JP2007533687A5 - - Google Patents
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- JP2007533687A5 JP2007533687A5 JP2007508812A JP2007508812A JP2007533687A5 JP 2007533687 A5 JP2007533687 A5 JP 2007533687A5 JP 2007508812 A JP2007508812 A JP 2007508812A JP 2007508812 A JP2007508812 A JP 2007508812A JP 2007533687 A5 JP2007533687 A5 JP 2007533687A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- pharmaceutical composition
- flibanserin
- sexual
- disorder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- PPRRDFIXUUSXRA-UHFFFAOYSA-N Flibanserin Chemical compound FC(F)(F)C1=CC=CC(N2CCN(CCN3C(NC4=CC=CC=C43)=O)CC2)=C1 PPRRDFIXUUSXRA-UHFFFAOYSA-N 0.000 claims 7
- 229960002053 Flibanserin Drugs 0.000 claims 7
- 239000002253 acid Substances 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000011780 sodium chloride Substances 0.000 claims 7
- 230000001568 sexual Effects 0.000 claims 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 201000008175 pain disease Diseases 0.000 claims 3
- VZCYOOQTPOCHFL-OWOJBTEDSA-N (E)-but-2-enedioate;hydron Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 206010051537 Premenstrual dysphoric disease Diseases 0.000 claims 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 201000001880 sexual dysfunction Diseases 0.000 claims 2
- 231100000872 sexual dysfunction Toxicity 0.000 claims 2
- FEWJPZIEWOKRBE-XIXRPRMCSA-N Mesotartaric acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-XIXRPRMCSA-N 0.000 claims 1
- 208000008238 Muscle Spasticity Diseases 0.000 claims 1
- 206010036618 Premenstrual syndrome Diseases 0.000 claims 1
- 206010040466 Sexual arousal disease Diseases 0.000 claims 1
- 206010040469 Sexual aversion disease Diseases 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N fumaric acid Chemical compound OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- 239000001530 fumaric acid Substances 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- 229940098779 methanesulfonic acid Drugs 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000001384 succinic acid Substances 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- 229960001367 tartaric acid Drugs 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
Claims (9)
- 任意で薬理的に許容される酸付加塩の形態にある、治療有効量のフリバンセリンを含む、月経前の障害の治療のための医薬組成物。
- 月経前不快気分、月経前症候群及び月経前不快気分障害から成る群より選択される月経前の障害を治療するための、請求項１に記載の医薬組成物。
- 任意で薬理的に許容される酸付加塩の形態にある、治療有効量のフリバンセリンを含む、女性における性的嫌悪障害の治療のための医薬組成物。
- 任意で薬理的に許容される酸付加塩の形態にある、治療有効量のフリバンセリンを含む、女性における性的覚醒障害の治療のための医薬組成物。
- 任意で薬理的に許容される酸付加塩の形態にある、治療有効量のフリバンセリンを含む、女性におけるオルガスムス障害の治療のための医薬組成物。
- 任意で薬理的に許容される酸付加塩の形態にある、治療有効量のフリバンセリンを含む、女性における性的な疼痛障害の治療のための医薬組成物。
- 性交疼痛症、膣痙、性交を伴わない性的な疼痛障害、一般的な医療情況による性的機能不全及び物質誘発性の性的機能不全から成る群より選択される性的な疼痛障害を治療するための、請求項６に記載の医薬組成物。
- 以下から選択される酸により形成された塩から選択される、医薬品として許容される酸付加塩の形態においてフリバンセリンが適用されることを特徴とする、請求項１から７のいずれかに記載する医薬組成物：コハク酸、臭化水素酸、酢酸、フマル酸、マレイン酸、メタンスルホン酸、乳酸、リン酸、塩酸、硫酸、酒石酸、クエン酸及びこれらの混合物。
- フリバンセリンが１日当たり０．１から４００ｍｇの投与量範囲で適用されることを特徴とする、請求項１から８のいずれかに記載の医薬組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56466004P | 2004-04-22 | 2004-04-22 | |
| PCT/EP2005/004086 WO2005102343A1 (en) | 2004-04-22 | 2005-04-18 | Use of flibanserin in the treatment of premenstrual and other female sexual disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007533687A JP2007533687A (ja) | 2007-11-22 |
| JP2007533687A5 true JP2007533687A5 (ja) | 2008-06-05 |
Family
ID=34965482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007508812A Pending JP2007533687A (ja) | 2004-04-22 | 2005-04-18 | 月経前の及び他の女性の性的障害の治療におけるフリバンセリンの使用 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20050239798A1 (ja) |
| EP (1) | EP1740180B1 (ja) |
| JP (1) | JP2007533687A (ja) |
| KR (1) | KR20070014186A (ja) |
| CN (1) | CN1946403A (ja) |
| AR (1) | AR048833A1 (ja) |
| AT (1) | ATE474578T1 (ja) |
| AU (1) | AU2005235423A1 (ja) |
| BR (1) | BRPI0510094A (ja) |
| CA (2) | CA2802600A1 (ja) |
| DE (1) | DE602005022427D1 (ja) |
| ES (1) | ES2345894T3 (ja) |
| IL (1) | IL178758A0 (ja) |
| MX (1) | MXPA06012116A (ja) |
| NZ (1) | NZ551418A (ja) |
| PE (1) | PE20060257A1 (ja) |
| RU (1) | RU2384333C2 (ja) |
| TW (1) | TW200603807A (ja) |
| UY (1) | UY28860A1 (ja) |
| WO (1) | WO2005102343A1 (ja) |
| ZA (1) | ZA200608024B (ja) |
Families Citing this family (29)
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| UA78974C2 (en) * | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
| US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
| US20040048877A1 (en) * | 2002-05-22 | 2004-03-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions containing flibanserin |
| AU2005235422B2 (en) * | 2004-04-22 | 2011-08-11 | Boehringer Ingelheim International Gmbh | New pharmaceutical compositions for the treatment of sexual disorders II |
| US20060025420A1 (en) * | 2004-07-30 | 2006-02-02 | Boehringer Ingelheimn International GmbH | Pharmaceutical compositions for the treatment of female sexual disorders |
| EP1789048A1 (en) * | 2004-09-03 | 2007-05-30 | Boehringer Ingelheim International GmbH | Method for the treatment of attention deficit hyperactivity disorder |
| JP2008538741A (ja) * | 2005-03-04 | 2008-11-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 鬱病の治療用及び／又は予防用の医薬組成物 |
| WO2006096439A2 (en) * | 2005-03-04 | 2006-09-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of schizophrenia and related diseases |
| JP2008531714A (ja) * | 2005-03-04 | 2008-08-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 不安障害の治療用及び／又は予防用の医薬組成物 |
| CA2608249A1 (en) * | 2005-05-06 | 2006-11-16 | Boehringer Ingelheim International Gmbh | Method for the treatment of drug abuse with flibanserin |
| JP2008540672A (ja) * | 2005-05-19 | 2008-11-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 病状に起因する性的機能不全の治療方法 |
| US20060264511A1 (en) * | 2005-05-19 | 2006-11-23 | Boehringer Ingelheim International Gmbh | Method for the treatment of drug-induced sexual dysfunction |
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| EP1945214A1 (en) * | 2005-10-29 | 2008-07-23 | Boehringer Ingelheim International GmbH | Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders |
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| EP2021006B1 (en) * | 2006-05-09 | 2015-08-12 | Sprout Pharmaceuticals, Inc. | Use of flibanserin for the treatment of post-menopausal sexual desire disorders |
| JP2009541443A (ja) | 2006-06-30 | 2009-11-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 尿失禁及び関連疾患の治療のためのフリバンセリン |
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| CA2660476C (en) * | 2006-08-14 | 2015-11-17 | Boehringer Ingelheim International Gmbh | Formulations of flibanserin and method for manufacturing the same |
| JP5220746B2 (ja) * | 2006-08-25 | 2013-06-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 制御放出システム及びその製造方法 |
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| US20060025420A1 (en) * | 2004-07-30 | 2006-02-02 | Boehringer Ingelheimn International GmbH | Pharmaceutical compositions for the treatment of female sexual disorders |
| EP1789048A1 (en) * | 2004-09-03 | 2007-05-30 | Boehringer Ingelheim International GmbH | Method for the treatment of attention deficit hyperactivity disorder |
| WO2006096439A2 (en) * | 2005-03-04 | 2006-09-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of schizophrenia and related diseases |
| JP2008538741A (ja) * | 2005-03-04 | 2008-11-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 鬱病の治療用及び／又は予防用の医薬組成物 |
| JP2008531714A (ja) * | 2005-03-04 | 2008-08-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 不安障害の治療用及び／又は予防用の医薬組成物 |
| CA2608249A1 (en) * | 2005-05-06 | 2006-11-16 | Boehringer Ingelheim International Gmbh | Method for the treatment of drug abuse with flibanserin |
| US20060258640A1 (en) * | 2005-05-13 | 2006-11-16 | Boehringer Ingelheim International Gmbh | Use of Flibanserin in the treatment of chronic pain |
| US20060264511A1 (en) * | 2005-05-19 | 2006-11-23 | Boehringer Ingelheim International Gmbh | Method for the treatment of drug-induced sexual dysfunction |
| JP2008540672A (ja) * | 2005-05-19 | 2008-11-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 病状に起因する性的機能不全の治療方法 |
| CA2617546C (en) * | 2005-08-03 | 2014-07-15 | Boehringer Ingelheim International Gmbh | Use of flibanserin in the treatment of obesity |
| US20070123540A1 (en) * | 2005-10-29 | 2007-05-31 | Angelo Ceci | Sexual desire enhancing medicaments comprising benzimidazolone derivatives |
| EP1945214A1 (en) * | 2005-10-29 | 2008-07-23 | Boehringer Ingelheim International GmbH | Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders |
| US20070105869A1 (en) * | 2005-11-08 | 2007-05-10 | Stephane Pollentier | Use of flibanserin for the treatment of pre-menopausal sexual desire disorders |
| WO2007093624A2 (en) * | 2006-02-18 | 2007-08-23 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment of attention deficit hyperactivity disorder comprising flibanserin |
| WO2007096300A1 (en) * | 2006-02-20 | 2007-08-30 | Boehringer Ingelheim International Gmbh | Benzimidazolone derivatives for the treatment of urinary incontinence |
| EP1991228A1 (en) * | 2006-02-28 | 2008-11-19 | Boehringer Ingelheim International GmbH | Treatment of prevention of valvular heart disease with flibanserin |
| EP2021006B1 (en) * | 2006-05-09 | 2015-08-12 | Sprout Pharmaceuticals, Inc. | Use of flibanserin for the treatment of post-menopausal sexual desire disorders |
| JP2009541443A (ja) * | 2006-06-30 | 2009-11-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 尿失禁及び関連疾患の治療のためのフリバンセリン |
| WO2008006838A1 (en) * | 2006-07-14 | 2008-01-17 | Boehringer Ingelheim International Gmbh | Use of flibanserin for the treatment of sexual disorders in females |
| EP2043649A2 (en) * | 2006-07-14 | 2009-04-08 | Boehringer Ingelheim International GmbH | Combinations of flibanserin with caffeine, process for their preparation and use thereof as medicaments |
| CA2660476C (en) * | 2006-08-14 | 2015-11-17 | Boehringer Ingelheim International Gmbh | Formulations of flibanserin and method for manufacturing the same |
| CL2007002214A1 (es) * | 2006-08-14 | 2008-03-07 | Boehringer Ingelheim Int | Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp |
| JP5220746B2 (ja) * | 2006-08-25 | 2013-06-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 制御放出システム及びその製造方法 |
-
2005
- 2005-04-04 US US11/097,939 patent/US20050239798A1/en not_active Abandoned
- 2005-04-18 WO PCT/EP2005/004086 patent/WO2005102343A1/en active Application Filing
- 2005-04-18 JP JP2007508812A patent/JP2007533687A/ja active Pending
- 2005-04-18 CA CA2802600A patent/CA2802600A1/en not_active Abandoned
- 2005-04-18 AT AT05735420T patent/ATE474578T1/de active
- 2005-04-18 KR KR1020067024530A patent/KR20070014186A/ko not_active Application Discontinuation
- 2005-04-18 NZ NZ551418A patent/NZ551418A/en unknown
- 2005-04-18 MX MXPA06012116A patent/MXPA06012116A/es active IP Right Grant
- 2005-04-18 EP EP05735420A patent/EP1740180B1/en active Active
- 2005-04-18 CN CNA2005800126174A patent/CN1946403A/zh active Pending
- 2005-04-18 RU RU2006140964/14A patent/RU2384333C2/ru not_active IP Right Cessation
- 2005-04-18 BR BRPI0510094-1A patent/BRPI0510094A/pt not_active IP Right Cessation
- 2005-04-18 AU AU2005235423A patent/AU2005235423A1/en not_active Abandoned
- 2005-04-18 ES ES05735420T patent/ES2345894T3/es active Active
- 2005-04-18 DE DE602005022427T patent/DE602005022427D1/de active Active
- 2005-04-18 CA CA2563167A patent/CA2563167C/en not_active Expired - Fee Related
- 2005-04-19 UY UY28860A patent/UY28860A1/es not_active Application Discontinuation
- 2005-04-20 PE PE2005000433A patent/PE20060257A1/es not_active Application Discontinuation
- 2005-04-21 TW TW094112654A patent/TW200603807A/zh unknown
- 2005-04-22 AR ARP050101599A patent/AR048833A1/es not_active Suspension/Interruption
-
2006
- 2006-09-27 ZA ZA200608024A patent/ZA200608024B/xx unknown
- 2006-10-19 IL IL178758A patent/IL178758A0/en unknown
-
2012
- 2012-07-27 US US13/559,852 patent/US20130079356A1/en not_active Abandoned
-
2014
- 2014-09-03 US US14/475,755 patent/US20150111898A1/en not_active Abandoned
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