JP2003525240A - 糖尿病性腎障害の処置のためのｐｄｇｆ受容体チロシンキナーゼ阻害剤の使用 - Google Patents
糖尿病性腎障害の処置のためのｐｄｇｆ受容体チロシンキナーゼ阻害剤の使用Info
- Publication number
- JP2003525240A JP2003525240A JP2001563097A JP2001563097A JP2003525240A JP 2003525240 A JP2003525240 A JP 2003525240A JP 2001563097 A JP2001563097 A JP 2001563097A JP 2001563097 A JP2001563097 A JP 2001563097A JP 2003525240 A JP2003525240 A JP 2003525240A
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- formula
- receptor tyrosine
- hydrogen
- tyrosine kinase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
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| EP00810181 | 2000-03-03 | ||
| EP00810181.8 | 2000-03-03 | ||
| PCT/EP2001/002340 WO2001064200A2 (en) | 2000-03-03 | 2001-03-01 | Use of pdgf receptor tyrosine kinase inhibitors for the treatment of diabetic nephropathy |
Publications (2)
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| JP2003525240A true JP2003525240A (ja) | 2003-08-26 |
| JP2003525240A5 JP2003525240A5 (enExample) | 2014-05-22 |
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| EP (1) | EP1259242B1 (enExample) |
| JP (1) | JP2003525240A (enExample) |
| AT (1) | ATE369860T1 (enExample) |
| AU (2) | AU4832401A (enExample) |
| CA (1) | CA2401812C (enExample) |
| DE (1) | DE60129934T2 (enExample) |
| ES (1) | ES2291306T3 (enExample) |
| PT (1) | PT1259242E (enExample) |
| WO (1) | WO2001064200A2 (enExample) |
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| US6878697B2 (en) | 2001-06-21 | 2005-04-12 | Ariad Pharmaceuticals, Inc. | Phenylamino-pyrimidines and uses thereof |
| CA2452368A1 (en) | 2001-06-29 | 2003-01-09 | Ab Science | New potent, selective and non toxic c-kit inhibitors |
| WO2003004007A2 (en) | 2001-06-29 | 2003-01-16 | Ab Science | Use of tyrosine kinase inhibitors for treating inflammatory bowel diseases (ibd) |
| DK1401413T3 (da) | 2001-06-29 | 2007-03-26 | Ab Science | Anvendelse af tyrosinkinaseinhibitorer til behandling af allergiske sygdomme |
| EP1401415B1 (en) | 2001-06-29 | 2006-06-21 | AB Science | Use of n-phenyl-2-pyrimidine-amine derivatives for treating inflammatory diseases |
| IL160310A0 (en) * | 2001-08-25 | 2004-07-25 | Arakis Ltd | The use of anthroquinones in the treatment of kidney disease |
| US7332330B2 (en) * | 2001-09-11 | 2008-02-19 | Renamed Biologics, Inc. | Device for maintaining vascularization near an implant |
| EP1469810A4 (en) * | 2002-01-04 | 2009-01-14 | Univ Rockefeller | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING BETA-AMYLOID PEPTIDE-RELATED DISORDERS |
| CA2490989A1 (en) * | 2002-05-13 | 2003-11-20 | Beth Israel Deaconess Medical Center | Methods and compositions for the treatment of graft failure |
| EP1525200B1 (en) | 2002-08-02 | 2007-10-10 | AB Science | 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors |
| US8450302B2 (en) | 2002-08-02 | 2013-05-28 | Ab Science | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors |
| GB0222514D0 (en) | 2002-09-27 | 2002-11-06 | Novartis Ag | Organic compounds |
| EP1631291B1 (en) * | 2003-05-27 | 2009-08-12 | Robert P. Hägerkvist | Use of tyrosine kinase inhibitors to treat diabetes |
| CA2535242A1 (en) * | 2003-08-15 | 2005-02-24 | Ab Science | Use of c-kit inhibitors for treating type ii diabetes |
| KR20120008093A (ko) | 2003-11-17 | 2012-01-25 | 노파르티스 아게 | 디펩티딜 펩티다제 ⅳ 억제제의 용도 |
| WO2008093246A2 (en) | 2007-02-02 | 2008-08-07 | Vegenics Limited | Vegf receptor antagonist for treating organ transplant alloimmunity and arteriosclerosis |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| PT2300013T (pt) | 2008-05-21 | 2017-10-31 | Ariad Pharma Inc | Derivados de fósforo como inibidores de cinases |
| WO2011016861A2 (en) | 2009-08-05 | 2011-02-10 | Intra-Cellular Therapies, Inc. | Novel regulatory proteins and inhibitors |
| EP2704572B1 (en) | 2011-05-04 | 2015-12-30 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
| AU2013204563B2 (en) | 2012-05-05 | 2016-05-19 | Takeda Pharmaceutical Company Limited | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| CN107573322A (zh) * | 2017-09-06 | 2018-01-12 | 南京优科生物医药研究有限公司 | 伊马替尼双氮氧化物、其制备方法和用途 |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| WO2020245208A1 (en) | 2019-06-04 | 2020-12-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of cd9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
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| JPH10182644A (ja) * | 1996-11-01 | 1998-07-07 | Takeda Chem Ind Ltd | 三環性化合物、その製造法及び剤 |
| WO1999003854A1 (en) * | 1997-07-18 | 1999-01-28 | Novartis Ag | Crystal modification of a n-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use |
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| US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| JP2602735B2 (ja) * | 1989-09-27 | 1997-04-23 | 株式会社大塚製薬工場 | 抗活性酸素剤 |
| TW225528B (enExample) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| JP3810020B2 (ja) | 1993-04-22 | 2006-08-16 | 武田薬品工業株式会社 | 腎疾患の予防または治療剤 |
| US5795910A (en) | 1994-10-28 | 1998-08-18 | Cor Therapeutics, Inc. | Method and compositions for inhibiting protein kinases |
| US5721277A (en) | 1995-04-21 | 1998-02-24 | Sugen, Inc. | Compounds and methods for inhibiting hyper-proliferative cell growth |
| CA2214393A1 (en) | 1996-09-02 | 1998-03-02 | Takeda Chemical Industries, Ltd. | Tricyclic compounds, their production and use |
| CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| GB9809869D0 (en) | 1998-05-09 | 1998-07-08 | Medical Res Council | Inhibition of protein kinases |
| PT1105136E (pt) | 1998-08-13 | 2007-12-03 | Novartis Ag | Método para tratar doenças oculares neovasculares |
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2001
- 2001-01-03 US US10/220,214 patent/US7087608B2/en not_active Expired - Fee Related
- 2001-03-01 JP JP2001563097A patent/JP2003525240A/ja not_active Ceased
- 2001-03-01 EP EP01921298A patent/EP1259242B1/en not_active Expired - Lifetime
- 2001-03-01 CA CA002401812A patent/CA2401812C/en not_active Expired - Fee Related
- 2001-03-01 PT PT01921298T patent/PT1259242E/pt unknown
- 2001-03-01 AU AU4832401A patent/AU4832401A/xx active Pending
- 2001-03-01 AT AT01921298T patent/ATE369860T1/de active
- 2001-03-01 DE DE60129934T patent/DE60129934T2/de not_active Expired - Lifetime
- 2001-03-01 AU AU2001248324A patent/AU2001248324B2/en not_active Ceased
- 2001-03-01 ES ES01921298T patent/ES2291306T3/es not_active Expired - Lifetime
- 2001-03-01 WO PCT/EP2001/002340 patent/WO2001064200A2/en not_active Ceased
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH10182644A (ja) * | 1996-11-01 | 1998-07-07 | Takeda Chem Ind Ltd | 三環性化合物、その製造法及び剤 |
| WO1999003854A1 (en) * | 1997-07-18 | 1999-01-28 | Novartis Ag | Crystal modification of a n-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use |
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| JPN5002022830; ＢＩＲＤ ＥＩＬＥＥＮ: ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＡＭＥＲＩＣＡＮ ＳＯＣＩＥＴＹ ＯＦ ＮＥＰＨＲＯＬＯＧＹ Ｖ１０, 19991108, Ｐ５６８Ａ * |
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Also Published As
| Publication number | Publication date |
|---|---|
| DE60129934T2 (de) | 2008-05-08 |
| CA2401812C (en) | 2009-06-09 |
| WO2001064200A2 (en) | 2001-09-07 |
| HK1052864A1 (en) | 2003-10-03 |
| DE60129934D1 (de) | 2007-09-27 |
| US20030186977A1 (en) | 2003-10-02 |
| AU2001248324B2 (en) | 2005-09-15 |
| EP1259242A2 (en) | 2002-11-27 |
| ES2291306T3 (es) | 2008-03-01 |
| WO2001064200A3 (en) | 2002-01-17 |
| US7087608B2 (en) | 2006-08-08 |
| PT1259242E (pt) | 2007-11-15 |
| ATE369860T1 (de) | 2007-09-15 |
| EP1259242B1 (en) | 2007-08-15 |
| CA2401812A1 (en) | 2001-09-07 |
| AU4832401A (en) | 2001-09-12 |
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