JP2007535493A5 - - Google Patents
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- JP2007535493A5 JP2007535493A5 JP2006542793A JP2006542793A JP2007535493A5 JP 2007535493 A5 JP2007535493 A5 JP 2007535493A5 JP 2006542793 A JP2006542793 A JP 2006542793A JP 2006542793 A JP2006542793 A JP 2006542793A JP 2007535493 A5 JP2007535493 A5 JP 2007535493A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- peptide
- bound
- component
- peptide component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- 238000000034 method Methods 0.000 claims 12
- NNRFRJQMBSBXGO-CIUDSAMLSA-N (3s)-3-[[2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-oxobutanoic acid Chemical group NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O NNRFRJQMBSBXGO-CIUDSAMLSA-N 0.000 claims 7
- 101000829980 Homo sapiens Ral guanine nucleotide dissociation stimulator Proteins 0.000 claims 7
- 102100023320 Ral guanine nucleotide dissociation stimulator Human genes 0.000 claims 7
- -1 amphiphile compound Chemical class 0.000 claims 7
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 7
- XQQUSYWGKLRJRA-RABCQHRBSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s,3s)-2-amino-3-methylpentanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-3-methylbutanoic acid Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(O)=O XQQUSYWGKLRJRA-RABCQHRBSA-N 0.000 claims 6
- MWOGMBZGFFZBMK-LJZWMIMPSA-N (2s)-2-[[(2s)-2-[[2-[[(2s,3s)-2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound NC(N)=NCCC[C@@H](C(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 MWOGMBZGFFZBMK-LJZWMIMPSA-N 0.000 claims 6
- 125000003277 amino group Chemical group 0.000 claims 6
- 108010088381 isoleucyl-lysyl-valyl-alanyl-valine Proteins 0.000 claims 6
- 238000002823 phage display Methods 0.000 claims 6
- 108010052768 tyrosyl-isoleucyl-glycyl-seryl-arginine Proteins 0.000 claims 6
- 230000002209 hydrophobic effect Effects 0.000 claims 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 4
- 235000001014 amino acid Nutrition 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 239000002609 medium Substances 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 239000004471 Glycine Substances 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 239000012736 aqueous medium Substances 0.000 claims 2
- 239000000693 micelle Substances 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 230000000975 bioactive effect Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52744203P | 2003-12-05 | 2003-12-05 | |
| US60/527,442 | 2003-12-05 | ||
| PCT/US2004/040546 WO2005056576A2 (en) | 2003-12-05 | 2004-12-06 | Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007535493A JP2007535493A (ja) | 2007-12-06 |
| JP2007535493A5 true JP2007535493A5 (https=) | 2008-06-26 |
| JP4741510B2 JP4741510B2 (ja) | 2011-08-03 |
Family
ID=34676744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006542793A Expired - Fee Related JP4741510B2 (ja) | 2003-12-05 | 2004-12-06 | 分岐ペプチド両親媒性物質、関連するエピトープ化合物およびその自己集合構造物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7452679B2 (https=) |
| EP (1) | EP1696944A4 (https=) |
| JP (1) | JP4741510B2 (https=) |
| KR (1) | KR20070004561A (https=) |
| CN (1) | CN1905893A (https=) |
| AU (1) | AU2004297211A1 (https=) |
| CA (1) | CA2549391A1 (https=) |
| MX (1) | MXPA06006387A (https=) |
| WO (1) | WO2005056576A2 (https=) |
Families Citing this family (52)
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| US11087873B2 (en) | 2000-05-18 | 2021-08-10 | Carefusion 303, Inc. | Context-aware healthcare notification system |
| US10353856B2 (en) | 2011-03-17 | 2019-07-16 | Carefusion 303, Inc. | Scalable communication system |
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| AU2003262760A1 (en) | 2002-08-21 | 2004-03-11 | Northwestern University | Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom |
| US7554021B2 (en) | 2002-11-12 | 2009-06-30 | Northwestern University | Composition and method for self-assembly and mineralization of peptide amphiphiles |
| AU2003298647A1 (en) | 2002-11-14 | 2004-06-15 | Claussen, Randal, C. | Synthesis and self-assembly of abc triblock bola peptide |
| EP1606065A4 (en) * | 2003-02-11 | 2010-09-29 | Univ Northwestern | METHOD AND MATERIALS FOR NANOCRYSTALLINE SURFACE COATINGS AND ATTACHMENT OF AMPHIPHILENE PEPTIDE NANO FIBERS THEREOF |
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| EP2545072B1 (en) * | 2010-03-12 | 2017-11-22 | The Regents of The University of California | Lipid-peptide-polymer conjugates and nanoparticles thereof |
| US8546338B2 (en) | 2010-12-08 | 2013-10-01 | Johnson & Johnson Consumer Companies, Inc. | Self-assembling hydrogels based on dicephalic peptide amphiphiles |
| US9949927B2 (en) | 2012-04-10 | 2018-04-24 | The Regents Of The University Of California | Bis-polymer lipid-peptide conjugates and nanoparticles thereof |
| US9169294B2 (en) * | 2013-03-11 | 2015-10-27 | Northwestern University | Anti-angiogenic molecules, nanostructures and uses thereof |
| CN114267429A (zh) | 2013-03-13 | 2022-04-01 | 康尔福盛303公司 | 预测性用药安全 |
| ES2831801T3 (es) | 2013-03-13 | 2021-06-09 | Carefusion 303 Inc | Sistema de gestión de medicaciones específicas para el paciente |
| US9821278B2 (en) | 2014-08-25 | 2017-11-21 | The Governors Of The University Of Alberta | Functionalized beta-sheet peptide stabilized membrane proteins, constructs comprising same, and methods of forming and using same |
| US20160159869A1 (en) | 2014-12-09 | 2016-06-09 | Northwestern University | Bmp-2-binding peptide amphiphile nanofibers |
| DE102015000363A1 (de) | 2015-01-20 | 2016-07-21 | Emc Microcollections Gmbh | Neue modular funktionalisierbare Peptid-Hydrogele |
| US11867696B2 (en) | 2015-02-06 | 2024-01-09 | Cell Idx, Inc. | Antigen-coupled immunoreagents |
| US20170051016A1 (en) | 2015-08-17 | 2017-02-23 | Northwestern University | Anti-inflammatory nanofibers |
| CN118271422A (zh) * | 2015-08-28 | 2024-07-02 | 分子传递有限公司 | 转染络合物和其使用方法 |
| EP3362079B1 (en) | 2015-10-14 | 2022-04-06 | Northwestern University | Nanofiber paste for growth factor delivery and bone regeneration |
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| US10738294B2 (en) | 2016-09-26 | 2020-08-11 | Northwestern University | Tissue factor (TF)—targeted nanotherapy |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| WO2018075885A1 (en) | 2016-10-21 | 2018-04-26 | Northwestern University | Anti-microbial supramolecular structures |
| US11174288B2 (en) | 2016-12-06 | 2021-11-16 | Northeastern University | Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria |
| WO2019195741A1 (en) | 2018-04-06 | 2019-10-10 | Northwestern University | Bdnf mimetic peptide amphiphiles |
| WO2019200326A1 (en) | 2018-04-13 | 2019-10-17 | Rarecyte, Inc. | Kits for labeling of biomarkers and methods of using the same |
| WO2019200298A1 (en) | 2018-04-13 | 2019-10-17 | Northwestern University | Nanomolecules for the treatment of inflammatory bowel diseases |
| WO2020154631A1 (en) | 2019-01-24 | 2020-07-30 | Northwestern University | Dynamics within supramolecular 1kvav matrices enhance functional maturation of human ipscs-der1ved neurons and regeneration |
| US12214076B2 (en) | 2019-02-18 | 2025-02-04 | Northwestern University | Drug delivery vehicles for atherosclerosis nanomedicine |
| CN110917136B (zh) * | 2019-11-25 | 2021-08-24 | 中国人民解放军陆军军医大学 | 一种抗肿瘤的纳米乳佐剂鼻腔粘膜疫苗及其制备方法 |
| US11964000B2 (en) | 2020-04-10 | 2024-04-23 | Northwestern University | Cancer treatment methods using nanofiber stabilized growth factors |
| US12247063B2 (en) | 2020-07-13 | 2025-03-11 | Northwestern University | Cell surface modification by coating with peptide amphiphiles (PAs) |
| US11998589B2 (en) | 2020-07-13 | 2024-06-04 | Northwestern University | PEGylated peptide amphiphile nanofibers and methods of use |
| US12116461B2 (en) | 2020-08-21 | 2024-10-15 | Northwestern University | Host-guest interactions for pa superstructure formation |
| WO2023010082A1 (en) | 2021-07-29 | 2023-02-02 | Northwestern University | SELF-ASSEMBLING PEPTIDE AMPHIPHILES DISPLAYING A TRANSFORMING GROWTH FACTOR BETA 1 (TGF-β1) MIMETIC EPITOPE |
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| AU2003222167A1 (en) | 2002-04-02 | 2003-10-20 | Northwestern University | Peptide amphiphile solutions and self assembled peptide nanofiber networks |
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| AU2003304280A1 (en) * | 2002-11-12 | 2005-01-21 | Northwestern University | Composition and method for self-assembly and mineralization of peptide amphiphiles |
| US7554021B2 (en) * | 2002-11-12 | 2009-06-30 | Northwestern University | Composition and method for self-assembly and mineralization of peptide amphiphiles |
| AU2003298647A1 (en) | 2002-11-14 | 2004-06-15 | Claussen, Randal, C. | Synthesis and self-assembly of abc triblock bola peptide |
| EP1606065A4 (en) * | 2003-02-11 | 2010-09-29 | Univ Northwestern | METHOD AND MATERIALS FOR NANOCRYSTALLINE SURFACE COATINGS AND ATTACHMENT OF AMPHIPHILENE PEPTIDE NANO FIBERS THEREOF |
| EP1696944A4 (en) | 2003-12-05 | 2008-11-05 | Univ Northwestern | BRANCHED PEPTIDE AMPHIPHILES, RELATED EPITOPES COMPOUNDS AND SELF-ASSOCIATED STRUCTURES THEREOF |
| US7544661B2 (en) * | 2003-12-05 | 2009-06-09 | Northwestern University | Self-assembling peptide amphiphiles and related methods for growth factor delivery |
| US20050214257A1 (en) | 2003-12-23 | 2005-09-29 | Northwestern University | Compositions and methods for controlling stem cell and tumor cell differentiation, growth, and formation |
| AU2006206194A1 (en) * | 2005-01-21 | 2006-07-27 | Northwestern University | Methods and compositions for encapsulation of cells |
| WO2006096614A2 (en) | 2005-03-04 | 2006-09-14 | Northwestern University | Angiogenic heparin binding peptide amphiphiles |
-
2004
- 2004-12-06 EP EP04817012A patent/EP1696944A4/en not_active Withdrawn
- 2004-12-06 AU AU2004297211A patent/AU2004297211A1/en not_active Abandoned
- 2004-12-06 MX MXPA06006387A patent/MXPA06006387A/es not_active Application Discontinuation
- 2004-12-06 KR KR1020067013465A patent/KR20070004561A/ko not_active Withdrawn
- 2004-12-06 WO PCT/US2004/040546 patent/WO2005056576A2/en not_active Ceased
- 2004-12-06 US US11/005,314 patent/US7452679B2/en not_active Expired - Fee Related
- 2004-12-06 CN CNA2004800406518A patent/CN1905893A/zh active Pending
- 2004-12-06 JP JP2006542793A patent/JP4741510B2/ja not_active Expired - Fee Related
- 2004-12-06 CA CA002549391A patent/CA2549391A1/en not_active Abandoned
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