JPS6493A - Novel organoplatinum complex - Google Patents
Novel organoplatinum complexInfo
- Publication number
- JPS6493A JPS6493A JP63038247A JP3824788A JPS6493A JP S6493 A JPS6493 A JP S6493A JP 63038247 A JP63038247 A JP 63038247A JP 3824788 A JP3824788 A JP 3824788A JP S6493 A JPS6493 A JP S6493A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound shown
- substituted
- novel
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
NEW MATERIAL:A compound shown by formula I [R1 is H or lower alkyl; R2 is (substituted) lower alkyl, lower alkenyl, lower alkenyl, lower alkanoyl, mono- or di- lower alkylamino, (substituted) nitrogen-containing heterocyclic group, oxygen-containing hetero monocyclic group or -CH2O(CH2CH2O)m (m is 1 or 2 ); X is carbonyl or sulfonyl].
EXAMPLE: [2-[(Hydroxyacetyl)amino]malonato(trans-l-1,2-diaminocyclo-hexane) platinum (II).
USE: An antitumor agent having excellent multiplication inhibitory effects especially on solid tumor and hardly showing nephrotoxicity.
PREPARATION: A 1,2-diaminocyclohexane platinum complex (X1 and X2 are reactive residue) is reacted with a 2-(substituted amino)malonic acid (salt) shown by formula III. The compound shown by formula III is a novel compound and obtained by condensing a compound shown by formula IV with a compound shown by formula V.
COPYRIGHT: (C)1989,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63038247A JPS6493A (en) | 1987-02-20 | 1988-02-19 | Novel organoplatinum complex |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3824087 | 1987-02-20 | ||
| JP62-38240 | 1987-02-20 | ||
| JP63038247A JPS6493A (en) | 1987-02-20 | 1988-02-19 | Novel organoplatinum complex |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0193A JPH0193A (en) | 1989-01-05 |
| JPS6493A true JPS6493A (en) | 1989-01-05 |
Family
ID=26377449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63038247A Pending JPS6493A (en) | 1987-02-20 | 1988-02-19 | Novel organoplatinum complex |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6493A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007522244A (en) * | 2004-02-13 | 2007-08-09 | アクセス ファーマシューティカルズ， インコーポレイテッド | O, O'-amidmalonate and N, O-amidmalonate platinum complexes |
| WO2014203691A1 (en) * | 2013-06-18 | 2014-12-24 | 株式会社ヤクルト本社 | Novel medicine containing platinum complex |
-
1988
- 1988-02-19 JP JP63038247A patent/JPS6493A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007522244A (en) * | 2004-02-13 | 2007-08-09 | アクセス ファーマシューティカルズ， インコーポレイテッド | O, O'-amidmalonate and N, O-amidmalonate platinum complexes |
| JP2011105736A (en) * | 2004-02-13 | 2011-06-02 | Access Pharmaceuticals Inc | O,o'-amidomalonate and n,o-amidomalonate platinum complex |
| JP4717016B2 (en) * | 2004-02-13 | 2011-07-06 | アクセス ファーマシューティカルズ， インコーポレイテッド | O, O'-amidmalonate and N, O-amidmalonate platinum complexes |
| WO2014203691A1 (en) * | 2013-06-18 | 2014-12-24 | 株式会社ヤクルト本社 | Novel medicine containing platinum complex |
| JPWO2014203691A1 (en) * | 2013-06-18 | 2017-02-23 | 株式会社ヤクルト本社 | New drugs containing platinum complexes |
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