JPS57212169A - Guanidine derivative and its preparation - Google Patents
Guanidine derivative and its preparationInfo
- Publication number
- JPS57212169A JPS57212169A JP56098940A JP9894081A JPS57212169A JP S57212169 A JPS57212169 A JP S57212169A JP 56098940 A JP56098940 A JP 56098940A JP 9894081 A JP9894081 A JP 9894081A JP S57212169 A JPS57212169 A JP S57212169A
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- guanidine
- preparation
- formula
- guanidine derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000002357 guanidines Chemical class 0.000 title abstract 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 3
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 2
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 2
- 230000009858 acid secretion Effects 0.000 abstract 1
- KCXMKQUNVWSEMD-UHFFFAOYSA-N benzyl chloride Chemical compound ClCC1=CC=CC=C1 KCXMKQUNVWSEMD-UHFFFAOYSA-N 0.000 abstract 1
- 229940073608 benzyl chloride Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
Abstract
NEW MATERIAL:A guanidine derivative of formulaI(Bz is formula II, connecting to 1- or 3-position).
EXAMPLE: N-methyl-N'-cyano-N"-2-{[({[1-benzyl-4-methyl-5-imidazoyl)methylthio] ethyl]guanidine.
USE: It has a pharmacological activity such as inhibition of stomach acid secretion.
PREPARATION: The reaction of N-methyl-N'-cyano-N"-{2[4-methyl-5-imidazoyl) methylthio]ethyl}guanidine of formula III or its salt with benzyl chloride of formula IV is carried out in a solvent, preferably in the presence of a base, at room temperature to 150°C for 5W12hr to give the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56098940A JPS57212169A (en) | 1981-06-25 | 1981-06-25 | Guanidine derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56098940A JPS57212169A (en) | 1981-06-25 | 1981-06-25 | Guanidine derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57212169A true JPS57212169A (en) | 1982-12-27 |
Family
ID=14233109
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56098940A Pending JPS57212169A (en) | 1981-06-25 | 1981-06-25 | Guanidine derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57212169A (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5698938A (en) * | 1980-01-09 | 1981-08-08 | Rohm Co Ltd | Signal switching circuit |
-
1981
- 1981-06-25 JP JP56098940A patent/JPS57212169A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5698938A (en) * | 1980-01-09 | 1981-08-08 | Rohm Co Ltd | Signal switching circuit |
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