JP2007509980A5 - - Google Patents
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- Publication number
- JP2007509980A5 JP2007509980A5 JP2006538361A JP2006538361A JP2007509980A5 JP 2007509980 A5 JP2007509980 A5 JP 2007509980A5 JP 2006538361 A JP2006538361 A JP 2006538361A JP 2006538361 A JP2006538361 A JP 2006538361A JP 2007509980 A5 JP2007509980 A5 JP 2007509980A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- unsaturated
- alkenyl
- saturated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920006395 saturated elastomer Polymers 0.000 claims 39
- 125000000217 alkyl group Chemical group 0.000 claims 38
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 29
- 125000003118 aryl group Chemical group 0.000 claims 25
- 229910052760 oxygen Inorganic materials 0.000 claims 25
- 150000001875 compounds Chemical class 0.000 claims 24
- 229910052757 nitrogen Inorganic materials 0.000 claims 23
- 229910052717 sulfur Inorganic materials 0.000 claims 23
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 21
- 239000001301 oxygen Chemical group 0.000 claims 21
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 20
- 239000011593 sulfur Chemical group 0.000 claims 20
- 125000000304 alkynyl group Chemical group 0.000 claims 18
- 125000005842 heteroatom Chemical group 0.000 claims 18
- 125000003342 alkenyl group Chemical group 0.000 claims 17
- 150000002148 esters Chemical class 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 17
- 239000000651 prodrug Substances 0.000 claims 17
- 229940002612 prodrug Drugs 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 17
- 239000000203 mixture Substances 0.000 claims 15
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 13
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 10
- 125000004429 atom Chemical group 0.000 claims 9
- 125000000623 heterocyclic group Chemical group 0.000 claims 9
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 8
- 241000124008 Mammalia Species 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 125000002252 acyl group Chemical group 0.000 claims 4
- 229910052740 iodine Inorganic materials 0.000 claims 4
- 229910052794 bromium Inorganic materials 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 150000001336 alkenes Chemical class 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 208000030852 Parasitic disease Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 1
- 150000002118 epoxides Chemical class 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 230000004899 motility Effects 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 0 C*(BC(C)(C)NO[C@]([C@@](C)O[C@]([C@]1O)O[C@]([C@](C)[C@](*[C@@](C2)O[C@@](C)[C@](*)[C@]2(C)OC)[C@@](C)C(OC(*)[C@@](*)[C@](*)[C@@](C)N[C@](C)C2)=C)[C@]2(C)O*2CC2)[C@@]1N(**)*=*)*[C@](CN1*)*C1=O Chemical compound C*(BC(C)(C)NO[C@]([C@@](C)O[C@]([C@]1O)O[C@]([C@](C)[C@](*[C@@](C2)O[C@@](C)[C@](*)[C@]2(C)OC)[C@@](C)C(OC(*)[C@@](*)[C@](*)[C@@](C)N[C@](C)C2)=C)[C@]2(C)O*2CC2)[C@@]1N(**)*=*)*[C@](CN1*)*C1=O 0.000 description 9
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51590903P | 2003-10-30 | 2003-10-30 | |
| PCT/US2004/036146 WO2005042554A1 (en) | 2003-10-30 | 2004-10-29 | Bifunctional macrolide heterocyclic compounds and methods of making and using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007509980A JP2007509980A (ja) | 2007-04-19 |
| JP2007509980A5 true JP2007509980A5 (https=) | 2007-11-29 |
Family
ID=34549459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006538361A Pending JP2007509980A (ja) | 2003-10-30 | 2004-10-29 | 二官能性マクロライド複素環式化合物およびそれらの化合物を調製および使用する方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20070149463A1 (https=) |
| EP (1) | EP1682563A1 (https=) |
| JP (1) | JP2007509980A (https=) |
| WO (1) | WO2005042554A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR043050A1 (es) | 2002-09-26 | 2005-07-13 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos |
| CN1780846A (zh) * | 2003-03-05 | 2006-05-31 | Rib－X医药品有限公司 | 双官能杂环化合物及其制备和使用方法 |
| JP2007512256A (ja) * | 2003-11-18 | 2007-05-17 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | 二官能性マクロライド複素環化合物ならびにこれらを製造する方法およびこれらを使用する方法 |
| JP5383037B2 (ja) * | 2004-02-27 | 2014-01-08 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | 大環状化合物およびそれらを製造し使用する方法 |
| US7582611B2 (en) * | 2005-05-24 | 2009-09-01 | Pfizer Inc. | Motilide compounds |
| JP2009506063A (ja) | 2005-08-24 | 2009-02-12 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | トリアゾール化合物ならびにこれを作製する方法および使用する方法 |
| EP3290427A1 (en) | 2005-08-24 | 2018-03-07 | Melinta Therapeutics, Inc. | Triazole compounds and methods of making and using the same |
| JP2009518396A (ja) * | 2005-12-08 | 2009-05-07 | ファイザー・インク | エリスロマイシン化合物の３’−ジメチルアミノ基を脱メチルする方法 |
| US8871728B2 (en) | 2007-06-29 | 2014-10-28 | Georgia Tech Research Corporation | Non-peptide macrocyclic histone deacetylese (HDAC) inhibitors and methods of making and using thereof |
| WO2009006403A2 (en) * | 2007-06-29 | 2009-01-08 | Georgia Tech Research Corporation | Non-peptide macrocyclic histone deacetylase (hdac) inhibitors and methods of making and using thereof |
| ES3063764T3 (en) * | 2018-11-19 | 2026-04-20 | Zikani Therapeutics Inc | C10-alkylene substituted 13-membered macrolides and uses thereof |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US569379A (en) * | 1896-10-13 | Machine | ||
| US3629232A (en) * | 1969-08-19 | 1971-12-21 | Abbott Lab | 2'-o-alkanoyl-4'-alkanoyloxy derivatives of erythromycin |
| US3681325A (en) * | 1970-09-30 | 1972-08-01 | Abbott Lab | De(n-methyl)-n-substituted derivatives of erythromycin |
| US4404201A (en) * | 1981-11-13 | 1983-09-13 | Warner-Lambert Company | Cephalosporins |
| US4546176A (en) * | 1982-12-14 | 1985-10-08 | Eisai Co., Ltd. | 7-Carboxymethoxyphenylacetamido-3-cephem derivatives and antibacterial preparations containing the same |
| US5232918A (en) * | 1987-07-23 | 1993-08-03 | Imperial Chemical Industries Plc | Cephalosporin derivatives |
| US5336768A (en) * | 1988-05-24 | 1994-08-09 | Hoffmann-La Roche Inc. | Antibacterial cephalosporin compounds |
| US5180719A (en) * | 1988-10-24 | 1993-01-19 | Norwich Eaton Pharmaceuticals, Inc. | Antimicrobial quinolonyl lactam esters |
| US6446032B1 (en) * | 1990-09-21 | 2002-09-03 | Massachusetts Institute Of Technology | Designing compounds specifically inhibiting ribonucleic acid by binding to the minor groove |
| IL114589A (en) * | 1990-11-21 | 1999-12-22 | Roussel Uclaf | Intermediates for the preparation of erythromycin derivatives |
| ES2101119T3 (es) * | 1991-10-01 | 1997-07-01 | Procter & Gamble Pharma | Procedimiento para preparar quinolonil-lactamas antimicrobianas. |
| US5215980A (en) * | 1992-01-17 | 1993-06-01 | Merck & Co., Inc. | 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof |
| MY113693A (en) * | 1992-05-26 | 2002-05-31 | Chugai Pharmaceutical Co Ltd | Erythromycin derivatives having an enterokinesis stimulating action |
| FR2697524B1 (fr) * | 1992-11-05 | 1994-12-23 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| US5527780A (en) * | 1992-11-05 | 1996-06-18 | Roussel Uclaf | Erythromycin derivatives |
| US5693791A (en) * | 1995-04-11 | 1997-12-02 | Truett; William L. | Antibiotics and process for preparation |
| US6274715B1 (en) * | 1995-11-08 | 2001-08-14 | Abbott Laboratories | Tricyclic erythromycin derivatives |
| US5891643A (en) * | 1995-11-14 | 1999-04-06 | Abbott Laboratories | Use of nuclear magnetic resonance to design ligands to target biomolecules |
| FR2742757B1 (fr) * | 1995-12-22 | 1998-01-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| UA51730C2 (uk) * | 1996-09-04 | 2002-12-16 | Ебботт Лабораторіз | 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців |
| US5780605A (en) * | 1997-09-08 | 1998-07-14 | Abbott Laboratories | 6,9-bridged erythromycin derivatives |
| US6034069A (en) * | 1997-09-30 | 2000-03-07 | Abbott Laboratories | 3-'N-modified 6-O-substituted erythromycin ketolide derivatives having antibacterial activity |
| US5955440A (en) * | 1998-03-27 | 1999-09-21 | Abbott Laboratories | Macrolide LHRH antagonists |
| US6437119B1 (en) * | 1998-05-07 | 2002-08-20 | William Lawrence Truett | Compounds formed from two or three antibiotics and their processes of preparation |
| US6541669B1 (en) * | 1998-06-08 | 2003-04-01 | Theravance, Inc. | β2-adrenergic receptor agonists |
| US6420354B1 (en) * | 1998-06-08 | 2002-07-16 | Advanced Medicine, Inc. | Sodium channel drugs and uses |
| EP1085845A2 (en) * | 1998-06-08 | 2001-03-28 | Advanced Medicine, Inc. | Multibinding inhibitors of cyclooxygenase-2 |
| WO1999063929A2 (en) * | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Multibinding inhibitors of microsomal triglyceride transferase protein |
| WO1999063994A1 (en) * | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | MULTIBINDING INHIBITORS OF HMG-CoA REDUCTASE |
| IT1301968B1 (it) * | 1998-07-30 | 2000-07-20 | Zambon Spa | Derivati di eritromicina ad attivita' antibiotica |
| US6020521A (en) * | 1998-08-26 | 2000-02-01 | Abbott Laboratories | Macrolide LHRH antagonists |
| US6479498B1 (en) * | 1999-06-04 | 2002-11-12 | Theravance, Inc. | Sodium channel drugs and uses |
| EP1299109B1 (en) * | 2000-04-27 | 2009-07-15 | The Scripps Research Institute | Bifunctional antibiotics |
| US20030158093A1 (en) * | 2001-08-17 | 2003-08-21 | Binyuan Sun | Bifunctional glycopeptide antibiotics and combinatorial libararies thereof |
| US6576615B2 (en) * | 2001-11-08 | 2003-06-10 | Enanta Pharmaceuticals, Inc. | 4′-O-substituted tylosin analogs |
| US6664240B2 (en) * | 2001-11-15 | 2003-12-16 | Enanta Pharmaceuticals, Inc. | Tylosin derivatives having antibacterial activity |
| PL371335A1 (en) * | 2002-01-22 | 2005-06-13 | Pharmacia & Upjohn Company | Infection-resistant medical devices |
| AU2003211113B2 (en) * | 2002-02-15 | 2007-08-09 | Merckle Gmbh | Antibiotic conjugates |
| AU2003219770B2 (en) * | 2002-02-15 | 2008-10-09 | Merckle Gmbh | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
| US6710034B2 (en) * | 2002-04-19 | 2004-03-23 | Enanta Pharmaceuticals, Inc. | 5-O-mycaminosyltylonide derivatives |
| US6753415B2 (en) * | 2002-04-19 | 2004-06-22 | Enanta Pharmaceuticals, Inc. | 23-O-substituted 5-O-mycaminosyltylonide derivatives |
| KR100661973B1 (ko) * | 2002-05-13 | 2006-12-28 | 이난타 파마슈티칼스, 인코포레이티드 | 6,11 바이사이클릭 에리스로마이신 유도체 |
| US6878691B2 (en) * | 2002-05-13 | 2005-04-12 | Enanta Pharmaceuticals, Inc. | 6-11 bicyclic ketolide derivatives |
| US7064110B2 (en) * | 2002-05-13 | 2006-06-20 | Enanta Pharmaceuticals, Inc. | 6-11 bicycle ketolide derivatives |
| US7157433B2 (en) * | 2002-07-08 | 2007-01-02 | Glaxosmithkline Istrazivacki Centar Zagreb | Compounds, compositions as carriers for steroid/nonsteroid anti-inflammatory; antienoplastic and antiviral active molecules |
| RU2330858C2 (ru) * | 2002-07-08 | 2008-08-10 | Глаксомитклайн Истраживацки Центар Загреб Д.О.О. | Новые соединения, составы и способы лечения воспалительных заболеваний и состояний |
| PL374646A1 (en) * | 2002-07-08 | 2005-10-31 | Pliva-Istrazivacki Institutt D.O.O. | Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use |
| AR043050A1 (es) * | 2002-09-26 | 2005-07-13 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos |
| CN1780846A (zh) * | 2003-03-05 | 2006-05-31 | Rib－X医药品有限公司 | 双官能杂环化合物及其制备和使用方法 |
-
2004
- 2004-10-29 WO PCT/US2004/036146 patent/WO2005042554A1/en not_active Ceased
- 2004-10-29 JP JP2006538361A patent/JP2007509980A/ja active Pending
- 2004-10-29 EP EP04810147A patent/EP1682563A1/en not_active Withdrawn
- 2004-10-29 US US10/577,903 patent/US20070149463A1/en not_active Abandoned
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