JP2007525461A5 - - Google Patents

Download PDF

Info

Publication number
JP2007525461A5
JP2007525461A5 JP2006513416A JP2006513416A JP2007525461A5 JP 2007525461 A5 JP2007525461 A5 JP 2007525461A5 JP 2006513416 A JP2006513416 A JP 2006513416A JP 2006513416 A JP2006513416 A JP 2006513416A JP 2007525461 A5 JP2007525461 A5 JP 2007525461A5
Authority
JP
Japan
Prior art keywords
drug
delivery device
drug delivery
permeable polymeric
section
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2006513416A
Other languages
English (en)
Japanese (ja)
Other versions
JP4898431B2 (ja
JP2007525461A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2004/013172 external-priority patent/WO2004096151A2/en
Publication of JP2007525461A publication Critical patent/JP2007525461A/ja
Publication of JP2007525461A5 publication Critical patent/JP2007525461A5/ja
Application granted granted Critical
Publication of JP4898431B2 publication Critical patent/JP4898431B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2006513416A 2003-04-29 2004-04-29 複数薬物の持続放出のための方法およびデバイス Expired - Lifetime JP4898431B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US46631803P 2003-04-29 2003-04-29
US60/466,318 2003-04-29
US47357903P 2003-05-27 2003-05-27
US60/473,579 2003-05-27
PCT/US2004/013172 WO2004096151A2 (en) 2003-04-29 2004-04-29 Methods and devices for the sustained release of multiple drugs

Publications (3)

Publication Number Publication Date
JP2007525461A JP2007525461A (ja) 2007-09-06
JP2007525461A5 true JP2007525461A5 (https=) 2007-10-18
JP4898431B2 JP4898431B2 (ja) 2012-03-14

Family

ID=33423604

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006513416A Expired - Lifetime JP4898431B2 (ja) 2003-04-29 2004-04-29 複数薬物の持続放出のための方法およびデバイス

Country Status (8)

Country Link
US (7) US7833545B2 (https=)
EP (1) EP1620060B1 (https=)
JP (1) JP4898431B2 (https=)
AT (1) ATE461681T1 (https=)
AU (1) AU2004233997C1 (https=)
CA (1) CA2523859C (https=)
DE (1) DE602004026173D1 (https=)
WO (1) WO2004096151A2 (https=)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6764505B1 (en) 2001-04-12 2004-07-20 Advanced Cardiovascular Systems, Inc. Variable surface area stent
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
US7169178B1 (en) * 2002-11-12 2007-01-30 Advanced Cardiovascular Systems, Inc. Stent with drug coating
AU2004274000B2 (en) 2003-09-19 2009-07-30 Drugtech Corporation Pharmaceutical delivery system
US8865200B2 (en) 2004-07-09 2014-10-21 Laboratoire Hra Pharma Sustained release compositions containing progesterone receptor modulators
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
WO2006065873A2 (en) * 2004-12-14 2006-06-22 Poly-Med, Inc. Intravaginal ringed mesh device and applicator therefor
BRPI0711525A2 (pt) 2006-06-02 2011-11-01 Pear Tree Women S Health Care composição farmacêutica e método para tratar sintomas de vaginite atrófica
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
AU2007274081B2 (en) * 2006-07-12 2012-08-02 Controlled Therapeutics (Scotland) Ltd. Drug delivery polymer with hydrochloride salt of clindamycin
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
WO2008074153A1 (en) 2006-12-18 2008-06-26 Electronic Dietary Foods Inc. Device for delivery of a substance
WO2009061569A1 (en) * 2007-11-05 2009-05-14 Repros Therapeutics Inc. Compositions and methods for treating dysfunctional uterine bleeding
EP2057972A1 (en) * 2007-11-07 2009-05-13 N.V. Organon Intrauterine deposit
PL2062569T3 (pl) * 2007-11-22 2011-10-31 Bayer Oy Dopochwowy układ dostarczania leku
EP2062568A1 (en) * 2007-11-22 2009-05-27 Bayer Schering Pharma Oy Vaginal delivery system
PL2359807T3 (pl) 2008-02-04 2017-12-29 Ferring B.V. Monolityczne pierścienie dopochwowe zawierające progesteron oraz metody ich wytwarzania i stosowania
WO2009129459A1 (en) * 2008-04-18 2009-10-22 Combinent Biomedical Systems, Inc. Devices that include ethylene-vinyl acetate copolymers and methods of making and using same
TWI477276B (zh) 2008-04-28 2015-03-21 Repros Therapeutics Inc 抗黃體素給藥方案
US9034365B2 (en) 2008-05-20 2015-05-19 Poly-Med, Inc. Biostable, multipurpose, microbicidal intravaginal devices
EP2140860A1 (en) * 2008-07-03 2010-01-06 Bayer Schering Pharma Oy An improved method of contraception
US20100040671A1 (en) * 2008-08-12 2010-02-18 Ahmed Salah U Intravaginal Devices With a Rigid Support, Methods of Making, and Uses Thereof
CA2739147A1 (en) * 2008-11-07 2010-05-14 Combinent Biomedical Systems, Inc. Therapeutic peptide drug delivery and device
FI121000B (fi) * 2008-11-19 2010-06-15 Bayer Schering Pharma Oy Intravaginaalinen antojärjestelmä ja menetelmä sen valmistamiseksi
US8568374B2 (en) * 2009-05-04 2013-10-29 Merck Sharp & Dohme B.V. Intrauterine system
EP2437684B1 (en) 2009-06-03 2022-06-15 ForSight Vision5, Inc. Anterior segment drug delivery
CN102497855B (zh) 2009-07-21 2013-12-25 人口委员会股份有限公司 多层梯度的阴道环
ES2773079T3 (es) * 2010-02-08 2020-07-09 Shenzhen Evergreen Therapeutics Co Ltd Métodos para el uso de progestágeno como sensibilizador de glucocorticoides
WO2011126810A2 (en) 2010-03-28 2011-10-13 Evestra, Inc. Intravaginal drug delivery device
EP2571526B1 (en) 2010-05-17 2019-03-13 Novaer Holdings, Inc. Drug delivery devices for delivery of ocular therapeutic agents
EP2585011A4 (en) * 2010-06-22 2014-10-15 Teva Womens Health Inc INTRAVAGINAL DEVICES HAVING CHOLINOLYTIC AGENTS AND METHODS OF MAKING SAME
US8580294B2 (en) 2010-10-19 2013-11-12 International Partnership For Microbicides Platinum-catalyzed intravaginal rings
RU2591786C2 (ru) 2010-11-12 2016-07-20 Дзе Юниверсити Оф Юта Рисерч Фаундейшн Интравагинальные устройства для контролируемой доставки лубрикантов
KR101263916B1 (ko) 2011-01-11 2013-05-13 이장희 성 호르몬 방출 장치 및 이를 이용한 동물 피임 및 발정 유도 방법
WO2012121811A1 (en) * 2011-03-04 2012-09-13 Arstat, Inc. Treatment of excessive menstrual blood loss by intravaginal administration of low doses of antifibronlytic or hemostatic agent
US9168303B2 (en) 2011-07-15 2015-10-27 Universiteit Gent Intravaginal delivery system
JP5989780B2 (ja) 2011-09-14 2016-09-07 フォーサイト・ビジョン5・インコーポレイテッドForsight Vision5,Inc. 眼挿入装置および方法
EP2755634A4 (en) * 2011-09-14 2015-06-10 Royer Biomedical Inc BIORESORBABLE MEDICAMENT-RELATED MATRICES BASED ON NETWORKED POLYSACCHARIDES AND METHOD OF DOSING THEREOF FOR DELAYED / CONTROLLED ACTIVE SUBSTRATE
US8633178B2 (en) 2011-11-23 2014-01-21 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130166931A1 (en) * 2011-12-23 2013-06-27 Lsi Corporation Reducing power consumption of memory
CN103039688B (zh) 2012-01-20 2016-01-06 奥驰亚客户服务公司 口腔用产品
CN103040090B (zh) * 2012-01-20 2016-03-30 奥驰亚客户服务公司 脱除烟草的口腔用产品
CN102754908B (zh) 2012-01-20 2015-06-10 奥驰亚客户服务公司 口腔用烟草产品
US9854831B2 (en) 2012-01-20 2018-01-02 Altria Client Services Llc Oral product
CN102754907B (zh) 2012-01-20 2015-06-24 奥驰亚客户服务公司 口腔用产品
DE102012009057A1 (de) * 2012-05-09 2013-11-14 Dr. Arabin GmbH & Co. KG Rotationspessar mit zusätzlicher Wirkstoffkomponente
CA2872644A1 (en) 2012-05-31 2013-12-05 Allergan Pharmaceuticals International Limited Formulations and methods for vaginal delivery of antiprogestins
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
RU2652063C2 (ru) 2012-10-26 2018-04-24 Форсайт Вижн5, Инк. Офтальмологическая система для замедленного высвобождения лекарственного средства в глазу
US9545411B2 (en) 2012-11-02 2017-01-17 Repros Therapeutics Inc. Methods and compositions for treating progesterone-dependent conditions
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10137031B2 (en) 2013-11-14 2018-11-27 International Partnership For Microbicides, Inc. Combination therapy intravaginal rings
EP3145489A1 (en) 2014-05-22 2017-03-29 TherapeuticsMD, Inc. Natural combination hormone replacement formulations and therapies
US9820994B2 (en) 2014-06-28 2017-11-21 Laboratorios Andromaco S.A. Cerclage pessary containing progesterone of prolonged, sustained, and continuous release useful for prevention of preterm birth
CN105277633B (zh) * 2014-07-26 2017-06-23 浙江仙琚制药股份有限公司 一种炔诺酮衍生物及其中间体的杂质检测分析方法
RU2016141135A (ru) 2014-07-29 2018-08-28 Терапьютиксмд, Инк. Трансдермальный крем
TW201618783A (zh) 2014-08-07 2016-06-01 艾森塔製藥公司 以布魯頓(Bruton)氏酪胺酸激酶(BTK)佔據和BTK再合成速率為基礎之治療癌症、免疫和自體免疫疾病及發炎性疾病之方法
EP3017809A1 (en) 2014-11-07 2016-05-11 Ferring B.V. Drug-device unit containing quinagolide
US20180008536A1 (en) 2015-01-21 2018-01-11 Bayer Oy Drug delivery system comprising a non-steroidal anti-inflammatory (nsaid) and a progestogenic compound and methods for manufacturing
FI3250183T3 (fi) * 2015-01-30 2024-08-06 Ligalli B V Vaginaalinen lääkkeenantolaite
US20160296532A1 (en) 2015-04-13 2016-10-13 Forsight Vision5, Inc. Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent
CN108135910B (zh) * 2015-05-13 2022-12-02 拜耳股份有限公司 长效药物递送装置及其在避孕中的用途
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
GB201517523D0 (en) * 2015-10-05 2015-11-18 Ostara Biomedical Ltd Methods and compositions for managing reproduction
WO2017123577A1 (en) * 2016-01-12 2017-07-20 Repros Therapeutics Inc. Trans-clomiphene and progesterone receptor antagonist combination therapy for treating hormone-dependent conditions
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
WO2017173071A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
GB201708224D0 (en) 2017-05-23 2017-07-05 Juniper Pharmaceuticals Uk Ltd Device
FR3070619B1 (fr) * 2017-09-01 2024-10-04 Ab7 Innovation Piece moulee monolithique en matrice multiple pour la diffusion d’actifs et son procede d’obtention
US12220345B2 (en) 2017-10-27 2025-02-11 Axena Health, Inc. Devices, systems, and methods for training pelvic floor muscles
CN108186553B (zh) * 2018-02-13 2020-10-02 广东药科大学 一种黄体酮长效栓剂及其制备方法
CN111971039A (zh) * 2018-04-10 2020-11-20 里加利私人有限公司 阴道全身药物递送
WO2019210066A1 (en) * 2018-04-27 2019-10-31 Evestra, Inc. Estrogen prodrugs and methods of administering estrogen prodrugs
MX2020012459A (es) 2018-05-24 2021-04-28 Celanese Eva Performance Polymers Llc Dispositivo implantable para liberacion sostenida de un compuesto de farmaco macromolecular.
EP3803866A4 (en) 2018-05-24 2022-03-16 Nureva Inc. METHOD, APPARATUS, AND COMPUTER READABLE MATERIALS FOR MANAGING SEMI-CONSTANT (PERSISTENT) SOUND SOURCES IN MICROPHONE CATCH/HOME AREAS
KR20260007295A (ko) 2018-05-24 2026-01-13 셀라니즈 이브이에이 퍼포먼스 폴리머스 엘엘씨 거대 분자 약물 화합물의 지속적인 방출을 위한 이식가능 장치
MX2021011885A (es) * 2019-03-29 2022-04-18 Juniper Pharmaceuticals Inc N/K/A Catalent Jnp Inc Anillos intravaginales segmentados de eva que contienen progesterona.
WO2021068239A1 (zh) * 2019-10-12 2021-04-15 国家卫生健康委科学技术研究所 用于黄体支持的阴道缓释给药系统及其制备方法与应用
IL293106A (en) * 2019-11-18 2022-07-01 Dare Bioscience Inc Intravaginal ring devices
FR3107203B1 (fr) * 2020-02-14 2023-11-24 Ab7 Innovation Matrice solide composite pour la délivrance prolongée d’actifs
USD935018S1 (en) * 2020-04-07 2021-11-02 The Population Council, Inc. Contraceptive
BR112023022439A2 (pt) 2021-04-26 2023-12-26 Celanese Eva Performance Polymers Llc Dispositivo implantável para liberação sustentada de um composto de fármaco macromolecular
WO2023031218A1 (en) 2021-08-31 2023-03-09 Ferring B.V. Diagnosis and treatment of ectopic endometriosis
CN118475375A (zh) * 2021-12-30 2024-08-09 泰利福医疗公司 热塑性聚合物组合物中复配的活性药物成分及制备方法
CA3251695A1 (en) * 2022-02-22 2023-08-31 Celanese Eva Performance Polymers Llc Intravaginal ring device for the administration of an aromatase inhibitor
WO2023172387A1 (en) * 2022-03-08 2023-09-14 Celanese Eva Performance Polymers Llc Implantable medical device for the delivery of aromatase inhibitor
CN120569187A (zh) * 2023-01-09 2025-08-29 戴尔生物科学公司 用于激素替代疗法的方法和装置
WO2024155775A2 (en) 2023-01-19 2024-07-25 Dare Bioscience, Inc. Compositions and techniques for treatment of polycystic ovarian syndrome (pcos) and endometriosis
WO2024155777A2 (en) 2023-01-19 2024-07-25 Dare Bioscience, Inc. Compositions and techniques for treatment of polycystic ovarian syndrome (pcos) and endometriosis
WO2025174767A1 (en) * 2024-02-13 2025-08-21 Biraj Investments, Llc Highly loaded implantable devices with high tensile strength for drug delivery

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1945275U (de) * 1965-04-30 1966-09-01 Ortho Pharma Corp Intrauterine vorrichtung zur empfaengnisverhuetung.
US3454004A (en) * 1967-08-18 1969-07-08 Holland Rantos Co Inc Intrauterine contraceptive device
US3545439A (en) 1968-01-04 1970-12-08 Upjohn Co Medicated devices and methods
NL6903028A (https=) 1969-02-26 1970-08-28
US4069307A (en) * 1970-10-01 1978-01-17 Alza Corporation Drug-delivery device comprising certain polymeric materials for controlled release of drug
US3903880A (en) 1972-08-17 1975-09-09 Alza Corp Intrauterine device for managing the reproductive process
US3920805A (en) 1971-12-09 1975-11-18 Upjohn Co Pharmaceutical devices and method
US3938515A (en) 1971-12-20 1976-02-17 Alza Corporation Novel drug permeable wall
US3708511A (en) 1972-01-18 1973-01-02 Organon Novel {66 -steroids of the oestrane series
NL7204025A (https=) 1972-03-24 1973-09-26
US3780935A (en) 1972-07-10 1973-12-25 Lukacs & Jacoby Ass Serum separating method
NL7210262A (https=) 1972-07-26 1974-01-29
US4016251A (en) * 1972-08-17 1977-04-05 Alza Corporation Vaginal drug dispensing device
US3963119A (en) 1973-10-13 1976-06-15 Lucaks And Jacoby Associates Serum separating apparatus
US4043928A (en) 1973-10-31 1977-08-23 Lukacs And Jacoby Associates Serum separating composition of matter
US4155991A (en) * 1974-10-18 1979-05-22 Schering Aktiengesellschaft Vaginal ring
IL48277A (en) 1974-10-18 1978-03-10 Schering Ag Vaginal ring
US4093709A (en) 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
US4144317A (en) * 1975-05-30 1979-03-13 Alza Corporation Device consisting of copolymer having acetoxy groups for delivering drugs
US4096860A (en) 1975-10-08 1978-06-27 Mclaughlin William F Dual flow encatheter
US3995634A (en) 1975-12-02 1976-12-07 The Procter & Gamble Company Vaginal cavity dispensing means and method
US3995633A (en) 1975-12-02 1976-12-07 The Procter & Gamble Company Vaginal Medicament dispensing device
US4219426A (en) 1976-03-19 1980-08-26 Organon Teknika B.V. Dialysis device
US4237885A (en) 1978-10-23 1980-12-09 Alza Corporation Delivery system with mated members for storing and releasing a plurality of beneficial agents
US4292965A (en) 1978-12-29 1981-10-06 The Population Council, Inc. Intravaginal ring
DE3040978A1 (de) 1980-10-28 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Vaginalring
US4484559A (en) * 1982-03-01 1984-11-27 Mcdermott Incorporated Apparatus for removing material such as concrete from underwater pipelines
DE3214667C2 (de) 1982-04-21 1985-07-18 Akzo Gmbh, 5600 Wuppertal Zusammengesetzter Körper für die Langzeitabgabe von Wirkstoffen
CA1223831A (en) 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US4629449A (en) * 1982-07-29 1986-12-16 Alza Corporation Vaginal dispenser for dispensing beneficial hormone
NL8301035A (nl) 1983-03-23 1984-10-16 Organon Teknika Bv Macromoleculair materiaal met carbonylgroepen geschikt als sorbent voor stikstofverbindingen.
US4558996A (en) 1983-06-30 1985-12-17 Organon Teknika Corporation Easy load peristaltic pump
US4484599A (en) 1983-09-23 1984-11-27 Organon Teknika Corporation Pinch-type pressure- or flow-regulating valve
ZA857643B (en) * 1984-10-12 1986-05-28 Akzo Nv Release system for two or more active substances
US4596576A (en) * 1984-10-12 1986-06-24 Akzo N.V. Release system for two or more active substances
US4645502A (en) 1985-05-03 1987-02-24 Alza Corporation Transdermal delivery of highly ionized fat insoluble drugs
US4762717A (en) * 1986-03-21 1988-08-09 The General Hospital Corporation Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use as a contraceptive
SE8602666D0 (sv) 1986-06-16 1986-06-16 Leo Ab Intravaginal devices
US4938759A (en) 1986-09-02 1990-07-03 Alza Corporation Transdermal delivery device having a rate controlling adhesive
CA1331563C (en) 1987-08-03 1994-08-23 Gaylen M. Zentner Device for the controlled release of drugs with donnan-like modulation by charged insoluble resins
EP0303306B1 (en) 1987-08-08 1993-03-10 Akzo N.V. Contraceptive implant
US5474783A (en) 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
NO179479C (no) 1988-03-11 1996-10-16 Teikoku Seiyaku Kk Fremgangsmåte for fremstilling av et intravaginalt farmasöytisk preparat
US5034229A (en) 1988-12-13 1991-07-23 Alza Corporation Dispenser for increasing feed conversion of hog
US5002540A (en) 1989-05-22 1991-03-26 Warren Kirschbaum Intravaginal device and method for delivering a medicament
US5252334A (en) 1989-09-08 1993-10-12 Cygnus Therapeutic Systems Solid matrix system for transdermal drug delivery
HU208495B (en) 1990-06-27 1993-11-29 Alkaloida Vegyeszeti Gyar Process for producing retarde pharmaceutical compositions
IE67345B1 (en) 1991-03-12 1996-03-20 Akzo Nv Low dose dry pharmaceutical preparations
US5211952A (en) 1991-04-12 1993-05-18 University Of Southern California Contraceptive methods and formulations for use therein
US5340585A (en) 1991-04-12 1994-08-23 University Of Southern California Method and formulations for use in treating benign gynecological disorders
US5302397A (en) * 1991-11-19 1994-04-12 Amsden Brian G Polymer-based drug delivery system
US6013853A (en) 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
EP0566135A1 (en) 1992-04-17 1993-10-20 Takeda Chemical Industries, Ltd. Transmucosal composition comprising a peptide and a cytidine derivative
CA2098889A1 (en) 1992-07-06 1994-01-07 Takashi Chinuki Slow-releasing medicated resin moldings and process for producing the same
US5482702A (en) * 1993-04-27 1996-01-09 Church & Dwight Co., Inc. Hydrophilic polymer-coated microcrystallites of bicarbonate salt
US5919478A (en) 1993-06-25 1999-07-06 Alza Corporation Incorporating poly-N-vinyl amide in a transdermal system
GB2282384B8 (en) 1993-08-18 1997-09-04 Europ Economic Community Drug delivery agents incorporating mitomycin
US5543150A (en) 1993-09-15 1996-08-06 Columbia Laboratories, Inc. Method of progesterone delivery and affect thereof
CZ187796A3 (en) 1993-12-27 1997-01-15 Akzo Nobel Nv Pharmaceutical preparation
FR2717688B1 (fr) 1994-03-28 1996-07-05 Lhd Lab Hygiene Dietetique Système matriciel transdermique d'administration d'un oestrogène et/ou un progestatif à base d'EVA.
FI97944C (fi) * 1994-07-05 1997-03-25 Leiras Oy Vaikuttavaa ainetta luovuttava laite
US5681568A (en) 1994-08-19 1997-10-28 Cambridge Neuroscience, Inc. Device for delivery of substances and methods of use thereof
US5593965A (en) 1994-10-20 1997-01-14 Creighton University Anti-tumor effects of GnRH-III
IL116433A (en) 1994-12-19 2002-02-10 Galen Chemicals Ltd INTRAVAGINAL DRUG DELIVERY DEVICES FOR THE ADMINISTRATION OF 17β-OESTRADIOL PRECURSORS
EP0818990A1 (en) 1995-04-03 1998-01-21 Abbott Laboratories Homogeneous mixtures of low temperature-melting drugs and additives for controlled release
US5601839A (en) 1995-04-26 1997-02-11 Theratech, Inc. Triacetin as a penetration enhancer for transdermal delivery of a basic drug
US6572879B1 (en) 1995-06-07 2003-06-03 Alza Corporation Formulations for transdermal delivery of pergolide
WO1997002015A1 (en) * 1995-07-04 1997-01-23 Akzo Nobel N.V. Ring-shaped devices
FR2739032B1 (fr) 1995-09-27 1997-11-21 Lhd Lab Hygiene Dietetique Systeme matriciel transdermique d'administration d'un oestrogene et/ou d'un progestatif a base d'eva, procede de preparation et utilisation en therapeutique
US5780435A (en) 1995-12-15 1998-07-14 Praecis Pharmaceuticals Incorporated Methods for treating prostate cancer with LHRH-R antagonists
US6156331A (en) 1996-02-02 2000-12-05 Alza Corporation Sustained delivery of an active agent using an implantable system
US5869081A (en) 1996-06-28 1999-02-09 The Population Council Progesterone vaginal ring for treatment of infertility
US6139873A (en) 1996-07-10 2000-10-31 Cedars-Sinai Medical Center Combined pharmaceutical estrogen-androgen-progestin
US5972372A (en) 1996-07-31 1999-10-26 The Population Council, Inc. Intravaginal rings with insertable drug-containing core
US5945128A (en) 1996-09-04 1999-08-31 Romano Deghenghi Process to manufacture implants containing bioactive peptides
PT839525E (pt) 1996-10-31 2004-10-29 Takeda Chemical Industries Ltd Preparacao de libertacao prolongada
US5985861A (en) 1996-11-04 1999-11-16 Columbia Laboratories, Inc. Progesterone for treating or reducing ischemia
JPH10138432A (ja) 1996-11-14 1998-05-26 Teijin Ltd 磁気テープ用二軸配向積層ポリエステルフィルム
US5968895A (en) 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
JPH10279499A (ja) 1997-04-04 1998-10-20 Takeda Chem Ind Ltd 子宮粘膜適用製剤
IL123813A0 (en) 1997-04-11 1998-10-30 Akzo Nobel Nv Drug delivery system for two or more active substances
MY118835A (en) 1997-04-18 2005-01-31 Ipsen Pharma Biotech Sustained release compositions and the process for their preparation
US6572874B1 (en) 1998-05-15 2003-06-03 Umd, Inc. Vaginal delivery of bisphosphonates
US6197327B1 (en) 1997-06-11 2001-03-06 Umd, Inc. Device and method for treatment of dysmenorrhea
US6905701B2 (en) 1997-06-11 2005-06-14 Umd, Inc. Formulations for transmucosal vaginal delivery of bisphosphonates
US6416779B1 (en) 1997-06-11 2002-07-09 Umd, Inc. Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections
US6039968A (en) * 1997-06-24 2000-03-21 Hoechst Marion Roussel Intravaginal drug delivery device
US5941844A (en) 1997-11-17 1999-08-24 Alza Corporation Method and device for controlling mammalian reproductive cycle
KR100568917B1 (ko) 1997-12-30 2006-04-07 알자 코포레이션 멤브레인 플러그를 갖는 익제 전달장치
USD442688S1 (en) 1998-01-28 2001-05-22 N.V. Organon Vaginal ring applicator
EP0940678A1 (en) 1998-03-02 1999-09-08 Akzo Nobel N.V. Analytical test device
US5945123A (en) 1998-04-02 1999-08-31 K-V Pharmaceutical Company Maximizing effectiveness of substances used to improve health and well being
DE69929055T2 (de) * 1998-05-01 2006-07-20 Duramed Pharmaceuticals Inc., Cincinnati Verfahren zur spritzgussherstellung von vorrichtungen mit kontrollierter wirkstofffreisetzung und damit hergestellte vorrichtung
US6218367B1 (en) 1998-09-15 2001-04-17 Organomed Corporation Paclitaxel-carbohydrate conjugates: design, synthesis and biological evaluations
US6143314A (en) 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
US6159491A (en) 1999-02-12 2000-12-12 Biovector Technologies, Inc. Prolonged release bioadhesive vaginal gel dosage form
WO2001014478A1 (en) 1999-08-25 2001-03-01 Dai-Ichi Kogyo Seiyaku Co., Ltd Gel-form molded resin composition, packaged volatile gel-form chemical, and process for producing the same
US6264973B1 (en) 1999-08-26 2001-07-24 Fei Enterprises, Ltd. Apparatus and method for anesthetizing the cervical region of a female
US7052714B1 (en) 1999-10-13 2006-05-30 Senju Pharmaceutical Co., Ltd Ophthalmic adhesive preparations for percutaneous adsorption
US6264981B1 (en) 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
GB0102342D0 (en) * 2001-01-30 2001-03-14 Smithkline Beecham Plc Pharmaceutical formulation
US6687178B1 (en) * 2001-02-23 2004-02-03 Western Digital (Fremont), Inc. Temperature dependent write current source for magnetic tunnel junction MRAM

Similar Documents

Publication Publication Date Title
JP2007525461A5 (https=)
CA2523859A1 (en) Methods and devices for the sustained release of multiple drugs
US4402695A (en) Device for delivering agent in vagina
US10532025B2 (en) Intrauterine delivery system for contraception
US4250611A (en) Process for making drug delivery device with reservoir
US4629449A (en) Vaginal dispenser for dispensing beneficial hormone
AU2005271865B2 (en) Coated vaginal device for delivery of anti-migraine and anti-nausea drugs and a method for treatment of migraine and nausea
AR066166A1 (es) Sistema de suministro de droga
AU2009317127B2 (en) Intravaginal delivery system and process for manufacturing it
RU2648827C2 (ru) Внутривлагалищное устройство для доставки лекарственного средства
JP2005507874A (ja) 癌治療のための化学療法剤及び膜流出システム阻害剤の経膣送達
CN101827581A (zh) 用于递送大分子和水溶性药物的阴道内药物递送装置
MX2011001605A (es) Dispositivos intravaginales con un soporte rigido, metodos de fabricacion y usos de los mismos.
JP2012523446A (ja) オンデマンド避妊方法
WO2019200694A1 (zh) 一种宫腔内具备重新激活内膜基底层功能的弹性膜及其制备方法
US20190201418A1 (en) Treatment of uterine fibroids by intravaginal administration of a low dose of selective progesterone receptor modulator (sprm), anti-progestin, or anti-progestational agent
TW202320878A (zh) 用於遞送避孕藥之可再填充植入式裝置
das Neves et al. Vaginal drug delivery
CA1143289A (en) Microparticle drug delivery system
CN202044643U (zh) 一种防治宫腔粘连的药物带膜支架
US8980304B2 (en) Barrel-shaped vaginal ring
Prashant et al. Intravaginal Drug Delivery System: Compherensive Approach to Vaginal Formulations.
WO2020201767A1 (en) Drug delivery and administration device
Malcolm et al. 21 Vagina and Uterus as Drug-Absorbing Organs
CN202892184U (zh) 一种防止宫腔再次粘连的宫内节育器