JP2007537284A - 核酸マイクロスフェア、その生成および送達 - Google Patents

核酸マイクロスフェア、その生成および送達 Download PDF

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JP2007537284A
JP2007537284A JP2007513364A JP2007513364A JP2007537284A JP 2007537284 A JP2007537284 A JP 2007537284A JP 2007513364 A JP2007513364 A JP 2007513364A JP 2007513364 A JP2007513364 A JP 2007513364A JP 2007537284 A JP2007537284 A JP 2007537284A
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microsphere
microspheres
micrometers
particle size
route
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JP2007537284A5 (enExample
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テレンス エル． スコット，
デブラ ラフレニエール，
ベレッド ビースカー−ライブ，
ラリー アール． ブラウン，
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Baxter Healthcare SA
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    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
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JP2007513364A 2004-05-12 2005-05-12 核酸マイクロスフェア、その生成および送達 Pending JP2007537284A (ja)

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US57027304P 2004-05-12 2004-05-12
US62531104P 2004-11-05 2004-11-05
PCT/US2005/016660 WO2005112894A1 (en) 2004-05-12 2005-05-12 Nucleic acid microspheres, production and delivery thereof

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US (2) US7815941B2 (enExample)
EP (3) EP1765294B1 (enExample)
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007537288A (ja) * 2004-05-12 2007-12-20 バクスター インターナショナル インコーポレイテッド オリゴヌクレオチド含有マイクロスフェア、１型糖尿病を処置する医薬の製造のための、その使用
JP2011519365A (ja) * 2008-04-18 2011-07-07 バクスター・インターナショナル・インコーポレイテッド 初発自己免疫性糖尿病を予防するため、および／または逆転させるためのマイクロスフェアに基づく組成物
JP2011520813A (ja) * 2008-05-07 2011-07-21 サーモディクス，インコーポレイティド 粒子からの核酸複合体の送達
JP2011256203A (ja) * 2004-05-12 2011-12-22 Baxter Internatl Inc 核酸マイクロスフェア、その生成および送達

Families Citing this family (29)

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US20080026068A1 (en) * 2001-08-16 2008-01-31 Baxter Healthcare S.A. Pulmonary delivery of spherical insulin microparticles
US8728525B2 (en) 2004-05-12 2014-05-20 Baxter International Inc. Protein microspheres retaining pharmacokinetic and pharmacodynamic properties
JP2008539259A (ja) * 2005-04-27 2008-11-13 バクスター・インターナショナル・インコーポレイテッド 表面を修飾した微粒子およびその形成方法および使用
US20070281031A1 (en) * 2006-06-01 2007-12-06 Guohan Yang Microparticles and methods for production thereof
AU2013213750B2 (en) * 2006-08-04 2013-09-26 Baxter Healthcare S.A. Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes
CN101500616A (zh) * 2006-08-04 2009-08-05 巴克斯特国际公司 预防和/或逆转新发作自身免疫糖尿病的基于微球的组合物
MX2009003661A (es) * 2006-10-06 2009-04-22 Baxter Int Microcapsulas que contienen microparticulas modificadas en la superficie y metodos para formar y utilizar las mismas.
US8808747B2 (en) 2007-04-17 2014-08-19 Baxter International Inc. Nucleic acid microparticles for pulmonary delivery
US8323615B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing multi-phasic dispersions
US8367427B2 (en) 2008-08-20 2013-02-05 Baxter International Inc. Methods of processing compositions containing microparticles
US8323685B2 (en) 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing compositions containing microparticles
US20100047292A1 (en) * 2008-08-20 2010-02-25 Baxter International Inc. Methods of processing microparticles and compositions produced thereby
US8822663B2 (en) 2010-08-06 2014-09-02 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
CA2821992A1 (en) 2010-10-01 2012-04-05 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US8901092B2 (en) 2010-12-29 2014-12-02 Surmodics, Inc. Functionalized polysaccharides for active agent delivery
DE12722942T1 (de) 2011-03-31 2021-09-30 Modernatx, Inc. Freisetzung und formulierung von manipulierten nukleinsäuren
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
HRP20220250T1 (hr) 2011-10-03 2022-04-29 Modernatx, Inc. Modificirani nukleozidi, nukleotidi i nukleinske kiseline, te njihove uporabe
SI2791160T1 (sl) 2011-12-16 2022-07-29 Modernatx, Inc. Sestave modificirane MRNA
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
AU2013243952A1 (en) 2012-04-02 2014-10-30 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
SMT202200337T1 (it) 2012-11-26 2022-09-14 Modernatx Inc Rna modificato al livello del terminale
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
US20160230174A1 (en) * 2013-09-26 2016-08-11 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Tolerogenic dendritic cells to treat inflammatory bowel disease
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
US10323076B2 (en) 2013-10-03 2019-06-18 Modernatx, Inc. Polynucleotides encoding low density lipoprotein receptor
CN116064746B (zh) * 2022-09-16 2025-05-23 上海伯杰医疗科技股份有限公司 用于核酸扩增的微球制剂、扩增方法及在联合检测中的应用

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JP2002538174A (ja) * 1999-03-02 2002-11-12 ウエスト・ファーマシューティカル・サービセズ・ドラッグ・デリバリー・アンド・クリニカル・リサーチ・センター・リミテッド ポリヌクレオチドデリバリーのためのポリマー組成物
JP2003502283A (ja) * 1999-04-19 2003-01-21 カトリーケ・ウニベルジテート・ニイメゲン 樹状細胞−ｔ細胞の相互作用を調節するための組成物及び方法
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