|
WO2010045659A1
(en)
|
2008-10-17 |
2010-04-22 |
American Gene Technologies International Inc. |
Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules
|
|
WO2013066438A2
(en)
|
2011-07-22 |
2013-05-10 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
US20150166984A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting alpha-antitrypsin point mutations
|
|
AU2015298571B2
(en)
|
2014-07-30 |
2020-09-03 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
US11980663B2
(en)
|
2015-07-08 |
2024-05-14 |
American Gene Technologies International Inc. |
HIV pre-immunization and immunotherapy
|
|
JP7059179B2
(ja)
|
2015-10-20 |
2022-04-25 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
遺伝子操作のための方法及び製品
|
|
WO2017070632A2
(en)
|
2015-10-23 |
2017-04-27 |
President And Fellows Of Harvard College |
Nucleobase editors and uses thereof
|
|
IL297238B2
(en)
|
2016-01-15 |
2024-08-01 |
American Gene Tech Int Inc |
Methods and preparations for gamma-delta T-cell activation
|
|
US10137144B2
(en)
|
2016-01-15 |
2018-11-27 |
American Gene Technologies International Inc. |
Methods and compositions for the activation of gamma-delta T-cells
|
|
JP7153332B2
(ja)
|
2016-02-08 |
2022-10-14 |
アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド |
Ｈｉｖワクチン接種および免疫療法
|
|
ES2911448T3
(es)
|
2016-03-09 |
2022-05-19 |
American Gene Tech Int Inc |
Vectores combinados y métodos para el tratamiento del cáncer
|
|
WO2017213697A1
(en)
|
2016-06-08 |
2017-12-14 |
American Gene Technologies International Inc. |
Non-integrating viral delivery system and methods related thereto
|
|
CA3028982A1
(en)
|
2016-07-08 |
2018-01-11 |
American Gene Technologies International Inc. |
Hiv pre-immunization and immunotherapy
|
|
WO2018017882A1
(en)
|
2016-07-21 |
2018-01-25 |
American Gene Technologies International Inc. |
Viral vectors for treating parkinson's disease
|
|
WO2018027078A1
(en)
|
2016-08-03 |
2018-02-08 |
President And Fellows Of Harard College |
Adenosine nucleobase editors and uses thereof
|
|
AU2017308889B2
(en)
|
2016-08-09 |
2023-11-09 |
President And Fellows Of Harvard College |
Programmable Cas9-recombinase fusion proteins and uses thereof
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
KR20240007715A
(ko)
|
2016-10-14 |
2024-01-16 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵염기 에디터의 aav 전달
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
KR20190123328A
(ko)
|
2017-03-09 |
2019-10-31 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
암 백신
|
|
WO2018165504A1
(en)
|
2017-03-09 |
2018-09-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
|
CN110914310A
(zh)
|
2017-03-10 |
2020-03-24 |
哈佛大学的校长及成员们 |
胞嘧啶至鸟嘌呤碱基编辑器
|
|
IL306092A
(en)
|
2017-03-23 |
2023-11-01 |
Harvard College |
Nucleic base editors that include nucleic acid programmable DNA binding proteins
|
|
US11820999B2
(en)
|
2017-04-03 |
2023-11-21 |
American Gene Technologies International Inc. |
Compositions and methods for treating phenylketonuria
|
|
WO2018195360A1
(en)
|
2017-04-21 |
2018-10-25 |
Seattle Children's Hospital (Dba Seattle Childern's Research Institute) |
Therapeutic genome editing in wiskott-aldrich syndrome and x-linked thrombocytopenia
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
US12559769B2
(en)
|
2017-06-16 |
2026-02-24 |
American Gene Technologies International Inc. |
Methods and compositions for the activation of tumor cytotoxicity via human gamma-delta t-cells
|
|
EP3658573A1
(en)
|
2017-07-28 |
2020-06-03 |
President and Fellows of Harvard College |
Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace)
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
CA3082251A1
(en)
|
2017-10-16 |
2019-04-25 |
The Broad Institute, Inc. |
Uses of adenosine base editors
|
|
US12406749B2
(en)
|
2017-12-15 |
2025-09-02 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
KR102446690B1
(ko)
*
|
2017-12-22 |
2022-09-23 |
에이에스엠엘 네델란즈 비.브이. |
광학 수차를 포함하는 패터닝 공정 개선
|
|
JP2019198250A
(ja)
*
|
2018-05-14 |
2019-11-21 |
石原産業株式会社 |
ゲノム編集用キット
|
|
WO2019226953A1
(en)
|
2018-05-23 |
2019-11-28 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
EP3820495A4
(en)
|
2018-07-09 |
2022-07-20 |
The Broad Institute Inc. |
RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES
|
|
US20210261957A1
(en)
*
|
2018-07-10 |
2021-08-26 |
Alia Therapeutics S.R.L. |
Vesicles for traceless delivery of guide rna molecules and/or guide rna molecule/rna-guided nuclease complex(es) and a production method thereof
|
|
JP7306721B2
(ja)
*
|
2018-07-13 |
2023-07-11 |
国立大学法人京都大学 |
ウイルス様粒子及びその使用
|
|
WO2020022802A1
(ko)
*
|
2018-07-25 |
2020-01-30 |
주식회사 툴젠 |
인위적인 유전자 조작을 통한 자가면역질환 치료
|
|
EP3852813A4
(en)
|
2018-09-18 |
2022-06-22 |
VNV Newco Inc. |
ARC-BASED CAPSIDS AND THEIR USES
|
|
US20210403907A1
(en)
|
2018-09-18 |
2021-12-30 |
Vnv Newco Inc. |
Arc-based capsids and uses thereof
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
EP3876952A4
(en)
|
2018-11-05 |
2022-08-24 |
American Gene Technologies International Inc. |
VECTOR SYSTEM FOR EXPRESSING REGULATORY RNA
|
|
CN113330023A
(zh)
|
2018-11-08 |
2021-08-31 |
代表亚利桑那州立大学的亚利桑那校董会 |
体内具有crispr超级阻遏子的合成免疫调控
|
|
WO2020102709A1
(en)
*
|
2018-11-16 |
2020-05-22 |
The Regents Of The University Of California |
Compositions and methods for delivering crispr/cas effector polypeptides
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
US20220194990A1
(en)
*
|
2019-01-31 |
2022-06-23 |
Board Of Regents Of The University Of Nebraska |
Virus-like particles and methods of use thereof
|
|
WO2020191241A1
(en)
|
2019-03-19 |
2020-09-24 |
The Broad Institute, Inc. |
Methods and compositions for editing nucleotide sequences
|
|
WO2020214842A1
(en)
|
2019-04-17 |
2020-10-22 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
US20220259617A1
(en)
|
2019-06-13 |
2022-08-18 |
The General Hospital Corporation |
Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells
|
|
EP4009972A4
(en)
|
2019-08-09 |
2023-03-08 |
University of Utah Research Foundation |
"trpswitch" - a step function chemo-optogenetic ligand
|
|
EP4025698A1
(en)
|
2019-09-03 |
2022-07-13 |
Sana Biotechnology, Inc. |
Cd24-associated particles and related methods and uses thereof
|
|
US12551560B2
(en)
|
2019-09-09 |
2026-02-17 |
Scribe Therapeutics Inc. |
Compositions and methods for use in immunotherapy
|
|
EP4028522A1
(en)
|
2019-09-09 |
2022-07-20 |
Scribe Therapeutics Inc. |
Compositions and methods for the targeting of sod1
|
|
CN114616336B
(zh)
*
|
2019-09-20 |
2025-11-14 |
博德研究所 |
用于将货物递送至靶细胞的组合物和方法
|
|
US20240083973A1
(en)
|
2019-10-09 |
2024-03-14 |
Ecole Normale Supérieure de Lyon |
T cells modified to express mutated cxcr4 or partially deleted and uses thereof
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
WO2021113763A1
(en)
*
|
2019-12-06 |
2021-06-10 |
Scribe Therapeutics Inc. |
Compositions and methods for the targeting of rhodopsin
|
|
WO2021113772A1
(en)
*
|
2019-12-06 |
2021-06-10 |
Scribe Therapeutics Inc. |
Particle delivery systems
|
|
EP4069846A1
(en)
*
|
2019-12-07 |
2022-10-12 |
Scribe Therapeutics Inc. |
Compositions and methods for the targeting of htt
|
|
CA3177481A1
(en)
|
2020-05-08 |
2021-11-11 |
David R. Liu |
Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
|
|
BR112023001272A2
(pt)
*
|
2020-07-24 |
2023-04-04 |
Massachusetts Gen Hospital |
Partículas semelhantes a vírus aprimoradas e métodos de uso das mesmas para entrega às células
|
|
US12565647B2
(en)
|
2021-05-28 |
2026-03-03 |
The Regents Of The University Of California |
Compositions and methods for targeted delivery of CRISPR-Cas effector polypeptides and transgenes
|
|
IL308836A
(en)
|
2021-05-28 |
2024-01-01 |
Sana Biotechnology Inc |
Lipid Particles Containing Baboon Truncated Endogenous Retrovirus (BAEV) Envelope Glycoprotein and Related Methods and Uses
|
|
WO2022261150A2
(en)
*
|
2021-06-09 |
2022-12-15 |
Scribe Therapeutics Inc. |
Particle delivery systems
|
|
IL311610A
(en)
|
2021-09-21 |
2024-05-01 |
Scribe Therapeutics Inc |
Engineered CASX suppressor systems
|
|
WO2023077107A1
(en)
|
2021-10-29 |
2023-05-04 |
Sana Biotechnology, Inc. |
Methods and reagents for amplifying viral vector nucleic acid products
|
|
US20250223584A2
(en)
*
|
2021-12-03 |
2025-07-10 |
The Broad Institute, Inc. |
Compositions and methods for efficient in vivo delivery
|
|
IL313146A
(en)
*
|
2021-12-03 |
2024-07-01 |
Harvard College |
Self-assembling virus-like particles for delivery of prime editors and methods of making and using same
|
|
AU2022400961A1
(en)
*
|
2021-12-03 |
2024-05-30 |
President And Fellows Of Harvard College |
Self-assembling virus-like particles for delivery of nucleic acid programmable fusion proteins and methods of making and using same
|
|
WO2023114949A1
(en)
|
2021-12-16 |
2023-06-22 |
Sana Biotechnology, Inc. |
Methods and systems of particle production
|
|
EP4448775A1
(en)
|
2021-12-17 |
2024-10-23 |
Sana Biotechnology, Inc. |
Modified paramyxoviridae attachment glycoproteins
|
|
US20250059239A1
(en)
|
2021-12-17 |
2025-02-20 |
Sana Biotechnology, Inc. |
Modified paramyxoviridae fusion glycoproteins
|
|
US20250082777A1
(en)
|
2022-01-10 |
2025-03-13 |
Sana Biotechnology, Inc. |
Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
|
|
WO2023150518A1
(en)
|
2022-02-01 |
2023-08-10 |
Sana Biotechnology, Inc. |
Cd3-targeted lentiviral vectors and uses thereof
|
|
WO2023150647A1
(en)
|
2022-02-02 |
2023-08-10 |
Sana Biotechnology, Inc. |
Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses
|
|
US20260027145A1
(en)
|
2022-07-27 |
2026-01-29 |
Sana Biotechnology, Inc. |
Methods of transduction using a viral vector and inhibitors of antiviral restriction factors
|
|
WO2024044655A1
(en)
|
2022-08-24 |
2024-02-29 |
Sana Biotechnology, Inc. |
Delivery of heterologous proteins
|
|
EP4590688A1
(en)
|
2022-09-21 |
2025-07-30 |
Sana Biotechnology, Inc. |
Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof
|
|
EP4602174A1
(en)
|
2022-10-13 |
2025-08-20 |
Sana Biotechnology, Inc. |
Viral particles targeting hematopoietic stem cells
|
|
WO2024119157A1
(en)
|
2022-12-02 |
2024-06-06 |
Sana Biotechnology, Inc. |
Lipid particles with cofusogens and methods of producing and using the same
|
|
WO2024197008A2
(en)
*
|
2023-03-20 |
2024-09-26 |
The Broad Institute, Inc. |
Nuclease-guided non-ltr retrotransposons and uses thereof
|
|
EP4698666A1
(en)
|
2023-04-18 |
2026-02-25 |
Sana Biotechnology, Inc. |
Universal protein g fusogens and adapter systems thereof and related lipid particles and uses
|
|
WO2024220560A1
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Engineered protein g fusogens and related lipid particles and methods thereof
|
|
AU2024274792A1
(en)
|
2023-05-23 |
2025-10-23 |
Sana Biotechnology, Inc. |
Tandem fusogens and related lipid particles
|
|
WO2025137322A1
(en)
*
|
2023-12-20 |
2025-06-26 |
The Board Of Trustees Of The Leland Stanford Junior University |
Secreted particle information transfer (spit) system for genetic engineering
|
|
AU2025208175A1
(en)
|
2024-01-12 |
2026-06-25 |
Sana Biotechnology, Inc. |
Safety switches to control in vitro and in vivo proliferation of cell therapy products
|
|
WO2025184529A1
(en)
|
2024-03-01 |
2025-09-04 |
Sana Biotechnology, Inc. |
Viral particles with fusogen display and related compositions and methods
|
|
CN118547011A
(zh)
*
|
2024-06-05 |
2024-08-27 |
广州达博生物制品有限公司 |
一种稳定高表达人源悬浮细胞系的构建方法
|
|
WO2025262314A1
(en)
|
2024-06-21 |
2025-12-26 |
Institut National De La Sante Et De La Recherche Medicale |
Methods and products for prime editing genetic engineering
|
|
WO2025262311A1
(en)
|
2024-06-21 |
2025-12-26 |
Institut National De La Sante Et De La Recherche Medicale |
Methods and products for prime editing genetic engineering
|
|
WO2026107131A2
(en)
|
2024-11-14 |
2026-05-21 |
Orbital Therapeutics, Inc. |
Engineered viral particles for targeted delivery
|