JP2007525520A5 - - Google Patents
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- Publication number
- JP2007525520A5 JP2007525520A5 JP2007501005A JP2007501005A JP2007525520A5 JP 2007525520 A5 JP2007525520 A5 JP 2007525520A5 JP 2007501005 A JP2007501005 A JP 2007501005A JP 2007501005 A JP2007501005 A JP 2007501005A JP 2007525520 A5 JP2007525520 A5 JP 2007525520A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- unsaturated
- alkyl
- heterocycle
- heteroatoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 86
- 229920006395 saturated elastomer Polymers 0.000 claims 85
- 125000005842 heteroatom Chemical group 0.000 claims 67
- 125000000623 heterocyclic group Chemical group 0.000 claims 59
- 229910052760 oxygen Inorganic materials 0.000 claims 54
- 125000003118 aryl group Chemical group 0.000 claims 51
- 229910052717 sulfur Inorganic materials 0.000 claims 51
- 229910052757 nitrogen Inorganic materials 0.000 claims 50
- DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 claims 47
- 125000000217 alkyl group Chemical group 0.000 claims 47
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 45
- 239000001301 oxygen Substances 0.000 claims 45
- 150000001875 compounds Chemical class 0.000 claims 44
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 42
- 239000011593 sulfur Substances 0.000 claims 42
- 239000000203 mixture Substances 0.000 claims 21
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 20
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 19
- 125000004429 atom Chemical group 0.000 claims 19
- 125000001072 heteroaryl group Chemical group 0.000 claims 14
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 13
- 125000000304 alkynyl group Chemical group 0.000 claims 13
- 239000003120 macrolide antibiotic agent Substances 0.000 claims 13
- 229910052799 carbon Inorganic materials 0.000 claims 12
- 125000003342 alkenyl group Chemical group 0.000 claims 11
- 150000001204 N-oxides Chemical class 0.000 claims 10
- 150000002148 esters Chemical class 0.000 claims 10
- 239000000651 prodrug Substances 0.000 claims 10
- 229940002612 prodrug Drugs 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 9
- 241000124008 Mammalia Species 0.000 claims 9
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 125000002252 acyl group Chemical group 0.000 claims 7
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- 125000004122 cyclic group Chemical group 0.000 claims 5
- 229910052731 fluorine Inorganic materials 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 229910052740 iodine Inorganic materials 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- 125000003107 substituted aryl group Chemical group 0.000 claims 5
- 229910052794 bromium Inorganic materials 0.000 claims 4
- 150000001721 carbon Chemical group 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 3
- 125000001054 5 membered carbocyclic group Chemical group 0.000 claims 3
- 125000004008 6 membered carbocyclic group Chemical group 0.000 claims 3
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 3
- 125000004414 alkyl thio group Chemical group 0.000 claims 3
- 125000002619 bicyclic group Chemical group 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 3
- KIWSYRHAAPLJFJ-DNZSEPECSA-N n-[(e,2z)-4-ethyl-2-hydroxyimino-5-nitrohex-3-enyl]pyridine-3-carboxamide Chemical compound [O-][N+](=O)C(C)C(/CC)=C/C(=N/O)/CNC(=O)C1=CC=CN=C1 KIWSYRHAAPLJFJ-DNZSEPECSA-N 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 2
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 150000001336 alkenes Chemical class 0.000 claims 2
- 125000005841 biaryl group Chemical group 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 150000002118 epoxides Chemical group 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 208000017228 Gastrointestinal motility disease Diseases 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 208000030852 Parasitic disease Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 150000002016 disaccharides Chemical class 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 1
- 229930182470 glycoside Natural products 0.000 claims 1
- 150000002338 glycosides Chemical class 0.000 claims 1
- -1 halo sugars Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 150000002772 monosaccharides Chemical class 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 0 C*=C(C)[*@]([C@](C(C(*)O[C@]1OIC)OC(NN*)=C)[C@]1OCC=*)C=I Chemical compound C*=C(C)[*@]([C@](C(C(*)O[C@]1OIC)OC(NN*)=C)[C@]1OCC=*)C=I 0.000 description 10
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54828004P | 2004-02-27 | 2004-02-27 | |
| US60/548,280 | 2004-02-27 | ||
| US57594904P | 2004-06-01 | 2004-06-01 | |
| US60/575,949 | 2004-06-01 | ||
| PCT/US2005/006082 WO2005085266A2 (en) | 2004-02-27 | 2005-02-25 | Macrocyclic compounds and methods of making and using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012034350A Division JP5631909B2 (ja) | 2004-02-27 | 2012-02-20 | 大環状化合物およびそれらを製造し使用する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007525520A JP2007525520A (ja) | 2007-09-06 |
| JP2007525520A5 true JP2007525520A5 (https=) | 2008-04-03 |
| JP5383037B2 JP5383037B2 (ja) | 2014-01-08 |
Family
ID=34922681
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007501005A Expired - Fee Related JP5383037B2 (ja) | 2004-02-27 | 2005-02-25 | 大環状化合物およびそれらを製造し使用する方法 |
| JP2012034350A Expired - Fee Related JP5631909B2 (ja) | 2004-02-27 | 2012-02-20 | 大環状化合物およびそれらを製造し使用する方法 |
| JP2014161364A Pending JP2014208707A (ja) | 2004-02-27 | 2014-08-07 | 大環状化合物およびそれらを製造し使用する方法 |
| JP2016136733A Pending JP2017019786A (ja) | 2004-02-27 | 2016-07-11 | 大環状化合物およびそれらを製造し使用する方法 |
| JP2018009418A Pending JP2018104437A (ja) | 2004-02-27 | 2018-01-24 | 大環状化合物およびそれらを製造し使用する方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012034350A Expired - Fee Related JP5631909B2 (ja) | 2004-02-27 | 2012-02-20 | 大環状化合物およびそれらを製造し使用する方法 |
| JP2014161364A Pending JP2014208707A (ja) | 2004-02-27 | 2014-08-07 | 大環状化合物およびそれらを製造し使用する方法 |
| JP2016136733A Pending JP2017019786A (ja) | 2004-02-27 | 2016-07-11 | 大環状化合物およびそれらを製造し使用する方法 |
| JP2018009418A Pending JP2018104437A (ja) | 2004-02-27 | 2018-01-24 | 大環状化合物およびそれらを製造し使用する方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US8202843B2 (https=) |
| EP (2) | EP1723159B1 (https=) |
| JP (5) | JP5383037B2 (https=) |
| CN (1) | CN102816194A (https=) |
| WO (1) | WO2005085266A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200420573A (en) | 2002-09-26 | 2004-10-16 | Rib X Pharmaceuticals Inc | Bifunctional heterocyclic compounds and methods of making and using same |
| EP1723159B1 (en) | 2004-02-27 | 2019-06-12 | Melinta Therapeutics, Inc. | Macrocyclic compounds and methods of making and using the same |
| DE102004045870A1 (de) * | 2004-04-07 | 2005-12-01 | Dynamit Nobel Gmbh Explosivstoff- Und Systemtechnik | Verfahren zur Herstellung von Azidoalkylaminen |
| US20090170790A1 (en) * | 2004-10-25 | 2009-07-02 | Biswajit Das | Ketolide derivatives as antibacterial agents |
| MX2007014490A (es) | 2005-05-25 | 2008-02-11 | Basf Ag | Serina amidas sustituidas con heteroaroilo. |
| EP3290427A1 (en) * | 2005-08-24 | 2018-03-07 | Melinta Therapeutics, Inc. | Triazole compounds and methods of making and using the same |
| EP1934237A2 (en) * | 2005-08-24 | 2008-06-25 | Rib-X Pharmaceuticals, Inc. | Triazole compounds and methods of making and using the same |
| EP1957085A2 (en) * | 2005-11-08 | 2008-08-20 | Ranbaxy Laboratories, Ltd. | Macrolides as anti-inflammatory agents |
| US20090005325A1 (en) * | 2005-11-23 | 2009-01-01 | Biswajit Bas | Ketolide Derivatives as Antibacterial Agents |
| EP2102226B1 (en) * | 2006-12-12 | 2012-08-22 | ZAMBON S.p.A. | Macrolide compounds endowed with antiinflammatory activity |
| WO2008106204A1 (en) * | 2007-02-28 | 2008-09-04 | Rib-X-Pharmaceuticals, Inc. | Macrolide compounds and methods of making and using the same |
| EP2188281A1 (en) * | 2007-08-10 | 2010-05-26 | Y's Therapeutics Co, Ltd. | Modulation of immune responses by administration of roxithromycin or its derivative |
| EP2315802A4 (en) * | 2008-07-31 | 2012-04-18 | 3M Innovative Properties Co | AZIUM COMPOSITIONS AND METHOD FOR THEIR PREPARATION AND USE |
| US8288005B2 (en) | 2008-07-31 | 2012-10-16 | 3M Innovative Properties Company | Fluoropolymer compositions and method of making and using thereof |
| ES2582794T3 (es) | 2009-08-13 | 2016-09-15 | Basilea Pharmaceutica Ag | Nuevos macrólidos y su uso |
| IN2012DN03297A (https=) * | 2009-09-30 | 2015-10-23 | Tranzyme Pharma Inc | |
| WO2013058824A1 (en) | 2011-04-07 | 2013-04-25 | Cornell University | Monomers capable of dimerizing in an aqueous solution, and methods of using same |
| JP6170064B2 (ja) * | 2011-11-25 | 2017-07-26 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 抗菌性チロシン誘導体およびその製造方法 |
| WO2017150341A1 (ja) * | 2016-03-04 | 2017-09-08 | 株式会社カネカ | アーク防護服用布帛及びアーク防護服 |
| WO2018191682A1 (en) * | 2017-04-15 | 2018-10-18 | Melinta Therapeutics, Inc. | Triazole compounds and methods of making and using the same |
| KR20210072026A (ko) | 2018-10-02 | 2021-06-16 | 루넬라 바이오테크 인코포레이티드 | 세놀리틱 약물로서 아지트로마이신 및 록시스로마이신 유도체 |
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-
2005
- 2005-02-25 EP EP05723790.1A patent/EP1723159B1/en not_active Expired - Lifetime
- 2005-02-25 CN CN2012102533942A patent/CN102816194A/zh active Pending
- 2005-02-25 US US10/590,782 patent/US8202843B2/en not_active Expired - Fee Related
- 2005-02-25 WO PCT/US2005/006082 patent/WO2005085266A2/en not_active Ceased
- 2005-02-25 EP EP13178998.4A patent/EP2716647A3/en not_active Withdrawn
- 2005-02-25 JP JP2007501005A patent/JP5383037B2/ja not_active Expired - Fee Related
-
2012
- 2012-02-20 JP JP2012034350A patent/JP5631909B2/ja not_active Expired - Fee Related
- 2012-06-18 US US13/525,900 patent/US8841263B2/en not_active Expired - Lifetime
-
2014
- 2014-07-09 US US14/327,452 patent/US20150158901A1/en not_active Abandoned
- 2014-08-07 JP JP2014161364A patent/JP2014208707A/ja active Pending
-
2016
- 2016-07-11 JP JP2016136733A patent/JP2017019786A/ja active Pending
-
2017
- 2017-04-21 US US15/493,344 patent/US20180066007A1/en not_active Abandoned
-
2018
- 2018-01-24 JP JP2018009418A patent/JP2018104437A/ja active Pending
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