JP2008501357A5 - - Google Patents
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- Publication number
- JP2008501357A5 JP2008501357A5 JP2007526577A JP2007526577A JP2008501357A5 JP 2008501357 A5 JP2008501357 A5 JP 2008501357A5 JP 2007526577 A JP2007526577 A JP 2007526577A JP 2007526577 A JP2007526577 A JP 2007526577A JP 2008501357 A5 JP2008501357 A5 JP 2008501357A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- genetically modified
- human mammal
- gene
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000005260 human cell Anatomy 0.000 claims 25
- 238000000034 method Methods 0.000 claims 22
- 108090000623 proteins and genes Proteins 0.000 claims 22
- 101710117460 Mannan-binding lectin serine protease 2 Proteins 0.000 claims 12
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 241000124008 Mammalia Species 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 210000001671 embryonic stem cell Anatomy 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 5
- 102100026046 Mannan-binding lectin serine protease 2 Human genes 0.000 claims 4
- 241000699666 Mus <mouse, genus> Species 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical group 0.000 claims 4
- 210000004962 mammalian cell Anatomy 0.000 claims 3
- 241000699670 Mus sp. Species 0.000 claims 2
- 239000003550 marker Substances 0.000 claims 2
- 238000011144 upstream manufacturing Methods 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 102000004856 Lectins Human genes 0.000 claims 1
- 108090001090 Lectins Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 210000002459 blastocyst Anatomy 0.000 claims 1
- 230000024203 complement activation Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000016784 immunoglobulin production Effects 0.000 claims 1
- 238000009399 inbreeding Methods 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 239000002523 lectin Substances 0.000 claims 1
- 238000000520 microinjection Methods 0.000 claims 1
- 210000000287 oocyte Anatomy 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000005215 recombination Methods 0.000 claims 1
- 230000006798 recombination Effects 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 238000001890 transfection Methods 0.000 claims 1
- 108700026220 vif Genes Proteins 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0412966.4A GB0412966D0 (en) | 2004-06-10 | 2004-06-10 | Genetically modified non-human mammals and cells |
| PCT/GB2005/050086 WO2005120222A2 (en) | 2004-06-10 | 2005-06-08 | Genetically modified non-human mammals and cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008501357A JP2008501357A (ja) | 2008-01-24 |
| JP2008501357A5 true JP2008501357A5 (enExample) | 2008-07-24 |
Family
ID=32732258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007526577A Pending JP2008501357A (ja) | 2004-06-10 | 2005-06-08 | 遺伝子改変された非ヒト哺乳動物および非ヒト細胞 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US8785717B2 (enExample) |
| EP (1) | EP1766033B1 (enExample) |
| JP (1) | JP2008501357A (enExample) |
| ES (1) | ES2535639T3 (enExample) |
| GB (1) | GB0412966D0 (enExample) |
| WO (1) | WO2005120222A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6969601B2 (en) | 1997-04-03 | 2005-11-29 | Jensenius Jens Chr | MASP-2, a complement-fixing enzyme, and uses for it |
| PT2374819T (pt) | 2003-05-12 | 2017-07-04 | Helion Biotech Aps | Anticorpos para masp-2 |
| PL2465534T3 (pl) * | 2004-06-10 | 2017-08-31 | Omeros Corporation | Sposoby leczenia stanów związanych z aktywacją dopełniacza zależną od masp-2 |
| US8840893B2 (en) | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| US7919094B2 (en) * | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| CN106390117A (zh) | 2009-10-16 | 2017-02-15 | 奥默罗斯公司 | 通过抑制masp‑2依赖性补体活化治疗弥散性血管内凝血的方法 |
| US9644035B2 (en) | 2011-04-08 | 2017-05-09 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| KR20220044616A (ko) | 2011-04-08 | 2022-04-08 | 유니버시티 오브 레스터 | Ｍａｓｐ-2 의존적 보체 활성화와 관련된 질병을 치료하는 방법 |
| EP2704743B1 (en) | 2011-05-04 | 2020-03-11 | Omeros Corporation | Compositions for inhibiting masp-2 dependent complement acitivation |
| CN112481302B (zh) * | 2021-02-05 | 2021-05-14 | 百奥赛图(北京)医药科技股份有限公司 | Masp2基因人源化的非人动物的构建方法及应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5464764A (en) * | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| EP0438803B1 (en) | 1990-01-26 | 1997-03-12 | Immunomedics, Inc. | Vaccines against cancer and infectious diseases |
| US6969601B2 (en) | 1997-04-03 | 2005-11-29 | Jensenius Jens Chr | MASP-2, a complement-fixing enzyme, and uses for it |
| EP1140171A4 (en) | 1998-12-15 | 2002-03-13 | Brigham & Womens Hospital | METHODS AND PRODUCTS FOR REGULATING THE COMPLEMENT ACTIVATION ASSOCIATED WITH THE LECTIN COMPLEMENT SYSTEM |
| US7273925B1 (en) | 1998-12-15 | 2007-09-25 | Brigham And Women's Hospital, Inc. | Methods and products for regulating lectin complement pathway associated complement activation |
| WO2001012212A1 (en) | 1999-08-13 | 2001-02-22 | The Brigham And Women's Hospital, Inc. | Inhibitors of the lectin complement pathway (lcp) and their use |
| EP2026073B1 (en) | 2000-04-29 | 2016-03-30 | University Of Iowa Research Foundation | Diagnostics and therapeutics for macular degeneration-related disorders |
| WO2002006460A2 (en) | 2000-07-13 | 2002-01-24 | Jens Christian Jensenius | Masp-2, a complement-fixing enzyme, and uses for it |
| US20020094332A1 (en) | 2001-01-18 | 2002-07-18 | Alexion Pharmaceuticals | Method of prophylaxis against large myocardial infractions |
| US20030049260A1 (en) | 2001-07-26 | 2003-03-13 | Leonard Bell | Method of improving cognitive function |
| WO2003061765A1 (en) | 2002-01-22 | 2003-07-31 | Alexion Pharmaceuticals, Inc. | Method of prophylaxis against large myocardial infarctions |
| US20060275764A1 (en) | 2002-12-03 | 2006-12-07 | Aarhus Universitet | Method for determining predisposition to manifestation of immune system related diseases |
| US7361339B2 (en) | 2003-01-09 | 2008-04-22 | Alexion Pharmaceuticals, Inc. | Methods for reducing morality associated with acute myocardial infarction |
| WO2004075837A2 (en) * | 2003-02-21 | 2004-09-10 | Tanox, Inc. | Methods for preventing and treating tissue damage associated with ischemia-reperfusion injury |
| PT2374819T (pt) * | 2003-05-12 | 2017-07-04 | Helion Biotech Aps | Anticorpos para masp-2 |
| WO2005014849A2 (en) | 2003-07-03 | 2005-02-17 | Euro-Celtique, S.A. | Genes associated with responses to neuropathic pain |
| US7482376B2 (en) | 2003-07-03 | 2009-01-27 | 3-Dimensional Pharmaceuticals, Inc. | Conjugated complement cascade inhibitors |
| EP1670910A1 (en) | 2003-09-05 | 2006-06-21 | Natimmune A/S | Masp-2 crystal structure and uses thereof |
| WO2005123776A1 (en) | 2004-06-10 | 2005-12-29 | Omeros Corporation | Methods for treating conditions associated with lectin-dependent complement activation |
| PL2465534T3 (pl) | 2004-06-10 | 2017-08-31 | Omeros Corporation | Sposoby leczenia stanów związanych z aktywacją dopełniacza zależną od masp-2 |
-
2004
- 2004-06-10 GB GBGB0412966.4A patent/GB0412966D0/en not_active Ceased
-
2005
- 2005-06-08 WO PCT/GB2005/050086 patent/WO2005120222A2/en not_active Ceased
- 2005-06-08 ES ES05748982.5T patent/ES2535639T3/es not_active Expired - Lifetime
- 2005-06-08 EP EP05748982.5A patent/EP1766033B1/en not_active Expired - Lifetime
- 2005-06-08 US US11/570,087 patent/US8785717B2/en active Active
- 2005-06-08 JP JP2007526577A patent/JP2008501357A/ja active Pending
-
2014
- 2014-06-26 US US14/316,235 patent/US20150067897A1/en not_active Abandoned
-
2016
- 2016-11-10 US US15/348,162 patent/US10660317B2/en not_active Expired - Lifetime
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