JP2008500284A5 - - Google Patents
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- Publication number
- JP2008500284A5 JP2008500284A5 JP2007513296A JP2007513296A JP2008500284A5 JP 2008500284 A5 JP2008500284 A5 JP 2008500284A5 JP 2007513296 A JP2007513296 A JP 2007513296A JP 2007513296 A JP2007513296 A JP 2007513296A JP 2008500284 A5 JP2008500284 A5 JP 2008500284A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridin
- urea
- tert
- phenyl
- butylphenoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 **C(CCCCCCCC1)C1NC(N*)=C Chemical compound **C(CCCCCCCC1)C1NC(N*)=C 0.000 description 10
- SIJBDWPVNAYVGY-UHFFFAOYSA-N CC1(C)OCCO1 Chemical compound CC1(C)OCCO1 SIJBDWPVNAYVGY-UHFFFAOYSA-N 0.000 description 1
- NHDVFXNUAUYRHR-UHFFFAOYSA-N CC1(C)c(cccc2)c2OC(C)(C)C1 Chemical compound CC1(C)c(cccc2)c2OC(C)(C)C1 NHDVFXNUAUYRHR-UHFFFAOYSA-N 0.000 description 1
- UBWYINVCVLFJME-KRWDZBQOSA-O CCCC[C@H](C)C[SH+]CCOC(C)(C)c1c(CC)cccc1 Chemical compound CCCC[C@H](C)C[SH+]CCOC(C)(C)c1c(CC)cccc1 UBWYINVCVLFJME-KRWDZBQOSA-O 0.000 description 1
- AGOHPTPGKWPXRZ-UHFFFAOYSA-N CCOC1(C)CCOCC1 Chemical compound CCOC1(C)CCOCC1 AGOHPTPGKWPXRZ-UHFFFAOYSA-N 0.000 description 1
- UPSPWHCGQUKZSJ-UHFFFAOYSA-N CCOC1(CCOCC1)c1ccccc1 Chemical compound CCOC1(CCOCC1)c1ccccc1 UPSPWHCGQUKZSJ-UHFFFAOYSA-N 0.000 description 1
- LZTRCELOJRDYMQ-UHFFFAOYSA-N OC(c1ccccc1)(c1ccccc1)c1ccccc1 Chemical compound OC(c1ccccc1)(c1ccccc1)c1ccccc1 LZTRCELOJRDYMQ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57028804P | 2004-05-12 | 2004-05-12 | |
| US66581705P | 2005-03-28 | 2005-03-28 | |
| PCT/US2005/016422 WO2005113511A1 (en) | 2004-05-12 | 2005-05-11 | Urea antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
| US11/126,915 US7388021B2 (en) | 2004-05-12 | 2005-05-11 | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008500284A JP2008500284A (ja) | 2008-01-10 |
| JP2008500284A5 true JP2008500284A5 (https=) | 2008-02-21 |
Family
ID=35456856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007513296A Pending JP2008500284A (ja) | 2004-05-12 | 2005-05-11 | 血栓症の治療に有用なp2y1レセプターのウレアアンタゴニスト |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7388021B2 (https=) |
| EP (1) | EP1751113B1 (https=) |
| JP (1) | JP2008500284A (https=) |
| KR (1) | KR20070032648A (https=) |
| AT (1) | ATE460402T1 (https=) |
| AU (1) | AU2005245389A1 (https=) |
| DE (1) | DE602005019874D1 (https=) |
| ES (1) | ES2340179T3 (https=) |
| MX (1) | MXPA06013022A (https=) |
| NO (1) | NO20065534L (https=) |
| WO (1) | WO2005113511A1 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050026844A1 (en) | 2003-04-03 | 2005-02-03 | Regents Of The University Of California | Inhibitors for the soluble epoxide hydrolase |
| WO2005089380A2 (en) | 2004-03-16 | 2005-09-29 | The Regents Of The University Of California | Reducing nephropathy with inhibitors of soluble epoxide hydrolase and epoxyeicosanoids |
| US7470712B2 (en) * | 2004-01-21 | 2008-12-30 | Bristol-Myers Squibb Company | Amino-benzazoles as P2Y1 receptor inhibitors |
| US7550499B2 (en) | 2004-05-12 | 2009-06-23 | Bristol-Myers Squibb Company | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| JP2008517072A (ja) | 2004-10-20 | 2008-05-22 | ザ レジェンツ オブ ザ ユニバーシティー オブ カリフォルニア | 可溶性エポキシド加水分解酵素の改良された阻害剤 |
| WO2006078621A2 (en) * | 2005-01-19 | 2006-07-27 | Bristol-Myers Squibb Company | 2-phenoxy-n- (1, 3 , 4-thiadizol-2-yl) pyridin-3-amine derivatives and related compounds as p2y1 receptor inhibitors for the treatment of thromboembolic disorders |
| TW200726764A (en) | 2005-06-27 | 2007-07-16 | Bristol Myers Squibb Co | N-linked heterocyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| DE602006017694D1 (de) * | 2005-06-27 | 2010-12-02 | Bristol Myers Squibb Co | C-verknüpfte zyklische antagonisten des p2y1-rezeptors mit eignung bei der behandlung thrombotischer leiden |
| WO2007002634A1 (en) * | 2005-06-27 | 2007-01-04 | Bristol-Myers Squibb Company | Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
| ATE502924T1 (de) * | 2005-06-27 | 2011-04-15 | Bristol Myers Squibb Co | Lineare harnstoffmimetika-antagonisten des p2y1- rezeptors zur behandlung von thromboseleiden |
| AR059826A1 (es) | 2006-03-13 | 2008-04-30 | Univ California | Inhibidores de urea conformacionalmente restringidos de epoxido hidrolasa soluble |
| WO2008023235A1 (en) * | 2006-08-25 | 2008-02-28 | Pfizer Products Inc. | Pyrazole derivatives as anti-platelet and anti-thrombotic agents |
| US7960569B2 (en) * | 2006-10-17 | 2011-06-14 | Bristol-Myers Squibb Company | Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| AR064866A1 (es) * | 2007-01-12 | 2009-04-29 | Astrazeneca Ab | Analogos de piridina |
| CL2008000093A1 (es) * | 2007-01-12 | 2008-08-22 | Astrazeneca Ab | Compuestos derivados de piridina, inhibidores de p2y12; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento de un desorden de agregacion plaquetaria. |
| AR064864A1 (es) * | 2007-01-12 | 2009-04-29 | Astrazeneca Ab | Compuestos analogos de piridina vii 543 y composicion farmaceutica |
| CA2693232A1 (en) | 2007-07-18 | 2009-01-22 | Novartis Ag | Bicyclic heteroaryl compounds and their use as kinase inhibitors |
| WO2009035949A2 (en) * | 2007-09-13 | 2009-03-19 | Arete Therapeutics, Inc. | Soluble epoxide hydrolase inhibitors |
| JP2012504591A (ja) | 2008-10-02 | 2012-02-23 | レスピバート・リミテツド | p38MAPキナーゼ阻害剤 |
| GB0818033D0 (en) | 2008-10-02 | 2008-11-05 | Respivert Ltd | Novel compound |
| JP5773877B2 (ja) | 2008-10-22 | 2015-09-02 | アキュセラ インコーポレイテッド | 眼の疾患及び障害を治療する化合物 |
| PE20110946A1 (es) * | 2008-11-21 | 2012-01-05 | Iroko Cardio Llc | Metodo para reducir la trombocitopenia y mortalidad asociada a la trombocitopenia |
| MX2011006219A (es) | 2008-12-11 | 2011-06-28 | Respivert Ltd | Inhibidores de la proteina cinasa activada por el mitogeno p38. |
| GB0905955D0 (en) | 2009-04-06 | 2009-05-20 | Respivert Ltd | Novel compounds |
| US8377970B2 (en) * | 2009-10-08 | 2013-02-19 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel |
| WO2012054093A2 (en) | 2010-01-29 | 2012-04-26 | The Regents Of The University Of California | Acyl piperidine inhibitors of soluble epoxide hydrolase |
| US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
| AU2011223790A1 (en) * | 2010-03-01 | 2012-08-30 | Myrexis, Inc. | Compounds and therapeutic uses thereof |
| FR2965262A1 (fr) * | 2010-09-24 | 2012-03-30 | Sanofi Aventis | Derives de nicotinamide, leur preparation et leur application en therapeutique |
| EP2739144A4 (en) * | 2011-06-20 | 2015-04-01 | Alzheimer S Inst Of America Inc | COMPOUNDS AND ITS THERAPEUTIC USE |
| US9540323B2 (en) * | 2012-08-01 | 2017-01-10 | Bristol-Myers Squibb Company | 7-hydroxy-indolinyl antagonists of P2Y1 receptor |
| US9428504B2 (en) * | 2012-08-01 | 2016-08-30 | Bristol-Myers Squibb Company | 7-hydroxy-spiropipiperidine indolinyl antagonists of P2Y1 receptor |
| EP2970114B1 (en) * | 2013-03-15 | 2019-05-15 | Bristol-Myers Squibb Company | Ido inhibitors |
| GB201705863D0 (en) | 2017-04-11 | 2017-05-24 | Univ London | Pyridinium salts and uses thereof |
| CN110709255B (zh) | 2017-06-08 | 2021-08-06 | 日本曹达株式会社 | 记录材料及化合物 |
| EP3720326A4 (en) | 2017-12-07 | 2021-08-11 | Pitco Frialator, Inc. | FLUID SENSOR AND CONTROL SYSTEM |
| DE102018113646B4 (de) | 2018-06-07 | 2021-06-24 | Helmholtz-Zentrum Dresden - Rossendorf E.V. | 2-Phenoxypyridin-3-amin-Derivate und deren Verwendung |
| WO2021222637A1 (en) * | 2020-04-30 | 2021-11-04 | United States Government As Represented By The Department Of Veterans Affairs | Krüppel-like factor 15 (klf15) small molecule agonists in kidney disease |
| EP4095134A1 (en) | 2021-05-25 | 2022-11-30 | UCL Business Ltd | Polycyclic compounds for the treatment of neurological indications |
| EP4094762A1 (en) * | 2021-05-25 | 2022-11-30 | UCL Business Ltd | Treatment of neurological indications |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL254871A (https=) * | 1959-08-14 | |||
| DE3484096D1 (de) * | 1983-11-30 | 1991-03-14 | Janssen Pharmaceutica Nv | Bizyklisches heterozyklyl aufveisende n-(bizyklisches heterozyklyl-4-piperidinamine. |
| JPS62280847A (ja) * | 1986-05-30 | 1987-12-05 | Konica Corp | 新規なマゼンタカプラ−を含有するハロゲン化銀写真感光材料 |
| CA1317939C (en) * | 1987-07-01 | 1993-05-18 | Janssen Pharmaceutica Naamloze Vennootschap | ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines |
| JPH0339740A (ja) * | 1989-07-06 | 1991-02-20 | Konica Corp | 転写型熱現像カラー感光材料 |
| NZ238863A (en) * | 1990-07-19 | 1993-03-26 | Janssen Pharmaceutica Nv | Substituted thiazolyl and pyridinyl derivatives |
| JP3395285B2 (ja) | 1993-10-06 | 2003-04-07 | 日本製紙株式会社 | 感熱記録体 |
| US5547966A (en) * | 1993-10-07 | 1996-08-20 | Bristol-Myers Squibb Company | Aryl urea and related compounds |
| DE4443641A1 (de) | 1994-12-08 | 1996-06-13 | Bayer Ag | Substituierte Carbonsäureamide |
| JPH11503110A (ja) * | 1995-02-17 | 1999-03-23 | スミスクライン・ビーチャム・コーポレイション | Il−8受容体拮抗剤 |
| US5691364A (en) * | 1995-03-10 | 1997-11-25 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
| DE69630214T2 (de) | 1995-03-10 | 2004-07-15 | Berlex Laboratories, Inc., Richmond | Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien |
| EP0929218A4 (en) | 1996-10-30 | 2001-05-16 | Univ North Carolina | P2Y RECEPTOR ANTAGONISTS |
| US6093742A (en) * | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
| DE69831013T2 (de) * | 1997-12-22 | 2006-04-20 | Bayer Pharmaceuticals Corp., West Haven | Inhibierung der raf-kinase durch substituierte heterocyclische harnstoffverbindungen |
| US6329395B1 (en) * | 1998-06-08 | 2001-12-11 | Schering Corporation | Neuropeptide Y5 receptor antagonists |
| EP1123918B1 (en) | 1998-10-20 | 2005-03-09 | Takeda Pharmaceutical Company Limited | Aromatic amine derivatives, process for the preparation thereof and agents containing the same |
| JP2001089412A (ja) | 1999-09-22 | 2001-04-03 | Otsuka Pharmaceut Co Ltd | ベンゼン誘導体またはその医薬的に許容される塩 |
| WO2001023358A1 (en) * | 1999-09-27 | 2001-04-05 | Sagami Chemical Research Center | Pyrazole derivatives, intermediates for the preparation thereof, processes for the preparation of both and herbicides containing the derivatives as the active ingredient |
| CA2385972A1 (en) * | 1999-10-01 | 2001-04-12 | Haruhisa Ogita | Novel diarylamide derivatives and use thereof as medicines |
| US7087589B2 (en) | 2000-01-14 | 2006-08-08 | The United States Of America As Represented By The Department Of Health And Human Services | Methanocarba cycloakyl nucleoside analogues |
| HUP0204272A3 (en) * | 2000-01-18 | 2005-03-29 | Pfizer Prod Inc | Corticotropin releasing factor antagonists, pharmaceutical compositions containing them and their use |
| MXPA03009847A (es) * | 2001-04-27 | 2004-02-12 | Vertex Pharma | Inhibidores de cinasa derivados de pirazol. |
| AU2002317377A1 (en) * | 2001-07-20 | 2003-03-03 | Cancer Research Technology Limited | Biphenyl apurinic/apyrimidinic site endonuclease inhibitors to treat cancer |
| AU2002342607B2 (en) * | 2001-08-06 | 2006-10-19 | Pharmacia Italia S.P.A. | Aminoisoxazole derivatives active as kinase inhibitors |
| WO2003068229A1 (en) * | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
| SI1478358T1 (sl) * | 2002-02-11 | 2013-09-30 | Bayer Healthcare Llc | Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi |
| RU2004135386A (ru) * | 2002-05-06 | 2005-07-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Тиадиазолы или оксадиазолы и их применение в качестве ингибиторов протеинкиназы jak |
| AU2003243921B2 (en) | 2002-06-27 | 2009-05-07 | Novo Nordisk A/S | Aryl carbonyl derivatives as therapeutic agents |
| US7470712B2 (en) * | 2004-01-21 | 2008-12-30 | Bristol-Myers Squibb Company | Amino-benzazoles as P2Y1 receptor inhibitors |
| US7550499B2 (en) * | 2004-05-12 | 2009-06-23 | Bristol-Myers Squibb Company | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| WO2006078621A2 (en) * | 2005-01-19 | 2006-07-27 | Bristol-Myers Squibb Company | 2-phenoxy-n- (1, 3 , 4-thiadizol-2-yl) pyridin-3-amine derivatives and related compounds as p2y1 receptor inhibitors for the treatment of thromboembolic disorders |
| ATE502924T1 (de) * | 2005-06-27 | 2011-04-15 | Bristol Myers Squibb Co | Lineare harnstoffmimetika-antagonisten des p2y1- rezeptors zur behandlung von thromboseleiden |
| WO2007002634A1 (en) * | 2005-06-27 | 2007-01-04 | Bristol-Myers Squibb Company | Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
-
2005
- 2005-05-11 AU AU2005245389A patent/AU2005245389A1/en not_active Abandoned
- 2005-05-11 EP EP05747470A patent/EP1751113B1/en not_active Expired - Lifetime
- 2005-05-11 WO PCT/US2005/016422 patent/WO2005113511A1/en not_active Ceased
- 2005-05-11 US US11/126,915 patent/US7388021B2/en not_active Expired - Lifetime
- 2005-05-11 ES ES05747470T patent/ES2340179T3/es not_active Expired - Lifetime
- 2005-05-11 DE DE602005019874T patent/DE602005019874D1/de not_active Expired - Lifetime
- 2005-05-11 MX MXPA06013022A patent/MXPA06013022A/es active IP Right Grant
- 2005-05-11 KR KR1020067023622A patent/KR20070032648A/ko not_active Ceased
- 2005-05-11 JP JP2007513296A patent/JP2008500284A/ja active Pending
- 2005-05-11 AT AT05747470T patent/ATE460402T1/de not_active IP Right Cessation
-
2006
- 2006-11-30 NO NO20065534A patent/NO20065534L/no not_active Application Discontinuation
-
2008
- 2008-05-08 US US12/117,005 patent/US7674828B2/en not_active Expired - Lifetime
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