JP2008506710A5 - - Google Patents
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- Publication number
- JP2008506710A5 JP2008506710A5 JP2007521685A JP2007521685A JP2008506710A5 JP 2008506710 A5 JP2008506710 A5 JP 2008506710A5 JP 2007521685 A JP2007521685 A JP 2007521685A JP 2007521685 A JP2007521685 A JP 2007521685A JP 2008506710 A5 JP2008506710 A5 JP 2008506710A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- aralkyl
- pharmaceutical composition
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 29
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 125000003710 aryl alkyl group Chemical group 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 2
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 230000008018 melting Effects 0.000 claims 2
- 238000002844 melting Methods 0.000 claims 2
- AOJFQRQNPXYVLM-UHFFFAOYSA-N pyridin-1-ium;chloride Chemical compound [Cl-].C1=CC=[NH+]C=C1 AOJFQRQNPXYVLM-UHFFFAOYSA-N 0.000 claims 2
- 229910052711 selenium Inorganic materials 0.000 claims 2
- SHGAZHPCJJPHSC-ZVCIMWCZSA-N 9-cis-retinoic acid Chemical compound OC(=O)/C=C(\C)/C=C/C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-ZVCIMWCZSA-N 0.000 claims 1
- 208000036762 Acute promyelocytic leukaemia Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 208000014767 Myeloproliferative disease Diseases 0.000 claims 1
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000033826 Promyelocytic Acute Leukemia Diseases 0.000 claims 1
- 208000009527 Refractory anemia Diseases 0.000 claims 1
- 206010072684 Refractory cytopenia with unilineage dysplasia Diseases 0.000 claims 1
- 229960001445 alitretinoin Drugs 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 210000000601 blood cell Anatomy 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 201000006491 bone marrow cancer Diseases 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000004696 endometrium Anatomy 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 210000003128 head Anatomy 0.000 claims 1
- 230000002489 hematologic effect Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- -1 methyl compound Chemical class 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000003739 neck Anatomy 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 229930002330 retinoic acid Natural products 0.000 claims 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N retinoic acid group Chemical group C\C(=C/C(=O)O)\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- MUTNCGKQJGXKEM-UHFFFAOYSA-N tamibarotene Chemical compound C=1C=C2C(C)(C)CCC(C)(C)C2=CC=1NC(=O)C1=CC=C(C(O)=O)C=C1 MUTNCGKQJGXKEM-UHFFFAOYSA-N 0.000 claims 1
- 210000001550 testis Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58859604P | 2004-07-16 | 2004-07-16 | |
| US60/588,596 | 2004-07-16 | ||
| PCT/US2005/025192 WO2006020048A2 (en) | 2004-07-16 | 2005-07-15 | Compounds and methods for treatment of cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011227543A Division JP2012051919A (ja) | 2004-07-16 | 2011-10-17 | 癌の治療のための化合物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008506710A JP2008506710A (ja) | 2008-03-06 |
| JP2008506710A5 true JP2008506710A5 (https=) | 2008-07-31 |
| JP5618461B2 JP5618461B2 (ja) | 2014-11-05 |
Family
ID=35414967
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007521685A Expired - Fee Related JP5618461B2 (ja) | 2004-07-16 | 2005-07-15 | 癌の治療のための化合物および方法 |
| JP2011227543A Withdrawn JP2012051919A (ja) | 2004-07-16 | 2011-10-17 | 癌の治療のための化合物および方法 |
| JP2014037807A Expired - Lifetime JP5745660B2 (ja) | 2004-07-16 | 2014-02-28 | 癌の治療のための化合物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011227543A Withdrawn JP2012051919A (ja) | 2004-07-16 | 2011-10-17 | 癌の治療のための化合物および方法 |
| JP2014037807A Expired - Lifetime JP5745660B2 (ja) | 2004-07-16 | 2014-02-28 | 癌の治療のための化合物および方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7405314B2 (https=) |
| EP (1) | EP1771459A2 (https=) |
| JP (3) | JP5618461B2 (https=) |
| KR (5) | KR20140013110A (https=) |
| CN (3) | CN104163833A (https=) |
| AU (1) | AU2005274926B2 (https=) |
| CA (2) | CA2777473C (https=) |
| HK (1) | HK1204476A1 (https=) |
| IL (2) | IL180729A (https=) |
| TW (3) | TWI411431B (https=) |
| WO (1) | WO2006020048A2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6911471B2 (en) | 2002-01-07 | 2005-06-28 | The Texas A&M University System | S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer |
| US7628810B2 (en) | 2003-05-28 | 2009-12-08 | Acufocus, Inc. | Mask configured to maintain nutrient transport without producing visible diffraction patterns |
| TWI411431B (zh) * | 2004-07-16 | 2013-10-11 | Texas A & M Univ Sys | 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物 |
| ES2532666T3 (es) | 2005-07-29 | 2015-03-30 | Solasia Pharma K.K. | Compuestos y métodos para el tratamiento del cáncer |
| WO2007082104A2 (en) | 2006-01-13 | 2007-07-19 | The Texas A & M University System | Compounds and methods for the treatment of cancer |
| RU2318519C2 (ru) * | 2006-03-06 | 2008-03-10 | ФГУ Ростовский научно-исследовательский онкологический институт Росздрава | Способ химиотерапии острого лейкоза |
| TW200829261A (en) | 2006-09-29 | 2008-07-16 | Ziopharm Oncology Inc | Method for controlling angiogenesis in animals |
| KR20100100835A (ko) * | 2007-11-02 | 2010-09-15 | 지오팜 온콜로지 인코포레이티드 | 유기 비소제와의 병용 요법 |
| SG186599A1 (en) * | 2007-12-12 | 2013-01-30 | Ziopharm Oncology Inc | Compounds and methods for the treatment of cancer |
| RU2534606C2 (ru) * | 2008-08-20 | 2014-11-27 | Зайофарм Онколоджи, Инк. | Мышьякорганические соединения и способы лечения рака |
| CN102060722B (zh) * | 2009-05-01 | 2014-06-11 | 常州高新技术产业开发区三维工业技术研究所有限公司 | 一种含砷化合物及其制备方法和用途 |
| US10004593B2 (en) | 2009-08-13 | 2018-06-26 | Acufocus, Inc. | Intraocular lens with elastic mask |
| US9492272B2 (en) | 2009-08-13 | 2016-11-15 | Acufocus, Inc. | Masked intraocular implants and lenses |
| JP2014516075A (ja) | 2011-06-06 | 2014-07-07 | シェブロン フィリップス ケミカル カンパニー エルピー | 癌治療のためのメタロセン化合物の使用 |
| EP2785296B1 (en) | 2011-12-02 | 2018-06-20 | AcuFocus, Inc. | Ocular mask having selective spectral transmission |
| US9427922B2 (en) | 2013-03-14 | 2016-08-30 | Acufocus, Inc. | Process for manufacturing an intraocular lens with an embedded mask |
| TWI617305B (zh) * | 2013-12-05 | 2018-03-11 | 蘇愛康制藥有限公司 | 治療癌症的化合物及其應用程序 |
| GB201418491D0 (en) * | 2014-10-17 | 2014-12-03 | Monfort University De | Compounds |
| EP3220859B8 (en) | 2014-11-19 | 2020-06-10 | AcuFocus, Inc. | Fracturable mask for treating presbyopia |
| US10687935B2 (en) | 2015-10-05 | 2020-06-23 | Acufocus, Inc. | Methods of molding intraocular lenses |
| JP7055747B2 (ja) | 2015-11-24 | 2022-04-18 | アキュフォーカス・インコーポレーテッド | 焦点深度の拡張を伴うトーリック小開口眼内レンズ |
| CN105330701B (zh) * | 2015-11-27 | 2017-05-31 | 昆明医科大学 | 一种含砷化合物及其制备方法和应用 |
| EP3790508B1 (en) | 2018-05-09 | 2026-04-29 | AcuFocus, Inc. | Intraocular implant with optic |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001519366A (ja) * | 1997-10-15 | 2001-10-23 | ポーラクス バイオファーマシュティカルズ，インコーポレーテッド | ヒ素化合物を用いた、原発性および転移性の腫瘍性疾患を治療するための組成物および方法 |
| IL136051A0 (en) * | 1997-11-10 | 2001-05-20 | Sloan Kettering Inst Cancer | Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol |
| CN1233476A (zh) * | 1998-04-24 | 1999-11-03 | 陆道培 | 治疗急性白血病的药物及其制备方法 |
| EP1002537A1 (en) | 1998-10-30 | 2000-05-24 | Assistance Publique, Hopitaux De Paris | Use of melarsoprol for the manufacture of a medicament for treating B-cell lymphoproliferative diseases, such as multiple myeloma |
| US6191123B1 (en) * | 1999-03-19 | 2001-02-20 | Parker Hughes Institute | Organic-arsenic compounds |
| EP1328253B1 (en) * | 2000-04-26 | 2006-03-22 | Oregon Health Sciences University | Administration of a thiol-based chemoprotectant compound |
| US6911471B2 (en) * | 2002-01-07 | 2005-06-28 | The Texas A&M University System | S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer |
| TWI411431B (zh) * | 2004-07-16 | 2013-10-11 | Texas A & M Univ Sys | 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物 |
-
2005
- 2005-07-14 TW TW094123873A patent/TWI411431B/zh not_active IP Right Cessation
- 2005-07-14 TW TW103121164A patent/TW201440760A/zh unknown
- 2005-07-14 TW TW102125370A patent/TW201350113A/zh unknown
- 2005-07-15 CA CA2777473A patent/CA2777473C/en not_active Expired - Fee Related
- 2005-07-15 JP JP2007521685A patent/JP5618461B2/ja not_active Expired - Fee Related
- 2005-07-15 KR KR1020147000020A patent/KR20140013110A/ko not_active Withdrawn
- 2005-07-15 CA CA2574032A patent/CA2574032C/en not_active Expired - Fee Related
- 2005-07-15 KR KR1020147030246A patent/KR20140136525A/ko not_active Ceased
- 2005-07-15 KR KR1020137021239A patent/KR20130095857A/ko not_active Ceased
- 2005-07-15 CN CN201310451346.9A patent/CN104163833A/zh active Pending
- 2005-07-15 AU AU2005274926A patent/AU2005274926B2/en not_active Ceased
- 2005-07-15 KR KR1020077003723A patent/KR101252866B1/ko not_active Expired - Fee Related
- 2005-07-15 KR KR1020127030429A patent/KR20130001323A/ko not_active Ceased
- 2005-07-15 CN CN2005800303713A patent/CN101076533B/zh not_active Expired - Fee Related
- 2005-07-15 EP EP05790733A patent/EP1771459A2/en not_active Withdrawn
- 2005-07-15 CN CN201610256017.2A patent/CN105777811A/zh active Pending
- 2005-07-15 WO PCT/US2005/025192 patent/WO2006020048A2/en not_active Ceased
- 2005-10-17 US US11/252,966 patent/US7405314B2/en not_active Expired - Lifetime
-
2007
- 2007-01-16 IL IL180729A patent/IL180729A/en not_active IP Right Cessation
- 2007-08-20 US US11/894,766 patent/US20080090793A1/en not_active Abandoned
-
2011
- 2011-10-17 JP JP2011227543A patent/JP2012051919A/ja not_active Withdrawn
- 2011-10-25 IL IL215896A patent/IL215896A0/en unknown
-
2014
- 2014-02-28 JP JP2014037807A patent/JP5745660B2/ja not_active Expired - Lifetime
-
2015
- 2015-05-26 HK HK15104992.3A patent/HK1204476A1/xx unknown
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