JP2007522244A5 - - Google Patents

Info

Publication number

JP2007522244A5

JP2007522244A5 JP2006553332A JP2006553332A JP2007522244A5 JP 2007522244 A5 JP2007522244 A5 JP 2007522244A5 JP 2006553332 A JP2006553332 A JP 2006553332A JP 2006553332 A JP2006553332 A JP 2006553332A JP 2007522244 A5 JP2007522244 A5 JP 2007522244A5

Authority

JP

Japan

Prior art keywords

group

complex according

complex

aqueous solution

amidomalonate

Prior art date

2005-02-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 238000000034 method Methods 0.000 claims description 13
• 239000007864 aqueous solution Substances 0.000 claims description 12
• 125000001931 aliphatic group Chemical group 0.000 claims description 5
• 239000002253 acid Substances 0.000 claims description 3
• 229920000642 polymer Polymers 0.000 claims description 2
• BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 28
• 206010028980 Neoplasm Diseases 0.000 claims 9
• -1 cycloaliphatic Chemical group 0.000 claims 9
• 229910052697 platinum Inorganic materials 0.000 claims 9
• 230000008685 targeting Effects 0.000 claims 8
• 239000000203 mixture Substances 0.000 claims 6
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
• 239000002202 Polyethylene glycol Substances 0.000 claims 4
• 150000001413 amino acids Chemical class 0.000 claims 4
• 239000000872 buffer Substances 0.000 claims 4
• 239000013522 chelant Substances 0.000 claims 4
• FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 claims 4
• OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 4
• 150000002224 folic acids Chemical class 0.000 claims 4
• 229910052739 hydrogen Inorganic materials 0.000 claims 4
• 239000001257 hydrogen Substances 0.000 claims 4
• 229920001223 polyethylene glycol Polymers 0.000 claims 4
• 238000000108 ultra-filtration Methods 0.000 claims 4
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
• 150000001768 cations Chemical class 0.000 claims 3
• 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 3
• 125000005647 linker group Chemical group 0.000 claims 3
• 229910052757 nitrogen Inorganic materials 0.000 claims 3
• 239000000126 substance Substances 0.000 claims 3
• AUTOLBMXDDTRRT-JGVFFNPUSA-N (4R,5S)-dethiobiotin Chemical compound C[C@@H]1NC(=O)N[C@@H]1CCCCCC(O)=O AUTOLBMXDDTRRT-JGVFFNPUSA-N 0.000 claims 2
• OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 claims 2
• OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 2
• 125000000217 alkyl group Chemical group 0.000 claims 2
• 150000001408 amides Chemical class 0.000 claims 2
• 125000003277 amino group Chemical group 0.000 claims 2
• 229940045687 antimetabolites folic acid analogs Drugs 0.000 claims 2
• 125000003118 aryl group Chemical group 0.000 claims 2
• 125000004429 atom Chemical group 0.000 claims 2
• 229960002685 biotin Drugs 0.000 claims 2
• 235000020958 biotin Nutrition 0.000 claims 2
• 239000011616 biotin Substances 0.000 claims 2
• 150000001615 biotins Chemical class 0.000 claims 2
• 229910052799 carbon Inorganic materials 0.000 claims 2
• 125000004432 carbon atom Chemical group C* 0.000 claims 2
• 150000001867 cobalamins Chemical class 0.000 claims 2
• SSJXIUAHEKJCMH-UHFFFAOYSA-N cyclohexane-1,2-diamine Chemical compound NC1CCCCC1N SSJXIUAHEKJCMH-UHFFFAOYSA-N 0.000 claims 2
• 229960000304 folic acid Drugs 0.000 claims 2
• 235000019152 folic acid Nutrition 0.000 claims 2
• 239000011724 folic acid Substances 0.000 claims 2
• 125000000623 heterocyclic group Chemical group 0.000 claims 2
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
• 230000003647 oxidation Effects 0.000 claims 2
• 238000007254 oxidation reaction Methods 0.000 claims 2
• 239000008363 phosphate buffer Substances 0.000 claims 2
• 229920001308 poly(aminoacid) Polymers 0.000 claims 2
• 150000003141 primary amines Chemical class 0.000 claims 2
• 150000003335 secondary amines Chemical class 0.000 claims 2
• 150000003512 tertiary amines Chemical class 0.000 claims 2
• 125000001302 tertiary amino group Chemical group 0.000 claims 2
• SSJXIUAHEKJCMH-PHDIDXHHSA-N (1r,2r)-cyclohexane-1,2-diamine Chemical group N[C@@H]1CCCC[C@H]1N SSJXIUAHEKJCMH-PHDIDXHHSA-N 0.000 claims 1
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
• 108010020346 Polyglutamic Acid Proteins 0.000 claims 1
• 108010039918 Polylysine Proteins 0.000 claims 1
• 125000002877 alkyl aryl group Chemical group 0.000 claims 1
• 125000003710 aryl alkyl group Chemical group 0.000 claims 1
• 229920001577 copolymer Polymers 0.000 claims 1
• 238000009295 crossflow filtration Methods 0.000 claims 1
• 150000002148 esters Chemical class 0.000 claims 1
• 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 claims 1
• 150000004676 glycans Chemical class 0.000 claims 1
• YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical group [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 claims 1
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• OKPYIWASQZGASP-UHFFFAOYSA-N n-(2-hydroxypropyl)-2-methylprop-2-enamide Chemical compound CC(O)CNC(=O)C(C)=C OKPYIWASQZGASP-UHFFFAOYSA-N 0.000 claims 1
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 108010064470 polyaspartate Proteins 0.000 claims 1
• 229920000656 polylysine Polymers 0.000 claims 1
• 229920001282 polysaccharide Polymers 0.000 claims 1
• 239000005017 polysaccharide Substances 0.000 claims 1
• 125000001453 quaternary ammonium group Chemical group 0.000 claims 1
• 229920005604 random copolymer Polymers 0.000 claims 1
• 0 *NC1C(N*S)=CCC=C1 Chemical compound *NC1C(N*S)=CCC=C1 0.000 description 2
• 239000000243 solution Substances 0.000 description 2
• 125000002723 alicyclic group Chemical group 0.000 description 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1