JPS6494A - Novel organoplatinum complex - Google Patents
Novel organoplatinum complexInfo
- Publication number
- JPS6494A JPS6494A JP63051178A JP5117888A JPS6494A JP S6494 A JPS6494 A JP S6494A JP 63051178 A JP63051178 A JP 63051178A JP 5117888 A JP5117888 A JP 5117888A JP S6494 A JPS6494 A JP S6494A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- substituted
- compound
- amino
- heteromonocyclic group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
NEW MATERIAL:A compound shown by formula I [R1 is H or lower alkyl; R2 is H, (substituted) lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy lower alkanoyl, amino, (substituted) nitrogen-containing heteromonocyclic group or oxygen-containing heteromonocyclic group; Alk is lower alkylene; X is carbonyl or sulfonyl; n is 1 or 2].
EXAMPLE: [2-[{N-(Chloroacetyl)glycyl}amino]malonato](trans-l-1-2-diaminocyclo hexane)platinum (II).
USE: An antitumor agent being preferably parenterally administered.
PREPARATION: A 1,2-diaminocyclohexane platinum complex shown by formula II (X1 and X2 are reactive residue ) is reacted with a 2-(substituted) aminomalonic acid (salt) shown by formula III. The compounds shown by formu la III is a novel substance and is obtained by reacting a compound shown by formula IV (h does not exceed n and is 0W2) with a compound by formula V.
COPYRIGHT: (C)1989,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63051178A JPS6494A (en) | 1987-03-06 | 1988-03-03 | Novel organoplatinum complex |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5282387 | 1987-03-06 | ||
JP62-52823 | 1987-03-06 | ||
JP63051178A JPS6494A (en) | 1987-03-06 | 1988-03-03 | Novel organoplatinum complex |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH0194A JPH0194A (en) | 1989-01-05 |
JPS6494A true JPS6494A (en) | 1989-01-05 |
Family
ID=26391713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP63051178A Pending JPS6494A (en) | 1987-03-06 | 1988-03-03 | Novel organoplatinum complex |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6494A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003530317A (en) * | 2000-01-04 | 2003-10-14 | アクセス ファーマシューティカルズ, インコーポレイテッド | N, O-amidomalonate platinum complex |
JP2007522244A (en) * | 2004-02-13 | 2007-08-09 | アクセス ファーマシューティカルズ, インコーポレイテッド | O, O'-amidmalonate and N, O-amidmalonate platinum complexes |
-
1988
- 1988-03-03 JP JP63051178A patent/JPS6494A/en active Pending
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003530317A (en) * | 2000-01-04 | 2003-10-14 | アクセス ファーマシューティカルズ, インコーポレイテッド | N, O-amidomalonate platinum complex |
JP2011137046A (en) * | 2000-01-04 | 2011-07-14 | Access Pharmaceuticals Inc | N, o-amidomalonate platinum complex |
JP5025062B2 (en) * | 2000-01-04 | 2012-09-12 | アクセス ファーマシューティカルズ, インコーポレイテッド | N, O-amidmalonate platinum complex |
JP2007522244A (en) * | 2004-02-13 | 2007-08-09 | アクセス ファーマシューティカルズ, インコーポレイテッド | O, O'-amidmalonate and N, O-amidmalonate platinum complexes |
JP2011105736A (en) * | 2004-02-13 | 2011-06-02 | Access Pharmaceuticals Inc | O,o'-amidomalonate and n,o-amidomalonate platinum complex |
JP4717016B2 (en) * | 2004-02-13 | 2011-07-06 | アクセス ファーマシューティカルズ, インコーポレイテッド | O, O'-amidmalonate and N, O-amidmalonate platinum complexes |
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