JP2008504531A - 切断可能なリンカーを有するアレイ - Google Patents
切断可能なリンカーを有するアレイ Download PDFInfo
- Publication number
- JP2008504531A JP2008504531A JP2007518318A JP2007518318A JP2008504531A JP 2008504531 A JP2008504531 A JP 2008504531A JP 2007518318 A JP2007518318 A JP 2007518318A JP 2007518318 A JP2007518318 A JP 2007518318A JP 2008504531 A JP2008504531 A JP 2008504531A
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- JP
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- Prior art keywords
- glycan
- array
- glycans
- linker
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Landscapes
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PCT/US2005/022517 WO2006002382A2 (fr) | 2004-06-24 | 2005-06-24 | Reseaux de liants clivables |
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JP2007146691A Pending JP2007312776A (ja) | 2004-06-24 | 2007-06-01 | 切断可能なリンカーを有するアレイ |
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US (2) | US20070213278A1 (fr) |
EP (1) | EP1771733A2 (fr) |
JP (2) | JP2008504531A (fr) |
AU (1) | AU2005258281A1 (fr) |
CA (1) | CA2571431A1 (fr) |
WO (1) | WO2006002382A2 (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2012531458A (ja) * | 2009-07-03 | 2012-12-10 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | カチオン非依存性マンノース6−リン酸受容体を標的とする化合物 |
JP2017021039A (ja) * | 2008-07-15 | 2017-01-26 | アカデミア シニカAcademia Sinica | Ptfe様のアルミニウム・コート・ガラススライド上のグリカンアレイおよび関連する方法 |
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US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
SG10201605686XA (en) * | 2008-02-01 | 2016-08-30 | Fujimi Inc | Polishing Composition And Polishing Method Using The Same |
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US20120190581A1 (en) * | 2009-08-25 | 2012-07-26 | The Johns Hopkins University | Detection of Auto-Antibodies to Specific Glycans as Diagnostic Tests for Autoimmune Diseases |
EP2501711B1 (fr) * | 2009-11-16 | 2014-01-08 | Centre National De La Recherche Scientifique CNRS | Composés et procédés de purification de peptides produits par synthèse de peptides en phase solide |
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WO2011127179A1 (fr) * | 2010-04-07 | 2011-10-13 | Glycomimetics, Inc. | Composés glycomimétiques et méthodes d'inhibition d'une infection par le vih |
WO2011130332A1 (fr) * | 2010-04-12 | 2011-10-20 | Academia Sinica | Puces au glycane pour la recherche par criblage haut débit de virus |
US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
CA2807942C (fr) | 2010-08-10 | 2021-07-27 | Ecole Polytechnique Federale De Lausanne | Agents therapeutiques se liant aux erythrocytes |
WO2012037034A1 (fr) | 2010-09-14 | 2012-03-22 | Glycomimetics, Inc. | Antagonistes de l'e-sélectine |
AU2012358150B2 (en) | 2011-12-22 | 2017-07-20 | Glycomimetics, Inc. | E-selectin antagonist compounds, compositions, and methods of use |
US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
WO2014031498A1 (fr) | 2012-08-18 | 2014-02-27 | Academia Sinica | Sondes perméables aux cellules pour l'identification et l'imagerie de sialidases |
CA2891514C (fr) | 2012-12-07 | 2020-08-25 | Glycomimetics, Inc. | Composes, compositions et procedes utilisant des antagonistes d'e-selectine pour la mobilisation de cellules hematopoietiques |
EP3013365B1 (fr) | 2013-06-26 | 2019-06-05 | Academia Sinica | Antigènes rm2 et leur utilisation |
EP3013347B1 (fr) | 2013-06-27 | 2019-12-11 | Academia Sinica | Conjugués de glycane et leur utilisation |
CN105682666B (zh) | 2013-09-06 | 2021-06-01 | 中央研究院 | 使用醣脂激活人类iNKT细胞 |
US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
WO2015109180A2 (fr) | 2014-01-16 | 2015-07-23 | Academia Sinica | Compositions et méthodes pour traiter et détecter des cancers |
US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
MX2016010835A (es) | 2014-02-21 | 2017-07-11 | Anokion Sa | Terapeuticos dirigidos a la glucosa. |
US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
TWI797430B (zh) | 2014-03-27 | 2023-04-01 | 中央研究院 | 反應性標記化合物及其用途 |
US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
CA2950415A1 (fr) | 2014-05-27 | 2015-12-03 | Academia Sinica | Glycoanticorps anti-cd20 et leurs utilisations |
KR102576850B1 (ko) | 2014-05-27 | 2023-09-11 | 아카데미아 시니카 | 박테로이드 기원의 푸코시다제 및 이의 사용 방법 |
JP7062361B2 (ja) | 2014-05-27 | 2022-05-06 | アカデミア シニカ | 抗her2糖操作抗体群およびその使用 |
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GB201414021D0 (en) * | 2014-08-07 | 2014-09-24 | Nascient Ltd | Biological materials and uses thereof |
JP6899321B2 (ja) | 2014-09-08 | 2021-07-07 | アカデミア シニカAcademia Sinica | 糖脂質を使用するヒトiNKT細胞活性化 |
EP3204537A4 (fr) * | 2014-10-10 | 2018-08-08 | Siamab Therapeutics, Inc. | Analyse et profilage de glycanes |
HUE061672T2 (hu) | 2014-11-12 | 2023-08-28 | Seagen Inc | Glikán-interakcióban lévõ vegyületek és felhasználási módszerek |
US9879087B2 (en) | 2014-11-12 | 2018-01-30 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
CA2968391C (fr) | 2014-12-03 | 2022-04-26 | Glycomimetics, Inc. | Inhibiteurs heterobifonctionnels des e-selectines et des recepteurs aux chimiokines cxcr4 |
US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
TWI736523B (zh) * | 2015-01-24 | 2021-08-21 | 中央研究院 | 新穎聚醣結合物及其使用方法 |
EA036102B9 (ru) * | 2015-09-19 | 2020-12-30 | Эколь Политекник Федераль Де Лозан | Терапевтические средства с углевод-опосредованной адресной доставкой |
JP7066613B2 (ja) | 2015-11-12 | 2022-05-13 | シージェン インコーポレイテッド | グリカン相互作用化合物および使用方法 |
US11291678B2 (en) | 2016-03-02 | 2022-04-05 | Glycomimetics, Inc | Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin |
JP2019515876A (ja) | 2016-03-08 | 2019-06-13 | アカデミア シニカAcademia Sinica | N−グリカンおよびそのアレイのモジュール合成のための方法 |
EP3497131B1 (fr) | 2016-08-08 | 2022-03-09 | GlycoMimetics, Inc. | Combinaison d'inhibiteurs des points de contrôle des lymphocytes t avec des inhibiteurs de e-sélectine ou de cxcr4, ou avec des inhibiteurs hétérobifonctionnels de e-sélectine et de cxcr4 |
EP3500594A4 (fr) | 2016-08-22 | 2020-03-11 | Cho Pharma Inc. | Anticorps, fragments de liaison, et procédés d'utilisation |
JP7069136B2 (ja) | 2016-10-07 | 2022-05-17 | グリコミメティクス, インコーポレイテッド | 極めて強力な多量体e-セレクチンアンタゴニスト |
WO2018094143A1 (fr) | 2016-11-17 | 2018-05-24 | Siamab Therapeutics, Inc. | Composés interagissant avec le glycane et méthodes d'utilisation |
KR102653141B1 (ko) | 2017-03-03 | 2024-04-01 | 씨젠 인크. | 글리칸-상호작용 화합물 및 사용 방법 |
US11197877B2 (en) | 2017-03-15 | 2021-12-14 | Glycomimetics. Inc. | Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists |
EP3638296A1 (fr) | 2017-06-16 | 2020-04-22 | The University Of Chicago | Compositions et procédés d'induction d'une tolérance immunitaire |
US11712446B2 (en) | 2017-11-30 | 2023-08-01 | Glycomimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
EP3732186A1 (fr) | 2017-12-29 | 2020-11-04 | GlycoMimetics, Inc. | Inhibiteurs hétérobifonctionnels de e-sélectine et de galectine -3 |
CN111867601A (zh) | 2018-03-05 | 2020-10-30 | 糖模拟物有限公司 | 用于治疗急性髓系白血病及相关病症的方法 |
EP3794597A4 (fr) | 2018-06-11 | 2022-02-23 | Merck Sharp & Dohme Corp. | Systèmes, appareils et procédés d'identification de sous-structure de molécule complexe |
US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
EP4239335A4 (fr) * | 2020-12-01 | 2024-09-25 | Univ Kyushu Nat Univ Corp | Sonde, trousse et procédé de détection de structure de biomolécules |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001192399A (ja) * | 2000-01-11 | 2001-07-17 | Takashi Fujii | gp120に親和性を有するペプチド |
WO2002059154A2 (fr) * | 2001-01-26 | 2002-08-01 | Abgenix, Inc. | Utilisation de souris transgenique pour isoler efficacement de nouveaux anticorps monoclonaux humains a activite de neutralisation de souches primaires du vih-1 et nouveaux anticorps de neutralisation du vih-1 |
WO2003093511A1 (fr) * | 2002-04-30 | 2003-11-13 | Merck & Co., Inc. | Test multiplexe de papillomavirus humain (hpv) |
WO2004015420A1 (fr) * | 2002-08-02 | 2004-02-19 | Glycominds Ltd. | Procede de diagnostic de sclerose en plaques |
WO2004040308A1 (fr) * | 2002-10-30 | 2004-05-13 | Plasso Technology Ltd | Surface de liaison de sucres |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4925796A (en) * | 1986-03-07 | 1990-05-15 | Massachusetts Institute Of Technology | Method for enhancing glycoprotein stability |
GB9610811D0 (en) * | 1996-05-23 | 1996-07-31 | Pharmacia Spa | Combinatorial solid phase synthesis of a library of indole derivatives |
US5958703A (en) * | 1996-12-03 | 1999-09-28 | Glaxo Group Limited | Use of modified tethers in screening compound libraries |
ATE478083T1 (de) * | 1999-03-05 | 2010-09-15 | Massachusetts Inst Technology | Linker zur synthese von oligosacchariden auf festträgern |
JP2002538790A (ja) * | 1999-03-08 | 2002-11-19 | プロトジーン・ラボラトリーズ・インコーポレーテッド | 長いdna配列を経済的に合成し、そして組み立てるための方法および組成物 |
US20020098513A1 (en) * | 2000-02-17 | 2002-07-25 | Glycominds Ltd. | Combinatorial complex carbohydrate libraries and methods for the manufacture and uses thereof |
DE10041766A1 (de) * | 2000-08-25 | 2002-03-14 | Friz Biochem Gmbh | Verfahren zur Markierung chemischer Substanzen |
DE10249608A1 (de) * | 2002-10-18 | 2004-05-06 | Gkss-Forschungszentrum Geesthacht Gmbh | Vorrichtung und Verfahren zur Strukturanalyse und Detektion von komplexen Glykostrukturen |
US7592150B2 (en) * | 2003-12-03 | 2009-09-22 | Glycominds, Ltd | Method for diagnosing diseases based on levels of anti-glycan antibodies |
-
2005
- 2005-06-24 AU AU2005258281A patent/AU2005258281A1/en not_active Abandoned
- 2005-06-24 JP JP2007518318A patent/JP2008504531A/ja active Pending
- 2005-06-24 CA CA002571431A patent/CA2571431A1/fr not_active Abandoned
- 2005-06-24 WO PCT/US2005/022517 patent/WO2006002382A2/fr active Application Filing
- 2005-06-24 EP EP05789058A patent/EP1771733A2/fr not_active Withdrawn
-
2006
- 2006-12-22 US US11/645,273 patent/US20070213278A1/en not_active Abandoned
- 2006-12-22 US US11/645,188 patent/US20070213297A1/en not_active Abandoned
-
2007
- 2007-06-01 JP JP2007146691A patent/JP2007312776A/ja active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001192399A (ja) * | 2000-01-11 | 2001-07-17 | Takashi Fujii | gp120に親和性を有するペプチド |
WO2002059154A2 (fr) * | 2001-01-26 | 2002-08-01 | Abgenix, Inc. | Utilisation de souris transgenique pour isoler efficacement de nouveaux anticorps monoclonaux humains a activite de neutralisation de souches primaires du vih-1 et nouveaux anticorps de neutralisation du vih-1 |
WO2003093511A1 (fr) * | 2002-04-30 | 2003-11-13 | Merck & Co., Inc. | Test multiplexe de papillomavirus humain (hpv) |
WO2004015420A1 (fr) * | 2002-08-02 | 2004-02-19 | Glycominds Ltd. | Procede de diagnostic de sclerose en plaques |
WO2004040308A1 (fr) * | 2002-10-30 | 2004-05-13 | Plasso Technology Ltd | Surface de liaison de sucres |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017021039A (ja) * | 2008-07-15 | 2017-01-26 | アカデミア シニカAcademia Sinica | Ptfe様のアルミニウム・コート・ガラススライド上のグリカンアレイおよび関連する方法 |
JP2012531458A (ja) * | 2009-07-03 | 2012-12-10 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | カチオン非依存性マンノース6−リン酸受容体を標的とする化合物 |
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WO2006002382A2 (fr) | 2006-01-05 |
JP2007312776A (ja) | 2007-12-06 |
CA2571431A1 (fr) | 2006-01-05 |
WO2006002382A3 (fr) | 2006-10-12 |
US20070213297A1 (en) | 2007-09-13 |
US20070213278A1 (en) | 2007-09-13 |
AU2005258281A1 (en) | 2006-01-05 |
EP1771733A2 (fr) | 2007-04-11 |
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