JP2023076465A - デクスメデトミジン製剤を使用する睡眠障害の予防または治療 - Google Patents
デクスメデトミジン製剤を使用する睡眠障害の予防または治療 Download PDFInfo
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Abstract
Description
Claims (21)
- 被験体の口腔粘膜を通過するデクスメデトミジンの送達のために製剤化された、治療法上効果的な量のデクスメデトミジンまたはその薬学的に許容される塩、その溶媒和物もしくはその誘導体を含む、組成物。
- 前記デクスメデトミジンまたはその薬学的に許容される塩、その溶媒和物もしくはその誘導体が、舌下経路を介する送達のために製剤化される、請求項1に記載の組成物。
- 前記デクスメデトミジンの治療法上効果的な量が、約0.1mg~約5mgの範囲内である、先行請求項のいずれか一項に記載の組成物。
- α2-アドレナリン受容体アゴニストによる治療に感受性のある疾患または病態に罹患する患者を選択すること、及び治療法上効果的な量のデクスメデトミジンまたはその薬学的に許容される塩、その溶媒和物もしくはその誘導体を患者へ投与することを含む、α2-アドレナリン受容体アゴニストによる治療に感受性のある疾患または病態を治療または予防する方法。
- 睡眠障害に罹患する患者を選択すること、及び治療法上効果的な量のデクスメデトミジンまたはその薬学的に許容される塩、その溶媒和物もしくはその誘導体を患者へ投与することを含む、睡眠障害を治療する方法。
- 投与が口腔粘膜へ適用することを含み、前記デクスメデトミジンまたはその薬学的に許容される塩もしくはその誘導体が、口腔粘膜を介して吸収される、請求項4または5に記載の方法。
- 前記デクスメデトミジンまたはその薬学的に許容される塩もしくはその誘導体が、舌下経路を介して送達される、請求項6に記載の方法。
- 前記睡眠障害が不眠症である、請求項5に記載の方法。
- 前記不眠症が、入眠障害不眠症、睡眠維持障害不眠症、早朝覚醒不眠症、一過性不眠症、真夜中不眠症、深夜不眠症、入眠後覚醒延長障害不眠症、及び睡眠維持障害不眠症である、請求項8に記載の方法。
- 睡眠障害の治療のためのデクスメデトミジン医薬製剤の使用。
- 前記睡眠障害が不眠症である、請求項10に記載の使用。
- 前記不眠症が、入眠障害不眠症、睡眠維持障害不眠症、早朝覚醒不眠症、一過性不眠症、真夜中不眠症、深夜不眠症、入眠後覚醒延長障害不眠症、及び睡眠維持障害不眠症である、請求項11に記載の使用。
- デクスメデトミジンの送達が被験体の口腔粘膜を通過する、請求項10に記載の使用。
- 前記デクスメデトミジンの送達が舌下経路を介する、請求項10に記載の使用。
- 前記デクスメデトミジンが、約0.1mg~約5mgの範囲内で投与される、先行請求項のいずれかに記載の方法または使用。
- 治療のための実効時間が、約3~約30分の範囲中である、先行請求項のいずれかに記載の方法または使用。
- 慢性疼痛が睡眠障害の主要な理由である、睡眠障害の治療のためのデクスメデトミジン医薬製剤の使用。
- 効果的な量のデクスメデトミジンまたはその薬学的に許容される塩を舌下に投与することを含む、哺乳類における不眠症を治療する追加の利益を備えて慢性疼痛を治療する方法。
- 前記方法が慢性疼痛に起因する睡眠障害を有する患者に好適である、請求項5に記載の方法。
- 前頭側頭認知症に罹患する患者の治療のためのデクスメデトミジン医薬製剤の使用。
- 興奮性不眠及び/または過覚醒と関連する不眠症に罹患する患者の治療のためのデクスメデトミジン医薬製剤の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462064205P | 2014-10-15 | 2014-10-15 | |
US62/064,205 | 2014-10-15 | ||
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KR20240031326A (ko) * | 2016-12-31 | 2024-03-07 | 바이오엑셀 테라퓨틱스 인코포레이티드 | 불안의 치료를 위한 설하 덱스메데토미딘의 용도 |
CA3103431A1 (en) | 2018-06-27 | 2020-01-02 | Bioxcel Therapeutics, Inc. | Film formulations containing dexmedetomidine and methods of producing them |
CA3145388A1 (en) | 2019-07-19 | 2021-01-28 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
CN113827590A (zh) * | 2020-06-08 | 2021-12-24 | 四川普锐特药业有限公司 | 右美托咪定在助眠药物制备中的应用 |
KR20230159515A (ko) | 2021-03-19 | 2023-11-21 | 오리온 코포레이션 | 타시피미딘 제형 및 이의 용도 |
WO2024023261A1 (en) | 2022-07-27 | 2024-02-01 | Universität Zürich | Dexmedetomidine for the treatment of sleep disorders |
US11806334B1 (en) | 2023-01-12 | 2023-11-07 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
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US7632517B2 (en) * | 1997-10-01 | 2009-12-15 | Novadel Pharma Inc. | Buccal, polar and non-polar spray containing zolpidem |
WO2002089794A1 (en) * | 2001-05-07 | 2002-11-14 | Universite Catholique De Louvain | Method for treating neuropathic pain and pharmaceutical preparation therefor |
US20050222270A1 (en) * | 2004-02-26 | 2005-10-06 | Olney John W | Prolonged administration of NMDA antagonist drug and safener drug to create improved stable neural homeostasis |
AU2005286733B2 (en) * | 2004-09-23 | 2009-11-05 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
US20090076156A1 (en) * | 2005-07-18 | 2009-03-19 | Masud Husain | Use of a noradrenergic agonist, e.g. guanfacine, for the treatment of cognitive disorders |
PT1986642E (pt) * | 2006-02-13 | 2014-01-30 | Orient Pharma Samoa Co Ltd | Combinação de agonista do receptor alfa-2 (clonidina) e um agente antimuscarínico (oxibutinina) para o tratamento de sialorreia |
WO2008091588A1 (en) * | 2007-01-22 | 2008-07-31 | Targacept, Inc. | Intranasal, buccal, and sublingual administration of metanicotine analogs |
CN101801346A (zh) * | 2007-05-10 | 2010-08-11 | 诺瓦德尔药品公司 | 抗失眠症组合物及方法 |
PE20091084A1 (es) * | 2007-12-07 | 2009-07-23 | Schering Plough Healthcare | Formulaciones farmaceuticas de fenilefrina y composiciones para absorcion transmucosal |
EP2370136A4 (en) * | 2008-12-01 | 2015-12-30 | Map Pharmaceuticals Inc | INHALATIVE RELEASE PROCEDURES AND DEVICES |
EP2429521B1 (en) * | 2009-05-15 | 2017-10-18 | Recro Pharma, Inc. | Sublingual dexmedetomidine compositions and methods of use thereof |
RU2012133969A (ru) * | 2010-01-08 | 2014-02-20 | Рекро Фарма, Инк. | Локальные трансдермальные композиции дексмедетомидина и способы их применения |
US8241661B1 (en) * | 2011-06-24 | 2012-08-14 | Fuisz Richard C | Biocompatible film with variable cross-sectional properties |
US20130116215A1 (en) * | 2011-10-28 | 2013-05-09 | Mireia Coma | Combination therapies for treating neurological disorders |
EP3406247A1 (en) * | 2011-12-11 | 2018-11-28 | Recro Pharma, Inc. | Intranasal dexmedetomidine compositions and methods of use thereof |
CN106456561B (zh) * | 2013-10-07 | 2020-02-28 | 帝国制药美国公司 | 使用右旋美托咪啶经皮组合物治疗注意力缺陷多动症、焦虑症和失眠症的方法和组合物 |
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US20230414572A1 (en) | 2023-12-28 |
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MA41689A (fr) | 2017-08-22 |
JP2017534613A (ja) | 2017-11-24 |
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