JP2003525240A5 - - Google Patents
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- JP2003525240A5 JP2003525240A5 JP2001563097A JP2001563097A JP2003525240A5 JP 2003525240 A5 JP2003525240 A5 JP 2003525240A5 JP 2001563097 A JP2001563097 A JP 2001563097A JP 2001563097 A JP2001563097 A JP 2001563097A JP 2003525240 A5 JP2003525240 A5 JP 2003525240A5
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- JP
- Japan
- Prior art keywords
- rats
- cells
- glomerular
- mesangial
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- YLMAHDNUQAMNNX-UHFFFAOYSA-N imatinib methanesulfonate Chemical compound CS(O)(=O)=O.C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 YLMAHDNUQAMNNX-UHFFFAOYSA-N 0.000 description 10
- 206010012601 diabetes mellitus Diseases 0.000 description 9
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- 108091003079 Bovine Serum Albumin Proteins 0.000 description 5
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- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
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- 229920000084 Gum arabic Polymers 0.000 description 2
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- 101000934372 Homo sapiens Macrosialin Proteins 0.000 description 1
- 208000010159 IgA glomerulonephritis Diseases 0.000 description 1
- 206010021263 IgA nephropathy Diseases 0.000 description 1
- 102100025136 Macrosialin Human genes 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 206010037601 Pyelonephritis chronic Diseases 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 1
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 1
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- 201000005206 focal segmental glomerulosclerosis Diseases 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
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- 238000003304 gavage Methods 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 description 1
- 229960002411 imatinib Drugs 0.000 description 1
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- 239000007928 intraperitoneal injection Substances 0.000 description 1
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- 229940049954 penicillin Drugs 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 210000000557 podocyte Anatomy 0.000 description 1
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- 201000001474 proteinuria Diseases 0.000 description 1
- 230000008085 renal dysfunction Effects 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 229960001052 streptozocin Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- 210000001519 tissue Anatomy 0.000 description 1
- 238000009804 total hysterectomy Methods 0.000 description 1
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- 208000014001 urinary system disease Diseases 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00810181 | 2000-03-03 | ||
| EP00810181.8 | 2000-03-03 | ||
| PCT/EP2001/002340 WO2001064200A2 (en) | 2000-03-03 | 2001-03-01 | Use of pdgf receptor tyrosine kinase inhibitors for the treatment of diabetic nephropathy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003525240A JP2003525240A (ja) | 2003-08-26 |
| JP2003525240A5 true JP2003525240A5 (enExample) | 2014-05-22 |
Family
ID=8174580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001563097A Ceased JP2003525240A (ja) | 2000-03-03 | 2001-03-01 | 糖尿病性腎障害の処置のためのｐｄｇｆ受容体チロシンキナーゼ阻害剤の使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7087608B2 (enExample) |
| EP (1) | EP1259242B1 (enExample) |
| JP (1) | JP2003525240A (enExample) |
| AT (1) | ATE369860T1 (enExample) |
| AU (2) | AU4832401A (enExample) |
| CA (1) | CA2401812C (enExample) |
| DE (1) | DE60129934T2 (enExample) |
| ES (1) | ES2291306T3 (enExample) |
| PT (1) | PT1259242E (enExample) |
| WO (1) | WO2001064200A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6878697B2 (en) | 2001-06-21 | 2005-04-12 | Ariad Pharmaceuticals, Inc. | Phenylamino-pyrimidines and uses thereof |
| CA2452368A1 (en) | 2001-06-29 | 2003-01-09 | Ab Science | New potent, selective and non toxic c-kit inhibitors |
| WO2003004007A2 (en) | 2001-06-29 | 2003-01-16 | Ab Science | Use of tyrosine kinase inhibitors for treating inflammatory bowel diseases (ibd) |
| DK1401413T3 (da) | 2001-06-29 | 2007-03-26 | Ab Science | Anvendelse af tyrosinkinaseinhibitorer til behandling af allergiske sygdomme |
| EP1401415B1 (en) | 2001-06-29 | 2006-06-21 | AB Science | Use of n-phenyl-2-pyrimidine-amine derivatives for treating inflammatory diseases |
| IL160310A0 (en) * | 2001-08-25 | 2004-07-25 | Arakis Ltd | The use of anthroquinones in the treatment of kidney disease |
| US7332330B2 (en) * | 2001-09-11 | 2008-02-19 | Renamed Biologics, Inc. | Device for maintaining vascularization near an implant |
| EP1469810A4 (en) * | 2002-01-04 | 2009-01-14 | Univ Rockefeller | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING BETA-AMYLOID PEPTIDE-RELATED DISORDERS |
| CA2490989A1 (en) * | 2002-05-13 | 2003-11-20 | Beth Israel Deaconess Medical Center | Methods and compositions for the treatment of graft failure |
| EP1525200B1 (en) | 2002-08-02 | 2007-10-10 | AB Science | 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors |
| US8450302B2 (en) | 2002-08-02 | 2013-05-28 | Ab Science | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors |
| GB0222514D0 (en) | 2002-09-27 | 2002-11-06 | Novartis Ag | Organic compounds |
| EP1631291B1 (en) * | 2003-05-27 | 2009-08-12 | Robert P. Hägerkvist | Use of tyrosine kinase inhibitors to treat diabetes |
| CA2535242A1 (en) * | 2003-08-15 | 2005-02-24 | Ab Science | Use of c-kit inhibitors for treating type ii diabetes |
| KR20120008093A (ko) | 2003-11-17 | 2012-01-25 | 노파르티스 아게 | 디펩티딜 펩티다제 ⅳ 억제제의 용도 |
| WO2008093246A2 (en) | 2007-02-02 | 2008-08-07 | Vegenics Limited | Vegf receptor antagonist for treating organ transplant alloimmunity and arteriosclerosis |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| PT2300013T (pt) | 2008-05-21 | 2017-10-31 | Ariad Pharma Inc | Derivados de fósforo como inibidores de cinases |
| WO2011016861A2 (en) | 2009-08-05 | 2011-02-10 | Intra-Cellular Therapies, Inc. | Novel regulatory proteins and inhibitors |
| EP2704572B1 (en) | 2011-05-04 | 2015-12-30 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
| AU2013204563B2 (en) | 2012-05-05 | 2016-05-19 | Takeda Pharmaceutical Company Limited | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| CN107573322A (zh) * | 2017-09-06 | 2018-01-12 | 南京优科生物医药研究有限公司 | 伊马替尼双氮氧化物、其制备方法和用途 |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| WO2020245208A1 (en) | 2019-06-04 | 2020-12-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of cd9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| JP2602735B2 (ja) * | 1989-09-27 | 1997-04-23 | 株式会社大塚製薬工場 | 抗活性酸素剤 |
| TW225528B (enExample) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| JP3810020B2 (ja) | 1993-04-22 | 2006-08-16 | 武田薬品工業株式会社 | 腎疾患の予防または治療剤 |
| US5795910A (en) | 1994-10-28 | 1998-08-18 | Cor Therapeutics, Inc. | Method and compositions for inhibiting protein kinases |
| US5721277A (en) | 1995-04-21 | 1998-02-24 | Sugen, Inc. | Compounds and methods for inhibiting hyper-proliferative cell growth |
| CA2214393A1 (en) | 1996-09-02 | 1998-03-02 | Takeda Chemical Industries, Ltd. | Tricyclic compounds, their production and use |
| JPH10182644A (ja) * | 1996-11-01 | 1998-07-07 | Takeda Chem Ind Ltd | 三環性化合物、その製造法及び剤 |
| CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| GB9809869D0 (en) | 1998-05-09 | 1998-07-08 | Medical Res Council | Inhibition of protein kinases |
| PT1105136E (pt) | 1998-08-13 | 2007-12-03 | Novartis Ag | Método para tratar doenças oculares neovasculares |
-
2001
- 2001-01-03 US US10/220,214 patent/US7087608B2/en not_active Expired - Fee Related
- 2001-03-01 JP JP2001563097A patent/JP2003525240A/ja not_active Ceased
- 2001-03-01 EP EP01921298A patent/EP1259242B1/en not_active Expired - Lifetime
- 2001-03-01 CA CA002401812A patent/CA2401812C/en not_active Expired - Fee Related
- 2001-03-01 PT PT01921298T patent/PT1259242E/pt unknown
- 2001-03-01 AU AU4832401A patent/AU4832401A/xx active Pending
- 2001-03-01 AT AT01921298T patent/ATE369860T1/de active
- 2001-03-01 DE DE60129934T patent/DE60129934T2/de not_active Expired - Lifetime
- 2001-03-01 AU AU2001248324A patent/AU2001248324B2/en not_active Ceased
- 2001-03-01 ES ES01921298T patent/ES2291306T3/es not_active Expired - Lifetime
- 2001-03-01 WO PCT/EP2001/002340 patent/WO2001064200A2/en not_active Ceased
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