인코퍼레이티드 Car-t 세포의 조절 방법
IL310031A (en) 2017-05-01 2024-03-01 Juno Therapeutics Inc A combination of cellular therapy and an immune modulatory compound
EP3630132A1 (en) 2017-06-02 2020-04-08 Juno Therapeutics, Inc. Articles of manufacture and methods for treatment using adoptive cell therapy
US20220225597A1 (en) 2017-06-29 2022-07-21 Juno Therapeutics, Inc. Mouse model for assessing toxicities associated with immunotherapies
US20200246393A1 (en) 2017-09-28 2020-08-06 Celularity, Inc. Tumor suppression using human placenta-derived intermediate natural killer (pink) cells in combination with an antibody
WO2019089858A2 (en) 2017-11-01 2019-05-09 Juno Therapeutics, Inc. Methods of assessing or monitoring a response to a cell therapy
CA3080904A1 (en) 2017-11-01 2019-05-09 Juno Therapeutics, Inc. Antibodies and chimeric antigen receptors specific for b-cell maturation antigen
EP3724225A1 (en) 2017-12-15 2020-10-21 Juno Therapeutics, Inc. Anti-cct5 binding molecules and methods of use thereof
US11325907B2 (en) 2018-01-29 2022-05-10 Medshine Discovery Inc. Crystal form of 1H-imidazo[4,5-b]pyridine-2(3H)-one compound and preparation process therefor
CA3092037A1 (en) 2018-02-21 2019-08-29 Celgene Corporation Bcma-binding antibodies and uses thereof
EP3876958A1 (en) 2018-11-08 2021-09-15 Juno Therapeutics, Inc. Methods and combinations for treatment and t cell modulation
EP3880238A1 (en) 2018-11-16 2021-09-22 Juno Therapeutics, Inc. Methods of dosing engineered t cells for the treatment of b cell malignancies
PL3886875T3 (pl) 2018-11-30 2024-09-09 Juno Therapeutics, Inc. Metody leczenia z wykorzystaniem adoptywnej terapii komórkowej
BR112021014833A2 (pt) 2019-01-29 2021-10-05 Juno Therapeutics, Inc. Anticorpos e receptores antigênicos quiméricos específicos para receptor órfão 1 de tipo tirosina quinase de receptor (ror1)
CN113527179B (zh) * 2020-04-13 2023-07-07 苏州璞正医药有限公司 链烃取代异吲哚啉-1,3-二酮类pde4抑制剂及其药物用途
CN113956190B (zh) * 2021-10-29 2023-05-02 大连理工大学 可激活肿瘤细胞焦亡的细胞器靶向光敏剂及其制备方法和应用
CN119546638A (zh) 2022-06-22 2025-02-28 朱诺治疗学股份有限公司 用于cd19靶向的car t细胞的二线疗法的治疗方法
WO2024097905A1 (en) 2022-11-02 2024-05-10 Celgene Corporation Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4173652A (en) 1976-12-18 1979-11-06 Akzona Incorporated Pharmaceutical hydroxamic acid compositions and uses thereof
SE434638B (sv) 1980-06-06 1984-08-06 Lekemedelsfabriken Medica Ab Nya terapeutiska verdefulla taurinderivat och deras framstellning
US4820828A (en) 1987-03-04 1989-04-11 Ortho Pharmaceutical Corporation Cinnamohydroxamic acids
US5605914A (en) 1993-07-02 1997-02-25 Celgene Corporation Imides
US5698579A (en) 1993-07-02 1997-12-16 Celgene Corporation Cyclic amides
US5801195A (en) 1994-12-30 1998-09-01 Celgene Corporation Immunotherapeutic aryl amides
US5703098A (en) 1994-12-30 1997-12-30 Celgene Corporation Immunotherapeutic imides/amides
AU711755B2 (en) 1995-07-26 1999-10-21 Pfizer Inc. N-(aroyl)glycine hydroxamic acid derivatives and related compounds
US5728845A (en) 1995-08-29 1998-03-17 Celgene Corporation Immunotherapeutic nitriles
US5728844A (en) 1995-08-29 1998-03-17 Celgene Corporation Immunotherapeutic agents
US5658940A (en) 1995-10-06 1997-08-19 Celgene Corporation Succinimide and maleimide cytokine inhibitors
EP0871439B1 (en) 1996-01-02 2004-03-31 Aventis Pharmaceuticals Inc. Substituted (aryl, heteroaryl, arylmethyl or heteroarylmethyl) hydroxamic acid compounds
SK17799A3 (en) 1996-08-12 1999-11-08 Celgene Corp Cyano and carboxy derivatives of substituted styrenes, pharmaceutical composition containing same and their use
US6020358A (en) * 1998-10-30 2000-02-01 Celgene Corporation Substituted phenethylsulfones and method of reducing TNFα levels
US6667316B1 (en) * 1999-11-12 2003-12-23 Celgene Corporation Pharmaceutically active isoindoline derivatives
US6699899B1 (en) 1999-12-21 2004-03-02 Celgene Corporation Substituted acylhydroxamic acids and method of reducing TNFα levels
BR0317885A (pt) * 2002-12-30 2005-12-06 Celgene Corp Composto, isÈmeros s e r enantiomericamente puros do mesmo, composição farmacêutica e métodos de inibir pde4 e mmp, de modular a produção de tnf-alfa, de tratar ou prevenir mds, de tratar doença mieloproliferativa, angiogênese indesejada, câncer, uma doença, inflamação dos pulmões, depressão, distúrbio pulmonar obstrutivo crÈnico, doença inflamatória do intestino, dermatite atópica, psorìase, doença de crohn, artrite reumatóide, asma, eslcerose múltipla e doença cardìaca em um mamìfero e de tratar, prevenir ou controlar a sìndrome de dor regional complexa
NZ542670A (en) * 2003-03-12 2008-11-28 Celgene Corp N-alkyl-hydroxamic acid-isoindolyl compounds and their pharmaceutical uses
BRPI0408223A (pt) * 2003-03-12 2006-03-01 Celgene Corp composto, isÈmeros, composição farmacêutica, e, métodos de inibir pde4 e mmp, de modular a produção de tnf-alfa em um mamìfero e de tratar, previnir ou controlar uma doença ou condição
US7244759B2 (en) 2004-07-28 2007-07-17 Celgene Corporation Isoindoline compounds and methods of making and using the same
US7405237B2 (en) * 2004-07-28 2008-07-29 Celgene Corporation Isoindoline compounds and methods of their use

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