KR20070004561A - 분지형 펩티드 친양매성 화합물들, 그들의 관련된 에피토프화합물들 및 자가조립된 구조들 - Google Patents
분지형 펩티드 친양매성 화합물들, 그들의 관련된 에피토프화합물들 및 자가조립된 구조들 Download PDFInfo
- Publication number
- KR20070004561A KR20070004561A KR1020067013465A KR20067013465A KR20070004561A KR 20070004561 A KR20070004561 A KR 20070004561A KR 1020067013465 A KR1020067013465 A KR 1020067013465A KR 20067013465 A KR20067013465 A KR 20067013465A KR 20070004561 A KR20070004561 A KR 20070004561A
- Authority
- KR
- South Korea
- Prior art keywords
- peptide
- compounds
- compound
- bound
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 151
- 150000001875 compounds Chemical class 0.000 title claims abstract description 55
- 150000002634 lipophilic molecules Chemical class 0.000 title claims description 60
- 125000003277 amino group Chemical group 0.000 claims abstract description 20
- 235000001014 amino acid Nutrition 0.000 claims description 44
- 150000001413 amino acids Chemical class 0.000 claims description 43
- 230000002209 hydrophobic effect Effects 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 29
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 25
- 239000004472 Lysine Substances 0.000 claims description 25
- 230000027455 binding Effects 0.000 claims description 22
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 15
- 239000000693 micelle Substances 0.000 claims description 15
- 125000000217 alkyl group Chemical group 0.000 claims description 11
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 10
- 125000000539 amino acid group Chemical group 0.000 claims description 10
- -1 amphiphile compound Chemical class 0.000 claims description 9
- 230000000975 bioactive effect Effects 0.000 claims description 9
- MWOGMBZGFFZBMK-LJZWMIMPSA-N (2s)-2-[[(2s)-2-[[2-[[(2s,3s)-2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound NC(N)=NCCC[C@@H](C(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 MWOGMBZGFFZBMK-LJZWMIMPSA-N 0.000 claims description 8
- 239000000523 sample Substances 0.000 claims description 8
- 108010052768 tyrosyl-isoleucyl-glycyl-seryl-arginine Proteins 0.000 claims description 8
- XQQUSYWGKLRJRA-RABCQHRBSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s,3s)-2-amino-3-methylpentanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-3-methylbutanoic acid Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(O)=O XQQUSYWGKLRJRA-RABCQHRBSA-N 0.000 claims description 7
- 108010088381 isoleucyl-lysyl-valyl-alanyl-valine Proteins 0.000 claims description 7
- 239000004471 Glycine Substances 0.000 claims description 5
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 5
- 235000004279 alanine Nutrition 0.000 claims description 5
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 4
- 238000002823 phage display Methods 0.000 claims description 4
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 3
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 3
- 239000003153 chemical reaction reagent Substances 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 2
- 238000002372 labelling Methods 0.000 claims 5
- 239000002609 medium Substances 0.000 claims 4
- 239000012736 aqueous medium Substances 0.000 claims 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 150000003018 phosphorus compounds Chemical class 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract description 10
- 230000008878 coupling Effects 0.000 abstract description 3
- 238000010168 coupling process Methods 0.000 abstract description 3
- 238000005859 coupling reaction Methods 0.000 abstract description 3
- 239000002121 nanofiber Substances 0.000 description 34
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical group N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 26
- 235000018977 lysine Nutrition 0.000 description 25
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 18
- 210000004027 cell Anatomy 0.000 description 17
- 102000004196 processed proteins & peptides Human genes 0.000 description 14
- 229960002685 biotin Drugs 0.000 description 13
- 235000020958 biotin Nutrition 0.000 description 13
- 239000011616 biotin Substances 0.000 description 13
- 150000001412 amines Chemical group 0.000 description 12
- 238000001338 self-assembly Methods 0.000 description 11
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 10
- 230000021164 cell adhesion Effects 0.000 description 10
- NNRFRJQMBSBXGO-CIUDSAMLSA-N (3s)-3-[[2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-oxobutanoic acid Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O NNRFRJQMBSBXGO-CIUDSAMLSA-N 0.000 description 9
- 230000015572 biosynthetic process Effects 0.000 description 9
- 125000000524 functional group Chemical group 0.000 description 9
- 239000000499 gel Substances 0.000 description 9
- 125000006239 protecting group Chemical group 0.000 description 9
- 230000008901 benefit Effects 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 8
- 239000003446 ligand Substances 0.000 description 7
- 239000011347 resin Substances 0.000 description 7
- 229920005989 resin Polymers 0.000 description 7
- 108090001008 Avidin Proteins 0.000 description 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- 101000829980 Homo sapiens Ral guanine nucleotide dissociation stimulator Proteins 0.000 description 6
- 102100023320 Ral guanine nucleotide dissociation stimulator Human genes 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 239000000835 fiber Substances 0.000 description 6
- 108010081400 fluorescein isothiocyante avidin Proteins 0.000 description 6
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 6
- 230000001413 cellular effect Effects 0.000 description 5
- 238000013461 design Methods 0.000 description 5
- 102000005962 receptors Human genes 0.000 description 5
- 108020003175 receptors Proteins 0.000 description 5
- 238000004627 transmission electron microscopy Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000010647 peptide synthesis reaction Methods 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 125000004042 4-aminobutyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] 0.000 description 3
- 235000021314 Palmitic acid Nutrition 0.000 description 3
- WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000004132 cross linking Methods 0.000 description 3
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 3
- 238000010511 deprotection reaction Methods 0.000 description 3
- 239000007850 fluorescent dye Substances 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 238000011065 in-situ storage Methods 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 238000002595 magnetic resonance imaging Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000007790 solid phase Substances 0.000 description 3
- 238000010532 solid phase synthesis reaction Methods 0.000 description 3
- 238000010189 synthetic method Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 238000004630 atomic force microscopy Methods 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 238000006664 bond formation reaction Methods 0.000 description 2
- 230000024245 cell differentiation Effects 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000000978 circular dichroism spectroscopy Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 2
- 210000002744 extracellular matrix Anatomy 0.000 description 2
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 2
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 230000004962 physiological condition Effects 0.000 description 2
- 108010039042 prolyl-histidyl-seryl-arginyl-asparagine Proteins 0.000 description 2
- 238000010791 quenching Methods 0.000 description 2
- 230000000171 quenching effect Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 230000008467 tissue growth Effects 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- MZHROOGPARRVHS-UHFFFAOYSA-N triacetylene Chemical group C#CC#CC#C MZHROOGPARRVHS-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- YPTNAIDIXCOZAJ-LHEWISCISA-N (2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-6-[[(4-methylphenyl)-diphenylmethyl]amino]hexanoic acid Chemical compound C1=CC(C)=CC=C1C(C=1C=CC=CC=1)(C=1C=CC=CC=1)NCCCC[C@@H](C(O)=O)NC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21 YPTNAIDIXCOZAJ-LHEWISCISA-N 0.000 description 1
- BLCJBICVQSYOIF-UHFFFAOYSA-N 2,2-diaminobutanoic acid Chemical compound CCC(N)(N)C(O)=O BLCJBICVQSYOIF-UHFFFAOYSA-N 0.000 description 1
- PECYZEOJVXMISF-UHFFFAOYSA-N 3-aminoalanine Chemical compound [NH3+]CC(N)C([O-])=O PECYZEOJVXMISF-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 108050001049 Extracellular proteins Proteins 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 102000016359 Fibronectins Human genes 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 101710167839 Morphogenetic protein Proteins 0.000 description 1
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 1
- 238000003917 TEM image Methods 0.000 description 1
- 108010031318 Vitronectin Proteins 0.000 description 1
- 102100035140 Vitronectin Human genes 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 108010089975 arginyl-glycyl-aspartyl-serine Proteins 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000003592 biomimetic effect Effects 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 230000005859 cell recognition Effects 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000005660 hydrophilic surface Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 102000006495 integrins Human genes 0.000 description 1
- 108010044426 integrins Proteins 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- IYDGMDWEHDFVQI-UHFFFAOYSA-N phosphoric acid;trioxotungsten Chemical compound O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.OP(O)(O)=O IYDGMDWEHDFVQI-UHFFFAOYSA-N 0.000 description 1
- BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000002278 reconstructive surgery Methods 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 238000002390 rotary evaporation Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 239000002109 single walled nanotube Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- ATHGHQPFGPMSJY-UHFFFAOYSA-Q spermidine(3+) Chemical compound [NH3+]CCCC[NH2+]CCC[NH3+] ATHGHQPFGPMSJY-UHFFFAOYSA-Q 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 229940126577 synthetic vaccine Drugs 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/641—Branched, dendritic or hypercomb peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Nanotechnology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52744203P | 2003-12-05 | 2003-12-05 | |
| US60/527,442 | 2003-12-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20070004561A true KR20070004561A (ko) | 2007-01-09 |
Family
ID=34676744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020067013465A Withdrawn KR20070004561A (ko) | 2003-12-05 | 2004-12-06 | 분지형 펩티드 친양매성 화합물들, 그들의 관련된 에피토프화합물들 및 자가조립된 구조들 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7452679B2 (https=) |
| EP (1) | EP1696944A4 (https=) |
| JP (1) | JP4741510B2 (https=) |
| KR (1) | KR20070004561A (https=) |
| CN (1) | CN1905893A (https=) |
| AU (1) | AU2004297211A1 (https=) |
| CA (1) | CA2549391A1 (https=) |
| MX (1) | MXPA06006387A (https=) |
| WO (1) | WO2005056576A2 (https=) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10029047B2 (en) | 2013-03-13 | 2018-07-24 | Carefusion 303, Inc. | Patient-specific medication management system |
| US10867265B2 (en) | 2013-03-13 | 2020-12-15 | Carefusion 303, Inc. | Predictive medication safety |
| US10983946B2 (en) | 2011-03-17 | 2021-04-20 | Carefusion 303, Inc. | Scalable communication system |
| US11087873B2 (en) | 2000-05-18 | 2021-08-10 | Carefusion 303, Inc. | Context-aware healthcare notification system |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7491690B2 (en) | 2001-11-14 | 2009-02-17 | Northwestern University | Self-assembly and mineralization of peptide-amphiphile nanofibers |
| AU2003215280A1 (en) | 2002-02-15 | 2003-09-09 | Northwestern University | Self-assembly of peptide-amphiphile nanofibers under physiological conditions |
| WO2004018628A2 (en) * | 2002-08-21 | 2004-03-04 | Northwestern University | Charged peptide-amphiphile solutions & self-assembled peptide nanofiber networks formed therefrom |
| US7554021B2 (en) | 2002-11-12 | 2009-06-30 | Northwestern University | Composition and method for self-assembly and mineralization of peptide amphiphiles |
| US7683025B2 (en) | 2002-11-14 | 2010-03-23 | Northwestern University | Synthesis and self-assembly of ABC triblock bola peptide amphiphiles |
| WO2004072104A2 (en) * | 2003-02-11 | 2004-08-26 | Northwestern University | Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon |
| AU2004297211A1 (en) | 2003-12-05 | 2005-06-23 | Northwestern University | Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof |
| ES2380340T3 (es) | 2003-12-05 | 2012-05-10 | Northwestern University | Anfífilos peptídicos auto-ensamblantes y métodos relacionados para la administración de factores de crecimiento |
| US7923109B2 (en) * | 2004-01-05 | 2011-04-12 | Board Of Regents, The University Of Texas System | Inorganic nanowires |
| CN101150954A (zh) * | 2005-01-21 | 2008-03-26 | 西北大学 | 包封细胞的方法和组合物 |
| MX2007010771A (es) | 2005-03-04 | 2008-03-10 | Univ Northwestern | Anfifilos peptidicos para union a heparina angiogenicos. |
| US20070154946A1 (en) * | 2005-12-29 | 2007-07-05 | Rajasekaran John J | Massively parallel synthesis of biopolymeric arrays |
| US8834840B1 (en) * | 2006-10-04 | 2014-09-16 | Northwestern University | Magnetic resonance imaging of self-assembled biomaterial scaffolds |
| US7622295B2 (en) * | 2006-12-19 | 2009-11-24 | Edelmira Cabezas | Molecular microarrays and helical peptides |
| US8772228B2 (en) * | 2007-02-14 | 2014-07-08 | Northwestern University | Aligned nanofibers and related methods of use |
| US8076295B2 (en) | 2007-04-17 | 2011-12-13 | Nanotope, Inc. | Peptide amphiphiles having improved solubility and methods of using same |
| WO2009026233A2 (en) * | 2007-08-17 | 2009-02-26 | Northwestern University | Self assembling peptide systems and methods |
| US9457056B2 (en) * | 2007-12-04 | 2016-10-04 | Ben-Gurion University Of The Negev Research And Development Authority | Peptides comprising alternating hydrophobic and anionic amino acids for treatment of osteoporosis |
| WO2010111652A2 (en) * | 2009-03-27 | 2010-09-30 | Kansas State University Research Foundation | Branched amphipathic oligo-peptides that self-assemble into vesicles |
| WO2010120830A1 (en) | 2009-04-13 | 2010-10-21 | Northwestern University | Novel peptide-based scaffolds for cartilage regeneration and methods for their use |
| US20100322979A1 (en) * | 2009-06-22 | 2010-12-23 | University Of South Carolina | Peptidomimetic Resorbable Peptide-Polymer Hybrid Polyester Nanoparticles |
| ES2659409T3 (es) * | 2010-03-12 | 2018-03-15 | The Regents Of The University Of California | Conjugados de lípido-péptido-polímero y nanopartículas de los mismos |
| US8546338B2 (en) | 2010-12-08 | 2013-10-01 | Johnson & Johnson Consumer Companies, Inc. | Self-assembling hydrogels based on dicephalic peptide amphiphiles |
| US9949927B2 (en) | 2012-04-10 | 2018-04-24 | The Regents Of The University Of California | Bis-polymer lipid-peptide conjugates and nanoparticles thereof |
| US9169294B2 (en) * | 2013-03-11 | 2015-10-27 | Northwestern University | Anti-angiogenic molecules, nanostructures and uses thereof |
| CN107074916A (zh) | 2014-08-25 | 2017-08-18 | 艾伯塔大学校董 | 官能化β折叠肽稳定的膜蛋白、包含其的构建体以及形成和使用其的方法 |
| US20160159869A1 (en) | 2014-12-09 | 2016-06-09 | Northwestern University | Bmp-2-binding peptide amphiphile nanofibers |
| DE102015000363A1 (de) | 2015-01-20 | 2016-07-21 | Emc Microcollections Gmbh | Neue modular funktionalisierbare Peptid-Hydrogele |
| JP7297408B2 (ja) | 2015-02-06 | 2023-06-26 | セル アイディーエックス， インコーポレイテッド | 抗原をカップリングさせた免疫試薬 |
| US20170051016A1 (en) | 2015-08-17 | 2017-02-23 | Northwestern University | Anti-inflammatory nanofibers |
| EP4710943A3 (en) | 2015-08-28 | 2026-04-29 | Molecular Transfer, Inc. | Transfection complexes and methods of using the same |
| CN108289926A (zh) | 2015-10-14 | 2018-07-17 | 西北大学 | 用于生长因子递送和骨再生的纳米纤维糊剂 |
| US12123874B2 (en) * | 2016-07-18 | 2024-10-22 | Cell Idx, Inc. | Reagent compounds, compositions, kits, and methods for amplified assays |
| US10738294B2 (en) | 2016-09-26 | 2020-08-11 | Northwestern University | Tissue factor (TF)—targeted nanotherapy |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| WO2018075885A1 (en) | 2016-10-21 | 2018-04-26 | Northwestern University | Anti-microbial supramolecular structures |
| US11174288B2 (en) | 2016-12-06 | 2021-11-16 | Northeastern University | Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria |
| US12122811B2 (en) | 2018-04-06 | 2024-10-22 | Northwestern University | BDNF mimetic peptide amphiphiles |
| WO2019200298A1 (en) | 2018-04-13 | 2019-10-17 | Northwestern University | Nanomolecules for the treatment of inflammatory bowel diseases |
| US10871485B2 (en) | 2018-04-13 | 2020-12-22 | Rarecyte, Inc. | Kits for labeling of biomarkers and methods of using the same |
| JP7560884B2 (ja) | 2019-01-24 | 2024-10-03 | ノースウエスタン ユニバーシティ | 超分子ｉｋｖａｖマトリックス内の動力学は、ヒトｉｐｓｃ由来のニューロンの機能的成熟と再生を増強する |
| US12214076B2 (en) | 2019-02-18 | 2025-02-04 | Northwestern University | Drug delivery vehicles for atherosclerosis nanomedicine |
| CN110917136B (zh) * | 2019-11-25 | 2021-08-24 | 中国人民解放军陆军军医大学 | 一种抗肿瘤的纳米乳佐剂鼻腔粘膜疫苗及其制备方法 |
| US11964000B2 (en) | 2020-04-10 | 2024-04-23 | Northwestern University | Cancer treatment methods using nanofiber stabilized growth factors |
| US12247063B2 (en) | 2020-07-13 | 2025-03-11 | Northwestern University | Cell surface modification by coating with peptide amphiphiles (PAs) |
| US11998589B2 (en) | 2020-07-13 | 2024-06-04 | Northwestern University | PEGylated peptide amphiphile nanofibers and methods of use |
| US12116461B2 (en) | 2020-08-21 | 2024-10-15 | Northwestern University | Host-guest interactions for pa superstructure formation |
| CA3225407A1 (en) | 2021-07-29 | 2023-02-02 | Shelby Chi YUAN | Self-assembling peptide amphiphiles displaying a transforming growth factor beta 1 (tgf-.beta.1) mimetic epitope |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| US5130123A (en) | 1981-03-04 | 1992-07-14 | The University Of Melbourne | Dentifrice |
| US4930077A (en) | 1987-04-06 | 1990-05-29 | Fan David P | Information processing expert system for text analysis and predicting public opinion based information available to the public |
| US5128319A (en) | 1987-08-28 | 1992-07-07 | Board Of Regents, The University Of Texas System | Prophylaxis and therapy of acquired immunodeficiency syndrome |
| JPH0399096A (ja) | 1989-09-11 | 1991-04-24 | Agency Of Ind Science & Technol | 短繊維型螺旋状分子会合体の長さ制御方法 |
| DE4026978A1 (de) | 1990-08-25 | 1992-02-27 | Bayer Ag | Auf traegern angebrachte ein- oder mehrlagige schichtelemente und ihre herstellung |
| CA2109085C (en) | 1991-04-25 | 2003-03-11 | Keith E. Dionne | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products |
| US5580563A (en) * | 1992-05-01 | 1996-12-03 | Tam; James P. | Multiple antigen peptide system having adjuvant properties, vaccines prepared therefrom and methods of use thereof |
| GB9215780D0 (en) | 1992-07-24 | 1992-09-09 | Univ London Pharmacy | Peptide compounds |
| US5955343A (en) | 1992-12-28 | 1999-09-21 | Massachusetts Institute Of Technology | Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor |
| US5670483A (en) | 1992-12-28 | 1997-09-23 | Massachusetts Insititute Of Technology | Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US6410690B1 (en) | 1995-06-07 | 2002-06-25 | Medarex, Inc. | Therapeutic compounds comprised of anti-Fc receptor antibodies |
| JPH11510837A (ja) | 1995-07-28 | 1999-09-21 | フォーカル，インコーポレイテッド | 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル |
| FR2739860B1 (fr) | 1995-10-17 | 1998-01-02 | Coletica | Complexes amphiphiles, procede pour leur preparation et compositions en renfermant |
| SE9504347D0 (sv) | 1995-12-01 | 1995-12-01 | Boerje Sellergren | Surface modification technique |
| US6051272A (en) | 1996-03-15 | 2000-04-18 | The Board Of Trustees Of The University Of Illinois | Method for synthesizing organoapatites on to surgical metal alloys |
| US5733868A (en) | 1996-04-16 | 1998-03-31 | Depuy Orthopaedics, Inc. | Poly(amino acid) adhesive tissue grafts |
| US6085206A (en) | 1996-06-20 | 2000-07-04 | Microsoft Corporation | Method and system for verifying accuracy of spelling and grammatical composition of a document |
| US5993541A (en) | 1996-07-31 | 1999-11-30 | Geo Centers Inc | Process for nucleation of ceramics and product thereof |
| US6096863A (en) | 1996-08-23 | 2000-08-01 | Regents Of The University Of Minnesota | Self-assembling amphiphiles for construction of peptide secondary structures |
| US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| BR9806793A (pt) | 1997-01-22 | 2000-05-16 | Univ Texas | Processos e composições de fator tissular para coagulação e tratamento de tumores. |
| US6331406B1 (en) | 1997-03-31 | 2001-12-18 | The John Hopkins University School Of Medicine | Human enbryonic germ cell and methods of use |
| US6181909B1 (en) | 1997-07-22 | 2001-01-30 | Educational Testing Service | System and method for computer-based automatic essay scoring |
| US6269368B1 (en) | 1997-10-17 | 2001-07-31 | Textwise Llc | Information retrieval using dynamic evidence combination |
| CA2312847C (en) | 1997-12-02 | 2014-09-30 | Zen Bio, Inc. | Differentiation of adipose stromal cells into osteoblasts and uses thereof |
| GB9801061D0 (en) | 1998-01-20 | 1998-03-18 | Univ Nottingham | Patterning technique |
| US6548048B1 (en) | 1998-04-28 | 2003-04-15 | Amersham Health As | Lipopeptide stabilized microbubbles as diagnostic/therapeutic agents |
| DK1107791T3 (da) | 1998-09-04 | 2007-09-03 | Scios Inc | Hydrogelpræparater til controlled release-administration af vækstfaktorer |
| ES2368988T3 (es) | 1999-02-01 | 2011-11-24 | Eidgenössische Technische Hochschule Zürich | Bio-materiales formados por reacción de adición nucleófila a grupos insaturados conjugados. |
| CA2361612A1 (en) | 1999-02-02 | 2000-08-10 | Thomas Jefferson University | Peptides modulating activities of heparin, other glycosaminoglycans or proteoglycans |
| WO2000052145A2 (en) | 1999-03-02 | 2000-09-08 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Embryonic or stem-like cell lines produced by cross species nuclear transplantation |
| US6473730B1 (en) | 1999-04-12 | 2002-10-29 | The Trustees Of Columbia University In The City Of New York | Method and system for topical segmentation, segment significance and segment function |
| AU3438199A (en) | 1999-04-22 | 2000-11-10 | Eth Zurich | Controlled release of growth factors from heparin containing matrices |
| CN1362965A (zh) | 1999-06-30 | 2002-08-07 | 先进细胞技术公司 | 细胞质转移使受体细胞去分化 |
| US6444723B1 (en) | 1999-11-10 | 2002-09-03 | The United States Of America As Represented By The Secretary Of Commerce | Crosslinked micellar gel composition |
| US6689165B2 (en) | 2000-03-31 | 2004-02-10 | Board Of Supervisors Of Louisana State University And Agricultural And Mechanical College | Surface modifications for enhanced epithelialization |
| CN1439023A (zh) | 2000-04-28 | 2003-08-27 | 国立爱尔兰都柏林大学 | 两亲大环衍生物及其类似物 |
| AU2001261506A1 (en) | 2000-05-11 | 2001-11-20 | University Of Southern California | Discourse parsing and summarization |
| EP1355965B1 (en) | 2000-10-19 | 2012-09-19 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Method of synthesizing block copolymers for multifunctional self-assembled systems |
| WO2002059857A1 (en) | 2001-01-23 | 2002-08-01 | Educational Testing Service | Methods for automated essay analysis |
| US7449180B2 (en) * | 2001-02-06 | 2008-11-11 | John Kisiday | Macroscopic scaffold containing amphiphilic peptides encapsulating cells |
| EP1367961B1 (en) | 2001-02-06 | 2008-12-31 | Massachusetts Institute Of Technology | Peptide scaffold encapsulation of tissue cells and uses thereof |
| WO2003006043A1 (en) | 2001-07-10 | 2003-01-23 | Massachusetts Institute Of Technology | Surfactant peptide nanostructures, and uses thereof |
| DE20111889U1 (de) | 2001-07-18 | 2001-10-18 | Jack Wolfskin Ausrüstung für Draussen GmbH, 65510 Idstein | Gurt sowie mit einem solchen Gurt ausgestattetes Behältnis |
| US20050260179A1 (en) | 2001-11-06 | 2005-11-24 | The General Hospital Corporation D/B/A Massachusetts General Hospital | Stem and progenitor cell capture for tissue regeneration |
| US7491690B2 (en) | 2001-11-14 | 2009-02-17 | Northwestern University | Self-assembly and mineralization of peptide-amphiphile nanofibers |
| AU2003215280A1 (en) | 2002-02-15 | 2003-09-09 | Northwestern University | Self-assembly of peptide-amphiphile nanofibers under physiological conditions |
| WO2003084980A2 (en) | 2002-04-02 | 2003-10-16 | Northwestern University | Peptide amphiphile solutions and self assembled peptide nanofiber networks |
| WO2003090255A2 (en) | 2002-04-18 | 2003-10-30 | Northwestern University | Encapsulation of nanotubes via self-assembled nanostructures |
| WO2004003561A1 (en) * | 2002-06-27 | 2004-01-08 | Northwestern University | Peptide rod amphiphiles and self-assembly of same |
| WO2004024778A2 (en) | 2002-07-23 | 2004-03-25 | Northwestern University | Self-assembled hybrid compositions and method of making, using and ordering same |
| WO2004018628A2 (en) * | 2002-08-21 | 2004-03-04 | Northwestern University | Charged peptide-amphiphile solutions & self-assembled peptide nanofiber networks formed therefrom |
| WO2004106359A2 (en) * | 2002-09-23 | 2004-12-09 | Northwestern University | Self-assembled peptide-amphiphiles & self-assembled peptide nanofiber networks presenting multiple signals |
| AU2003304280A1 (en) * | 2002-11-12 | 2005-01-21 | Northwestern University | Composition and method for self-assembly and mineralization of peptide amphiphiles |
| US7554021B2 (en) | 2002-11-12 | 2009-06-30 | Northwestern University | Composition and method for self-assembly and mineralization of peptide amphiphiles |
| US7683025B2 (en) | 2002-11-14 | 2010-03-23 | Northwestern University | Synthesis and self-assembly of ABC triblock bola peptide amphiphiles |
| WO2004072104A2 (en) | 2003-02-11 | 2004-08-26 | Northwestern University | Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon |
| AU2004297211A1 (en) | 2003-12-05 | 2005-06-23 | Northwestern University | Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof |
| ES2380340T3 (es) * | 2003-12-05 | 2012-05-10 | Northwestern University | Anfífilos peptídicos auto-ensamblantes y métodos relacionados para la administración de factores de crecimiento |
| US20050214257A1 (en) | 2003-12-23 | 2005-09-29 | Northwestern University | Compositions and methods for controlling stem cell and tumor cell differentiation, growth, and formation |
| CN101150954A (zh) * | 2005-01-21 | 2008-03-26 | 西北大学 | 包封细胞的方法和组合物 |
| MX2007010771A (es) | 2005-03-04 | 2008-03-10 | Univ Northwestern | Anfifilos peptidicos para union a heparina angiogenicos. |
-
2004
- 2004-12-06 AU AU2004297211A patent/AU2004297211A1/en not_active Abandoned
- 2004-12-06 JP JP2006542793A patent/JP4741510B2/ja not_active Expired - Fee Related
- 2004-12-06 KR KR1020067013465A patent/KR20070004561A/ko not_active Withdrawn
- 2004-12-06 MX MXPA06006387A patent/MXPA06006387A/es not_active Application Discontinuation
- 2004-12-06 CA CA002549391A patent/CA2549391A1/en not_active Abandoned
- 2004-12-06 EP EP04817012A patent/EP1696944A4/en not_active Withdrawn
- 2004-12-06 CN CNA2004800406518A patent/CN1905893A/zh active Pending
- 2004-12-06 US US11/005,314 patent/US7452679B2/en not_active Expired - Fee Related
- 2004-12-06 WO PCT/US2004/040546 patent/WO2005056576A2/en not_active Ceased
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11087873B2 (en) | 2000-05-18 | 2021-08-10 | Carefusion 303, Inc. | Context-aware healthcare notification system |
| US10983946B2 (en) | 2011-03-17 | 2021-04-20 | Carefusion 303, Inc. | Scalable communication system |
| US10029047B2 (en) | 2013-03-13 | 2018-07-24 | Carefusion 303, Inc. | Patient-specific medication management system |
| US10867265B2 (en) | 2013-03-13 | 2020-12-15 | Carefusion 303, Inc. | Predictive medication safety |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005056576A2 (en) | 2005-06-23 |
| EP1696944A2 (en) | 2006-09-06 |
| US7452679B2 (en) | 2008-11-18 |
| JP4741510B2 (ja) | 2011-08-03 |
| CN1905893A (zh) | 2007-01-31 |
| AU2004297211A1 (en) | 2005-06-23 |
| EP1696944A4 (en) | 2008-11-05 |
| MXPA06006387A (es) | 2006-09-04 |
| CA2549391A1 (en) | 2005-06-23 |
| WO2005056576A3 (en) | 2006-01-19 |
| US20050208589A1 (en) | 2005-09-22 |
| JP2007535493A (ja) | 2007-12-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7452679B2 (en) | Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof | |
| Mendes et al. | Self‐assembly in nature: using the principles of nature to create complex nanobiomaterials | |
| US8748569B2 (en) | Peptide amphiphiles and methods to electrostatically control bioactivity of the ikvav peptide epitope | |
| Cavalli et al. | Amphiphilic peptides and their cross-disciplinary role as building blocks for nanoscience | |
| US8076295B2 (en) | Peptide amphiphiles having improved solubility and methods of using same | |
| JP4851939B2 (ja) | 自己−集合性ペプチド両親媒性物質および増殖因子送達のための関連する方法 | |
| Toksöz et al. | Self-assembled peptidic nanostructures | |
| US20150218252A1 (en) | Self-assembling peptides, peptide nanostructures and uses thereof | |
| JP2001512739A (ja) | 抗生作用ペプチドから誘導される線状ペプチド、製法および活性物質を仲介する用途 | |
| JP2013525329A (ja) | 新規自己集合ペプチド、およびヒドロゲル形成におけるその使用 | |
| WO2004003561A9 (en) | Peptide rod amphiphiles and self-assembly of same | |
| WO2004106359A2 (en) | Self-assembled peptide-amphiphiles & self-assembled peptide nanofiber networks presenting multiple signals | |
| Boruah et al. | Advances in hybrid peptide-based self-assembly systems and their applications | |
| US20180030093A1 (en) | Self-assembling ultrashort aliphatic cyclic peptides for biomedical applications | |
| Kumar et al. | Self-assembling peptides: implications for patenting in drug delivery and tissue engineering | |
| Prakash Sharma et al. | Self-assembled peptide nanoarchitectures: applications and future aspects | |
| Ghosh et al. | Supramolecular self-assembled peptide-based nanostructures and their applications in biomedicine | |
| Luo et al. | Molecular-level design principles and strategies of peptide self-assembly nanomaterials: from sequence engineering to functional applications | |
| CN112826942B (zh) | 靶向颅脑损伤病灶的脂质纳米递药系统及其制备方法和应用 | |
| Adhikari et al. | Self-assembling peptides: from molecules to nanobiomaterials | |
| Ma et al. | Self-assembled nanofiber networks formed from biomineralization-directing genetically engineered peptides | |
| Cho | Self-Assembling Lipopeptide Nanocarriers for Targeted Cellular Uptake | |
| Williams | Enzyme assisted self-assembly | |
| Radmalekshahi | Self-assembled peptide nanostructures: production, structural characterization and in vivo application as cancer vaccine | |
| Bakota | Multidomain Peptides: Sequence-Nanostructure Relationships and Biological Applications |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20060704 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |