JP2008502683A5 - - Google Patents
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- Publication number
- JP2008502683A5 JP2008502683A5 JP2007516542A JP2007516542A JP2008502683A5 JP 2008502683 A5 JP2008502683 A5 JP 2008502683A5 JP 2007516542 A JP2007516542 A JP 2007516542A JP 2007516542 A JP2007516542 A JP 2007516542A JP 2008502683 A5 JP2008502683 A5 JP 2008502683A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- optionally substituted
- nitrogen
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57936204P | 2004-06-14 | 2004-06-14 | |
| US60/579,362 | 2004-06-14 | ||
| PCT/US2005/019901 WO2005123668A1 (en) | 2004-06-14 | 2005-06-08 | Glucagon receptor antagonists, preparation and therapeutic uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008502683A JP2008502683A (ja) | 2008-01-31 |
| JP2008502683A5 true JP2008502683A5 (cg-RX-API-DMAC7.html) | 2012-05-10 |
| JP5000492B2 JP5000492B2 (ja) | 2012-08-15 |
Family
ID=35219490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007516542A Expired - Lifetime JP5000492B2 (ja) | 2004-06-14 | 2005-06-08 | グルカゴン受容体拮抗物質及びその調製並びに治療的使用 |
Country Status (28)
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2337596T3 (es) * | 2004-06-14 | 2010-04-27 | Eli Lilly And Company | Antagonistas del receptor de glucacion, preparacion y usos terapeuticaos. |
| US7524870B2 (en) * | 2004-12-03 | 2009-04-28 | Hoffmann-La Roche Inc. | Biaryloxymethylarenecarboxylic acids as glycogen synthase activators |
| ES2332470T3 (es) * | 2005-02-11 | 2010-02-05 | Eli Lilly And Company | Derivados de tiofeno sustituidos como antagonistas del receptor de glucagon, preparacion y usos terapeuticos. |
| JP2008533200A (ja) | 2005-03-21 | 2008-08-21 | メルク エンド カムパニー インコーポレーテッド | 置換アリールおよびヘテロアリール誘導体、かかる化合物を含有する組成物および使用法 |
| ES2516691T3 (es) * | 2005-11-22 | 2014-10-31 | Eli Lilly & Company | Antagonistas del receptor de glucagón, preparación y usos terapéuticos |
| WO2007136577A2 (en) | 2006-05-16 | 2007-11-29 | Merck & Co., Inc. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
| CA2894112C (en) | 2007-02-09 | 2020-09-15 | Metabasis Therapeutics, Inc. | Novel antagonists of the glucagon receptor |
| EP2326618B1 (en) | 2008-08-13 | 2014-10-15 | Metabasis Therapeutics, Inc. | Glucagon antagonists |
| WO2010098948A1 (en) * | 2009-02-13 | 2010-09-02 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions containin such compounds and methods of use |
| US8039495B2 (en) * | 2009-11-16 | 2011-10-18 | Hoffman-La Roche Inc. | Biphenyl carboxylic acids and bioisosteres as glycogen synthase activators |
| BR112013016033A2 (pt) * | 2010-12-23 | 2018-06-05 | Pfizer | moduladores do receptor de glucagon |
| EP2673260B1 (en) * | 2011-02-08 | 2016-08-17 | Pfizer Inc | Glucagon receptor modulator |
| WO2013014569A1 (en) | 2011-07-22 | 2013-01-31 | Pfizer Inc. | Quinolinyl glucagon receptor modulators |
| US9453073B2 (en) | 2011-12-02 | 2016-09-27 | Eli Lilly And Company | Anti-glucagon antibodies and uses thereof |
| US20140210770A1 (en) * | 2012-10-04 | 2014-07-31 | Corning Incorporated | Pressure sensing touch systems and methods |
| TW201427658A (zh) | 2012-12-10 | 2014-07-16 | Merck Sharp & Dohme | 藉由投予升糖素受體拮抗劑及膽固醇吸收抑制劑治療糖尿病之方法 |
| US9649294B2 (en) | 2013-11-04 | 2017-05-16 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
| US10076504B2 (en) | 2014-06-12 | 2018-09-18 | Ligand Pharmaceuticals, Inc. | Glucagon antagonists |
| EP3383848B1 (en) | 2015-12-01 | 2020-01-08 | Basf Se | Pyridine compounds as fungicides |
| CN108290840A (zh) | 2015-12-01 | 2018-07-17 | 巴斯夫欧洲公司 | 作为杀真菌剂的吡啶化合物 |
| US11737463B2 (en) | 2017-05-30 | 2023-08-29 | Basf Se | Pyridine and pyrazine compounds |
| JP2021513564A (ja) | 2018-02-13 | 2021-05-27 | リガンド・ファーマシューティカルズ・インコーポレイテッド | グルカゴン受容体拮抗薬 |
| CN111184706B (zh) * | 2020-03-05 | 2020-11-17 | 牡丹江医学院 | 一种防治胆囊炎的活性药物及其用途 |
| KR102606541B1 (ko) * | 2021-04-23 | 2023-11-29 | 가천대학교 산학협력단 | 바이페닐설폰아마이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 글루카곤 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4973731A (en) | 1987-04-23 | 1990-11-27 | Riker Laboratories, Inc. | Di-t-butylphenyl alkyl and benzyl ether nitriles |
| GB9420557D0 (en) | 1994-10-12 | 1994-11-30 | Zeneca Ltd | Aromatic compounds |
| EP1054871A2 (en) * | 1998-04-01 | 2000-11-29 | Du Pont Pharmaceuticals Company | Pyrimidines and triazines as integrin antagonists |
| BR0010651A (pt) * | 1999-05-17 | 2002-03-19 | Novo Nordisk As | Composto, uso de um composto, composição farmacêutica, e, método para o tratamento e/ou prevenção de distúrbios ou de doenças mediadas por uma ação antagonìstica de glucagon |
| JP2004501897A (ja) * | 2000-06-23 | 2004-01-22 | ノボ ノルディスク アクティーゼルスカブ | グルカゴン拮抗薬／逆作用薬 |
| US6706744B2 (en) | 2000-11-17 | 2004-03-16 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| AU2002365622A1 (en) * | 2001-12-03 | 2003-06-17 | Novo Nordisk A/S | Novel glucagon antagonists |
| JP2006500325A (ja) * | 2002-06-27 | 2006-01-05 | ノボ ノルディスク アクティーゼルスカブ | 新規なグルカゴンアンタゴニスト |
| AU2003291959A1 (en) | 2002-12-20 | 2004-07-14 | Novo Nordisk A/S | Novel glucagon antagonists |
| WO2005102067A1 (en) | 2004-04-26 | 2005-11-03 | Ipn Ip B.V. | Packaged flowable ice product, such as a milk shake |
| WO2005118542A1 (en) | 2004-05-28 | 2005-12-15 | Eli Lilly And Company | Glucagon receptor antagonists, preparation and therapeutic uses |
| ES2337596T3 (es) | 2004-06-14 | 2010-04-27 | Eli Lilly And Company | Antagonistas del receptor de glucacion, preparacion y usos terapeuticaos. |
| ES2332470T3 (es) * | 2005-02-11 | 2010-02-05 | Eli Lilly And Company | Derivados de tiofeno sustituidos como antagonistas del receptor de glucagon, preparacion y usos terapeuticos. |
| JP2008533200A (ja) | 2005-03-21 | 2008-08-21 | メルク エンド カムパニー インコーポレーテッド | 置換アリールおよびヘテロアリール誘導体、かかる化合物を含有する組成物および使用法 |
| SI1951658T1 (sl) | 2005-11-17 | 2012-11-30 | Lilly Co Eli | Antagonisti glukagonskega receptorja priprava interapevtska uporaba |
| EP1951661B1 (en) | 2005-11-17 | 2012-08-08 | Eli Lilly And Company | Glucagon receptor antagonists, preparation and therapeutic uses |
| ATE473961T1 (de) | 2005-11-18 | 2010-07-15 | Lilly Co Eli | Glucagonrezeptorantagonisten, deren herstellung und therapeutische verwendung |
| ES2516691T3 (es) | 2005-11-22 | 2014-10-31 | Eli Lilly & Company | Antagonistas del receptor de glucagón, preparación y usos terapéuticos |
| SI1957484T1 (sl) | 2005-11-23 | 2010-07-30 | Lilly Co Eli | Antagonisti glukagonskega receptorja, priprava in terapevtske uporabe |
-
2005
- 2005-06-08 ES ES05757998T patent/ES2337596T3/es not_active Expired - Lifetime
- 2005-06-08 MX MXPA06014426A patent/MXPA06014426A/es active IP Right Grant
- 2005-06-08 SI SI200530975T patent/SI1758853T1/sl unknown
- 2005-06-08 WO PCT/US2005/019901 patent/WO2005123668A1/en not_active Ceased
- 2005-06-08 CN CN2005800194966A patent/CN1968921B/zh not_active Expired - Lifetime
- 2005-06-08 HR HR20100148T patent/HRP20100148T1/hr unknown
- 2005-06-08 DE DE602005019043T patent/DE602005019043D1/de not_active Expired - Lifetime
- 2005-06-08 AT AT05757998T patent/ATE455756T1/de active
- 2005-06-08 EP EP05757998A patent/EP1758853B1/en not_active Expired - Lifetime
- 2005-06-08 JP JP2007516542A patent/JP5000492B2/ja not_active Expired - Lifetime
- 2005-06-08 EA EA200700027A patent/EA013003B1/ru not_active IP Right Cessation
- 2005-06-08 AU AU2005254950A patent/AU2005254950B2/en not_active Ceased
- 2005-06-08 NZ NZ551015A patent/NZ551015A/en not_active IP Right Cessation
- 2005-06-08 US US11/570,449 patent/US7816557B2/en active Active
- 2005-06-08 PT PT05757998T patent/PT1758853E/pt unknown
- 2005-06-08 BR BRPI0512058-6A patent/BRPI0512058A/pt not_active IP Right Cessation
- 2005-06-08 DK DK05757998.9T patent/DK1758853T3/da active
- 2005-06-08 EP EP08170258A patent/EP2159221A1/en not_active Withdrawn
- 2005-06-08 KR KR1020067026229A patent/KR100835496B1/ko not_active Expired - Fee Related
- 2005-06-08 UA UAA200612965A patent/UA86621C2/ru unknown
- 2005-06-08 CA CA2569459A patent/CA2569459C/en not_active Expired - Fee Related
- 2005-06-08 RS RSP-2010/0134A patent/RS51202B/sr unknown
- 2005-06-08 PL PL05757998T patent/PL1758853T3/pl unknown
-
2006
- 2006-11-27 IL IL179599A patent/IL179599A/en not_active IP Right Cessation
- 2006-12-08 ZA ZA200610298A patent/ZA200610298B/en unknown
- 2006-12-13 EC EC2006007082A patent/ECSP067082A/es unknown
- 2006-12-29 MA MA29594A patent/MA28706B1/fr unknown
-
2007
- 2007-01-12 NO NO20070213A patent/NO341028B1/no not_active IP Right Cessation
-
2010
- 2010-02-11 CY CY20101100144T patent/CY1109787T1/el unknown
- 2010-08-26 US US12/868,773 patent/US20100324140A1/en not_active Abandoned
- 2010-11-19 AU AU2010246329A patent/AU2010246329A1/en not_active Abandoned
-
2011
- 2011-01-25 US US13/013,280 patent/US8609892B2/en active Active