JP2008507538A - 置換アミドβセクレターゼインヒビター - Google Patents
置換アミドβセクレターゼインヒビター Download PDFInfo
- Publication number
- JP2008507538A JP2008507538A JP2007522711A JP2007522711A JP2008507538A JP 2008507538 A JP2008507538 A JP 2008507538A JP 2007522711 A JP2007522711 A JP 2007522711A JP 2007522711 A JP2007522711 A JP 2007522711A JP 2008507538 A JP2008507538 A JP 2008507538A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- substituted
- aryl
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCCc1cc(C[C@@](CC*(*)CC*(Cc2ccccc2)C=O)*I)ccc1 Chemical compound CCCc1cc(C[C@@](CC*(*)CC*(Cc2ccccc2)C=O)*I)ccc1 0.000 description 3
- WRXOZRLZDJAYDR-UHFFFAOYSA-N Cc1cc(S)ccc1 Chemical compound Cc1cc(S)ccc1 WRXOZRLZDJAYDR-UHFFFAOYSA-N 0.000 description 2
- NPRAEQKJCWHOCK-UHFFFAOYSA-N C1CC2OCCOC2CC1 Chemical compound C1CC2OCCOC2CC1 NPRAEQKJCWHOCK-UHFFFAOYSA-N 0.000 description 1
- FTNJQNQLEGKTGD-UHFFFAOYSA-N C1Oc(cccc2)c2O1 Chemical compound C1Oc(cccc2)c2O1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 description 1
- GMVSBVSVUQDHNN-VWLOTQADSA-N C=CCOc1cc(C[C@@H](CO)N(Cc2ccccc2)Cc2ccccc2)cc(F)c1 Chemical compound C=CCOc1cc(C[C@@H](CO)N(Cc2ccccc2)Cc2ccccc2)cc(F)c1 GMVSBVSVUQDHNN-VWLOTQADSA-N 0.000 description 1
- SDGUHJAZKCARDF-UHFFFAOYSA-N C=CCOc1cc(F)cc(Br)c1 Chemical compound C=CCOc1cc(F)cc(Br)c1 SDGUHJAZKCARDF-UHFFFAOYSA-N 0.000 description 1
- DRXILRPKGACBCH-UHFFFAOYSA-N C=[Br]c1cc(F)cc(Cc2ccccc2)c1 Chemical compound C=[Br]c1cc(F)cc(Cc2ccccc2)c1 DRXILRPKGACBCH-UHFFFAOYSA-N 0.000 description 1
- ISUYMHMEEXPVGK-YTMVLYRLSA-N CC(C)(C)OC(N(CC1)CCN1c1cccc(C[C@@H](C[C@@H](C(N(Cc2ccccc2)CC2)=O)N2C(OC(C)(C)C)=O)N)c1)=O Chemical compound CC(C)(C)OC(N(CC1)CCN1c1cccc(C[C@@H](C[C@@H](C(N(Cc2ccccc2)CC2)=O)N2C(OC(C)(C)C)=O)N)c1)=O ISUYMHMEEXPVGK-YTMVLYRLSA-N 0.000 description 1
- OTBBDCMPKZSOMD-UHFFFAOYSA-N CC(C)(C)OC(N(CCN1Cc2ccccc2)CC1=O)=O Chemical compound CC(C)(C)OC(N(CCN1Cc2ccccc2)CC1=O)=O OTBBDCMPKZSOMD-UHFFFAOYSA-N 0.000 description 1
- BSUARKFCSLHTOC-QARUCVQPSA-N CC(C)(C)OC(N(CCN1Cc2ccccc2)[C@@H](C[C@H](Cc2cc(F)cc(OCC=C)c2)N(Cc2ccccc2)Cc2ccccc2)C1=O)=O Chemical compound CC(C)(C)OC(N(CCN1Cc2ccccc2)[C@@H](C[C@H](Cc2cc(F)cc(OCC=C)c2)N(Cc2ccccc2)Cc2ccccc2)C1=O)=O BSUARKFCSLHTOC-QARUCVQPSA-N 0.000 description 1
- MTUYSHOIUGFHHY-UNMCSNQZSA-N CC(C)(C)OC(N(CCN1Cc2ccccc2)[C@@H](C[C@H](Cc2cc(O)cc(F)c2)N)C1=O)=O Chemical compound CC(C)(C)OC(N(CCN1Cc2ccccc2)[C@@H](C[C@H](Cc2cc(O)cc(F)c2)N)C1=O)=O MTUYSHOIUGFHHY-UNMCSNQZSA-N 0.000 description 1
- UVTMJXOPXKLMLF-HSZRJFAPSA-N CC(C)(C)OC(N(CC[C@H](Cc1cc(O)cc(F)c1)NC)CCN(C)Cc1ccccc1)=O Chemical compound CC(C)(C)OC(N(CC[C@H](Cc1cc(O)cc(F)c1)NC)CCN(C)Cc1ccccc1)=O UVTMJXOPXKLMLF-HSZRJFAPSA-N 0.000 description 1
- BOULMKGNQBTPMU-AHWVRZQESA-N CC(C)CCOc1cc(F)cc(C[C@@H](C[C@@H]2NCCN(Cc3ccccc3)C2=O)NC(C)=O)c1 Chemical compound CC(C)CCOc1cc(F)cc(C[C@@H](C[C@@H]2NCCN(Cc3ccccc3)C2=O)NC(C)=O)c1 BOULMKGNQBTPMU-AHWVRZQESA-N 0.000 description 1
- NJVJZVPLAVBXPS-MUUNZHRXSA-N CC(N[C@H](CCNCCN(Cc1ccccc1)C=O)Cc1cc(OCc2ccccc2)cc(F)c1)=O Chemical compound CC(N[C@H](CCNCCN(Cc1ccccc1)C=O)Cc1cc(OCc2ccccc2)cc(F)c1)=O NJVJZVPLAVBXPS-MUUNZHRXSA-N 0.000 description 1
- JWWLQTYYINAHMF-XCZPVHLTSA-N CC(N[C@H](C[C@@H]1NCCN(Cc2ccccc2)C1=O)Cc1cc(OCc(cc2)ccc2Cl)cc(F)c1)=O Chemical compound CC(N[C@H](C[C@@H]1NCCN(Cc2ccccc2)C1=O)Cc1cc(OCc(cc2)ccc2Cl)cc(F)c1)=O JWWLQTYYINAHMF-XCZPVHLTSA-N 0.000 description 1
- CTDPUDMNFKYLIO-WNJJXGMVSA-N CC(N[C@H](C[C@@H]1NCCN(Cc2ccccc2)C1=O)Cc1cc(OCc2cc(OC)ccc2)cc(F)c1)=O Chemical compound CC(N[C@H](C[C@@H]1NCCN(Cc2ccccc2)C1=O)Cc1cc(OCc2cc(OC)ccc2)cc(F)c1)=O CTDPUDMNFKYLIO-WNJJXGMVSA-N 0.000 description 1
- CJLCMTOARKAILV-DHLKQENFSA-N CC(N[C@H](C[C@@H]1NCCN(Cc2ccccc2)C1=O)Cc1cc(OCc2ccc(C(F)(F)F)[o]2)cc(F)c1)=O Chemical compound CC(N[C@H](C[C@@H]1NCCN(Cc2ccccc2)C1=O)Cc1cc(OCc2ccc(C(F)(F)F)[o]2)cc(F)c1)=O CJLCMTOARKAILV-DHLKQENFSA-N 0.000 description 1
- ZNNRNQRZOJUYQY-BDYUSTAISA-N CC(N[C@H](C[C@@H]1NCCN(Cc2ccccc2)C1=O)Cc1cc(OCc2ccncc2)cc(F)c1)=O Chemical compound CC(N[C@H](C[C@@H]1NCCN(Cc2ccccc2)C1=O)Cc1cc(OCc2ccncc2)cc(F)c1)=O ZNNRNQRZOJUYQY-BDYUSTAISA-N 0.000 description 1
- LPMNPEVCDMMTKI-PJLXGWBQSA-N CC/C=C/COc1cc(F)cc(C[C@@H](C[C@@H](CN(Cc2ccccc2)CC2)N2C(OC(C)(C)C)=O)NC(C)=O)c1 Chemical compound CC/C=C/COc1cc(F)cc(C[C@@H](C[C@@H](CN(Cc2ccccc2)CC2)N2C(OC(C)(C)C)=O)NC(C)=O)c1 LPMNPEVCDMMTKI-PJLXGWBQSA-N 0.000 description 1
- MEDCXLXGWKVOGM-SMIXSIFNSA-N CC1C=CC=C(CN(CCN([C@H]2C[C@H](Cc3cc(N(CC4)CCN4C(OC(C)(C)C)=O)ccc3)N(Cc3ccccc3)Cc3ccccc3)C(OC(C)(C)C)=O)C2=O)C1 Chemical compound CC1C=CC=C(CN(CCN([C@H]2C[C@H](Cc3cc(N(CC4)CCN4C(OC(C)(C)C)=O)ccc3)N(Cc3ccccc3)Cc3ccccc3)C(OC(C)(C)C)=O)C2=O)C1 MEDCXLXGWKVOGM-SMIXSIFNSA-N 0.000 description 1
- HXSCURIRQIHACD-ALCCZGGFSA-N CCC(CC)=C/C=C\N Chemical compound CCC(CC)=C/C=C\N HXSCURIRQIHACD-ALCCZGGFSA-N 0.000 description 1
- CCILAFJQFQFGHX-VXKWHMMOSA-N CCCCCOc1cc(C[C@@H](C[C@@H](CNCC2)N2C(OC(C)(C)C)=O)NC(C)=O)cc(F)c1 Chemical compound CCCCCOc1cc(C[C@@H](C[C@@H](CNCC2)N2C(OC(C)(C)C)=O)NC(C)=O)cc(F)c1 CCILAFJQFQFGHX-VXKWHMMOSA-N 0.000 description 1
- QBNRGSJGJXTJTF-YDAXCOIMSA-N CCCc1cccc(C[C@@H](C[C@@H](C(N(Cc2ccccc2)CC2)=O)N2C(OC(C)(C)C)=O)N(Cc2ccccc2)Cc2ccccc2)c1 Chemical compound CCCc1cccc(C[C@@H](C[C@@H](C(N(Cc2ccccc2)CC2)=O)N2C(OC(C)(C)C)=O)N(Cc2ccccc2)Cc2ccccc2)c1 QBNRGSJGJXTJTF-YDAXCOIMSA-N 0.000 description 1
- YREZTNCZNWRAHR-DQEYMECFSA-N CCCc1cccc(C[C@@H](C[C@@H](C(N(Cc2ccccc2)CC2)=O)N2C(OC(C)(C)C)=O)N)c1 Chemical compound CCCc1cccc(C[C@@H](C[C@@H](C(N(Cc2ccccc2)CC2)=O)N2C(OC(C)(C)C)=O)N)c1 YREZTNCZNWRAHR-DQEYMECFSA-N 0.000 description 1
- ULVNWAWZNVCNRB-UHFFFAOYSA-N CCc1ccc(C(F)(F)F)[o]1 Chemical compound CCc1ccc(C(F)(F)F)[o]1 ULVNWAWZNVCNRB-UHFFFAOYSA-N 0.000 description 1
- MFEIKQPHQINPRI-UHFFFAOYSA-N CCc1cccnc1 Chemical compound CCc1cccnc1 MFEIKQPHQINPRI-UHFFFAOYSA-N 0.000 description 1
- NRGGMCIBEHEAIL-UHFFFAOYSA-N CCc1ncccc1 Chemical compound CCc1ncccc1 NRGGMCIBEHEAIL-UHFFFAOYSA-N 0.000 description 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Cc1ccccc1 Chemical compound Cc1ccccc1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 1
- FCSGCOXBPQGOIC-UHFFFAOYSA-N OC(c1ccccc1)c1cc(Br)cc(F)c1 Chemical compound OC(c1ccccc1)c1cc(Br)cc(F)c1 FCSGCOXBPQGOIC-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59010204P | 2004-07-22 | 2004-07-22 | |
| PCT/US2005/025780 WO2006014762A1 (en) | 2004-07-22 | 2005-07-20 | Substituted amide beta secretase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008507538A true JP2008507538A (ja) | 2008-03-13 |
| JP2008507538A5 JP2008507538A5 (https=) | 2008-08-14 |
Family
ID=35431616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007522711A Pending JP2008507538A (ja) | 2004-07-22 | 2005-07-20 | 置換アミドβセクレターゼインヒビター |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7803802B2 (https=) |
| EP (1) | EP1781625B1 (https=) |
| JP (1) | JP2008507538A (https=) |
| CN (1) | CN101014577A (https=) |
| AR (1) | AR049726A1 (https=) |
| AT (1) | ATE491693T1 (https=) |
| CA (1) | CA2574218A1 (https=) |
| DE (1) | DE602005025363D1 (https=) |
| ES (1) | ES2355733T3 (https=) |
| MX (1) | MX2007000760A (https=) |
| TW (1) | TW200621249A (https=) |
| WO (1) | WO2006014762A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| AU2006259675A1 (en) * | 2005-06-14 | 2006-12-28 | Schering Corporation | Aspartyl protease inhibitors |
| PE20070135A1 (es) | 2005-06-14 | 2007-03-09 | Schering Corp | Compuestos heterociclicos como inhibidores de aspartil proteasas |
| PE20080155A1 (es) | 2006-06-12 | 2008-03-10 | Schering Corp | Compuestos heterociclicos como inhibidores de aspartil-proteasa |
| US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| JP2010512389A (ja) | 2006-12-12 | 2010-04-22 | シェーリング コーポレイション | アスパルチルプロテアーゼ阻害剤 |
| JP5930573B2 (ja) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
| EP2142514B1 (en) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| US8518975B2 (en) | 2007-09-06 | 2013-08-27 | Merck Sharp + Dohme Corp. | Gamma secretase modulators |
| MX2010005028A (es) | 2007-11-05 | 2010-05-27 | Schering Corp | Moduladores de gamma secretasa. |
| EP2227471A1 (en) * | 2007-12-11 | 2010-09-15 | Schering Corporation | Gamma secretase modulators |
| CA2723222C (en) | 2008-04-22 | 2013-04-02 | Schering Corporation | Phenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as bace-1 inhibitors, compositions, and their use |
| MX2011005046A (es) | 2008-11-13 | 2011-06-01 | Schering Corp | Moduladores de gamma secretasa. |
| WO2010075204A2 (en) | 2008-12-22 | 2010-07-01 | Schering Corporation | Gamma secretase modulators |
| EP2379563B1 (en) | 2008-12-22 | 2014-07-16 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
| WO2010147973A1 (en) | 2009-06-16 | 2010-12-23 | Schering Corporation | Gamma secretase modulators |
| WO2010147969A2 (en) | 2009-06-16 | 2010-12-23 | Schering Corporation | Gamma secretase modulators |
| WO2010147975A1 (en) | 2009-06-16 | 2010-12-23 | Schering Corporation | Gamma secretase modulators |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| EP2485920B1 (en) | 2009-10-08 | 2016-04-27 | Merck Sharp & Dohme Corp. | Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use |
| UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
| WO2011044187A1 (en) | 2009-10-08 | 2011-04-14 | Schering Corporation | Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
| EP2485590B1 (en) | 2009-10-08 | 2015-01-07 | Merck Sharp & Dohme Corp. | Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| NZ602312A (en) | 2010-03-10 | 2014-02-28 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| EP2694489B1 (en) | 2011-04-07 | 2017-09-06 | Merck Sharp & Dohme Corp. | C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
| CN103874496A (zh) | 2011-08-22 | 2014-06-18 | 默沙东公司 | 作为bace抑制剂的2-螺-取代的亚氨基噻嗪类及其单和二氧化物、组合物及其用途 |
| WO2013036671A1 (en) * | 2011-09-07 | 2013-03-14 | Satori Pharmaceuticals, Inc. | Compounds useful for treating neurodegenerative disorders |
| CN104270945B (zh) | 2012-03-19 | 2017-03-29 | 巴克老龄化研究所 | App特异性bace抑制剂(asbi)及其用途 |
| EP2908824B1 (en) | 2012-10-17 | 2018-05-02 | Merck Sharp & Dohme Corp. | Tricyclic substituted thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
| US9422277B2 (en) | 2012-10-17 | 2016-08-23 | Merck Sharp & Dohme Corp. | Tricyclic substituted thiadiazine dioxide compounds as BACE inhibitors, compositions and their use |
| CA2899938C (en) | 2013-02-12 | 2021-10-19 | Buck Institute For Research On Aging | Hydantoins that modulate bace-mediated app processing |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003035613A2 (en) * | 2001-10-22 | 2003-05-01 | Enanta Pharmaceuticals, Inc. | Nitrogen heterocycle inhibitors of aspartyl protease |
| WO2004043916A1 (en) * | 2002-11-12 | 2004-05-27 | Merck & Co., Inc. | Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease |
| JP2007533741A (ja) * | 2004-04-22 | 2007-11-22 | イーライ リリー アンド カンパニー | Ｂａｃｅ阻害剤 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03500772A (ja) * | 1987-10-21 | 1991-02-21 | ジ・アップジョン・カンパニー | （１‐アミノ‐２‐ヒドロキシ‐２‐ヘテロサイクリック）エチル基を含有するレニン抑制物質類 |
| HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
| NZ514453A (en) | 1999-02-26 | 2003-04-29 | Merck & Co Inc | Novel sulfonamide compounds and uses thereof |
| DE19934145C2 (de) * | 1999-07-26 | 2001-05-23 | Deutsche Telekom Mobil | Verfahren zur Herstellung von Kommunikationsverbindungen zu einer, einem Fahrzeug oder sonstigen mobilen oder ortsfesten Einrichtung zugeordneten, vorzugsweise mobilen Kommunikationsendeinrichtung |
| US6589978B2 (en) | 2000-06-30 | 2003-07-08 | Hoffman-La Roche Inc. | 1-sulfonyl pyrrolidine derivatives |
| JP2004502664A (ja) | 2000-06-30 | 2004-01-29 | イーラン ファーマスーティカルズ、インコーポレイテッド | アルツハイマー病処置用化合物 |
| PE20020276A1 (es) | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
| US6846813B2 (en) | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
| EP1389194A2 (en) | 2001-04-27 | 2004-02-18 | Vertex Pharmaceuticals Incorporated | Inhibitors of bace |
| US7122675B2 (en) | 2001-08-03 | 2006-10-17 | Schering Corporation | Gamma secretase inhibitors |
| AR034390A1 (es) | 2001-08-03 | 2004-02-25 | Schering Corp | Derivados de 1-sulfonil-tetrahidro quinolinas sustituidas, composiciones farmaceuticas y el uso de las mismas para la elaboracion de medicamentos como inhibidores de la gama secretasa |
| JP3711131B2 (ja) | 2001-08-21 | 2005-10-26 | メルク シャープ エンド ドーム リミテッド | 新規のシクロヘキシルスルホン |
| TW200302717A (en) | 2002-02-06 | 2003-08-16 | Schering Corp | Novel gamma secretase inhibitors |
| AU2003229024A1 (en) | 2002-05-07 | 2003-11-11 | Elan Pharmaceuticals, Inc. | Succinoyl aminopyrazoles and related compounds |
| WO2004004396A1 (en) | 2002-06-26 | 2004-01-08 | Nokia Corporation | Method and network element for optimisation of radio resource utilisation in a radio access network |
| CA2629317A1 (en) * | 2005-11-16 | 2007-05-24 | Merck & Co., Inc. | Imidazolidinone compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease |
-
2005
- 2005-07-20 CA CA002574218A patent/CA2574218A1/en not_active Abandoned
- 2005-07-20 CN CNA2005800300344A patent/CN101014577A/zh active Pending
- 2005-07-20 AT AT05773473T patent/ATE491693T1/de not_active IP Right Cessation
- 2005-07-20 MX MX2007000760A patent/MX2007000760A/es active IP Right Grant
- 2005-07-20 WO PCT/US2005/025780 patent/WO2006014762A1/en not_active Ceased
- 2005-07-20 US US11/185,419 patent/US7803802B2/en active Active
- 2005-07-20 AR ARP050103000A patent/AR049726A1/es not_active Application Discontinuation
- 2005-07-20 JP JP2007522711A patent/JP2008507538A/ja active Pending
- 2005-07-20 EP EP05773473A patent/EP1781625B1/en not_active Expired - Lifetime
- 2005-07-20 DE DE602005025363T patent/DE602005025363D1/de not_active Expired - Lifetime
- 2005-07-20 ES ES05773473T patent/ES2355733T3/es not_active Expired - Lifetime
- 2005-07-21 TW TW094124686A patent/TW200621249A/zh unknown
-
2010
- 2010-08-23 US US12/861,347 patent/US8367712B2/en not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003035613A2 (en) * | 2001-10-22 | 2003-05-01 | Enanta Pharmaceuticals, Inc. | Nitrogen heterocycle inhibitors of aspartyl protease |
| WO2004043916A1 (en) * | 2002-11-12 | 2004-05-27 | Merck & Co., Inc. | Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease |
| JP2007533741A (ja) * | 2004-04-22 | 2007-11-22 | イーライ リリー アンド カンパニー | Ｂａｃｅ阻害剤 |
| JP2007533740A (ja) * | 2004-04-22 | 2007-11-22 | イーライ リリー アンド カンパニー | Ｂａｃｅ阻害剤としてのアミド |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006014762A1 (en) | 2006-02-09 |
| US8367712B2 (en) | 2013-02-05 |
| CN101014577A (zh) | 2007-08-08 |
| US20110003825A1 (en) | 2011-01-06 |
| AR049726A1 (es) | 2006-08-30 |
| ATE491693T1 (de) | 2011-01-15 |
| MX2007000760A (es) | 2007-04-09 |
| TW200621249A (en) | 2006-07-01 |
| US7803802B2 (en) | 2010-09-28 |
| US20060040994A1 (en) | 2006-02-23 |
| EP1781625B1 (en) | 2010-12-15 |
| CA2574218A1 (en) | 2006-02-09 |
| DE602005025363D1 (de) | 2011-01-27 |
| EP1781625A1 (en) | 2007-05-09 |
| ES2355733T3 (es) | 2011-03-30 |
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