JP2007533752A5 - - Google Patents
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- Publication number
- JP2007533752A5 JP2007533752A5 JP2007509585A JP2007509585A JP2007533752A5 JP 2007533752 A5 JP2007533752 A5 JP 2007533752A5 JP 2007509585 A JP2007509585 A JP 2007509585A JP 2007509585 A JP2007509585 A JP 2007509585A JP 2007533752 A5 JP2007533752 A5 JP 2007533752A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- thiophen
- thiazol
- amino
- ylmethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 18
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 5
- 125000004861 4-isopropyl phenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- NXTGYHATIFGITI-UHFFFAOYSA-N 3-[[4-[4-(2-methylpropyl)phenyl]-1,3-thiazol-2-yl]-(thiophen-2-ylmethyl)amino]propanoic acid Chemical compound C1=CC(CC(C)C)=CC=C1C1=CSC(N(CCC(O)=O)CC=2SC=CC=2)=N1 NXTGYHATIFGITI-UHFFFAOYSA-N 0.000 claims 3
- -1 4-trifluoromethylphenyl 4-tert-butylphenyl 4-isobutylphenyl 1-naphthyl 4-ethoxyphenyl 4-isobutoxyphenyl biphenyl-3-yl Chemical group 0.000 claims 3
- KWMRBXXPVSCWNZ-UHFFFAOYSA-N 3-[[4-(4-propan-2-ylphenyl)-1,3-thiazol-2-yl]-(thiophen-2-ylmethyl)amino]propanoic acid Chemical compound C1=CC(C(C)C)=CC=C1C1=CSC(N(CCC(O)=O)CC=2SC=CC=2)=N1 KWMRBXXPVSCWNZ-UHFFFAOYSA-N 0.000 claims 2
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- XACTZCKPVYVENO-UHFFFAOYSA-N 3-[[4-(4-propan-2-ylphenyl)-1,3-thiazol-2-yl]-(3-thiophen-2-ylpropyl)amino]propanoic acid Chemical compound C1=CC(C(C)C)=CC=C1C1=CSC(N(CCCC=2SC=CC=2)CCC(O)=O)=N1 XACTZCKPVYVENO-UHFFFAOYSA-N 0.000 claims 1
- RDMLOXWOYWGKEK-UHFFFAOYSA-N 3-[[4-[4-(2-methylpropyl)phenyl]-1,3-thiazol-2-yl]-(thiophen-2-ylmethyl)amino]propanoic acid;hydrochloride Chemical compound Cl.C1=CC(CC(C)C)=CC=C1C1=CSC(N(CCC(O)=O)CC=2SC=CC=2)=N1 RDMLOXWOYWGKEK-UHFFFAOYSA-N 0.000 claims 1
- AXWLHIHHYWOTMM-UHFFFAOYSA-N 5-[[4-(4-propan-2-ylphenyl)-1,3-thiazol-2-yl]-(thiophen-2-ylmethyl)amino]pentanoic acid Chemical compound C1=CC(C(C)C)=CC=C1C1=CSC(N(CCCCC(O)=O)CC=2SC=CC=2)=N1 AXWLHIHHYWOTMM-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- CXTREVCLAXUGDL-UHFFFAOYSA-M sodium;3-[[4-(4-propan-2-ylphenyl)-1,3-thiazol-2-yl]-(thiophen-2-ylmethyl)amino]propanoate Chemical compound [Na+].C1=CC(C(C)C)=CC=C1C1=CSC(N(CCC([O-])=O)CC=2SC=CC=2)=N1 CXTREVCLAXUGDL-UHFFFAOYSA-M 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56388204P | 2004-04-20 | 2004-04-20 | |
| US60/563,882 | 2004-04-20 | ||
| PCT/US2005/013386 WO2005103022A1 (en) | 2004-04-20 | 2005-04-20 | Substituted thiazole and pyrimidine derivatives as melanocortin receptor modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007533752A JP2007533752A (ja) | 2007-11-22 |
| JP2007533752A5 true JP2007533752A5 (enExample) | 2011-09-01 |
| JP4879165B2 JP4879165B2 (ja) | 2012-02-22 |
Family
ID=34971867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007509585A Expired - Fee Related JP4879165B2 (ja) | 2004-04-20 | 2005-04-20 | メラノコルチン受容体の調節因子としての置換チアゾール及びピリミジン誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7820704B2 (enExample) |
| EP (1) | EP1753735A1 (enExample) |
| JP (1) | JP4879165B2 (enExample) |
| CN (1) | CN1946703A (enExample) |
| AU (1) | AU2005236055B2 (enExample) |
| BR (1) | BRPI0510095A (enExample) |
| CA (1) | CA2562075C (enExample) |
| IL (1) | IL178597A0 (enExample) |
| MX (1) | MXPA06012130A (enExample) |
| NZ (1) | NZ550114A (enExample) |
| WO (1) | WO2005103022A1 (enExample) |
| ZA (1) | ZA200608225B (enExample) |
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| US7291641B2 (en) * | 1999-10-11 | 2007-11-06 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
| US20040132788A1 (en) * | 1999-10-11 | 2004-07-08 | Chabrier De Lassauniere Pierre-Etienne | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
| EP1125579A3 (en) * | 2000-01-18 | 2003-01-02 | Pfizer Products Inc. | Uses of agrp-melanocortin receptor binding modulating compounds |
| DE10006453A1 (de) | 2000-02-14 | 2001-08-16 | Bayer Ag | Piperidylcarbonsäuren als Integrinantagonisten |
| IL153688A0 (en) * | 2000-06-28 | 2003-07-06 | Teva Pharma | Carvedilol |
| CN1705649A (zh) * | 2000-06-29 | 2005-12-07 | 艾伯特公司 | 芳基苯基杂环基硫醚衍生物及其作为抑制细胞粘附的抗炎和免疫抑制剂的用途 |
| HUP0202719A3 (en) * | 2001-08-21 | 2006-01-30 | Pfizer Prod Inc | Pharmaceutical compositions for the treatment of female sexual dysfunctions |
| US20050014805A1 (en) * | 2001-10-12 | 2005-01-20 | Chenzhi Zhang | Phenyl substituted 5-membered nitrogen containing heterocycles for the treatment of obesity |
| SG176310A1 (en) | 2001-11-08 | 2011-12-29 | Ortho Mcneil Pharm Inc | Novel 1,2,4-thiadiazole derivatives as melanocortin receptor modulators |
| US7163952B2 (en) * | 2001-12-03 | 2007-01-16 | Japan Tobacco Inc. | Azole compound and medicinal use thereof |
| US20030158199A1 (en) * | 2002-01-25 | 2003-08-21 | Kylix, B.V. | Novel compounds for inhibition of Tie-2 |
| AU2003216274A1 (en) * | 2002-02-11 | 2003-09-04 | Neurocrine Biosciences, Inc. | Pyrrole derivatives as ligands of melanocortin receptors |
| RU2004129285A (ru) * | 2002-02-28 | 2005-10-27 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные тиазола в качестве антагонистов рецептора npy |
| UA79755C2 (en) * | 2002-04-16 | 2007-07-25 | Bayer Pharmaceuticals Corp | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation |
| WO2004004447A2 (en) | 2002-07-03 | 2004-01-15 | Merck & Co., Inc. | Agouti-related protein deficient cells, non-human transgenic animals and methods of selecting compounds which regulate energy metabolism |
| AU2003253364B2 (en) * | 2002-08-07 | 2007-06-07 | F. Hoffmann-La Roche Ag | Thiazole derivatives |
| JP3819415B2 (ja) | 2003-04-09 | 2006-09-06 | 日本たばこ産業株式会社 | 複素芳香５員環化合物及びその医薬用途 |
| US20050009891A1 (en) * | 2003-07-09 | 2005-01-13 | Lee Francis Y. | Combination of SRC Kinase inhibitors and chemotherapeutic agents for the treatment of proliferative diseases |
| WO2006038594A1 (ja) | 2004-10-04 | 2006-04-13 | Ono Pharmaceutical Co., Ltd. | Ｎ型カルシウムチャネル阻害薬 |
-
2005
- 2005-04-20 MX MXPA06012130A patent/MXPA06012130A/es active IP Right Grant
- 2005-04-20 CA CA2562075A patent/CA2562075C/en not_active Expired - Fee Related
- 2005-04-20 EP EP05757033A patent/EP1753735A1/en not_active Withdrawn
- 2005-04-20 JP JP2007509585A patent/JP4879165B2/ja not_active Expired - Fee Related
- 2005-04-20 CN CNA2005800125133A patent/CN1946703A/zh active Pending
- 2005-04-20 NZ NZ550114A patent/NZ550114A/en not_active IP Right Cessation
- 2005-04-20 WO PCT/US2005/013386 patent/WO2005103022A1/en not_active Ceased
- 2005-04-20 BR BRPI0510095-0A patent/BRPI0510095A/pt not_active IP Right Cessation
- 2005-04-20 US US11/110,499 patent/US7820704B2/en not_active Expired - Fee Related
- 2005-04-20 AU AU2005236055A patent/AU2005236055B2/en not_active Ceased
-
2006
- 2006-10-03 ZA ZA2006/08225A patent/ZA200608225B/en unknown
- 2006-10-15 IL IL178597A patent/IL178597A0/en unknown
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