JP2007509980A - 二官能性マクロライド複素環式化合物およびそれらの化合物を調製および使用する方法 - Google Patents

二官能性マクロライド複素環式化合物およびそれらの化合物を調製および使用する方法 Download PDF

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Publication number
JP2007509980A
JP2007509980A JP2006538361A JP2006538361A JP2007509980A JP 2007509980 A JP2007509980 A JP 2007509980A JP 2006538361 A JP2006538361 A JP 2006538361A JP 2006538361 A JP2006538361 A JP 2006538361A JP 2007509980 A JP2007509980 A JP 2007509980A
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group
alkyl
unsaturated
alkenyl
saturated
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Japanese (ja)
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JP2007509980A5 (https=
Inventor
アデグボイェーガ ケー． オイェラー，
ジェイ ジェイ． ファーマー，
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Melinta Subsidiary Corp
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Rib X Pharmaceuticals Inc
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Application filed by Rib X Pharmaceuticals Inc filed Critical Rib X Pharmaceuticals Inc
Publication of JP2007509980A publication Critical patent/JP2007509980A/ja
Publication of JP2007509980A5 publication Critical patent/JP2007509980A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Materials For Medical Uses (AREA)
JP2006538361A 2003-10-30 2004-10-29 二官能性マクロライド複素環式化合物およびそれらの化合物を調製および使用する方法 Pending JP2007509980A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51590903P 2003-10-30 2003-10-30
PCT/US2004/036146 WO2005042554A1 (en) 2003-10-30 2004-10-29 Bifunctional macrolide heterocyclic compounds and methods of making and using the same

Publications (2)

Publication Number Publication Date
JP2007509980A true JP2007509980A (ja) 2007-04-19
JP2007509980A5 JP2007509980A5 (https=) 2007-11-29

Family

ID=34549459

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006538361A Pending JP2007509980A (ja) 2003-10-30 2004-10-29 二官能性マクロライド複素環式化合物およびそれらの化合物を調製および使用する方法

Country Status (4)

Country Link
US (1) US20070149463A1 (https=)
EP (1) EP1682563A1 (https=)
JP (1) JP2007509980A (https=)
WO (1) WO2005042554A1 (https=)

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AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
CN1780846A (zh) * 2003-03-05 2006-05-31 Rib－X医药品有限公司 双官能杂环化合物及其制备和使用方法
JP2007512256A (ja) * 2003-11-18 2007-05-17 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 二官能性マクロライド複素環化合物ならびにこれらを製造する方法およびこれらを使用する方法
JP5383037B2 (ja) * 2004-02-27 2014-01-08 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 大環状化合物およびそれらを製造し使用する方法
US7582611B2 (en) * 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
JP2009506063A (ja) 2005-08-24 2009-02-12 リブ−エックス ファーマシューティカルズ，インコーポレイテッド トリアゾール化合物ならびにこれを作製する方法および使用する方法
EP3290427A1 (en) 2005-08-24 2018-03-07 Melinta Therapeutics, Inc. Triazole compounds and methods of making and using the same
JP2009518396A (ja) * 2005-12-08 2009-05-07 ファイザー・インク エリスロマイシン化合物の３’−ジメチルアミノ基を脱メチルする方法
US8871728B2 (en) 2007-06-29 2014-10-28 Georgia Tech Research Corporation Non-peptide macrocyclic histone deacetylese (HDAC) inhibitors and methods of making and using thereof
WO2009006403A2 (en) * 2007-06-29 2009-01-08 Georgia Tech Research Corporation Non-peptide macrocyclic histone deacetylase (hdac) inhibitors and methods of making and using thereof
ES3063764T3 (en) * 2018-11-19 2026-04-20 Zikani Therapeutics Inc C10-alkylene substituted 13-membered macrolides and uses thereof

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WO2003070254A1 (en) * 2002-02-15 2003-08-28 Sympore Gmbh Antibiotic conjugates
WO2003070174A2 (en) * 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
WO2004078770A1 (en) * 2003-03-05 2004-09-16 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using the same

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Publication number Priority date Publication date Assignee Title
JP2002517422A (ja) * 1998-06-08 2002-06-18 アドバンスド メディスン インコーポレーテッド 多価のマクロライド系抗生物質
WO2003070254A1 (en) * 2002-02-15 2003-08-28 Sympore Gmbh Antibiotic conjugates
WO2003070174A2 (en) * 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
WO2004078770A1 (en) * 2003-03-05 2004-09-16 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using the same

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US20070149463A1 (en) 2007-06-28
EP1682563A1 (en) 2006-07-26
WO2005042554A1 (en) 2005-05-12

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