JP2007535470A5 - - Google Patents
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- Publication number
- JP2007535470A5 JP2007535470A5 JP2006505418A JP2006505418A JP2007535470A5 JP 2007535470 A5 JP2007535470 A5 JP 2007535470A5 JP 2006505418 A JP2006505418 A JP 2006505418A JP 2006505418 A JP2006505418 A JP 2006505418A JP 2007535470 A5 JP2007535470 A5 JP 2007535470A5
- Authority
- JP
- Japan
- Prior art keywords
- probnp
- antibody
- unmodified
- detection
- acc2654
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100036836 Natriuretic peptides B Human genes 0.000 claims description 20
- 101710187802 Natriuretic peptides B Proteins 0.000 claims description 20
- 238000001514 detection method Methods 0.000 claims 4
- 210000004408 hybridoma Anatomy 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 206010019280 Heart failures Diseases 0.000 claims 2
- 238000011895 specific detection Methods 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000002967 competitive immunoassay Methods 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 238000012417 linear regression Methods 0.000 claims 1
- 239000013610 patient sample Substances 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000009918 complex formation Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03010591 | 2003-05-12 | ||
| PCT/EP2004/005091 WO2004099252A1 (en) | 2003-05-12 | 2004-05-12 | Method of detecting native probnp with amonoclonal antibody binding to the amino acids 38-44 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007535470A JP2007535470A (ja) | 2007-12-06 |
| JP2007535470A5 true JP2007535470A5 (https=) | 2009-09-10 |
| JP4430066B2 JP4430066B2 (ja) | 2010-03-10 |
Family
ID=33427054
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006505419A Expired - Lifetime JP5128125B2 (ja) | 2003-05-12 | 2004-05-12 | アミノ酸４１〜４６に結合するモノクローナル抗体を用いたｐｒｏＢＮＰの検出方法 |
| JP2006505418A Expired - Lifetime JP4430066B2 (ja) | 2003-05-12 | 2004-05-12 | アミノ酸３８〜４４に結合するモノクローナル抗体を用いたｐｒｏＢＮＰの検出方法 |
| JP2009204610A Expired - Lifetime JP4834136B2 (ja) | 2003-05-12 | 2009-09-04 | アミノ酸４１〜４６に結合するモノクローナル抗体を用いたｐｒｏＢＮＰの検出方法 |
| JP2012222436A Expired - Lifetime JP5649631B2 (ja) | 2003-05-12 | 2012-10-04 | アミノ酸４１〜４６に結合するモノクローナル抗体を用いたｐｒｏＢＮＰの検出方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006505419A Expired - Lifetime JP5128125B2 (ja) | 2003-05-12 | 2004-05-12 | アミノ酸４１〜４６に結合するモノクローナル抗体を用いたｐｒｏＢＮＰの検出方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009204610A Expired - Lifetime JP4834136B2 (ja) | 2003-05-12 | 2009-09-04 | アミノ酸４１〜４６に結合するモノクローナル抗体を用いたｐｒｏＢＮＰの検出方法 |
| JP2012222436A Expired - Lifetime JP5649631B2 (ja) | 2003-05-12 | 2012-10-04 | アミノ酸４１〜４６に結合するモノクローナル抗体を用いたｐｒｏＢＮＰの検出方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US7264939B2 (https=) |
| EP (4) | EP1625164B1 (https=) |
| JP (4) | JP5128125B2 (https=) |
| KR (2) | KR100857752B1 (https=) |
| CN (3) | CN100497393C (https=) |
| AT (2) | ATE517124T1 (https=) |
| AU (1) | AU2004235974B2 (https=) |
| BR (1) | BRPI0410261B8 (https=) |
| CA (2) | CA2522747C (https=) |
| DK (3) | DK1625164T3 (https=) |
| ES (3) | ES2369008T3 (https=) |
| HU (1) | HUE025169T2 (https=) |
| MX (1) | MXPA05011826A (https=) |
| PL (3) | PL1625164T3 (https=) |
| WO (2) | WO2004099253A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2843396B1 (fr) * | 2002-08-07 | 2005-04-15 | Bio Rad Pasteur | Anticorps specifiques pour le diagnostic de l'insuffisance cardiaque |
| CN100497393C (zh) * | 2003-05-12 | 2009-06-10 | 霍夫曼-拉罗奇有限公司 | 用结合脑钠尿肽前体分子氨基酸41-46的单克隆抗体检测脑钠尿肽前体分子的方法 |
| US20070037208A1 (en) * | 2003-05-29 | 2007-02-15 | Foote Robert S | Method for detecting cardiac ischemia via changes in b-natriuretic peptide levels |
| DE10355731A1 (de) | 2003-11-28 | 2005-06-30 | Roche Diagnostics Gmbh | Analytischer Sandwichtest zur Bestimmung von NT-proBNP |
| ATE364177T1 (de) * | 2004-07-07 | 2007-06-15 | Hoffmann La Roche | Kombinationen von markern zum nachweis von typ 1 und 2 diabetes |
| AT500800B1 (de) * | 2004-09-08 | 2008-07-15 | Biomedica Medizinprodukte Gmbh | Verfahren zur bestimmung von probnp |
| CN106908603B (zh) | 2007-01-25 | 2019-04-02 | 霍夫曼-拉罗奇有限公司 | Igfbp-7在心力衰竭评估中的用途 |
| KR100836322B1 (ko) * | 2007-08-31 | 2008-06-09 | 현대자동차주식회사 | 차량용 흡음재 제작장치 및 방법 |
| US9482677B2 (en) | 2008-02-27 | 2016-11-01 | Scios Inc. | Method, composition and device for sampling natriuretic peptides in a biological fluid |
| ES2526928T3 (es) | 2008-04-30 | 2015-01-16 | The Governing Council Of The University Of Toronto | Uso de SFRP-3 en la evaluación de la insuficiencia cardíaca |
| CN102549436A (zh) | 2009-07-27 | 2012-07-04 | 霍夫曼-拉罗奇有限公司 | mimecan在评价心力衰竭中的用途 |
| CA2780301A1 (en) * | 2009-11-13 | 2011-05-19 | Bg Medicine, Inc. | Risk factors and prediction of myocardial infarction |
| US8778699B2 (en) | 2010-08-04 | 2014-07-15 | Idexx Laboratories, Inc. | Detection of degradation products of canine NT-proBNP |
| AU2012262154B2 (en) | 2011-05-31 | 2016-08-04 | Idexx Laboratories, Inc. | Detection of degradation products of feline NT-proBNP |
| JP6119607B2 (ja) * | 2011-09-20 | 2017-04-26 | コニカミノルタ株式会社 | 検体希釈用液、それを用いたキットおよび蛍光測定方法 |
| US20140273273A1 (en) | 2012-11-01 | 2014-09-18 | Christie Mitchell Ballantyne | Biomarkers to improve prediction of heart failure risk |
| CN103304665A (zh) * | 2013-05-21 | 2013-09-18 | 上海贝西生物科技有限公司 | 一种抗氨基末端脑利钠肽前体单克隆抗体及其应用 |
| EP3206032B1 (en) * | 2014-10-10 | 2019-02-27 | Akira Matsumori | Method for detecting cardiac failure patient, method for discrimination of cardiac disease, test reagent for cardiac failure, test kit for cardiac failure, device for detecting cardiac failure, and program for detecting cardiac failure |
| EP3360570A1 (en) | 2017-02-13 | 2018-08-15 | Roche Diagnostics GmbH | Antibodies recognizing genetic variants |
| ES2948008T3 (es) | 2017-10-02 | 2023-08-25 | Otsuka Pharma Co Ltd | Método para detectar analito |
| EP3779438A4 (en) * | 2018-04-13 | 2022-01-26 | Kyoritsu Seiyaku Corporation | PROCEDURE FOR DETECTING HEART FAILURE, INSTRUMENT FOR DETECTING HEART FAILURE, SANDWICH IMMUNOASSAY PROCEDURE AND ANTIBODY COMBINATION |
| CN108752480B (zh) * | 2018-05-30 | 2022-03-29 | 中元汇吉生物技术股份有限公司 | 一种免疫原组合物、其制备方法及其用途 |
| US12400762B2 (en) | 2018-12-11 | 2025-08-26 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy |
| US11446009B2 (en) | 2018-12-11 | 2022-09-20 | Eko.Ai Pte. Ltd. | Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images |
| US12322100B2 (en) | 2018-12-11 | 2025-06-03 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity |
| US12001939B2 (en) | 2018-12-11 | 2024-06-04 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views |
| US11931207B2 (en) | 2018-12-11 | 2024-03-19 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device |
| CN111487222B (zh) * | 2019-01-28 | 2023-11-14 | 上海乐合生物科技有限公司 | 一种检测bnp的spr芯片的制备方法 |
| EP4014041A1 (en) | 2019-08-13 | 2022-06-22 | Gentian AS | Highly sensitive particle enhanced assay for the quantification of nt-probnp |
| US20230366894A1 (en) * | 2020-09-30 | 2023-11-16 | Roche Diagnostics Operations, Inc. | Circulating total-nt-probnp (glycosylated and unglycosylated nt-probnp) and its ratio with nt-probnp (unglycosylated nt-probnp) in the assessment of atrial fibrillation |
| CN112964885B (zh) * | 2021-02-20 | 2022-11-11 | 广东菲鹏生物有限公司 | 一种氨基末端脑尿钠肽检测方法和试剂盒 |
| CN112986586A (zh) * | 2021-02-20 | 2021-06-18 | 广东菲鹏生物有限公司 | 一种氨基末端脑尿钠肽检测方法和试剂盒 |
| EP4409297B1 (en) | 2021-10-01 | 2025-01-29 | Gentian AS | Novel method for determining a concentration of n-terminal pro-hormone bnp (nt-probnp) in a sample |
| JP2025508481A (ja) | 2022-03-18 | 2025-03-26 | エフ． ホフマン－ラ ロシュ アーゲー | ２型対１型の急性心筋梗塞の早期識別のためのトロポニンマーカーの組合せ |
| US20250232875A1 (en) | 2022-03-18 | 2025-07-17 | Roche Diagnostics Operations, Inc. | Cmybpc marker combinations for early discrimination of type 2 versus type 1 acute myocardial infarction |
| WO2024219421A1 (ja) * | 2023-04-19 | 2024-10-24 | 栄研化学株式会社 | ＮＴ－ｐｒｏＢＮＰに対する抗体、これを用いたＮＴ－ｐｒｏＢＮＰ検出方法、並びに、ＮＴ－ｐｒｏＢＮＰ検出に用いるための組成物及びキット |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3445816C1 (de) | 1984-12-15 | 1986-06-12 | Behringwerke Ag, 3550 Marburg | Flaechenfoermiges diagnostisches Mittel |
| JP2665850B2 (ja) | 1991-11-14 | 1997-10-22 | 塩野義製薬株式会社 | ｈＢＮＰのＣ端を認識するモノクロ−ナル抗体 |
| GB9211686D0 (en) | 1992-06-03 | 1992-07-15 | Medisinsk Innovation A S | Chemical compounds |
| ES2256952T3 (es) * | 1997-09-11 | 2006-07-16 | SHIONOGI & CO., LTD. | Inmunoanalisis para bnp. |
| GB9827348D0 (en) * | 1998-12-12 | 1999-02-03 | Univ Leicester | Natriuretic peptide |
| PL204235B1 (pl) * | 1999-01-29 | 2009-12-31 | Roche Diagnostics Gmbh | Sposób wykrywania natywnego N-końcowego proBNP, zastosowanie tego sposobu, zastosowanie zrekombinowanego N-końcowego proBNP, przeciwciała przeciw zrekombinowanemu N-końcowemu proBNP, linie komórkowe i sposoby wytwarzania przeciwciał poliklonalnych i monoklonalnych |
| US20030219734A1 (en) | 2001-04-13 | 2003-11-27 | Biosite Incorporated | Polypeptides related to natriuretic peptides and methods of their identification and use |
| US20040096919A1 (en) * | 2002-11-18 | 2004-05-20 | Michelle Davey | Polyclonal-monoclonal ELISA assay for detecting N-terminus proBNP |
| CN100497393C (zh) * | 2003-05-12 | 2009-06-10 | 霍夫曼-拉罗奇有限公司 | 用结合脑钠尿肽前体分子氨基酸41-46的单克隆抗体检测脑钠尿肽前体分子的方法 |
-
2004
- 2004-05-12 CN CNB200480012494XA patent/CN100497393C/zh not_active Expired - Lifetime
- 2004-05-12 BR BRPI0410261A patent/BRPI0410261B8/pt not_active IP Right Cessation
- 2004-05-12 AT AT04732282T patent/ATE517124T1/de active
- 2004-05-12 EP EP04732282A patent/EP1625164B1/en not_active Expired - Lifetime
- 2004-05-12 CA CA2522747A patent/CA2522747C/en not_active Expired - Lifetime
- 2004-05-12 CN CNA2004800124973A patent/CN1784425A/zh active Pending
- 2004-05-12 PL PL04732282T patent/PL1625164T3/pl unknown
- 2004-05-12 AU AU2004235974A patent/AU2004235974B2/en not_active Expired
- 2004-05-12 EP EP15161853.5A patent/EP2949669A1/en not_active Ceased
- 2004-05-12 AT AT04732278T patent/ATE522546T1/de active
- 2004-05-12 WO PCT/EP2004/005092 patent/WO2004099253A1/en not_active Ceased
- 2004-05-12 JP JP2006505419A patent/JP5128125B2/ja not_active Expired - Lifetime
- 2004-05-12 DK DK04732282.1T patent/DK1625164T3/da active
- 2004-05-12 JP JP2006505418A patent/JP4430066B2/ja not_active Expired - Lifetime
- 2004-05-12 ES ES04732282T patent/ES2369008T3/es not_active Expired - Lifetime
- 2004-05-12 DK DK04732278.9T patent/DK1625163T3/da active
- 2004-05-12 KR KR1020057021327A patent/KR100857752B1/ko not_active Expired - Lifetime
- 2004-05-12 HU HUE10172014A patent/HUE025169T2/en unknown
- 2004-05-12 WO PCT/EP2004/005091 patent/WO2004099252A1/en not_active Ceased
- 2004-05-12 EP EP10172014.2A patent/EP2256132B1/en not_active Expired - Lifetime
- 2004-05-12 PL PL04732278T patent/PL1625163T3/pl unknown
- 2004-05-12 DK DK10172014.2T patent/DK2256132T3/en active
- 2004-05-12 EP EP04732278A patent/EP1625163B8/en not_active Expired - Lifetime
- 2004-05-12 ES ES10172014.2T patent/ES2548327T3/es not_active Expired - Lifetime
- 2004-05-12 CN CN2010101190838A patent/CN101967190A/zh active Pending
- 2004-05-12 PL PL10172014T patent/PL2256132T3/pl unknown
- 2004-05-12 MX MXPA05011826A patent/MXPA05011826A/es active IP Right Grant
- 2004-05-12 CA CA2522378A patent/CA2522378C/en not_active Expired - Lifetime
- 2004-05-12 ES ES04732278T patent/ES2372282T3/es not_active Expired - Lifetime
- 2004-05-12 KR KR1020087000782A patent/KR20080011467A/ko not_active Ceased
-
2005
- 2005-11-10 US US11/271,651 patent/US7264939B2/en not_active Expired - Lifetime
- 2005-11-10 US US11/271,138 patent/US7264938B2/en not_active Expired - Lifetime
-
2006
- 2006-12-05 US US11/634,286 patent/US7807380B2/en not_active Expired - Lifetime
- 2006-12-22 US US11/644,565 patent/US7811770B2/en not_active Expired - Lifetime
-
2009
- 2009-09-04 JP JP2009204610A patent/JP4834136B2/ja not_active Expired - Lifetime
-
2012
- 2012-10-04 JP JP2012222436A patent/JP5649631B2/ja not_active Expired - Lifetime
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