JP2007530737A - 架橋アミンポリマー - Google Patents
架橋アミンポリマー Download PDFInfo
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- JP2007530737A JP2007530737A JP2007505079A JP2007505079A JP2007530737A JP 2007530737 A JP2007530737 A JP 2007530737A JP 2007505079 A JP2007505079 A JP 2007505079A JP 2007505079 A JP2007505079 A JP 2007505079A JP 2007530737 A JP2007530737 A JP 2007530737A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/02—Polyamines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/02—Polyamines
- C08G73/0206—Polyalkylene(poly)amines
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
- C08L39/02—Homopolymers or copolymers of vinylamine
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L79/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
- C08L79/02—Polyamines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/806,495 US7335795B2 (en) | 2004-03-22 | 2004-03-22 | Crosslinked amine polymers |
| US10/965,044 US7459502B2 (en) | 2003-11-03 | 2004-10-13 | Pharmaceutical compositions comprising crosslinked polyamine polymers |
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| PCT/US2005/009394 WO2005092039A2 (en) | 2004-03-22 | 2005-03-22 | Crosslinked amine polymers |
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Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
| US7381428B2 (en) * | 2003-08-26 | 2008-06-03 | Shire International Licensing B.V. | Stabilized lanthanum carbonate compositions |
| NZ545633A (en) * | 2003-08-26 | 2009-07-31 | Shire Holdings Ag | Pharmaceutical formulation comprising lanthanum compounds |
| US7767768B2 (en) * | 2003-11-03 | 2010-08-03 | Ilypsa, Inc. | Crosslinked amine polymers |
| US7608674B2 (en) * | 2003-11-03 | 2009-10-27 | Ilypsa, Inc. | Pharmaceutical compositions comprising cross-linked small molecule amine polymers |
| US7449605B2 (en) * | 2003-11-03 | 2008-11-11 | Ilypsa, Inc. | Crosslinked amine polymers |
| US7459502B2 (en) * | 2003-11-03 | 2008-12-02 | Ilypsa, Inc. | Pharmaceutical compositions comprising crosslinked polyamine polymers |
| US7385012B2 (en) * | 2003-11-03 | 2008-06-10 | Ilypsa, Inc. | Polyamine polymers |
| US7335795B2 (en) * | 2004-03-22 | 2008-02-26 | Ilypsa, Inc. | Crosslinked amine polymers |
| US7985418B2 (en) | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| US20060177415A1 (en) * | 2004-11-01 | 2006-08-10 | Burke Steven K | Once a day formulation for phosphate binders |
| JP2009507019A (ja) | 2005-09-02 | 2009-02-19 | ジェンザイム・コーポレーション | リン酸塩を除去する方法およびそれに使用される重合体 |
| NZ566030A (en) | 2005-09-14 | 2011-10-28 | Wisconsin Alumni Res Found | Forms of diaminobutane dendrimers and the use thereof for binding phosphate |
| US8114393B2 (en) * | 2005-09-14 | 2012-02-14 | Wisconsin Alumni Research Foundation | Methods and compositions for phosphate binding |
| KR101547925B1 (ko) | 2005-09-15 | 2015-08-27 | 젠자임 코포레이션 | 아민 중합체에 대한 샤셋 제형 |
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| EP2043627A2 (en) * | 2006-07-05 | 2009-04-08 | Genzyme Corporation | Iron(ii)-containing treatments for hyperphosphatemia |
| CA2658338A1 (en) * | 2006-07-18 | 2008-01-24 | Genzyme Corporation | Amine dendrimers |
| US7964182B2 (en) * | 2006-09-01 | 2011-06-21 | USV, Ltd | Pharmaceutical compositions comprising phosphate-binding polymer |
| WO2008042222A2 (en) | 2006-09-29 | 2008-04-10 | Genzyme Corporation | Amide dendrimer compositions |
| WO2008076242A1 (en) * | 2006-12-14 | 2008-06-26 | Genzyme Corporation | Amido-amine polymer compositions |
| SI2124884T1 (sl) * | 2006-12-22 | 2019-09-30 | Ironwood Pharmaceuticals, Inc. | Pripravki, ki obsegajo sekvestrante žolčnih kislin, za zdravljenje motenj požiralnika |
| EP2114376A1 (en) * | 2007-02-23 | 2009-11-11 | Genzyme Corporation | Amine polymer compositions |
| WO2008109095A1 (en) * | 2007-03-08 | 2008-09-12 | Genzyme Corporation | Sulfone polymer compositions |
| US20100166696A1 (en) * | 2007-04-27 | 2010-07-01 | Dhal Pradeep K | Amido-amine dendrimer compositions |
| WO2009008480A1 (ja) * | 2007-07-11 | 2009-01-15 | Toray Industries, Inc. | 架橋ポリアリルアミン又はその酸付加塩、及びその医薬用途 |
| WO2009023544A2 (en) * | 2007-08-10 | 2009-02-19 | Ilypsa, Inc. | Dosage unit anion-exchange polymer pharmaceutical compositions |
| WO2009055772A1 (en) * | 2007-10-26 | 2009-04-30 | The Board Of Trustees Of The University Of Illinois | Solvent-promoted self-healing materials |
| JP2011506449A (ja) * | 2007-12-14 | 2011-03-03 | ジェンザイム コーポレーション | コーティング医薬組成物 |
| PA8807201A1 (es) * | 2007-12-14 | 2009-07-23 | Genzyme Corp | Composiciones farmaceuticas |
| US8283384B2 (en) | 2008-01-24 | 2012-10-09 | University Of Utah Research Foundation | Adhesive complex coacervates and methods of making and using thereof |
| KR101540752B1 (ko) | 2008-01-24 | 2015-07-31 | 유타대학연구재단 | 접착성 복합 코아세르베이트 및 그 제조 방법 및 사용 방법 |
| WO2009097127A1 (en) * | 2008-01-31 | 2009-08-06 | Genzyme Corporation | Pharmaceutical compositions |
| WO2009154747A1 (en) * | 2008-06-20 | 2009-12-23 | Genzyme Corporation | Pharmaceutical compositions |
| US20120184044A1 (en) * | 2008-12-31 | 2012-07-19 | Raptor Detection, Inc. | Molecularly-imprinted polymeric materials for visual detection of explosives |
| AU2010209293A1 (en) * | 2009-01-22 | 2011-09-08 | Usv Limited | Pharmaceutical compositions comprising phosphate-binding polymer |
| CN103025360A (zh) | 2010-05-24 | 2013-04-03 | 犹他大学研究基金会 | 增强的粘合剂复合物凝聚层和其制备和使用方法 |
| US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| EP2637708A2 (en) | 2010-11-12 | 2013-09-18 | University of Utah Research Foundation | Simple adhesive coacervates and methods of making and using thereof |
| WO2014015121A1 (en) | 2012-07-19 | 2014-01-23 | Georgia-Pacific Chemicals Llc | High efficiency wet strength resins from new cross-linkers |
| WO2014123665A1 (en) | 2013-02-06 | 2014-08-14 | Kci Licensing, Inc. | Polymers, preparation and use thereof |
| IL239771B (en) * | 2014-07-03 | 2021-06-30 | Shlomo Nir | A method for the production of complexes in the form of granules of micelles-clay and an application for the removal of organic and inorganic pollutants and microorganisms from polluted water |
| CA2955048C (en) | 2014-07-14 | 2020-11-03 | University Of Utah Research Foundation | In situ solidifying compositions and methods of making and using therof |
| MX2017015378A (es) * | 2015-05-29 | 2018-03-15 | Ecolab Usa Inc | Resinas de resistencia a la humedad de alta eficiencia de nuevos reticuladores. |
| MA44875A (fr) | 2016-05-06 | 2019-03-13 | Tricida Inc | Compositions pour le traitement de troubles acido-basiques |
| WO2019090176A1 (en) | 2017-11-03 | 2019-05-09 | Tricida, Inc. | Compositions for and method of treating acid-base disorders |
| EP3743120A4 (en) | 2018-01-26 | 2021-10-13 | Fluidx Medical Technology, LLC | DEVICE AND METHOD FOR USING COMPLEX COACERVATES THAT CONSOLIDATE IN SITU FOR VASCULAR CLOSURE |
| US20240139234A1 (en) * | 2021-11-17 | 2024-05-02 | Waterstone Pharmaceuticals (Wuhan) Co., Ltd. | Pharmaceutical polymer for treating hyperkalemia and preparation method thereof |
| WO2024097346A1 (en) * | 2022-11-03 | 2024-05-10 | Celanese International Corporation | Process for producing functionalized porous composites |
Family Cites Families (111)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3308020A (en) | 1961-09-22 | 1967-03-07 | Merck & Co Inc | Compositions and method for binding bile acids in vivo including hypocholesteremics |
| US3499960A (en) | 1965-01-25 | 1970-03-10 | Merck & Co Inc | Palatable coated particles of an anion exchange resin |
| US3692895A (en) | 1970-09-08 | 1972-09-19 | Norman A Nelson | Method of reducing hypercholesteremia in humans employing a copolymer of polyethylenepolyamine and a bifunctional substance, such as epichlorohydria |
| US3974272A (en) | 1972-09-01 | 1976-08-10 | Merck & Co., Inc. | Palatable cholestyramine coacervate compositions |
| US4027009A (en) | 1973-06-11 | 1977-05-31 | Merck & Co., Inc. | Compositions and methods for depressing blood serum cholesterol |
| US3930810A (en) | 1974-07-31 | 1976-01-06 | Universal Oil Products Company | Additives for petroleum distillates |
| FR2292729A1 (fr) | 1974-11-29 | 1976-06-25 | Protex Manuf Prod Chimiq | Procede de preparation de resines cathioniques thermodurcissables, resines obtenues suivant ce procede et leurs applications, notamment pour l'amelioration de la resistance a l'etat humide du papier |
| US4015939A (en) | 1976-05-12 | 1977-04-05 | Bio-Rad Laboratories, Inc. | Competitive binding thyroid assay with improved bound-free separation step |
| US4135880A (en) | 1977-08-19 | 1979-01-23 | Bio-Rad Laboratories, Inc. | Folate assay with ion exchange resin bound-free separation |
| US4362711A (en) | 1980-07-11 | 1982-12-07 | Evreka Inc. | Blood cholesterol level reducing agent and method |
| US4410688A (en) | 1981-04-29 | 1983-10-18 | Allied Corporation | Macromolecular highly branched homogeneous compound |
| NL8103434A (nl) | 1981-07-21 | 1983-02-16 | Curver Bv | Kunststofkist met scharnierbaar kunststofdeksel. |
| US4631337A (en) | 1983-01-07 | 1986-12-23 | The Dow Chemical Company | Hydrolytically-stable dense star polyamine |
| US4558120A (en) | 1983-01-07 | 1985-12-10 | The Dow Chemical Company | Dense star polymer |
| US4568737A (en) | 1983-01-07 | 1986-02-04 | The Dow Chemical Company | Dense star polymers and dendrimers |
| US4507466A (en) | 1983-01-07 | 1985-03-26 | The Dow Chemical Corporation | Dense star polymers having core, core branches, terminal groups |
| US4737550A (en) | 1983-01-07 | 1988-04-12 | The Dow Chemical Company | Bridged dense star polymers |
| US4588120A (en) * | 1983-01-27 | 1986-05-13 | Oxford Industries, Inc. | Apparatus and method for forming belt loops and the like |
| JPS6090243A (ja) | 1983-10-25 | 1985-05-21 | Nitto Boseki Co Ltd | 小球状モノアリルアミン橋かけ重合体の製造方法 |
| US4587329A (en) | 1984-08-17 | 1986-05-06 | The Dow Chemical Company | Dense star polymers having two dimensional molecular diameter |
| US4599400A (en) | 1984-12-18 | 1986-07-08 | The Dow Chemical Company | Star/comb-branched polyamide |
| US4747881A (en) | 1985-02-05 | 1988-05-31 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
| US4734200A (en) | 1986-04-04 | 1988-03-29 | Advanced Separation Technologies Incorporated | Process for removal of fluoride and phosphorus-type contaminants from acidic wastewater |
| IT1190349B (it) | 1986-06-16 | 1988-02-16 | Prodotti Formenti Srl | Composizioni farmaceutiche ad attivita' sequestrante degli acidi biliari contenenti colestiramina quale principio attivo,e procedimento per prepararle |
| US5338532A (en) | 1986-08-18 | 1994-08-16 | The Dow Chemical Company | Starburst conjugates |
| US5807582A (en) | 1988-08-26 | 1998-09-15 | Pharmacia & Upjohn Company | Fine-beaded colestipol hydrochloride and pharmaceutically elegant dosage forms made therefrom |
| GB8829088D0 (en) | 1988-12-13 | 1989-01-25 | Smith Kline French Lab | Compounds |
| US5091175A (en) | 1990-05-14 | 1992-02-25 | Erbamont Inc. | Pharmaceutical composition containing bile acid sequestrant enclosed in a size-exclusion membrane |
| FR2680791B1 (fr) | 1991-08-30 | 1994-09-09 | Bp Chemicals Snc | Procede de fabrication d'un polymere reticule et utilisation du polymere. |
| BE1007260A3 (nl) | 1993-07-08 | 1995-05-02 | Dsm Nv | Werkwijze voor het bereiden van een dendritisch macromolekuul. |
| US5530092A (en) | 1992-01-13 | 1996-06-25 | Dsm N.V. | Dendritic macromolecule and the preparation thereof |
| EP0575596B2 (en) | 1992-01-13 | 2001-05-16 | Dsm N.V. | Dendritic macromolecule and the preparation thereof |
| US5380522A (en) | 1992-08-11 | 1995-01-10 | Day; Charles E. | Method for treatment of irritable bowel syndrome |
| US5556619A (en) | 1992-08-20 | 1996-09-17 | The Du Pont Merck Pharmaceutical Company | Crosslinked polymeric ammonium salts |
| US5451397A (en) | 1992-12-21 | 1995-09-19 | Rohm And Haas Company | Bile acid sequestrant |
| AU692432B2 (en) | 1993-02-17 | 1998-06-11 | British Technology Group Limited | Polymeric compounds |
| AU6818894A (en) | 1993-05-20 | 1994-12-20 | Geltex Pharmaceuticals, Inc. | Process for adjusting ion concentration in a patient and compositions therefor |
| US5487888A (en) | 1993-05-20 | 1996-01-30 | Geltex, Inc. | Iron-binding polymers for oral administration |
| US5607669A (en) | 1994-06-10 | 1997-03-04 | Geltex Pharmaceuticals, Inc. | Amine polymer sequestrant and method of cholesterol depletion |
| US6129910A (en) | 1993-06-02 | 2000-10-10 | Geltex Pharmaceuticals, Inc. | Water-insoluble noncrosslinked bile acid sequestrants |
| US5618530A (en) | 1994-06-10 | 1997-04-08 | Geltex Pharmaceuticals, Inc. | Hydrophobic amine polymer sequestrant and method of cholesterol depletion |
| CA2129079C (en) | 1993-08-03 | 2006-01-17 | Tatsuo Nomura | Orally administrable cholesterol lowering agent |
| US5667775A (en) * | 1993-08-11 | 1997-09-16 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5496545A (en) * | 1993-08-11 | 1996-03-05 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5414068A (en) | 1994-01-24 | 1995-05-09 | Rohm And Haas Company | Crosslinked anion exchange particles and method for producing the particles |
| ES2118554T3 (es) | 1994-01-28 | 1998-09-16 | Dsm Nv | Macromolecula dendritica y procedimiento para su preparacion. |
| BE1008134A3 (nl) | 1994-03-16 | 1996-01-23 | Dsm Nv | Bereiding van stervormig vertakte polymeren. |
| TW474813B (en) | 1994-06-10 | 2002-02-01 | Geltex Pharma Inc | Alkylated composition for removing bile salts from a patient |
| GB9503061D0 (en) | 1995-02-16 | 1995-04-05 | British Tech Group | Polymeric compounds |
| US6060604A (en) | 1995-03-31 | 2000-05-09 | Florida State University | Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups |
| NL1001973C2 (nl) | 1995-12-21 | 1997-06-24 | Stork Friesland Bv | Semipermeabel composietmembraan. |
| NL1001977C2 (nl) | 1995-12-22 | 1997-06-24 | Dsm Nv | Werkwijze voor de bereiding van een macromolekuul. |
| SE9600072D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral formulation of two active ingredients II |
| TW528597B (en) | 1996-03-05 | 2003-04-21 | Mitsubishi Electric Corp | Medicament for preventive and/or therapeutic treatment of hyperphosphatemia |
| JP3885130B2 (ja) | 1996-06-11 | 2007-02-21 | 株式会社大塚製薬工場 | グアニジノ化合物低下剤並びに水分及びカリウムイオン吸着剤 |
| US6034129A (en) | 1996-06-24 | 2000-03-07 | Geltex Pharmaceuticals, Inc. | Ionic polymers as anti-infective agents |
| EP0910351A1 (en) | 1996-06-27 | 1999-04-28 | G.D. Searle & Co. | Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications |
| WO1998003185A1 (en) | 1996-07-19 | 1998-01-29 | Nikken Chemicals Co., Ltd. | Remedies for hyperphosphatemia |
| ATE361335T1 (de) | 1996-10-23 | 2007-05-15 | Dow Global Technologies Inc | Wasserlösliche polymere für die verminderung der absorption von diätetikem phosphat oder oxalat |
| JPH10130154A (ja) | 1996-10-29 | 1998-05-19 | Otsuka Pharmaceut Factory Inc | 腎疾患患者用延命率改善薬 |
| WO1998042355A1 (en) | 1997-03-25 | 1998-10-01 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers combined with a calcium supplement for oral administration |
| TW592727B (en) | 1997-04-04 | 2004-06-21 | Chugai Pharmaceutical Co Ltd | Phosphate-binding polymer preparations |
| US6423754B1 (en) | 1997-06-18 | 2002-07-23 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with polyallylamine polymers |
| CN1210390C (zh) | 1997-09-15 | 2005-07-13 | 普罗格特-甘布尔公司 | 含有基于直链胺的聚合物以改善被洗涤织物的外观和完整效果的洗衣洗涤剂组合物 |
| US6007803A (en) | 1997-09-19 | 1999-12-28 | Geltex Pharmaceuticals, Inc. | Ionic polymers as toxin binding agents |
| US20040170600A1 (en) | 1997-10-22 | 2004-09-02 | Jaime Simon | Water-soluble polymers for the reduction of dietary phosphate or oxalate absorption |
| US6726905B1 (en) | 1997-11-05 | 2004-04-27 | Genzyme Corporation | Poly (diallylamines)-based phosphate binders |
| US6566407B2 (en) | 1997-11-05 | 2003-05-20 | Geltex Pharmaceuticals, Inc. | Method for reducing oxalate |
| US5985938A (en) | 1997-11-05 | 1999-11-16 | Geltex Pharmaceuticals, Inc. | Method for reducing oxalate |
| NZ505123A (en) | 1997-12-19 | 2003-07-25 | Smithkline Beecham Corp | Process for manufacturing bite-dispersion tablets by compressing medicaments and other ingredients into granulates then compressing the granulates and other ingredients into tablets, and the tablets thereof |
| WO1999040990A1 (en) | 1998-02-17 | 1999-08-19 | University Of Maryland | Anion binding polymers and the use thereof |
| US6333051B1 (en) | 1998-09-03 | 2001-12-25 | Supratek Pharma, Inc. | Nanogel networks and biological agent compositions thereof |
| TW568788B (en) | 1998-10-12 | 2004-01-01 | Chugai Pharmaceutical Co Ltd | Polymer combining with phosphoric acid and preparation containing the same |
| US6361768B1 (en) | 1998-12-29 | 2002-03-26 | Pmd Holdings Corp. | Hydrophilic ampholytic polymer |
| US6180754B1 (en) | 1999-09-03 | 2001-01-30 | The Dow Chemical Company | Process for producing cross-linked polyallylamine polymer |
| US6362266B1 (en) | 1999-09-03 | 2002-03-26 | The Dow Chemical Company | Process for reducing cohesiveness of polyallylamine polymer gels during drying |
| US20020054903A1 (en) | 1999-10-19 | 2002-05-09 | Joseph Tyler | Direct compression polymer tablet core |
| AU778262B2 (en) | 1999-10-19 | 2004-11-25 | Genzyme Corporation | Direct compression polymer tablet core |
| US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
| FI109353B (fi) | 1999-11-17 | 2002-07-15 | Neste Chemicals Oy | Maleimidimodifioidut poly(propyleeni-imiini)dendrimeerit ja menetelmä niiden valmistamiseksi |
| DE10011481A1 (de) | 2000-03-09 | 2001-10-18 | Fresenius Hemocare Gmbh | Adsorbens zum Absenken der Konzentration von Fibrinogen und/oder Fibrin, Verwendung des Adsorbens zur Herstellung eines Adsorbers und Adsorber mit dem Adsorbens |
| US20040059065A1 (en) | 2000-03-09 | 2004-03-25 | Takeshi Goto | Crosslinked anion-exchange resin or salt thereof |
| WO2001066607A1 (en) | 2000-03-09 | 2001-09-13 | Hisamitsu Pharmaceutical Co., Inc. | Crosslinked anion-exchange resin or salt thereof and phosphorus adsorbent comprising the same |
| AU2001241095A1 (en) | 2000-03-13 | 2001-09-24 | Hisamitsu Pharmaceutical Co. Inc. | Preventives and/or remedies for hyperphosphatemia |
| US6471968B1 (en) | 2000-05-12 | 2002-10-29 | Regents Of The University Of Michigan | Multifunctional nanodevice platform |
| MY133977A (en) | 2000-06-16 | 2007-11-30 | Nippon Catalytic Chem Ind | Crosslinked polymers containing tertiary amine and/or quaternary ammonium salt structures, processes for making and uses thereof |
| WO2002032974A2 (en) | 2000-10-18 | 2002-04-25 | Fujisawa Pharmaceutical Co., Ltd. | Polymer and its use for the treatment and/or prevention of hyperphosphoremia |
| DE10056840A1 (de) | 2000-11-16 | 2002-05-23 | Basf Ag | Verfahren zur Hydrierung von Nitrilen an Raney-Katalysatoren |
| US6908609B2 (en) | 2000-11-20 | 2005-06-21 | Dow Global Technologies Inc. | In vivo use of water absorbent polymers |
| WO2002066543A1 (en) | 2001-02-16 | 2002-08-29 | Genzyme Corporation | Method of drying a material having a cohesive phase |
| EP1373368B1 (en) | 2001-03-27 | 2013-02-27 | Firmenich SA | Compounds for a controlled release of active compounds |
| BR0209133A (pt) | 2001-04-18 | 2004-06-15 | Genzyme Corp | Método para tratar gota e para reduzir os nìveis de ácido úrico n0 sangue |
| WO2002085380A1 (en) | 2001-04-18 | 2002-10-31 | Geltex Pharmaceuticals, Inc. | Method for treating gout and reducing serum uric acid |
| WO2002085379A1 (en) | 2001-04-18 | 2002-10-31 | Geltex Pharmaceuticals, Inc. | Method for improving vascular access in patients with vascular shunts |
| KR20040018359A (ko) | 2001-04-18 | 2004-03-03 | 젠자임 코포레이션 | 지방족 폴리아민으로 x 증후군을 치료하는 방법 |
| WO2002085383A1 (en) | 2001-04-18 | 2002-10-31 | Genzyme Corporation | Method for reducing copper levels and treating copper toxicosis |
| ES2637020T3 (es) | 2001-04-18 | 2017-10-10 | Genzyme Corporation | Uso de polímero de amina para reducir la glucosa sérica |
| US6881484B2 (en) | 2001-05-30 | 2005-04-19 | Mitsubishi Kagaku Iatron, Inc. | Core-shell particle including signal-generating substance enclosed therein and process for producing the same |
| US6600011B2 (en) | 2001-10-09 | 2003-07-29 | Genzyme Corporation | Process for purification and drying of polymer hydrogels |
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| AU2003282867A1 (en) | 2002-10-22 | 2004-05-13 | Genzyme Corporation | Amine polymers for promoting bone formation |
| DE10305807A1 (de) | 2003-02-12 | 2004-08-26 | Basf Ag | Polymethylenamine und Verfahren zu deren Herstellung |
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| GB0422877D0 (en) | 2004-10-14 | 2004-11-17 | Univ Glasgow | Bioactive polymers |
-
2004
- 2004-11-03 US US10/980,991 patent/US7608674B2/en not_active Expired - Fee Related
-
2005
- 2005-03-22 EP EP05730071A patent/EP1742613A4/en not_active Withdrawn
- 2005-03-22 JP JP2007505079A patent/JP2007530737A/ja not_active Withdrawn
- 2005-03-22 WO PCT/US2005/009394 patent/WO2005092039A2/en not_active Ceased
-
2006
- 2006-08-17 US US11/465,444 patent/US7589238B2/en not_active Expired - Fee Related
-
2009
- 2009-05-22 US US12/471,220 patent/US7718746B2/en not_active Expired - Fee Related
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| KR101822608B1 (ko) * | 2010-02-24 | 2018-01-29 | 리립사, 인크. | 담즙산 격리제로서 사용하기 위한 아민 폴리머 |
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| US11147833B2 (en) | 2017-10-16 | 2021-10-19 | Fujifilm Corporation | Therapeutic agent for hyperphosphatemia |
| JP7018451B2 (ja) | 2017-10-16 | 2022-02-10 | 富士フイルム株式会社 | 高リン血症治療剤および粒子 |
| WO2019078197A1 (ja) * | 2017-10-16 | 2019-04-25 | 富士フイルム株式会社 | 高リン血症治療剤 |
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Also Published As
| Publication number | Publication date |
|---|---|
| US20100029897A1 (en) | 2010-02-04 |
| WO2005092039A2 (en) | 2005-10-06 |
| US7589238B2 (en) | 2009-09-15 |
| US7718746B2 (en) | 2010-05-18 |
| US20070110706A1 (en) | 2007-05-17 |
| US7608674B2 (en) | 2009-10-27 |
| WO2005092039A3 (en) | 2005-12-08 |
| EP1742613A2 (en) | 2007-01-17 |
| US20050147580A1 (en) | 2005-07-07 |
| EP1742613A4 (en) | 2008-02-13 |
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