JPS5728037A - Octadecenoic acid amide - Google Patents

Octadecenoic acid amide

Info

Publication number
JPS5728037A
JPS5728037A JP10470780A JP10470780A JPS5728037A JP S5728037 A JPS5728037 A JP S5728037A JP 10470780 A JP10470780 A JP 10470780A JP 10470780 A JP10470780 A JP 10470780A JP S5728037 A JPS5728037 A JP S5728037A
Authority
JP
Japan
Prior art keywords
formula
dioxo
trans
octadecenoic acid
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10470780A
Other languages
Japanese (ja)
Other versions
JPS6132304B2 (en
Inventor
Shingo Matsumura
Hiroshi Enomoto
Mitsuhiro Maehara
Masakuni Ozaki
Hideya Hayashi
Masato Matsuda
Masao Fujita
Ichiro Shirahase
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Priority to JP10470780A priority Critical patent/JPS5728037A/en
Priority to KR1019800004751A priority patent/KR840001669B1/en
Publication of JPS5728037A publication Critical patent/JPS5728037A/en
Publication of JPS6132304B2 publication Critical patent/JPS6132304B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

NEW MATERIAL:The 9,12-dioxo-trans-10-octadecenoic acid amide dervative of formula I [R is alkyl, alkenyl, cycloalkyl, aralkyl, furfuryl, (substituted) phenyl, or group of formula -(CH2)n-X (X is group of formula II, formula III, etc.; n is integer 0W3)].
EXAMPLE: N-Isopropyl-9,12-dioxo-trans-10-octadecenamide.
USE: Preventive and remedy for arteriosclerosis, cardiac infarction, etc. It has strong blood platelet coagulation inhibiting activity and carcinostatic activity.
PROCESS: The compound of formula I is prepared by converting the carboxyl group of the 9,12-dioxo-trans-10-octadecenoic acid of formula IV to a reactive derivative, and reacting the compound with the compound of formula R-NH2 in an inert organic solvent at -5°CWroom temperature.
COPYRIGHT: (C)1982,JPO&Japio
JP10470780A 1980-07-29 1980-07-29 Octadecenoic acid amide Granted JPS5728037A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP10470780A JPS5728037A (en) 1980-07-29 1980-07-29 Octadecenoic acid amide
KR1019800004751A KR840001669B1 (en) 1980-07-29 1980-12-13 Process for the preparation of octadecenic acid amide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10470780A JPS5728037A (en) 1980-07-29 1980-07-29 Octadecenoic acid amide

Publications (2)

Publication Number Publication Date
JPS5728037A true JPS5728037A (en) 1982-02-15
JPS6132304B2 JPS6132304B2 (en) 1986-07-25

Family

ID=14387947

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10470780A Granted JPS5728037A (en) 1980-07-29 1980-07-29 Octadecenoic acid amide

Country Status (2)

Country Link
JP (1) JPS5728037A (en)
KR (1) KR840001669B1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102770A1 (en) * 2001-06-18 2002-12-27 Maruha Corporation Novel aliphatic compound, method of synthesis, and method of utilization
KR100539965B1 (en) * 2002-08-29 2006-01-10 주식회사 코리아나화장품 Cosmetic Composition Comprising Novel Pseudo Ceramide for Preventing and Alleviating Atopic Dermatitis

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01150703U (en) * 1988-03-29 1989-10-18

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102770A1 (en) * 2001-06-18 2002-12-27 Maruha Corporation Novel aliphatic compound, method of synthesis, and method of utilization
US6949553B2 (en) 2001-06-18 2005-09-27 Maruha Corporation Aliphatic compounds, their synthesis method, and utilization of the same
KR100539965B1 (en) * 2002-08-29 2006-01-10 주식회사 코리아나화장품 Cosmetic Composition Comprising Novel Pseudo Ceramide for Preventing and Alleviating Atopic Dermatitis

Also Published As

Publication number Publication date
KR830004209A (en) 1983-07-06
KR840001669B1 (en) 1984-10-13
JPS6132304B2 (en) 1986-07-25

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