JP2007520214A5 - - Google Patents
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- JP2007520214A5 JP2007520214A5 JP2006547195A JP2006547195A JP2007520214A5 JP 2007520214 A5 JP2007520214 A5 JP 2007520214A5 JP 2006547195 A JP2006547195 A JP 2006547195A JP 2006547195 A JP2006547195 A JP 2006547195A JP 2007520214 A5 JP2007520214 A5 JP 2007520214A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- cell
- influenza virus
- plasmids
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 22
- 210000004027 cell Anatomy 0.000 claims description 10
- 241000712461 unidentified influenza virus Species 0.000 claims description 9
- 241000700605 Viruses Species 0.000 claims description 7
- 210000004102 animal cell Anatomy 0.000 claims description 7
- 108091034135 Vault RNA Proteins 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 2
- 102000011931 Nucleoproteins Human genes 0.000 claims description 2
- 108010061100 Nucleoproteins Proteins 0.000 claims description 2
- 102000004389 Ribonucleoproteins Human genes 0.000 claims description 2
- 108010081734 Ribonucleoproteins Proteins 0.000 claims description 2
- 230000001419 dependent effect Effects 0.000 claims description 2
- 239000013612 plasmid Substances 0.000 claims 6
- 210000003501 vero cell Anatomy 0.000 claims 2
- 241000712431 Influenza A virus Species 0.000 claims 1
- 241000713196 Influenza B virus Species 0.000 claims 1
- 241000713174 Influenza B virus (B/Ann Arbor/1/1966 [wild- type]) Species 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 230000029812 viral genome replication Effects 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53216403P | 2003-12-23 | 2003-12-23 | |
| US60/532,164 | 2003-12-23 | ||
| PCT/US2004/042669 WO2005062820A2 (en) | 2003-12-23 | 2004-12-22 | Multi plasmid system for the production of influenza virus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011084297A Division JP5264955B2 (ja) | 2003-12-23 | 2011-04-06 | インフルエンザウイルス作製のための多重プラスミド系 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007520214A JP2007520214A (ja) | 2007-07-26 |
| JP2007520214A5 true JP2007520214A5 (enExample) | 2007-10-18 |
| JP4771959B2 JP4771959B2 (ja) | 2011-09-14 |
Family
ID=34738759
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006547195A Expired - Lifetime JP4771959B2 (ja) | 2003-12-23 | 2004-12-22 | インフルエンザウイルス作製のための多重プラスミド系 |
| JP2011084297A Expired - Lifetime JP5264955B2 (ja) | 2003-12-23 | 2011-04-06 | インフルエンザウイルス作製のための多重プラスミド系 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011084297A Expired - Lifetime JP5264955B2 (ja) | 2003-12-23 | 2011-04-06 | インフルエンザウイルス作製のための多重プラスミド系 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US20050158342A1 (enExample) |
| EP (1) | EP1697521B1 (enExample) |
| JP (2) | JP4771959B2 (enExample) |
| AT (1) | ATE469972T1 (enExample) |
| AU (1) | AU2004308328B2 (enExample) |
| CA (1) | CA2551489C (enExample) |
| DE (1) | DE602004027537D1 (enExample) |
| ES (1) | ES2345492T3 (enExample) |
| WO (1) | WO2005062820A2 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6951754B2 (en) * | 2000-04-28 | 2005-10-04 | St. Jude Children's Research Hospital | DNA transfection system for the generation of infectious influenza virus |
| CN103540613A (zh) * | 2002-04-26 | 2014-01-29 | 米迪缪尼有限公司 | 制备流感病毒的多质粒系统 |
| US7465456B2 (en) * | 2002-04-26 | 2008-12-16 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
| US20060110406A1 (en) * | 2003-02-25 | 2006-05-25 | Medimmune Vaccines, Inc. | Refrigerator-temperature stable influenza vaccine compositions |
| KR101190932B1 (ko) | 2003-02-25 | 2012-10-16 | 메디뮨 엘엘씨 | 인플루엔자 백신 조성물의 제조 방법 |
| ATE469972T1 (de) | 2003-12-23 | 2010-06-15 | Medimmune Llc | Multiplasmid-system zur erzeugung des grippevirus |
| WO2005115448A2 (en) * | 2004-05-24 | 2005-12-08 | Medimmune Vaccines, Inc. | Multi plasmid system for the production of influenza virus |
| KR101346989B1 (ko) | 2004-10-06 | 2014-02-06 | 메디뮨 엘엘씨 | 냉장 온도 안정성 인플루엔자 백신 조성물 |
| KR20120128162A (ko) * | 2004-12-08 | 2012-11-26 | 메디뮨 엘엘씨 | 인플루엔자 백신 조성물의 제조 방법 |
| DK2368975T3 (en) | 2004-12-23 | 2015-01-05 | Medimmune Llc | Non-tumorigenic MDCK cell line for the propagation of viruses |
| US11865172B2 (en) | 2005-04-21 | 2024-01-09 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
| US7959929B2 (en) | 2005-04-21 | 2011-06-14 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
| CA2613284A1 (en) | 2005-06-21 | 2007-01-04 | Medimmune Vaccines, Inc. | Methods and compositions for expressing negative-sense viral rna in canine cells |
| US7790434B2 (en) * | 2005-06-21 | 2010-09-07 | Medimmune, Llc | Methods and compositions for expressing negative-sense viral RNA in canine cells |
| WO2007048089A2 (en) * | 2005-10-17 | 2007-04-26 | Medimmune, Llc | Multi-plasmid system for the production of influenza virus |
| KR101597534B1 (ko) * | 2005-10-19 | 2016-02-26 | 유니버시티 오브 플로리다 리서치 파운데이션, 인크. | 개과 동물의 호흡기 질병 조절을 위한 물질들 및 방법들 |
| NZ568210A (en) * | 2005-11-04 | 2012-12-21 | Novartis Vaccines & Diagnostic | Emulsions with free aqueous-phase surfactant as adjuvants for split influenza vaccines |
| US20100086485A1 (en) * | 2006-01-17 | 2010-04-08 | Heiko Apfel | Influenza vaccine |
| US9254318B2 (en) | 2006-03-31 | 2016-02-09 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
| US7682619B2 (en) | 2006-04-06 | 2010-03-23 | Cornell Research Foundation, Inc. | Canine influenza virus |
| RU2457250C2 (ru) | 2006-04-19 | 2012-07-27 | Медиммуне, Ллк | Способы и композиции для экспрессии антисмысловой вирусной рнк в клетках собаки |
| US9072701B2 (en) * | 2006-04-21 | 2015-07-07 | St. Jude Children's Research Hospital | Avian influenza viruses, vaccines, compositions, formulations, and methods |
| US7601356B2 (en) * | 2006-07-21 | 2009-10-13 | Medimmune, Llc | Methods and compositions for increasing replication capacity of an influenza virus |
| CN101627113B (zh) | 2006-09-15 | 2013-04-24 | 米迪缪尼有限公司 | 支持病毒生长到高效价的mdck细胞系和采用该细胞系的生物反应器方法 |
| US9662383B2 (en) * | 2007-03-26 | 2017-05-30 | University Of Massachusetts | Compositions and methods for increasing immunogenicity of glycoprotein vaccines |
| US20080294361A1 (en) * | 2007-05-24 | 2008-11-27 | Popp Shane M | Intelligent execution system for the monitoring and execution of vaccine manufacturing |
| US8673613B2 (en) | 2007-06-18 | 2014-03-18 | Medimmune, Llc | Influenza B viruses having alterations in the hemaglutinin polypeptide |
| US9474798B2 (en) | 2007-06-18 | 2016-10-25 | Wisconsin Alumni Research Foundation | Influenza M2 protein mutant viruses as live influenza attenuated vaccines |
| EP2045323A1 (en) * | 2007-10-05 | 2009-04-08 | Avir Green Hills Biotechnology Research Development Trade Ag | Linear expression constructs for production of influenza virus particles |
| BRPI0919250A2 (pt) | 2008-09-24 | 2015-12-15 | Medimmune Llc | métodos para a purificação de vírus |
| CN107365751B (zh) | 2008-12-16 | 2021-07-09 | 纳米医疗公司 | 流感疫苗的生产 |
| WO2010144797A2 (en) | 2009-06-12 | 2010-12-16 | Vaccine Technologies, Incorporated | Influenza vaccines with enhanced immunogenicity and uses thereof |
| CN102741399A (zh) * | 2009-10-20 | 2012-10-17 | 诺华有限公司 | 用于病毒拯救的改良反向遗传方法 |
| WO2011056591A1 (en) | 2009-10-26 | 2011-05-12 | Warf - Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in vero cells |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| US20140024101A1 (en) | 2011-04-08 | 2014-01-23 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method for increasing the replication capacity of an influenza virus in cultured cells |
| WO2012156476A2 (en) | 2011-05-16 | 2012-11-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for screening substances capable of modulating the replication of an influenza virus |
| EP2747778B1 (en) | 2011-08-26 | 2017-12-06 | Wisconsin Alumni Research Foundation | Influenza viruses with mutant pb2 gene segment as live attenuated vaccines |
| WO2013142329A1 (en) | 2012-03-22 | 2013-09-26 | Fraunhofer Usa, Inc. | Virus -like particles comprising a matrix protein from a plant enveloped virus and uses thereof |
| EP2880154B1 (en) | 2012-08-03 | 2019-05-15 | Sanofi Pasteur SA | Production of infectious influenza viruses |
| US9950057B2 (en) | 2013-07-15 | 2018-04-24 | Wisconsin Alumni Research Foundation (Warf) | High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| WO2017007839A1 (en) | 2015-07-06 | 2017-01-12 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| AU2017221444B2 (en) | 2016-02-19 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza B virus replication for vaccine development |
| MA45165A (fr) | 2016-06-02 | 2019-04-10 | Sanofi Pasteur Inc | Polypeptides antigéniques de la grippe modifiés et compositions immunogéniques associées |
| WO2018215937A1 (en) * | 2017-05-24 | 2018-11-29 | Novartis Ag | Interleukin-7 antibody cytokine engrafted proteins and methods of use in the treatment of cancer |
| JP2021500891A (ja) | 2017-10-25 | 2021-01-14 | ウィスコンシン アルムニ リサーチ ファンデイション | 卵における複製のための安定化されたｈａを有する組換えインフルエンザウイルス |
| AU2018392799A1 (en) | 2017-12-22 | 2020-05-28 | Codagenix, Inc. | Recombinant virus with codon-pair deoptimized region and uses thereof for the treatment of cancer |
| CA3091508A1 (en) | 2018-03-08 | 2019-09-12 | Codagenix Inc. | Attenuated flaviviruses |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| JP7655849B2 (ja) | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| WO2020167432A2 (en) | 2019-01-23 | 2020-08-20 | Yoshihiro Kawaoka | Mutations that confer genetic stability to additional genes in influenza viruses |
| US11851648B2 (en) | 2019-02-08 | 2023-12-26 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
| CN110042084A (zh) * | 2019-04-11 | 2019-07-23 | 浙江森卫生物医药发展有限公司 | 一种活病毒流感疫苗的生产方法以及制剂 |
| WO2020223699A1 (en) | 2019-05-01 | 2020-11-05 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| WO2021150874A1 (en) | 2020-01-24 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized na |
| US12290562B2 (en) | 2020-03-25 | 2025-05-06 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| WO2025074921A1 (ja) * | 2023-10-06 | 2025-04-10 | 株式会社微生物化学研究所 | ウイルスの生産方法 |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US450052A (en) * | 1891-04-07 | Eters co | ||
| US639958A (en) * | 1899-08-14 | 1899-12-26 | John Bartel | Hat-holder for milliners' use. |
| GB660109A (en) | 1946-10-01 | 1951-10-31 | American Cyanamid Co | Improvements in or relating to the treatment of allantoic fluid containing a propagated virus together with non-viral proteins to obtain the virus in purified and viable from for use in a vaccine |
| US3992522A (en) * | 1973-01-24 | 1976-11-16 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Temperature-sensitive recombinant mutant viruses and a process for producing same |
| US3874999A (en) | 1973-10-31 | 1975-04-01 | American Cyanamid Co | Process for the purification of virus vaccine |
| US4071618A (en) * | 1974-09-03 | 1978-01-31 | Research Foundation For Microbial Diseases Of Osaka University | Process for preparing virus disease live vaccines |
| US4000257A (en) | 1975-12-22 | 1976-12-28 | American Cyanamid Company | Process for the purification of influenza virus vaccine |
| US4057626A (en) | 1976-10-08 | 1977-11-08 | Richardson-Merrell Inc. | Process for detoxifying influenza B virus |
| US4338296A (en) | 1979-10-16 | 1982-07-06 | Smithkline-Rit | Influenza virus and process of producing a vaccine therefrom |
| US4337242A (en) | 1980-02-05 | 1982-06-29 | Merck & Co., Inc. | Vaccine stabilizer containing L-glutamic acid and L-arginine |
| US4512972A (en) | 1980-06-30 | 1985-04-23 | Kureha Chemical Industry Co., Ltd. | Nasal preparation and processes for their production |
| JPS57136528A (en) * | 1981-02-09 | 1982-08-23 | Hayashibara Biochem Lab Inc | Preparation of viral vaccine |
| FR2505657A1 (fr) | 1981-05-13 | 1982-11-19 | Pasteur Institut | Perfectionnements apportes aux agents de stabilisation de virus vivants pour la preparation de vaccins, et vaccins stabilises contenant lesdits agents de stabilisation |
| US4512285A (en) | 1983-12-27 | 1985-04-23 | Gof Manufacturing Company, Inc. | Apparatus and method for egg turning during incubation |
| US4634666A (en) | 1984-01-06 | 1987-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Human-murine hybridoma fusion partner |
| JPH0647260B2 (ja) * | 1985-07-30 | 1994-06-22 | 三菱油化株式会社 | 複合成形体 |
| GB8914968D0 (en) | 1989-06-29 | 1989-08-23 | Connaught Lab | Production of virus and purification of viral envelope proteins for vaccine use |
| US5166057A (en) * | 1989-08-28 | 1992-11-24 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand rna virus expression-systems |
| US5840520A (en) | 1989-08-28 | 1998-11-24 | Aviron | Recombinant negative strand RNA virus expression systems |
| US5854037A (en) * | 1989-08-28 | 1998-12-29 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand RNA virus expression systems and vaccines |
| US6887699B1 (en) * | 1990-05-22 | 2005-05-03 | Medimmune Vaccines, Inc. | Recombinant negative strand RNA virus expression systems and vaccines |
| DE69333856T2 (de) | 1992-04-14 | 2006-05-18 | Mount Sinai School Of Medicine Of The City University Of New York | Gentechnologisch abgeschwächter Virus |
| IL105456A (en) | 1992-04-21 | 1996-12-05 | American Home Prod | Vaccines of attenuated respiratory syncytial virus |
| CA2075521C (en) | 1992-05-05 | 1995-11-28 | Kuniaki Koyama | Stabilized live vaccine |
| PT702085E (pt) * | 1994-07-18 | 2004-04-30 | Karl Klaus Conzelmann | Virus de arn de cadeia negativa nao segmentada infeccioso recombinante |
| US5824536A (en) | 1994-08-23 | 1998-10-20 | St. Jude Children's Research Hospital | Influenza virus replicated in mammalian cell culture and vaccine production |
| US5789229A (en) * | 1994-09-30 | 1998-08-04 | Uab Research Foundation | Stranded RNA virus particles |
| AU3760495A (en) | 1994-09-30 | 1996-04-26 | Aviron | Chimeric Influenza Virus And Electroporation Method |
| US5716821A (en) * | 1994-09-30 | 1998-02-10 | Uab Research Foundation | Prevention and treatment of respiratory tract disease |
| US6146873A (en) * | 1994-11-10 | 2000-11-14 | Baxter Aktiengesellschaft | Production of orthomyxoviruses in monkey kidney cells using protein-free media |
| US7153510B1 (en) * | 1995-05-04 | 2006-12-26 | Yale University | Recombinant vesiculoviruses and their uses |
| US5690937A (en) | 1995-06-05 | 1997-11-25 | Aviron | Temperature sensitive clustered changed-to-alanine mutants of influenza virus PB2 gene |
| DE69510207T3 (de) | 1995-08-09 | 2007-02-15 | Schweiz. Serum- & Impfinstitut Bern | Verfahren zur Herstellung von infektiösen minussträngigen RNA-Viren |
| CA2230033C (en) | 1995-09-27 | 2010-01-26 | Peter L. Collins | Production of infectious respiratory syncytial virus from cloned nucleotide sequences |
| WO1997014434A1 (en) | 1995-10-20 | 1997-04-24 | Davidson, Clifford, M. | Influenza vaccine |
| EP0864645B9 (en) | 1995-10-31 | 2006-03-22 | Dnavec Research Inc. | Negative-strand rna virus vector having autonomously replicating activity |
| AU7335296A (en) | 1995-11-01 | 1997-05-22 | Dnavec Research Inc. | Recombinant sendai virus |
| US6090391A (en) * | 1996-02-23 | 2000-07-18 | Aviron | Recombinant tryptophan mutants of influenza |
| DE19612966B4 (de) | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
| BR9710363A (pt) | 1996-07-15 | 2000-01-11 | Us Gov Health & Human Serv | "vìrus sincicial respirátorio recombinante infeccioso isolado, partìcula do mesmo, processos para estimular o sistema imunológico de um indivìduo para induzir proteção contra o vìrus sincicial respiratório e para produzir uma partìcula de vìrus sincicial respiratório recombinante, vacina para induzir proteção contra o vìrus sincicial respiratório recombinante composição e ceta de vìrus sincicial respiratório recombinante" |
| EP0932684A2 (en) | 1996-09-27 | 1999-08-04 | American Cyanamid Company | 3' genomic promoter region and polymerase gene mutations responsible for attenuation in viruses of the order designated mononegavirales |
| KR100702523B1 (ko) | 1997-05-23 | 2007-04-04 | 더 가번먼트 오브 더 유나이티드 스테이츠 오브 아메리카, 에즈 레프리젠티드 바이 더 디파트먼트 오브 헬쓰 앤드 휴먼 서비시즈 | 클로닝된 뉴클레오타이드 서열로부터 약독화된파라인플루엔자 바이러스를 제조하는 방법 |
| JP4434478B2 (ja) | 1997-07-11 | 2010-03-17 | イエール ユニバーシティー | リエンジニアリングされた外被を有するラブドウイルス |
| CA2302867A1 (en) | 1997-09-19 | 1999-04-01 | American Cyanamid Company | Attenuated respiratory syncytial viruses |
| GB9815040D0 (en) | 1998-07-10 | 1998-09-09 | Medical Res Council | Conditional mutant |
| US6177082B1 (en) | 1998-08-13 | 2001-01-23 | The University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Cold-adapted equine influenza viruses |
| US6146642A (en) * | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
| US6544785B1 (en) * | 1998-09-14 | 2003-04-08 | Mount Sinai School Of Medicine Of New York University | Helper-free rescue of recombinant negative strand RNA viruses |
| CN1163613C (zh) | 1998-11-20 | 2004-08-25 | 中国科学院上海生物化学研究所 | 人白介素6核转录因子表达质粒系列及其在肿瘤治疗中的应用 |
| EP1035209A1 (en) | 1999-03-06 | 2000-09-13 | ARTEMIS Pharmaceuticals GmbH | Stable recombinant influenza viruses free of helper viruses |
| US8715940B2 (en) | 1999-04-06 | 2014-05-06 | Wisconsin Alumni Research Foundation | Method of making recombinant influenza virus |
| ATE368729T1 (de) | 1999-04-06 | 2007-08-15 | Wisconsin Alumni Res Found | Rekombinante influenzaviren zur vakzinherstellung und gentherapie |
| GB9923176D0 (en) | 1999-09-30 | 1999-12-01 | Smithkline Beecham Biolog | Novel composition |
| WO2001064860A2 (en) | 2000-03-02 | 2001-09-07 | Polymun Scientific Immunbiologische Forschung Gmbh | Recombinant influenza a viruses |
| US6951754B2 (en) * | 2000-04-28 | 2005-10-04 | St. Jude Children's Research Hospital | DNA transfection system for the generation of infectious influenza virus |
| EP1358319B1 (en) | 2000-09-25 | 2009-06-17 | Polymun Scientific Immunbiologische Forschung GmbH | Live influenza vaccine and method of manufacture |
| US7195905B2 (en) | 2001-12-10 | 2007-03-27 | Baxter Healthcare S.A. | Enveloped virus vaccine and method for production |
| US7465456B2 (en) | 2002-04-26 | 2008-12-16 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
| CN103540613A (zh) * | 2002-04-26 | 2014-01-29 | 米迪缪尼有限公司 | 制备流感病毒的多质粒系统 |
| KR101190932B1 (ko) | 2003-02-25 | 2012-10-16 | 메디뮨 엘엘씨 | 인플루엔자 백신 조성물의 제조 방법 |
| US20060110406A1 (en) | 2003-02-25 | 2006-05-25 | Medimmune Vaccines, Inc. | Refrigerator-temperature stable influenza vaccine compositions |
| US7566458B2 (en) | 2003-06-16 | 2009-07-28 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
| US7037707B2 (en) * | 2003-09-04 | 2006-05-02 | St. Jude Children's Research Hospital | Method for generating influenza viruses and vaccines |
| ATE469972T1 (de) | 2003-12-23 | 2010-06-15 | Medimmune Llc | Multiplasmid-system zur erzeugung des grippevirus |
| WO2005115448A2 (en) | 2004-05-24 | 2005-12-08 | Medimmune Vaccines, Inc. | Multi plasmid system for the production of influenza virus |
| KR101346989B1 (ko) | 2004-10-06 | 2014-02-06 | 메디뮨 엘엘씨 | 냉장 온도 안정성 인플루엔자 백신 조성물 |
| ES2382446T3 (es) | 2004-11-01 | 2012-06-08 | Eiken Kagaku Kabushiki Kaisha | Método de detección del virus de la gripe aviar H5 |
| US8673613B2 (en) | 2007-06-18 | 2014-03-18 | Medimmune, Llc | Influenza B viruses having alterations in the hemaglutinin polypeptide |
| KR20100136967A (ko) | 2008-02-15 | 2010-12-29 | 썬 파마 어드밴스트 리서치 컴패니 리미티드 | 파열 효과가 감소된 방출 제어 경구 정제 |
-
2004
- 2004-12-22 AT AT04814807T patent/ATE469972T1/de not_active IP Right Cessation
- 2004-12-22 AU AU2004308328A patent/AU2004308328B2/en not_active Ceased
- 2004-12-22 WO PCT/US2004/042669 patent/WO2005062820A2/en not_active Ceased
- 2004-12-22 DE DE602004027537T patent/DE602004027537D1/de not_active Expired - Lifetime
- 2004-12-22 ES ES04814807T patent/ES2345492T3/es not_active Expired - Lifetime
- 2004-12-22 JP JP2006547195A patent/JP4771959B2/ja not_active Expired - Lifetime
- 2004-12-22 CA CA2551489A patent/CA2551489C/en not_active Expired - Fee Related
- 2004-12-22 EP EP04814807A patent/EP1697521B1/en not_active Expired - Lifetime
- 2004-12-22 US US11/018,624 patent/US20050158342A1/en not_active Abandoned
-
2008
- 2008-12-16 US US12/336,158 patent/US8093033B2/en not_active Expired - Lifetime
-
2011
- 2011-04-06 JP JP2011084297A patent/JP5264955B2/ja not_active Expired - Lifetime
- 2011-12-01 US US13/309,498 patent/US8409843B2/en not_active Expired - Fee Related
-
2013
- 2013-02-27 US US13/779,549 patent/US9255253B2/en not_active Expired - Lifetime
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