JP2007532474A - セリンプロテアーゼ、特にｈｃｖのｎｓ３−ｎｓ４ａプロテアーゼの阻害剤 - Google Patents

セリンプロテアーゼ、特にｈｃｖのｎｓ３−ｎｓ４ａプロテアーゼの阻害剤 Download PDF

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Publication number
JP2007532474A
JP2007532474A JP2006534377A JP2006534377A JP2007532474A JP 2007532474 A JP2007532474 A JP 2007532474A JP 2006534377 A JP2006534377 A JP 2006534377A JP 2006534377 A JP2006534377 A JP 2006534377A JP 2007532474 A JP2007532474 A JP 2007532474A
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JP
Japan
Prior art keywords
ring
aliphatic
aryl
cycloalkyl
heteroaryl
Prior art date
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Pending
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JP2006534377A
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English (en)
Japanese (ja)
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JP2007532474A5 (US08039623-20111018-C00067.png
Inventor
ケビン・エム・コットレル
ロバート・ビー・パーニ
ヤーノシュ・ピトリク
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Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
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Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of JP2007532474A publication Critical patent/JP2007532474A/ja
Publication of JP2007532474A5 publication Critical patent/JP2007532474A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
JP2006534377A 2003-10-10 2004-10-08 セリンプロテアーゼ、特にｈｃｖのｎｓ３−ｎｓ４ａプロテアーゼの阻害剤 Pending JP2007532474A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51015603P 2003-10-10 2003-10-10
US51376803P 2003-10-23 2003-10-23
PCT/US2004/033238 WO2005037860A2 (en) 2003-10-10 2004-10-08 Inhibitors of serine proteases, particularly hcv ns3-ns4a protease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011179106A Division JP2011246487A (ja) 2003-10-10 2011-08-18 セリンプロテアーゼ、特にｈｃｖのｎｓ３−ｎｓ４ａプロテアーゼの阻害剤

Publications (2)

Publication Number Publication Date
JP2007532474A true JP2007532474A (ja) 2007-11-15
JP2007532474A5 JP2007532474A5 (US08039623-20111018-C00067.png) 2007-12-27

Family

ID=34467967

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2006534377A Pending JP2007532474A (ja) 2003-10-10 2004-10-08 セリンプロテアーゼ、特にｈｃｖのｎｓ３−ｎｓ４ａプロテアーゼの阻害剤
JP2011179106A Pending JP2011246487A (ja) 2003-10-10 2011-08-18 セリンプロテアーゼ、特にｈｃｖのｎｓ３−ｎｓ４ａプロテアーゼの阻害剤

Family Applications After (1)

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JP2011179106A Pending JP2011246487A (ja) 2003-10-10 2011-08-18 セリンプロテアーゼ、特にｈｃｖのｎｓ３−ｎｓ４ａプロテアーゼの阻害剤

Country Status (14)

Country Link
US (2) US7208600B2 (US08039623-20111018-C00067.png)
EP (2) EP2361925A1 (US08039623-20111018-C00067.png)
JP (2) JP2007532474A (US08039623-20111018-C00067.png)
KR (2) KR20120010278A (US08039623-20111018-C00067.png)
CN (1) CN101857631A (US08039623-20111018-C00067.png)
AU (1) AU2004282148A1 (US08039623-20111018-C00067.png)
CA (1) CA2541634A1 (US08039623-20111018-C00067.png)
IL (1) IL174863A0 (US08039623-20111018-C00067.png)
MX (1) MXPA06004006A (US08039623-20111018-C00067.png)
NO (1) NO20062101L (US08039623-20111018-C00067.png)
NZ (1) NZ546663A (US08039623-20111018-C00067.png)
RU (1) RU2006115558A (US08039623-20111018-C00067.png)
TW (1) TW200528472A (US08039623-20111018-C00067.png)
WO (1) WO2005037860A2 (US08039623-20111018-C00067.png)

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CA2541634A1 (en) 2005-04-28
WO2005037860A3 (en) 2005-11-10
RU2006115558A (ru) 2007-11-20
AU2004282148A1 (en) 2005-04-28
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US20070161789A1 (en) 2007-07-12
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