JP2005528348A5 - - Google Patents
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- Publication number
- JP2005528348A5 JP2005528348A5 JP2003572567A JP2003572567A JP2005528348A5 JP 2005528348 A5 JP2005528348 A5 JP 2005528348A5 JP 2003572567 A JP2003572567 A JP 2003572567A JP 2003572567 A JP2003572567 A JP 2003572567A JP 2005528348 A5 JP2005528348 A5 JP 2005528348A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- phenyl
- hydrogen
- thiazol
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 229910052739 hydrogen Inorganic materials 0.000 claims 50
- 239000001257 hydrogen Substances 0.000 claims 45
- 125000000217 alkyl group Chemical group 0.000 claims 34
- 150000002431 hydrogen Chemical class 0.000 claims 24
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 21
- 125000003118 aryl group Chemical group 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 16
- 229910052760 oxygen Inorganic materials 0.000 claims 14
- 229910052717 sulfur Inorganic materials 0.000 claims 9
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 125000000304 alkynyl group Chemical group 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 125000004199 4-trifluoromethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C(F)(F)F 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- OYDWHPGDTLGSKX-UHFFFAOYSA-N 1-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenyl]cyclopentane-1-carboxylic acid Chemical compound CC=1N=C(C=2C=CC(=CC=2)C(F)(F)F)SC=1CSC(C=C1)=CC=C1C1(C(O)=O)CCCC1 OYDWHPGDTLGSKX-UHFFFAOYSA-N 0.000 claims 1
- DDIWEYHLKGCWLH-UHFFFAOYSA-N 1-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenyl]cyclopropane-1-carboxylic acid Chemical compound CC=1N=C(C=2C=CC(=CC=2)C(F)(F)F)SC=1CSC(C=C1)=CC=C1C1(C(O)=O)CC1 DDIWEYHLKGCWLH-UHFFFAOYSA-N 0.000 claims 1
- AOZOEYIUPJEXEW-UHFFFAOYSA-N 1-[[3-methoxy-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenyl]methyl]pyrrolidine-2-carboxylic acid Chemical compound C=1C=C(SCC2=C(N=C(S2)C=2C=CC(=CC=2)C(F)(F)F)C)C(OC)=CC=1CN1CCCC1C(O)=O AOZOEYIUPJEXEW-UHFFFAOYSA-N 0.000 claims 1
- NABVXOJDCAFYIK-UHFFFAOYSA-N 2,2-difluoro-2-[5-methoxy-2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methoxy]phenyl]sulfanylacetic acid Chemical compound COC1=CC(SC(F)(F)C(O)=O)=C(C)C=C1OCC1=C(C)N=C(C=2C=CC(=CC=2)C(F)(F)F)S1 NABVXOJDCAFYIK-UHFFFAOYSA-N 0.000 claims 1
- HQUHMUAHNKEKBE-UHFFFAOYSA-N 2-[2,5-dimethyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid Chemical compound CC=1N=C(C=2C=CC(=CC=2)C(F)(F)F)SC=1CSC1=CC(C)=C(OCC(O)=O)C=C1C HQUHMUAHNKEKBE-UHFFFAOYSA-N 0.000 claims 1
- BTHTYPIDOTXIMQ-UHFFFAOYSA-N 2-[2,6-dimethyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid Chemical compound CC=1N=C(C=2C=CC(=CC=2)C(F)(F)F)SC=1CSC1=CC(C)=C(OCC(O)=O)C(C)=C1 BTHTYPIDOTXIMQ-UHFFFAOYSA-N 0.000 claims 1
- SXAOVCZJVBKWNV-UHFFFAOYSA-N 2-[2-methoxy-5-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid Chemical compound C1=C(OCC(O)=O)C(OC)=CC(SCC2=C(N=C(S2)C=2C=CC(=CC=2)C(F)(F)F)C)=C1C SXAOVCZJVBKWNV-UHFFFAOYSA-N 0.000 claims 1
- JIJNRQAPLDIKEJ-UHFFFAOYSA-N 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]-5-propan-2-ylphenoxy]acetic acid Chemical compound CC(C)C1=CC(OCC(O)=O)=C(C)C=C1SCC1=C(C)N=C(C=2C=CC(=CC=2)C(F)(F)F)S1 JIJNRQAPLDIKEJ-UHFFFAOYSA-N 0.000 claims 1
- UEOKXESYLLOOPO-UHFFFAOYSA-N 2-[3,5-dimethyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid Chemical compound CC=1N=C(C=2C=CC(=CC=2)C(F)(F)F)SC=1CSC1=C(C)C=C(OCC(O)=O)C=C1C UEOKXESYLLOOPO-UHFFFAOYSA-N 0.000 claims 1
- VNEQJQIWZLEZKJ-UHFFFAOYSA-N 2-[3-methoxy-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenyl]-2-methylpropanoic acid Chemical compound COC1=CC(C(C)(C)C(O)=O)=CC=C1SCC1=C(C)N=C(C=2C=CC(=CC=2)C(F)(F)F)S1 VNEQJQIWZLEZKJ-UHFFFAOYSA-N 0.000 claims 1
- AACIXTSGMFRFAX-UHFFFAOYSA-N 2-[3-methoxy-5-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid Chemical compound COC1=CC(OCC(O)=O)=CC(C)=C1SCC1=C(C)N=C(C=2C=CC(=CC=2)C(F)(F)F)S1 AACIXTSGMFRFAX-UHFFFAOYSA-N 0.000 claims 1
- URHSUAIFIXFSFV-UHFFFAOYSA-N 2-[4-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenyl]cyclohexyl]acetic acid Chemical compound CC=1N=C(C=2C=CC(=CC=2)C(F)(F)F)SC=1CSC(C=C1)=CC=C1C1CCC(CC(O)=O)CC1 URHSUAIFIXFSFV-UHFFFAOYSA-N 0.000 claims 1
- LKSOUOBHAZNKFE-UHFFFAOYSA-N 2-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]-2,6-di(propan-2-yl)phenoxy]acetic acid Chemical compound CC(C)C1=C(OCC(O)=O)C(C(C)C)=CC(SCC2=C(N=C(S2)C=2C=CC(=CC=2)C(F)(F)F)C)=C1 LKSOUOBHAZNKFE-UHFFFAOYSA-N 0.000 claims 1
- JFOBZYWLCOLFPS-UHFFFAOYSA-N 2-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenyl]cyclopropane-1-carboxylic acid Chemical compound CC=1N=C(C=2C=CC(=CC=2)C(F)(F)F)SC=1CSC(C=C1)=CC=C1C1CC1C(O)=O JFOBZYWLCOLFPS-UHFFFAOYSA-N 0.000 claims 1
- SPIHNOZNJYIWEG-UHFFFAOYSA-N 2-[5-acetamido-2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid Chemical compound CC(=O)NC1=CC(OCC(O)=O)=C(C)C=C1SCC1=C(C)N=C(C=2C=CC(=CC=2)C(F)(F)F)S1 SPIHNOZNJYIWEG-UHFFFAOYSA-N 0.000 claims 1
- JYBJPICHZOJTAF-UHFFFAOYSA-N 2-[5-chloro-2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid Chemical compound CC=1N=C(C=2C=CC(=CC=2)C(F)(F)F)SC=1CSC1=CC(C)=C(OCC(O)=O)C=C1Cl JYBJPICHZOJTAF-UHFFFAOYSA-N 0.000 claims 1
- XOOSHDNHFWJPFP-UHFFFAOYSA-N 2-[5-ethyl-2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid Chemical compound CCC1=CC(OCC(O)=O)=C(C)C=C1SCC1=C(C)N=C(C=2C=CC(=CC=2)C(F)(F)F)S1 XOOSHDNHFWJPFP-UHFFFAOYSA-N 0.000 claims 1
- BTCJJHQONSMXEO-UHFFFAOYSA-N 2-[5-fluoro-2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid Chemical compound CC=1N=C(C=2C=CC(=CC=2)C(F)(F)F)SC=1CSC1=CC(C)=C(OCC(O)=O)C=C1F BTCJJHQONSMXEO-UHFFFAOYSA-N 0.000 claims 1
- QCDNMSBIAQWUKE-UHFFFAOYSA-N 2-[5-methoxy-2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methoxy]phenyl]sulfanylacetic acid Chemical compound COC1=CC(SCC(O)=O)=C(C)C=C1OCC1=C(C)N=C(C=2C=CC(=CC=2)C(F)(F)F)S1 QCDNMSBIAQWUKE-UHFFFAOYSA-N 0.000 claims 1
- VQOUEAIDXMETIV-UHFFFAOYSA-N 2-[5-methoxy-2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid Chemical compound COC1=CC(OCC(O)=O)=C(C)C=C1SCC1=C(C)N=C(C=2C=CC(=CC=2)C(F)(F)F)S1 VQOUEAIDXMETIV-UHFFFAOYSA-N 0.000 claims 1
- FYWUOWGVPTVJNV-UHFFFAOYSA-N 2-[5-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]-2-propan-2-ylphenoxy]acetic acid Chemical compound C1=C(OCC(O)=O)C(C(C)C)=CC(SCC2=C(N=C(S2)C=2C=CC(=CC=2)C(F)(F)F)C)=C1C FYWUOWGVPTVJNV-UHFFFAOYSA-N 0.000 claims 1
- VGUHAIFLYNPBDW-UHFFFAOYSA-N 2-methyl-2-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenyl]propanoic acid Chemical compound CC=1N=C(C=2C=CC(=CC=2)C(F)(F)F)SC=1CSC1=CC=C(C(C)(C)C(O)=O)C=C1 VGUHAIFLYNPBDW-UHFFFAOYSA-N 0.000 claims 1
- BEMFECXVAHZOJO-UHFFFAOYSA-N 3-[2,4-dimethoxy-5-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenyl]propanoic acid Chemical compound C1=C(CCC(O)=O)C(OC)=CC(OC)=C1SCC1=C(C)N=C(C=2C=CC(=CC=2)C(F)(F)F)S1 BEMFECXVAHZOJO-UHFFFAOYSA-N 0.000 claims 1
- HWVUOUOJVCMKGU-UHFFFAOYSA-N 3-[2,5-dimethoxy-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenyl]propanoic acid Chemical compound C1=C(CCC(O)=O)C(OC)=CC(SCC2=C(N=C(S2)C=2C=CC(=CC=2)C(F)(F)F)C)=C1OC HWVUOUOJVCMKGU-UHFFFAOYSA-N 0.000 claims 1
- IHZSHMIYDORTAB-UHFFFAOYSA-N 3-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methoxy]phenyl]-2-phenylpropanoic acid Chemical compound CC=1N=C(C=2C=CC(=CC=2)C(F)(F)F)SC=1COC(C=C1)=CC=C1CC(C(O)=O)C1=CC=CC=C1 IHZSHMIYDORTAB-UHFFFAOYSA-N 0.000 claims 1
- AGGNDUBXBDODEW-UHFFFAOYSA-N 3-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methoxy]phenyl]-2-pyrrol-1-ylpropanoic acid Chemical compound CC=1N=C(C=2C=CC(=CC=2)C(F)(F)F)SC=1COC(C=C1)=CC=C1CC(C(O)=O)N1C=CC=C1 AGGNDUBXBDODEW-UHFFFAOYSA-N 0.000 claims 1
- NZRXUODRBKKPPF-UHFFFAOYSA-N 3-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]propanoic acid Chemical compound CC=1N=C(C=2C=CC(=CC=2)C(F)(F)F)SC=1CSC1=CC=C(OCCC(O)=O)C=C1 NZRXUODRBKKPPF-UHFFFAOYSA-N 0.000 claims 1
- NFDFSOZRWGDDMV-UHFFFAOYSA-N 3-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenyl]-2-pyrrol-1-ylpropanoic acid Chemical compound CC=1N=C(C=2C=CC(=CC=2)C(F)(F)F)SC=1CSC(C=C1)=CC=C1CC(C(O)=O)N1C=CC=C1 NFDFSOZRWGDDMV-UHFFFAOYSA-N 0.000 claims 1
- RICOCBHLOVJGHX-UHFFFAOYSA-N 3-methyl-3-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenyl]butanoic acid Chemical compound CC=1N=C(C=2C=CC(=CC=2)C(F)(F)F)SC=1CSC1=CC=C(C(C)(C)CC(O)=O)C=C1 RICOCBHLOVJGHX-UHFFFAOYSA-N 0.000 claims 1
- AUFCIMVSEPPGHN-UHFFFAOYSA-N 4-methyl-4-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenyl]pentanoic acid Chemical compound CC=1N=C(C=2C=CC(=CC=2)C(F)(F)F)SC=1CSC1=CC=C(C(C)(C)CCC(O)=O)C=C1 AUFCIMVSEPPGHN-UHFFFAOYSA-N 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002510 isobutoxy group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])O* 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- -1 methoxy, ethoxy, isopropoxy, n-propoxy, t-butoxy Chemical group 0.000 claims 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 229960003424 phenylacetic acid Drugs 0.000 claims 1
- 239000003279 phenylacetic acid Substances 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 0 *C1(*)CCCC1 Chemical compound *C1(*)CCCC1 0.000 description 3
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36240202P | 2002-03-07 | 2002-03-07 | |
| PCT/IB2003/000708 WO2003074050A1 (en) | 2002-03-07 | 2003-02-24 | Thiazole and oxazole derivatives which modulate ppar activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005528348A JP2005528348A (ja) | 2005-09-22 |
| JP2005528348A5 true JP2005528348A5 (enExample) | 2006-04-13 |
Family
ID=27789157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003572567A Abandoned JP2005528348A (ja) | 2002-03-07 | 2003-02-24 | Ｐｐａｒ活性を変調するチアゾールおよびオキサゾール誘導体 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US20030207924A1 (enExample) |
| EP (1) | EP1482935B1 (enExample) |
| JP (1) | JP2005528348A (enExample) |
| KR (1) | KR20040091693A (enExample) |
| AP (1) | AP2004003124A0 (enExample) |
| AR (1) | AR038881A1 (enExample) |
| AT (1) | ATE405260T1 (enExample) |
| AU (1) | AU2003206059A1 (enExample) |
| BR (1) | BR0308277A (enExample) |
| CA (1) | CA2478520A1 (enExample) |
| CO (1) | CO5601012A2 (enExample) |
| DE (1) | DE60323060D1 (enExample) |
| EA (1) | EA200400943A1 (enExample) |
| EC (1) | ECSP045285A (enExample) |
| ES (1) | ES2310650T3 (enExample) |
| HN (1) | HN2003000090A (enExample) |
| IS (1) | IS7377A (enExample) |
| MA (1) | MA27181A1 (enExample) |
| MX (1) | MXPA04007564A (enExample) |
| NO (1) | NO20044242L (enExample) |
| OA (1) | OA12780A (enExample) |
| PA (1) | PA8567801A1 (enExample) |
| PE (1) | PE20030989A1 (enExample) |
| PL (1) | PL372969A1 (enExample) |
| TN (1) | TNSN04168A1 (enExample) |
| TW (1) | TW200305403A (enExample) |
| UY (1) | UY27695A1 (enExample) |
| WO (1) | WO2003074050A1 (enExample) |
| ZA (1) | ZA200406068B (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6833380B2 (en) | 2002-03-07 | 2004-12-21 | Warner-Lambert Company, Llc | Compounds that modulate PPAR activity and methods of preparation |
| US6875780B2 (en) * | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
| US7244763B2 (en) * | 2003-04-17 | 2007-07-17 | Warner Lambert Company Llc | Compounds that modulate PPAR activity and methods of preparation |
| MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
| CN1787817B (zh) * | 2003-05-19 | 2011-09-07 | Irm责任有限公司 | 免疫抑制剂化合物及组合物 |
| EA011010B1 (ru) | 2004-02-27 | 2008-12-30 | Эмджен, Инк. | Соединения, модулирующие рецептор gpr40, фармацевтическая композиция, способ лечения заболеваний, чувствительных к модулированию рецептора gpr40 (варианты), способ модулирования функции gpr40 (варианты) и способ модулирования циркулирующей концентрации инсулина |
| JP2007536343A (ja) | 2004-05-05 | 2007-12-13 | ノボ ノルディスク アクティーゼルスカブ | Ｐｐａｒアゴニストとしてのフェノキシ酢酸誘導体 |
| EP1745014B1 (en) | 2004-05-05 | 2011-07-06 | High Point Pharmaceuticals, LLC | Novel compounds, their preparation and use |
| US7456164B2 (en) | 2004-05-07 | 2008-11-25 | Pfizer, Inc | 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands |
| AU2012200214B2 (en) * | 2004-05-14 | 2013-10-24 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| WO2005115384A2 (en) * | 2004-05-25 | 2005-12-08 | Metabolex, Inc. | Bicyclic, substituted triazoles as modulators of ppar and methods of their preparation |
| AU2005247473A1 (en) * | 2004-05-25 | 2005-12-08 | Metabolex, Inc. | Substituted triazoles as modulators of PPAR and methods of their preparation |
| RU2392274C2 (ru) * | 2005-02-25 | 2010-06-20 | Сеул Нэшнл Юниверсити Индастри Фаундейшн | Тиазольные производные в качестве лигандов ppar-дельта и способ их получения |
| US7982050B2 (en) * | 2005-05-07 | 2011-07-19 | Seoul National University Industry Foundation | Process for preparing ligands of PPARdelta and the intermediate compounds for preparing the same |
| US7465804B2 (en) | 2005-05-20 | 2008-12-16 | Amgen Inc. | Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders |
| US7943669B2 (en) | 2005-06-30 | 2011-05-17 | High Point Pharmaceuticals, Llc | Phenoxy acetic acids as PPAR delta activators |
| EP1916234B1 (en) * | 2005-07-29 | 2014-11-12 | Takeda Pharmaceutical Company Limited | Cyclopropanecarboxylic acid compound |
| EP1924546A1 (en) | 2005-09-14 | 2008-05-28 | Amgen, Inc | Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders |
| EA201101084A1 (ru) | 2005-12-22 | 2012-04-30 | ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Феноксиуксусные кислоты в качестве активаторов ppar дельта |
| JP2009132620A (ja) * | 2006-03-07 | 2009-06-18 | Astellas Pharma Inc | フェニルチアゾール誘導体 |
| JP2009529512A (ja) | 2006-03-09 | 2009-08-20 | ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー | 新規な化合物、それらの製造法、及び使用法 |
| US7687526B2 (en) | 2006-09-07 | 2010-03-30 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
| AU2007293028B2 (en) | 2006-09-07 | 2012-05-31 | Amgen Inc. | Heterocyclic GPR40 modulators |
| CA2683751C (en) | 2007-04-16 | 2013-01-08 | Amgen Inc. | Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators |
| KR20100090249A (ko) | 2007-10-10 | 2010-08-13 | 암젠 인크 | 치환된 비페닐 ｇｒｐ４０ 조절제 |
| WO2009078981A2 (en) * | 2007-12-13 | 2009-06-25 | Sri International | Ppar-delta ligands and methods of their use |
| RU2527177C2 (ru) | 2007-12-20 | 2014-08-27 | Энвиво Фармасьютикалз, Инк. | Четырехзамещенные бензолы |
| US8450522B2 (en) | 2008-03-06 | 2013-05-28 | Amgen Inc. | Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders |
| US8748462B2 (en) | 2008-10-15 | 2014-06-10 | Amgen Inc. | Spirocyclic GPR40 modulators |
| EP2540711A4 (en) * | 2010-02-25 | 2014-01-22 | Snu R&Db Foundation | Selenium-Zolderivate with ligand for the activation of the peroxisome-proliferator-activated receptor (PPAR), preparation method therefor and use of the chemical compounds |
| ES2811087T3 (es) | 2013-09-09 | 2021-03-10 | Vtv Therapeutics Llc | Uso de agonistas de PPAR-delta para tratar la atrofia muscular |
| WO2023147309A1 (en) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Use of ppar-delta agonists in the treatment of disease |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5859051A (en) * | 1996-02-02 | 1999-01-12 | Merck & Co., Inc. | Antidiabetic agents |
| IL128600A0 (en) * | 1996-08-19 | 2000-01-31 | Japan Tobacco Inc | Propionic acid derivatives and pharmaceutical compositions containing them |
| GB9914977D0 (en) * | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
| WO2002050047A1 (en) * | 2000-12-20 | 2002-06-27 | Glaxo Group Limited | Substitued oxazoles and thiazoles as hppar alpha agonists |
| GB0031107D0 (en) * | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
| GB0111523D0 (en) * | 2001-05-11 | 2001-07-04 | Glaxo Group Ltd | Chemical compounds |
| EA200400011A1 (ru) * | 2001-06-07 | 2004-06-24 | Эли Лилли Энд Компани | Модуляторы рецепторов, активируемых пролифераторами пероксисом (prar) |
-
2002
- 2002-12-20 US US10/324,148 patent/US20030207924A1/en not_active Abandoned
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2003
- 2003-02-24 OA OA1200400232A patent/OA12780A/en unknown
- 2003-02-24 AT AT03702943T patent/ATE405260T1/de not_active IP Right Cessation
- 2003-02-24 JP JP2003572567A patent/JP2005528348A/ja not_active Abandoned
- 2003-02-24 BR BR0308277-6A patent/BR0308277A/pt not_active IP Right Cessation
- 2003-02-24 KR KR10-2004-7013951A patent/KR20040091693A/ko not_active Ceased
- 2003-02-24 AP APAP/P/2004/003124A patent/AP2004003124A0/en unknown
- 2003-02-24 MX MXPA04007564A patent/MXPA04007564A/es active IP Right Grant
- 2003-02-24 EA EA200400943A patent/EA200400943A1/ru unknown
- 2003-02-24 PL PL03372969A patent/PL372969A1/xx not_active Application Discontinuation
- 2003-02-24 EP EP03702943A patent/EP1482935B1/en not_active Expired - Lifetime
- 2003-02-24 ES ES03702943T patent/ES2310650T3/es not_active Expired - Lifetime
- 2003-02-24 WO PCT/IB2003/000708 patent/WO2003074050A1/en not_active Ceased
- 2003-02-24 DE DE60323060T patent/DE60323060D1/de not_active Expired - Fee Related
- 2003-02-24 CA CA002478520A patent/CA2478520A1/en not_active Abandoned
- 2003-02-24 AU AU2003206059A patent/AU2003206059A1/en not_active Abandoned
- 2003-02-27 PA PA20038567801A patent/PA8567801A1/es unknown
- 2003-03-04 PE PE2003000210A patent/PE20030989A1/es not_active Application Discontinuation
- 2003-03-05 AR ARP030100737A patent/AR038881A1/es unknown
- 2003-03-06 TW TW092104790A patent/TW200305403A/zh unknown
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- 2003-03-06 UY UY27695A patent/UY27695A1/es not_active Application Discontinuation
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- 2004-08-30 MA MA27839A patent/MA27181A1/fr unknown
- 2004-09-03 TN TNP2004000168A patent/TNSN04168A1/fr unknown
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