JP2008500374A5 - - Google Patents

Info

Publication number

JP2008500374A5

JP2008500374A5 JP2007515458A JP2007515458A JP2008500374A5 JP 2008500374 A5 JP2008500374 A5 JP 2008500374A5 JP 2007515458 A JP2007515458 A JP 2007515458A JP 2007515458 A JP2007515458 A JP 2007515458A JP 2008500374 A5 JP2008500374 A5 JP 2008500374A5

Authority

JP

Japan

Prior art keywords

composition

compound

subject

syndrome

body weight

Prior art date

2005-05-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 150000001875 compounds Chemical class 0.000 claims 23
• 230000037396 body weight Effects 0.000 claims 6
• 208000011594 Autoinflammatory disease Diseases 0.000 claims 5
• 208000035690 Familial cold urticaria Diseases 0.000 claims 4
• 208000022993 cryopyrin-associated periodic syndrome Diseases 0.000 claims 4
• 208000011580 syndromic disease Diseases 0.000 claims 4
• 239000000090 biomarker Substances 0.000 claims 3
• 206010064570 familial cold autoinflammatory syndrome Diseases 0.000 claims 3
• 206010016207 Familial Mediterranean fever Diseases 0.000 claims 2
• 102000003810 Interleukin-18 Human genes 0.000 claims 2
• 108090000171 Interleukin-18 Proteins 0.000 claims 2
• 201000002795 Muckle-Wells syndrome Diseases 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 230000000737 periodic effect Effects 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 208000020408 systemic-onset juvenile idiopathic arthritis Diseases 0.000 claims 2
• 238000012360 testing method Methods 0.000 claims 2
• LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 claims 1
• 108010074051 C-Reactive Protein Proteins 0.000 claims 1
• 102100032752 C-reactive protein Human genes 0.000 claims 1
• 102000008857 Ferritin Human genes 0.000 claims 1
• 108050000784 Ferritin Proteins 0.000 claims 1
• 238000008416 Ferritin Methods 0.000 claims 1
• 102000014702 Haptoglobin Human genes 0.000 claims 1
• 108050005077 Haptoglobin Proteins 0.000 claims 1
• 102000001554 Hemoglobins Human genes 0.000 claims 1
• 108010054147 Hemoglobins Proteins 0.000 claims 1
• 208000032672 Histiocytosis haematophagic Diseases 0.000 claims 1
• 108060003951 Immunoglobulin Proteins 0.000 claims 1
• 102000003777 Interleukin-1 beta Human genes 0.000 claims 1
• 108090000193 Interleukin-1 beta Proteins 0.000 claims 1
• 102000004889 Interleukin-6 Human genes 0.000 claims 1
• 108090001005 Interleukin-6 Proteins 0.000 claims 1
• 102000004890 Interleukin-8 Human genes 0.000 claims 1
• 108090001007 Interleukin-8 Proteins 0.000 claims 1
• 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
• 208000004987 Macrophage activation syndrome Diseases 0.000 claims 1
• 108700028909 Serum Amyloid A Proteins 0.000 claims 1
• 102000054727 Serum Amyloid A Human genes 0.000 claims 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
• 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 claims 1
• 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 claims 1
• 238000004820 blood count Methods 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 210000003743 erythrocyte Anatomy 0.000 claims 1
• 102000018358 immunoglobulin Human genes 0.000 claims 1
• 208000027866 inflammatory disease Diseases 0.000 claims 1
• 230000005764 inhibitory process Effects 0.000 claims 1
• 229940100601 interleukin-6 Drugs 0.000 claims 1
• 229940096397 interleukin-8 Drugs 0.000 claims 1
• XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 1
• 210000000265 leukocyte Anatomy 0.000 claims 1
• 208000025487 periodic fever syndrome Diseases 0.000 claims 1
• 238000004062 sedimentation Methods 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1