JP2008505927A - ポリマー部分を含む多価ｖｌａ−４拮抗薬 - Google Patents

ポリマー部分を含む多価ｖｌａ−４拮抗薬 Download PDF

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JP2008505927A
JP2008505927A JP2007520561A JP2007520561A JP2008505927A JP 2008505927 A JP2008505927 A JP 2008505927A JP 2007520561 A JP2007520561 A JP 2007520561A JP 2007520561 A JP2007520561 A JP 2007520561A JP 2008505927 A JP2008505927 A JP 2008505927A
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alkyl
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formula
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コンラディ、アンドレイ、ダブリュー．
プレイス、マイケル、エー．
セムコ、クリストファー、エム．
イェドノック、テオドール
スミス、ジェニファー、エル．
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イーラン ファーマスーティカルズ、インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K31/785—Polymers containing nitrogen
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
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JP2007520561A 2004-07-08 2005-07-08 ポリマー部分を含む多価ｖｌａ−４拮抗薬 Pending JP2008505927A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58697504P 2004-07-08 2004-07-08
PCT/US2005/024369 WO2006010054A2 (en) 2004-07-08 2005-07-08 Multivalent vla-4 antagonists comprising polyethylene glycol moieties

Publications (1)

Publication Number Publication Date
JP2008505927A true JP2008505927A (ja) 2008-02-28

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JP2007520561A Pending JP2008505927A (ja) 2004-07-08 2005-07-08 ポリマー部分を含む多価ｖｌａ−４拮抗薬

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US (4) US7794700B2 (US07794700-20100914-C00077.png)
EP (4) EP2258400A3 (US07794700-20100914-C00077.png)
JP (1) JP2008505927A (US07794700-20100914-C00077.png)
KR (1) KR101273614B1 (US07794700-20100914-C00077.png)
CN (1) CN101035563B (US07794700-20100914-C00077.png)
AR (1) AR050425A1 (US07794700-20100914-C00077.png)
AU (1) AU2005265316B2 (US07794700-20100914-C00077.png)
BR (1) BRPI0513143A (US07794700-20100914-C00077.png)
CA (1) CA2573245C (US07794700-20100914-C00077.png)
EA (1) EA012433B1 (US07794700-20100914-C00077.png)
EC (1) ECSP077231A (US07794700-20100914-C00077.png)
HK (1) HK1111674A1 (US07794700-20100914-C00077.png)
IL (1) IL180558A0 (US07794700-20100914-C00077.png)
MA (1) MA28786B1 (US07794700-20100914-C00077.png)
MX (1) MX2007000228A (US07794700-20100914-C00077.png)
NO (1) NO20070216L (US07794700-20100914-C00077.png)
NZ (1) NZ588839A (US07794700-20100914-C00077.png)
TW (1) TWI418346B (US07794700-20100914-C00077.png)
WO (1) WO2006010054A2 (US07794700-20100914-C00077.png)
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008540686A (ja) * 2005-05-20 2008-11-20 イーラン ファーマスーティカルズ、インコーポレイテッド Ｖｌａ−４アンタゴニストとしてのイミダゾロンフェニルアラニン誘導体
JP2009501246A (ja) * 2005-07-08 2009-01-15 イーラン ファーマスーティカルズ、インコーポレイテッド 治療用、農業用、及び食品用添加剤化合物のポリマー複合体の調製
JP2009510097A (ja) * 2005-09-29 2009-03-12 エラン ファーマシューティカルズ，インコーポレイテッド Ｖｌａ−４によって媒介される白血球接着を阻害するピリミジニルアミド化合物
JP2012197319A (ja) * 2005-09-29 2012-10-18 Elan Pharmaceuticals Inc Ｖｌａ−４によって媒介される白血球粘着を阻害するカルバメート化合物

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU773538B2 (en) * 1999-01-22 2004-05-27 Elan Pharmaceuticals, Inc. Acyl derivatives which treat VLA-4 related disorders
EP1706399A1 (en) * 2004-01-23 2006-10-04 Elan Pharmaceuticals, Inc. Polyethylene glycol conjugates of heterocycloalkyl carboxamido propanoic acids
CN101035563B (zh) * 2004-07-08 2012-03-28 艾伦药物公司 包括聚合物部分的多价vla-4拮抗剂
CN101360736A (zh) * 2005-11-23 2009-02-04 阿斯利康(瑞典)有限公司 L-丙氨酸衍生物
CN101389611B (zh) * 2006-02-27 2012-07-18 伊兰制药公司 抑制由vla-4所介导的白血球粘附的嘧啶磺酰胺化合物
CA3127202A1 (en) 2006-02-28 2007-09-07 Biogen Ma Inc. Methods of treating inflammatory and autoimmune diseases with natalizumab
JP2009531304A (ja) * 2006-02-28 2009-09-03 エラン ファーマシューティカルズ，インコーポレイテッド α−４阻害剤化合物を用いて炎症性疾患および自己免疫疾患を治療する方法
CN101437541A (zh) 2006-03-03 2009-05-20 伊兰药品公司 用那他珠单抗治疗炎性疾病和自身免疫病的方法
SG172604A1 (en) 2006-05-22 2011-07-28 Elan Pharm Inc Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
WO2007141473A1 (en) * 2006-06-09 2007-12-13 Astrazeneca Ab N-(benzoyl)-o- [2- (pyridin- 2 -ylamino) ethyl] -l-tyrosine derivatives and related compounds as a5b1 antagonists for the treatment of solid tumors
WO2008093065A1 (en) * 2007-01-29 2008-08-07 Astrazeneca Ab L-ALANINE DERIVATIVES AS α5βL ANTAGONISTS
CA2714335A1 (en) 2007-02-20 2008-08-28 Merrimack Pharmaceuticals, Inc. Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist
WO2008125811A1 (en) * 2007-04-11 2008-10-23 Astrazeneca Ab N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS
WO2008153967A1 (en) * 2007-06-08 2008-12-18 Contec Therapeutics, Inc. Bk1 antagonist conjugates
JP2011506322A (ja) * 2007-12-07 2011-03-03 エラン ファーマシューティカルズ，インコーポレイテッド 液性腫瘍を治療するための方法および組成物
EP2085407A1 (en) 2008-02-04 2009-08-05 Sahltech I Göteborg AB Treatment of idiopathic thrombocytopenic purpura
US8367836B2 (en) * 2009-04-27 2013-02-05 Elan Pharmaceuticals, Inc. Pyridinone antagonists of alpha-4 integrins
US20120258093A1 (en) * 2009-08-20 2012-10-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
DK3339865T5 (da) 2010-01-11 2023-03-20 Biogen Ma Inc Assay for jc-virus-antistoffer
US11287423B2 (en) 2010-01-11 2022-03-29 Biogen Ma Inc. Assay for JC virus antibodies
WO2011089214A1 (en) * 2010-01-22 2011-07-28 Ascendis Pharma As Carrier-linked carbamate prodrug linkers
JP2013525435A (ja) 2010-04-30 2013-06-20 エラン ファーマシューティカルズ，インコーポレイテッド 選択的インテグリン阻害剤
WO2013019326A2 (en) * 2011-08-03 2013-02-07 Henkel Corporation Electrically conductive structural adhesive
US9487485B2 (en) 2013-02-28 2016-11-08 Takeda Pharmaceutical Company Limited Method for producing sulfonyl chloride compound
EP3004334A4 (en) 2013-05-28 2016-12-21 Biogen Ma Inc METHODS OF EVALUATION RISK OF DEVELOPMENT OF PML
AU2014285086A1 (en) * 2013-07-05 2016-01-21 Biogen Ma Inc. Compositions and methods for treatment of stroke
EP3104867B1 (en) * 2014-02-12 2022-01-19 7 Hills Pharma LLC Compositions and methods to improve the homing and grafting of hematopoetic stem cells
WO2017015544A1 (en) * 2015-07-23 2017-01-26 Biogen Ma Inc. Compositions and methods for treatment of stroke and other cns disorders
WO2020092383A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Compounds for inhibition of alpha 4 beta 7 integrin
EP3873605A1 (en) 2018-10-30 2021-09-08 Gilead Sciences, Inc. Compounds for inhibition of alpha4beta7 integrin
US11174256B2 (en) 2018-10-30 2021-11-16 Gilead Sciences, Inc. Imidazopyridine derivatives
KR20240015737A (ko) 2018-10-30 2024-02-05 길리애드 사이언시즈, 인코포레이티드 알파4베타7 인테그린 억제제로서의 퀴놀린 유도체
US11578069B2 (en) 2019-08-14 2023-02-14 Gilead Sciences, Inc. Compounds for inhibition of α4 β7 integrin

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001054690A1 (en) * 2000-01-28 2001-08-02 Biogen, Inc. Pharmaceutical compositions containing anti-beta 1 integrin compounds and uses
JP2001512114A (ja) * 1997-07-31 2001-08-21 エラン・ファーマシューティカルズ・インコーポレーテッド Ｖｌａ−４に媒介される白血球接着を阻害するカルバミルオキシ化合物
JP2002512625A (ja) * 1997-05-29 2002-04-23 メルク エンド カンパニー インコーポレーテッド 細胞接着阻害薬としての複素環アミド化合物
JP2002535317A (ja) * 1999-01-22 2002-10-22 エラン ファーマシューティカルズ，インコーポレイテッド Ｖｌａ−４関連障害を処置するアシル誘導体
US6489300B1 (en) * 1997-07-31 2002-12-03 Eugene D. Thorsett Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4
JP2003506491A (ja) * 1999-08-13 2003-02-18 バイオジェン インコーポレイテッド 細胞接着インヒビター
WO2003099231A2 (en) * 2002-05-24 2003-12-04 Elan Pharmaceuticals, Inc. Heteroaryl compounds which inhibit leukocyte adhesion mediated by alpha-4 integrins
WO2003099809A1 (en) * 2002-05-24 2003-12-04 Elan Pharmaceuticals, Inc. HETEROCYCLIC COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY α4 INTEGRINS

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
US5177059A (en) 1989-11-15 1993-01-05 Sandoz Ltd. Polymyxin B conjugates
DE4107857A1 (de) 1991-03-12 1992-09-17 Thomae Gmbh Dr K Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
WO1992016555A1 (en) 1991-03-18 1992-10-01 Enzon, Inc. Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers
US5824701A (en) 1993-10-20 1998-10-20 Enzon, Inc. Taxane-based prodrugs
US5880131A (en) 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
DE69833654T2 (de) 1997-05-29 2006-12-14 Merck & Co., Inc. (A New Jersey Corp.) Biarylalkansäuren in der verwendung als zelladhäsionsinhibitoren
US6939855B2 (en) * 1997-07-31 2005-09-06 Elan Pharmaceuticals, Inc. Anti-inflammatory compositions and method
ATE268609T1 (de) 1998-03-12 2004-06-15 Nektar Therapeutics Al Corp Polyethylenglycolderivate mit benachbarten reaktiven gruppen
GB9821061D0 (en) * 1998-09-28 1998-11-18 Celltech Therapeutics Ltd Chemical compounds
AU2623900A (en) 1999-01-22 2000-08-07 American Home Products Corporation Compounds which inhibit leukocyte adhesion mediated by vla-4
US6436904B1 (en) 1999-01-25 2002-08-20 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
AU2001282938A1 (en) 2000-07-21 2002-02-05 Elan Pharmaceuticals, Inc. Alpha amino acid derivatives--inhibitors of leukocyte adhesion mediated by vla-4
US20040043030A1 (en) 2001-07-31 2004-03-04 Immunomedics, Inc. Polymeric delivery systems
US6716821B2 (en) 2001-12-21 2004-04-06 Immunogen Inc. Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
ES2197003B1 (es) 2002-04-08 2005-03-16 J. URIACH & CIA S.A. Nuevos compuestos antagonistas de integrinas alfa.
KR101260497B1 (ko) 2003-01-24 2013-09-12 엘란 파마슈티칼스, 인크. 수초재생제의 투여에 의한 탈수초성 질환 및 마비의 치료 및 조성물
AU2004251754A1 (en) 2003-06-25 2005-01-06 Elan Pharmaceuticals, Inc. Methods and compositions for treating rheumatoid arthritis
EP1706399A1 (en) * 2004-01-23 2006-10-04 Elan Pharmaceuticals, Inc. Polyethylene glycol conjugates of heterocycloalkyl carboxamido propanoic acids
AU2005231467A1 (en) 2004-04-01 2005-10-20 Elan Pharmaceuticals, Inc. Steroid sparing agents and methods of using same
US7205310B2 (en) * 2004-04-30 2007-04-17 Elan Pharmaceuticals, Inc. Pyrimidine hydantoin analogues which inhibit leukocyte adhesion mediated by VLA-4
CN101035563B (zh) 2004-07-08 2012-03-28 艾伦药物公司 包括聚合物部分的多价vla-4拮抗剂
CN101300255A (zh) 2005-05-20 2008-11-05 艾伦药物公司 咪唑啉酮苯丙氨酸衍生物vla-4拮抗剂
MX2008000291A (es) * 2005-07-08 2008-04-04 Elan Pharm Inc Preparacion de conjugados polimericos de compuestos de aditivos terapeuticos, agricolas y alimentarios.
JP2011506322A (ja) 2007-12-07 2011-03-03 エラン ファーマシューティカルズ，インコーポレイテッド 液性腫瘍を治療するための方法および組成物

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002512625A (ja) * 1997-05-29 2002-04-23 メルク エンド カンパニー インコーポレーテッド 細胞接着阻害薬としての複素環アミド化合物
JP2001512114A (ja) * 1997-07-31 2001-08-21 エラン・ファーマシューティカルズ・インコーポレーテッド Ｖｌａ−４に媒介される白血球接着を阻害するカルバミルオキシ化合物
US6489300B1 (en) * 1997-07-31 2002-12-03 Eugene D. Thorsett Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4
JP2002535317A (ja) * 1999-01-22 2002-10-22 エラン ファーマシューティカルズ，インコーポレイテッド Ｖｌａ−４関連障害を処置するアシル誘導体
JP2003506491A (ja) * 1999-08-13 2003-02-18 バイオジェン インコーポレイテッド 細胞接着インヒビター
WO2001054690A1 (en) * 2000-01-28 2001-08-02 Biogen, Inc. Pharmaceutical compositions containing anti-beta 1 integrin compounds and uses
WO2003099231A2 (en) * 2002-05-24 2003-12-04 Elan Pharmaceuticals, Inc. Heteroaryl compounds which inhibit leukocyte adhesion mediated by alpha-4 integrins
WO2003099809A1 (en) * 2002-05-24 2003-12-04 Elan Pharmaceuticals, Inc. HETEROCYCLIC COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY α4 INTEGRINS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6011051878; ＪＯＮＥＳ，Ｄ．Ｓ．　ｅｔ　ａｌ: Ｂｉｏｃｏｎｊｕｇａｔｅ　ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１４，　Ｎｏ．６, 2003, ｐ．１０６７-７６ *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008540686A (ja) * 2005-05-20 2008-11-20 イーラン ファーマスーティカルズ、インコーポレイテッド Ｖｌａ−４アンタゴニストとしてのイミダゾロンフェニルアラニン誘導体
JP2009501246A (ja) * 2005-07-08 2009-01-15 イーラン ファーマスーティカルズ、インコーポレイテッド 治療用、農業用、及び食品用添加剤化合物のポリマー複合体の調製
JP2009510097A (ja) * 2005-09-29 2009-03-12 エラン ファーマシューティカルズ，インコーポレイテッド Ｖｌａ−４によって媒介される白血球接着を阻害するピリミジニルアミド化合物
JP2012197319A (ja) * 2005-09-29 2012-10-18 Elan Pharmaceuticals Inc Ｖｌａ−４によって媒介される白血球粘着を阻害するカルバメート化合物

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