JP4717016B2 - Ｏ，ｏ’−アミドマロネートおよびｎ，ｏ−アミドマロネート白金錯体 - Google Patents

Ｏ，ｏ’−アミドマロネートおよびｎ，ｏ−アミドマロネート白金錯体 Download PDF

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JP4717016B2
JP4717016B2 JP2006553332A JP2006553332A JP4717016B2 JP 4717016 B2 JP4717016 B2 JP 4717016B2 JP 2006553332 A JP2006553332 A JP 2006553332A JP 2006553332 A JP2006553332 A JP 2006553332A JP 4717016 B2 JP4717016 B2 JP 4717016B2
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ama
chelate
hpma
poly
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JP2007522244A (ja
JP2007522244A5 (enExample
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ポール ソード
ドナルド アール． ステュアート
デビッド ピー． ノボトニク
セルゲイ ヴィクトロヴィッチ シェフチュク
２ ケネス ブルース サーモンド
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アクセス ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2006553332A 2004-02-13 2005-02-11 Ｏ，ｏ’−アミドマロネートおよびｎ，ｏ−アミドマロネート白金錯体 Expired - Fee Related JP4717016B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/779,186 US7166733B2 (en) 2000-01-04 2004-02-13 O,O'-Amidomalonate and N,O-Amidomalonate platinum complexes
US10/779,186 2004-02-13
PCT/US2005/004704 WO2005079396A2 (en) 2004-02-13 2005-02-11 O,o'-amidomalonate and n,o-amidomalonate platinum complexes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011010328A Division JP2011105736A (ja) 2004-02-13 2011-01-21 Ｏ，ｏ’−アミドマロネートおよびｎ，ｏ−アミドマロネート白金錯体

Publications (3)

Publication Number Publication Date
JP2007522244A JP2007522244A (ja) 2007-08-09
JP2007522244A5 JP2007522244A5 (enExample) 2011-03-10
JP4717016B2 true JP4717016B2 (ja) 2011-07-06

Family

ID=34886574

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2006553332A Expired - Fee Related JP4717016B2 (ja) 2004-02-13 2005-02-11 Ｏ，ｏ’−アミドマロネートおよびｎ，ｏ−アミドマロネート白金錯体
JP2011010328A Pending JP2011105736A (ja) 2004-02-13 2011-01-21 Ｏ，ｏ’−アミドマロネートおよびｎ，ｏ−アミドマロネート白金錯体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011010328A Pending JP2011105736A (ja) 2004-02-13 2011-01-21 Ｏ，ｏ’−アミドマロネートおよびｎ，ｏ−アミドマロネート白金錯体

Country Status (9)

Country Link
US (2) US7166733B2 (enExample)
EP (1) EP1723158A4 (enExample)
JP (2) JP4717016B2 (enExample)
AU (1) AU2005214903A1 (enExample)
CA (1) CA2556192A1 (enExample)
NZ (1) NZ549829A (enExample)
TW (1) TWI329646B (enExample)
WO (1) WO2005079396A2 (enExample)
ZA (1) ZA200607643B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7166733B2 (en) * 2000-01-04 2007-01-23 Access Pharmaceuticals, Inc. O,O'-Amidomalonate and N,O-Amidomalonate platinum complexes
US7754684B2 (en) * 2003-06-11 2010-07-13 Access Pharmaceuticals, Inc. Macromolecular platinum chelates
WO2007008247A2 (en) * 2004-11-10 2007-01-18 University Of South Florida Platinum complexes for targeted drug delivery
RU2472812C2 (ru) 2005-12-05 2013-01-20 НИТТО ДЕНКО КОРПОРЭЙШН (Джэпэн/Джэпэн) Конъюгаты полиглутамат-аминокислота и способы
DK2155254T3 (da) * 2007-05-09 2013-03-04 Nitto Denko Corp Med platinlægemidler konjugerede polymere
US20080300389A1 (en) * 2007-06-04 2008-12-04 Yang David J Metal-polysaccharide conjugates: compositions, synthesis and methods for cancer therapy
PL2209814T3 (pl) * 2007-11-13 2017-08-31 Bio-Technology General (Israel) Ltd. Proces sterylizacji przez filtrację z rozcieńczaniem dla lepkosprężystych biopolimerów
AU2008331439B9 (en) * 2007-12-07 2014-04-10 Prana Biotechnology Ltd Compounds for therapy and diagnosis
KR101705077B1 (ko) * 2008-10-07 2017-02-09 렉산 파마슈티컬스, 인코포레이티드 Ｈｐｍａ-도세탁셀 또는 젬시타빈 컨쥬게이트 및 이의 용도
EP2488207A4 (en) 2009-10-13 2015-06-10 Rexahn Pharmaceuticals Inc POLYMERIC ANTIBODY RELEASE SYSTEMS
CN102863474A (zh) * 2011-07-09 2013-01-09 陈小平 一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用
US9884123B2 (en) * 2012-01-03 2018-02-06 Invictus Oncology Pvt. Ltd. Ligand-targeted molecules and methods thereof
WO2016196514A1 (en) * 2015-06-01 2016-12-08 Regents Of The University Of Minnesota Thiourea catalysts
KR20180019536A (ko) 2015-06-24 2018-02-26 니폰 가야꾸 가부시끼가이샤 신규한 백금(ⅳ) 착물
WO2017047497A1 (ja) 2015-09-14 2017-03-23 日本化薬株式会社 ６配位白金錯体の高分子結合体

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3614834A1 (de) * 1986-05-02 1987-11-05 Henkel Kgaa Verwendung von aminogruppen enthaltenden polyglykolethern als schaumdrueckende zusaetze in schaumarmen reinigungsmitteln
JPS6493A (en) * 1987-02-20 1989-01-05 Tanabe Seiyaku Co Ltd Novel organoplatinum complex
US4882447A (en) 1987-02-20 1989-11-21 Tanabe Seiyaku Co., Ltd. Novel organic platinum complex and process for the preparation thereof
IL85595A0 (en) 1987-03-06 1988-08-31 Tanabe Seiyaku Co Organic platinum complex and its preparation
JPS6494A (en) * 1987-03-06 1989-01-05 Tanabe Seiyaku Co Ltd Novel organoplatinum complex
US4870070A (en) * 1987-08-10 1989-09-26 American Cyanamid Company Water soluble platinum complexes of novel malonate derivatives
IT1216687B (it) * 1988-04-01 1990-03-08 Boehringer Biochemia Srl Complessi di platino (ii), loro preparazione e impiego come antitumorali.
JPH0256421A (ja) * 1988-08-19 1990-02-26 Tanabe Seiyaku Co Ltd 抗腫瘍剤
JPH0267217A (ja) * 1988-09-01 1990-03-07 Tanabe Seiyaku Co Ltd 抗腫瘍剤
US4946954A (en) 1989-01-17 1990-08-07 Georgetown University Platinum pharmaceutical agents
JPH04330090A (ja) * 1991-01-26 1992-11-18 Tanaka Kikinzoku Kogyo Kk 新規白金化合物
KR0164460B1 (ko) * 1995-10-02 1999-03-20 김은영 고분자 백금 착화합물, 그의 제조방법 및 그를 유효성분으로 하는 항암제
US5965118A (en) * 1997-04-18 1999-10-12 Access Pharmaceuticals, Inc. Polymer-platinum compounds
US6290947B1 (en) * 1997-09-19 2001-09-18 Geltex Pharmaceuticals, Inc. Ionic polymers as toxin-binding agents
AU2762101A (en) * 2000-01-04 2001-07-16 Access Pharmaceuticals, Inc. N,o-amidomalonate platinum complexes
US7166733B2 (en) * 2000-01-04 2007-01-23 Access Pharmaceuticals, Inc. O,O'-Amidomalonate and N,O-Amidomalonate platinum complexes
KR100363394B1 (ko) * 2000-08-21 2002-12-05 한국과학기술연구원 온도감응성을 갖는 포스파젠삼량체-백금착물 복합체, 그의제조방법 및 그를 함유하는 항암제 조성물
KR100499340B1 (ko) * 2003-04-29 2005-07-04 학교법인 이화학당 암 조직 선택성과 생분해성을 갖는폴리포스파젠-백금(ⅱ)착물 복합체 항암제 및 그 제조방법

Also Published As

Publication number Publication date
EP1723158A2 (en) 2006-11-22
US20040175387A1 (en) 2004-09-09
JP2011105736A (ja) 2011-06-02
NZ549829A (en) 2010-04-30
JP2007522244A (ja) 2007-08-09
US20070197427A1 (en) 2007-08-23
US7166733B2 (en) 2007-01-23
TWI329646B (en) 2010-09-01
CA2556192A1 (en) 2005-09-01
EP1723158A4 (en) 2010-05-19
WO2005079396A2 (en) 2005-09-01
TW200602076A (en) 2006-01-16
WO2005079396A3 (en) 2006-11-02
ZA200607643B (en) 2008-07-30
AU2005214903A1 (en) 2005-09-01

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