CN102816194A - 大环化合物以及其制作和使用方法 - Google Patents

大环化合物以及其制作和使用方法 Download PDF

Info

Publication number
CN102816194A
CN102816194A CN2012102533942A CN201210253394A CN102816194A CN 102816194 A CN102816194 A CN 102816194A CN 2012102533942 A CN2012102533942 A CN 2012102533942A CN 201210253394 A CN201210253394 A CN 201210253394A CN 102816194 A CN102816194 A CN 102816194A
Authority
CN
China
Prior art keywords
saturated
unsaturated
membered
mmol
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2012102533942A
Other languages
English (en)
Chinese (zh)
Inventor
杰伊·J·法默
阿肖克·包哈塔查杰
陈毅
乔尔·A·戈德伯格
约瑟夫·A·伊波利托
佐欧坦·F·凯尤
楼荣亮
阿德格博伊加·K·欧耶利尔
爱德华·C·舍瑞尔
乔伊斯·A·萨特克利夫
王德平
吴育生
杜严明
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Melinta Subsidiary Corp
Original Assignee
Rib X Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rib X Pharmaceuticals Inc filed Critical Rib X Pharmaceuticals Inc
Publication of CN102816194A publication Critical patent/CN102816194A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN2012102533942A 2004-02-27 2005-02-25 大环化合物以及其制作和使用方法 Pending CN102816194A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US54828004P 2004-02-27 2004-02-27
US60/548,280 2004-02-27
US57594904P 2004-06-01 2004-06-01
US60/575,949 2004-06-01

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN 200580013532 Division CN1950388A (zh) 2004-02-27 2005-02-25 大环化合物以及其制作和使用方法

Publications (1)

Publication Number Publication Date
CN102816194A true CN102816194A (zh) 2012-12-12

Family

ID=34922681

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2012102533942A Pending CN102816194A (zh) 2004-02-27 2005-02-25 大环化合物以及其制作和使用方法

Country Status (5)

Country Link
US (4) US8202843B2 (https=)
EP (2) EP2716647A3 (https=)
JP (5) JP5383037B2 (https=)
CN (1) CN102816194A (https=)
WO (1) WO2005085266A2 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
JP5383037B2 (ja) 2004-02-27 2014-01-08 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 大環状化合物およびそれらを製造し使用する方法
DE102004045870A1 (de) * 2004-04-07 2005-12-01 Dynamit Nobel Gmbh Explosivstoff- Und Systemtechnik Verfahren zur Herstellung von Azidoalkylaminen
EP1807439A2 (en) * 2004-10-25 2007-07-18 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
UA90720C2 (en) * 2005-05-25 2010-05-25 Басф Акциенгезелльшафт Heteroaroyl-substituted serine amides
EP3290427A1 (en) * 2005-08-24 2018-03-07 Melinta Therapeutics, Inc. Triazole compounds and methods of making and using the same
JP2009506063A (ja) * 2005-08-24 2009-02-12 リブ−エックス ファーマシューティカルズ，インコーポレイテッド トリアゾール化合物ならびにこれを作製する方法および使用する方法
WO2007054904A2 (en) * 2005-11-08 2007-05-18 Ranbaxy Laboratories Limited Macrolides as anti-inflammatory agents
WO2007060518A2 (en) * 2005-11-23 2007-05-31 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
EA017878B1 (ru) * 2006-12-12 2013-03-29 Замбон С.П.А. Макролидные соединения, обладающие противовоспалительной активностью
WO2008106224A1 (en) * 2007-02-28 2008-09-04 Rib-X Pharmaceuticals, Inc. Macrolide compounds and methods of making and using the same
CA2733706A1 (en) * 2007-08-10 2009-02-19 Y's Therapeutics Co., Ltd. Modulation of immune responses by administration of roxithromycin or its derivative
JP2011529977A (ja) 2008-07-31 2011-12-15 スリーエム イノベイティブ プロパティズ カンパニー フルオロポリマー組成物並びにその製造及び使用方法
EP2315802A4 (en) * 2008-07-31 2012-04-18 3M Innovative Properties Co AZIUM COMPOSITIONS AND METHOD FOR THEIR PREPARATION AND USE
WO2011018510A1 (en) 2009-08-13 2011-02-17 Basilea Pharmaceutica Ag New macrolides and their use
JP2013506676A (ja) * 2009-09-30 2013-02-28 トランザイム・ファーマ，インコーポレイテッド 大環状グレリン受容体アゴニストの塩、溶媒和物、および薬学的組成物、ならびにその使用方法
EP2694707B1 (en) 2011-04-07 2018-08-15 Cornell University Monomers capable of dimerizing in an aqueous solution, and methods of using same
PT2782922T (pt) * 2011-11-25 2018-02-05 The Kitasato Inst Derivados antibacterianos de tilosina e processos para a sua preparação
WO2017150341A1 (ja) * 2016-03-04 2017-09-08 株式会社カネカ アーク防護服用布帛及びアーク防護服
WO2018191682A1 (en) * 2017-04-15 2018-10-18 Melinta Therapeutics, Inc. Triazole compounds and methods of making and using the same
CU24717B1 (es) 2018-10-02 2024-08-15 Lunella Biotech Inc Derivados de azitromicina y roxitromicina como fármacos senolíticos

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3629232A (en) 1969-08-19 1971-12-21 Abbott Lab 2'-o-alkanoyl-4'-alkanoyloxy derivatives of erythromycin
US3681325A (en) 1970-09-30 1972-08-01 Abbott Lab De(n-methyl)-n-substituted derivatives of erythromycin
US4404201A (en) 1981-11-13 1983-09-13 Warner-Lambert Company Cephalosporins
US4546176A (en) 1982-12-14 1985-10-08 Eisai Co., Ltd. 7-Carboxymethoxyphenylacetamido-3-cephem derivatives and antibacterial preparations containing the same
US5008249A (en) 1985-08-31 1991-04-16 Kitasato Kenkyusho Therapeutic method of stimulating digestive tract contractile motion in mammals
EP0215355B1 (en) 1985-08-31 1994-04-06 Kitasato Kenkyusho Erythromycin derivative and process for preparing the same
US5232918A (en) 1987-07-23 1993-08-03 Imperial Chemical Industries Plc Cephalosporin derivatives
US5336768A (en) 1988-05-24 1994-08-09 Hoffmann-La Roche Inc. Antibacterial cephalosporin compounds
US5180719A (en) 1988-10-24 1993-01-19 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl lactam esters
US6446032B1 (en) 1990-09-21 2002-09-03 Massachusetts Institute Of Technology Designing compounds specifically inhibiting ribonucleic acid by binding to the minor groove
IL114589A (en) 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of erythromycin derivatives
US5686065A (en) 1991-03-27 1997-11-11 Special Advanced Biomaterials, Inc. Topical siloxane sunscreen compositions having enhanced performance and safety
ES2101119T3 (es) 1991-10-01 1997-07-01 Procter & Gamble Pharma Procedimiento para preparar quinolonil-lactamas antimicrobianas.
US5215980A (en) 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
MY113693A (en) * 1992-05-26 2002-05-31 Chugai Pharmaceutical Co Ltd Erythromycin derivatives having an enterokinesis stimulating action
TW355711B (en) 1992-11-04 1999-04-11 Chugai Pharmaceutical Co Ltd Erythromycin derivatives
FR2697524B1 (fr) 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
FR2719587B1 (fr) 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
IT1276901B1 (it) 1994-12-13 1997-11-03 Zambon Spa Derivati dell'eritromicina a 9-0-ossina dotati di attivita' antibiotica
US5693791A (en) 1995-04-11 1997-12-02 Truett; William L. Antibiotics and process for preparation
US6274715B1 (en) 1995-11-08 2001-08-14 Abbott Laboratories Tricyclic erythromycin derivatives
US5891643A (en) 1995-11-14 1999-04-06 Abbott Laboratories Use of nuclear magnetic resonance to design ligands to target biomolecules
FR2742757B1 (fr) 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
DE19604223A1 (de) 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
WO1997035195A1 (en) 1996-03-19 1997-09-25 The Salk Institute For Biological Studies In vitro methods for identifying modulators of members of the steroid/thyroid superfamily of receptors
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
US5712253A (en) 1996-06-18 1998-01-27 Abbott Laboratories Macrocyclic 13-membered ring derivatives of erythromycins A and B
UA51730C2 (uk) 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
HN1998000074A (es) 1997-06-11 1999-01-08 Pfizer Prod Inc Derivados de macrolidos c-4 sustituidos
CZ9904388A3 (cs) 1997-06-11 2002-10-16 Pfizer Products Inc. 9-Oximové deriváty erythromycinu
EP0895999A1 (en) 1997-08-06 1999-02-10 Pfizer Products Inc. C-4" substituted macrolide antibiotics
US5780605A (en) 1997-09-08 1998-07-14 Abbott Laboratories 6,9-bridged erythromycin derivatives
DK1025114T3 (da) * 1997-09-30 2004-07-05 Abbott Lab 3'-N-modificerede 6-O-substituerede erythromycin-ketolidderivater med antibakteriel aktivitet
US6034069A (en) 1997-09-30 2000-03-07 Abbott Laboratories 3-'N-modified 6-O-substituted erythromycin ketolide derivatives having antibacterial activity
ZA989885B (en) * 1997-10-31 1999-05-05 Abbott Lab Use of macrolides for the treatment of cancer and macular degeneration
WO1999028308A1 (en) 1997-11-29 1999-06-10 Truett William L Antibiotics and process for preparation
AU1694099A (en) 1997-12-26 1999-07-19 Cheil Jedang Corporation Cephem derivatives and a method for producing the compounds and an antibacterialcomposition containing the compounds
US5955440A (en) 1998-03-27 1999-09-21 Abbott Laboratories Macrolide LHRH antagonists
US6437119B1 (en) 1998-05-07 2002-08-20 William Lawrence Truett Compounds formed from two or three antibiotics and their processes of preparation
TR200003595T2 (tr) 1998-06-05 2001-07-23 Astrazeneca Ab Kimyasal bileşikler
GB9812019D0 (en) 1998-06-05 1998-07-29 Zeneca Ltd Chemical compounds
WO1999063929A2 (en) 1998-06-08 1999-12-16 Advanced Medicine, Inc. Multibinding inhibitors of microsomal triglyceride transferase protein
EP1086065A4 (en) 1998-06-08 2001-03-28 Advanced Medicine Inc Combinatorial synthesis of multibinding libraries
US6541669B1 (en) 1998-06-08 2003-04-01 Theravance, Inc. β2-adrenergic receptor agonists
WO1999063994A1 (en) 1998-06-08 1999-12-16 Advanced Medicine, Inc. MULTIBINDING INHIBITORS OF HMG-CoA REDUCTASE
US6420354B1 (en) 1998-06-08 2002-07-16 Advanced Medicine, Inc. Sodium channel drugs and uses
EP1085845A2 (en) 1998-06-08 2001-03-28 Advanced Medicine, Inc. Multibinding inhibitors of cyclooxygenase-2
IT1301968B1 (it) 1998-07-30 2000-07-20 Zambon Spa Derivati di eritromicina ad attivita' antibiotica
US6020521A (en) 1998-08-26 2000-02-01 Abbott Laboratories Macrolide LHRH antagonists
GB9821938D0 (en) 1998-10-09 1998-12-02 Zeneca Ltd Chemical compounds
HRP980646B1 (en) * 1998-12-30 2008-02-29 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. Novel oleandomycin derivatives
IT1306205B1 (it) 1999-01-15 2001-05-30 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
US6479498B1 (en) 1999-06-04 2002-11-12 Theravance, Inc. Sodium channel drugs and uses
HRP990192A2 (en) 1999-06-11 2001-04-30 Pliva D D 4'-DEMICAROZYL-8a-AZA-8a-HOMOTHILOSINE DERIVATIVES
US6413981B1 (en) 1999-08-12 2002-07-02 Ortho-Mcneil Pharamceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
IT1314261B1 (it) 1999-12-03 2002-12-06 Enichem Spa Composti metallocenici pontati, processo per la loro preparazione eloro uso come catalizzatori per la polimerizzazione di olefine.
GB9928499D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical processes and intermediates
JP2003522763A (ja) 2000-02-10 2003-07-29 ファルマシア・アンド・アップジョン・カンパニー ピペラジンアミド置換基を持つオキサゾリジノンチオアミド
JP2001261694A (ja) 2000-03-06 2001-09-26 Pfizer Prod Inc ケトライド抗生物質
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
EP1299109B1 (en) 2000-04-27 2009-07-15 The Scripps Research Institute Bifunctional antibiotics
DE10034627A1 (de) 2000-07-17 2002-01-31 Bayer Ag Aryl-substituierte Oxazolidinone mit Cytokin inhibitorischer Wirkung
IL180679A0 (en) 2000-10-27 2009-02-11 Pfizer Prod Inc Process for the preparation of non-steroidal glucocorticoid receptor modulators
ES2262612T3 (es) 2000-10-28 2006-12-01 Pfizer Products Inc. Moduladpres del receptor de glucocorticoides.
AU2002225724A1 (en) * 2000-12-01 2002-07-08 Kosan Biosciences, Inc. Motilide compounds
US6440942B1 (en) 2000-12-22 2002-08-27 Enanta Pharmaceuticals, Inc. 14-membered macrolides derived from leucomycins
GB0108764D0 (en) 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
ES2268011T3 (es) 2001-04-07 2007-03-16 Astrazeneca Ab Oxazolidinonas que contienen un grupo sulfonimida como antibioticos.
GB0108793D0 (en) 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
GB0108794D0 (en) 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compound
GB0113299D0 (en) 2001-06-01 2001-07-25 Astrazeneca Ab Chemical process & intermediates
GB0113297D0 (en) 2001-06-01 2001-07-25 Astrazeneca Ab Chemical Process
US6680299B2 (en) 2001-07-27 2004-01-20 Enanta Pharmaceuticals, Inc. 4'-substituted leucomycins
US20030158093A1 (en) 2001-08-17 2003-08-21 Binyuan Sun Bifunctional glycopeptide antibiotics and combinatorial libararies thereof
US7396847B2 (en) 2001-09-11 2008-07-08 Astrazeneca Ab Oxazolidinone and/or isoxazoline as antibacterial agents
EP1443930A1 (en) 2001-10-25 2004-08-11 AstraZeneca AB Isoxazoline derivatives useful as antimicrobials
GB2396350A (en) 2001-10-25 2004-06-23 Astrazeneca Ab Aryl substituted oxazolidinones with antibacterial activity
US6576615B2 (en) 2001-11-08 2003-06-10 Enanta Pharmaceuticals, Inc. 4′-O-substituted tylosin analogs
GB0127349D0 (en) 2001-11-14 2002-01-02 Glaxo Group Ltd Macrolides
US6664240B2 (en) 2001-11-15 2003-12-16 Enanta Pharmaceuticals, Inc. Tylosin derivatives having antibacterial activity
PL371335A1 (en) 2002-01-22 2005-06-13 Pharmacia & Upjohn Company Infection-resistant medical devices
AU2003211113B2 (en) 2002-02-15 2007-08-09 Merckle Gmbh Antibiotic conjugates
WO2003070173A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
AU2003219770B2 (en) 2002-02-15 2008-10-09 Merckle Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
JP2005524661A (ja) 2002-02-28 2005-08-18 アストラゼネカ アクチボラグ ３−シクリル−５−（窒素含有５員環）メチル−オキサゾリジノン誘導体と抗菌剤としてのその使用
US6710034B2 (en) 2002-04-19 2004-03-23 Enanta Pharmaceuticals, Inc. 5-O-mycaminosyltylonide derivatives
US6753415B2 (en) 2002-04-19 2004-06-22 Enanta Pharmaceuticals, Inc. 23-O-substituted 5-O-mycaminosyltylonide derivatives
US6878691B2 (en) 2002-05-13 2005-04-12 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US7064110B2 (en) 2002-05-13 2006-06-20 Enanta Pharmaceuticals, Inc. 6-11 bicycle ketolide derivatives
KR100661973B1 (ko) 2002-05-13 2006-12-28 이난타 파마슈티칼스, 인코포레이티드 6,11 바이사이클릭 에리스로마이신 유도체
RU2330858C2 (ru) 2002-07-08 2008-08-10 Глаксомитклайн Истраживацки Центар Загреб Д.О.О. Новые соединения, составы и способы лечения воспалительных заболеваний и состояний
PL374646A1 (en) 2002-07-08 2005-10-31 Pliva-Istrazivacki Institutt D.O.O. Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use
US7157433B2 (en) 2002-07-08 2007-01-02 Glaxosmithkline Istrazivacki Centar Zagreb Compounds, compositions as carriers for steroid/nonsteroid anti-inflammatory; antienoplastic and antiviral active molecules
ITMI20021726A1 (it) * 2002-08-01 2004-02-02 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
HRP20020886A2 (en) 2002-11-11 2005-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. SUBSTITUTED 9a-N-[N'-(BENZENSULFONYL)CARBAMOYL-γ-AMINOPROPYL) AND 9a-N(N' -(?-CYANOETHIL)-N' -(b
US20060116400A1 (en) 2002-11-28 2006-06-01 Astrazeneca Ab Oxazolidinone and/or isoxazoline derivatives as antibacterial agents
GB0229526D0 (en) 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
GB0229518D0 (en) 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
GB0229521D0 (en) 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
CN1780846A (zh) 2003-03-05 2006-05-31 Rib－X医药品有限公司 双官能杂环化合物及其制备和使用方法
ES2552682T3 (es) 2003-03-10 2015-12-01 Merck Sharp & Dohme Corp. Agentes antibacterianos novedosos
HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
NZ543757A (en) 2003-04-30 2009-02-28 Morphochem Ag Komb Chemie Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections
WO2004108745A2 (en) 2003-06-05 2004-12-16 Enanta Pharmaceuticals, Inc. 11-12 bicyclic erythromycin derivatives
US20040254126A1 (en) 2003-06-05 2004-12-16 Yao-Ling Qiu 11-12 Bicyclic erythromycin derivatives
US20070270484A1 (en) 2003-09-25 2007-11-22 Biswajit Das 3'-N-Substituted-3-O-Substituted Erythronolide a Derivatives
WO2005042554A1 (en) * 2003-10-30 2005-05-12 Rib-X Pharmaceuticals, Inc. Bifunctional macrolide heterocyclic compounds and methods of making and using the same
JP2007512256A (ja) 2003-11-18 2007-05-17 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 二官能性マクロライド複素環化合物ならびにこれらを製造する方法およびこれらを使用する方法
ITMI20040124A1 (it) 2004-01-29 2004-04-29 Zambon Spa Macrolidi ad attivita' antiinfiammatoria
JP5383037B2 (ja) 2004-02-27 2014-01-08 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 大環状化合物およびそれらを製造し使用する方法
WO2005118610A2 (en) 2004-06-01 2005-12-15 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
JP2009506063A (ja) 2005-08-24 2009-02-12 リブ−エックス ファーマシューティカルズ，インコーポレイテッド トリアゾール化合物ならびにこれを作製する方法および使用する方法
EP3290427A1 (en) 2005-08-24 2018-03-07 Melinta Therapeutics, Inc. Triazole compounds and methods of making and using the same

Also Published As

Publication number Publication date
US20150158901A1 (en) 2015-06-11
WO2005085266A8 (en) 2005-12-01
US20180066007A1 (en) 2018-03-08
JP2012102147A (ja) 2012-05-31
JP2007525520A (ja) 2007-09-06
US20080045585A1 (en) 2008-02-21
JP5383037B2 (ja) 2014-01-08
JP2017019786A (ja) 2017-01-26
WO2005085266A2 (en) 2005-09-15
EP2716647A3 (en) 2014-08-20
EP2716647A2 (en) 2014-04-09
US8841263B2 (en) 2014-09-23
EP1723159A2 (en) 2006-11-22
WO2005085266A3 (en) 2006-01-05
JP5631909B2 (ja) 2014-11-26
EP1723159B1 (en) 2019-06-12
JP2018104437A (ja) 2018-07-05
JP2014208707A (ja) 2014-11-06
US20120252747A1 (en) 2012-10-04
US8202843B2 (en) 2012-06-19

Similar Documents

Publication Publication Date Title
JP5631909B2 (ja) 大環状化合物およびそれらを製造し使用する方法
JP5981401B2 (ja) トリアゾール化合物ならびにこれを作製する方法および使用する方法
WO2008106226A2 (en) Macrolide compounds and methods of making and using the same
ES2216581T3 (es) Azalidas de 13 miembros y su uso como agentes antibioticos.
US9085600B2 (en) Triazole compounds and methods of making and using the same
CN108101948A (zh) 大环化合物以及其制作和使用方法
JP2006523229A (ja) 二官能性複素環式化合物ならびにその製造および使用方法
JP2007509980A (ja) 二官能性マクロライド複素環式化合物およびそれらの化合物を調製および使用する方法
WO2018191682A1 (en) Triazole compounds and methods of making and using the same
HK1178906A (en) Macrocyclic compounds and methods of making and using the same

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1178906

Country of ref document: HK

C53 Correction of patent for invention or patent application
CB02 Change of applicant information

Address after: American Connecticut

Applicant after: MELINTA THERAPEUTICS INC.

Address before: American Connecticut

Applicant before: Rib X. Pharmaceuticals Inc.

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: RIB X. PHARMACEUTICALS INC. TO: MELINTA THERAPEUTICS INC.

RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20121212

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1178906

Country of ref document: HK